Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: Distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair

Histochemistry and Cell Biology

Volumn 112, Issue 5, 1999, Pages 387-401

  Knittel, Thomas ^a,c   Kobold, Dominik ^a   Piscaglia, Fabio ^a   Saile, Bernhard ^a   Neubauer, Katrin ^a   Mehde, Mirko ^a   Timpl, Rupert ^b   Ramadori, Giuliano ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c DeveloGen AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; DESMIN; GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG INDUCED DISEASE; FIBROGENESIS; LIVER INJURY; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SCAR FORMATION; STELLATE CELL; TISSUE REPAIR;

ACTINS; ACUTE DISEASE; ANIMALS; CARBON TETRACHLORIDE POISONING; CHRONIC DISEASE; DESMIN; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; GLIAL FIBRILLARY ACIDIC PROTEIN; HEPATITIS, TOXIC; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERLEUKIN-6; LIVER; LIVER REGENERATION; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0032737478     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180050421     Document Type: Article

References (37)

1. Ballardini G, Fallani M, Biagini G, Bianchi FB, Pisi E (1988) Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis. Virchows Arch 56:45-49
2. Ballardini G, Groff P, Badiali de Giorgi L, Schuppan D, Bianchi F (1994) Ito cell heterogeneity: desmin-negative Ito cells in normal rat liver. Hepatology 19:440-446
3. Bhunchet E, Wake K (1992) Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology 16:1452-1473
4. Burt AD, Robertson JL, Heir J, MacSween RN (1986) Desmin-containing stellate cells in rat liver: distribution in normal animals and response to experimental acute liver injury. J Pathol 150:29-35
5. Dijkstra CD, A DE, Joling P, Kraal G (1985) The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulation in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology 54:589-599
6. Friedman SL (1996) Hepatic stellate cells. Prog Liver Dis 14:101-130
7. Geerts A, Lazou J, De Bleser P, Wisse E (1991) Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver. Hepatology 13:1193-1202
8. Gressner AM, Bachem MG (1995) Molecular mechanisms of liver fibrogenesis - a homage to the role of activated fat-storing cells. Digestion 56:335-346
9. Hautekeete ML, Geerts A (1997) The hepatic stellate (Ito) cell: its role in human liver disease. Virchows Arch 430:195-207
10. Herbst H, Frey A, Heinrichs O, Milani S, Bechstein WO, Neuhaus P, Schuppan D (1997) Heterogenity of liver cells expressing procollagen types I and IV in vivo. Histochem Cell Biol 107:399-409
11. Johnson S, Hines J, Burt A (1992) Phenotypic modulation of perisinusoidal cells following acute liver injury: a quantitative analysis. Int J Exp Pathol 73:765-772
12. Knittel T, Ramadori G (1994) Current concepts of liver fibrosis. Forum Trends Exp Clin Med 4:236-257
13. Knittel T, Armbrust T, Schwögler S, Schuppan D, Meyer zum Büschenfelde K-H, Ramadori G (1992a) Distribution and cellular origin of undulin in the rat liver. Lab Invest 67:779-787
14. Knittel T, Odenthal M, Schuppan D, Schwögler S, Just M, Meyer zum Büschenfelde K-H, Ramadori G (1992b) Synthesis of undulin by rat liver fat storing cells: comparison with fibronectin and tenascin. Exp Cell Res 203:312-320
15. Knittel T, Schuppan D, Meyer zum Büschenfelde K-H, Ramadori G (1992c) Differential expression of collagen types I, III, and IV by fat-storing (Ito) cells in vitro. Gastroenterology 102:1724-1735
16. Knittel T, Armbrust T, Neubauer K, Ramadori G (1995) Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells. Hepatology 21:470-476
17. Knittel T, Aurisch S, Neubauer K, Eichhorst S, Ramadori G (1996) Cell type specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver: up-regulation during in vitro activation and in hepatic tissue repair. Am J Pathol 149:449-462
18. Knittel T, Fellmer P, Neubauer K, Kawakami M, Grundmann A, Ramadori G (1997a) The complement activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo. Lab Invest 77:221-230
19. Knittel T, Müller L, Saile B, Ramadori G (1997b) Effect of tumor necrosis factor-alpha on proliferation, activation and protein synthesis of rat hepatic stellate cells. J Hepatol 27:1067-1080
20. Knittel T, Dinter C, Kobold D, Neubauer K, Mehde M, Eichhorst S, Ramadori G (1999a) Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in the recruitment of inflammatory cells during tissue repair. Am J Pathol 154:153-167
21. Knittel T, Kobold D, Saile B, Grundmann A, Neubauer K, Piscaglia F, Ramadori G (1999b) Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 117 (in press)
22. Neubauer K, Knittel T, Armbrust T, Ramadori G (1995) Accumulation and cellular localisation of fibrinogen/fibrin during short term and long term rat liver injury. Gastroenterology 108: 1124-1135
23. Neubauer K, Knittel T, Aurisch S, Fellmer P, Ramadori G (1996) Glial fibrillary acidic protein - a cell type specific marker protein for Ito cells in vivo and in vitro. J Hepatol 24:719-730
24. 4-induced fibrotic rat livers. Hepatology 23:1538-1545
25. Northemann W, Braciak TA, Hattori M, Lee F, Fey GH (1989) Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells. J Biol Chem 264:16072-16082
26. Pan T, Sasaki T, Zhang R, Fassler R, Timpl R, Chu M (1993) Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. J Cell Biol 123:1269-1277
27. Pinzani M (1995) Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 66:387-412
28. Ramadori G, Veit T, Schwögler S, Dienes HP, Knittel T, Rieder H, Meyer zum Büschenfelde K-H (1990) Expression of the gene of the alpha-smooth muscle actin isoform in rat liver and in rat fat storing (Ito) cells. Virchows Arch 59:349-357
29. Ramadori G, Schwögler S, Veit T, Rieder H, Chiquet-Ehrismann R, Mackie EJ, Meyer zum Büschenfelde K-H (1991) Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies. Virchows Arch B 60: 145-153
30. Ramadori G, Knittel T, Odenthal M, Schwögler S, Neubauer K, Meyer zum Büschenfelde K-H (1992) Synthesis of cellular fibronectin by rat liver fat-storing (Ito) cells: regulation by cytokines. Gastroenterology 103:1313-1321
31. Saile B, Knittel T, Matthes N, Schott P, Ramadori G (1997) CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol 151:1265-1272
32. Schmitt-Graff A, Kruger S, Bochard F, Gabbiani G, Denk H (1991) Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 138:1233-1242
33. Schmitt-Graff A, Chakroun G, Gabbiani G (1993) : Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis. Virchows Arch A 422: 99-107
34. Seifert W, Roholl P, Blauw B, van der Ham F, van Thiel-De Ruiter C, Seifert-Bock I, Bosma A, Knook D, Brouwer A (1994) : Fat-storing cells and myofibroblasts are involved in the initial phase of carbon tetrachloride-induced hepatic fibrosis in BN/BiRij rats. Int J Exp Pathol 75: 131-146
35. Tanaka Y, Nouchi T, Yamane M, Irie T, Miyakawa H, Sato C, Marumo F (1991) : Phenotypic modulation in lipocytes in experimental liver fibrosis. J Pathol 164: 273-278
36. Tang L, Tanaka Y, Marumo F, Sato C (1994) : Phenotypic change in portal fibroblasts in biliary fibrosis. Liver 14: 76-82
37. Tuchweber B, Desmouliere A, Bochaton PM, Rubbia BL, Gabbiani G (1996) : Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Lab Invest 74: 265-278