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Volumn 81, Issue 9, 2011, Pages 1065-1077

Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: Evidence from genetically modified mouse models and pharmacological inhibition

Author keywords

Antipsychotic; Attention; Cognition; Learning; NMDA

Indexed keywords

GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 1 INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROLEPTIC AGENT; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 79953683678     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.02.003     Document Type: Note
Times cited : (43)

References (134)
  • 1
    • 0015383552 scopus 로고
    • Catecholamines in the brain as mediators of amphetamine psychosis
    • S.H. Snyder Catecholamines in the brain as mediators of amphetamine psychosis Arch Gen Psychiatry 27 1972 169 179
    • (1972) Arch Gen Psychiatry , vol.27 , pp. 169-179
    • Snyder, S.H.1
  • 2
    • 0032814333 scopus 로고    scopus 로고
    • Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia
    • DOI 10.1016/S0006-3223(99)00061-X, PII S000632239900061X
    • D.A. Lewis, J.N. Pierri, D.W. Volk, D.S. Melchitzky, and T.U. Woo Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia Biol Psychiatry 46 1999 616 626 (Pubitemid 29401859)
    • (1999) Biological Psychiatry , vol.46 , Issue.5 , pp. 616-626
    • Lewis, D.A.1    Pierri, J.N.2    Volk, D.W.3    Melchitzky, D.S.4    Woo, T.-U.W.5
  • 3
    • 16344372645 scopus 로고    scopus 로고
    • Cortical inhibitory neurons and schizophrenia
    • DOI 10.1038/nrn1648
    • D.A. Lewis, T. Hashimoto, and D.W. Volk Cortical inhibitory neurons and schizophrenia Nat Rev Neurosci 6 2005 312 324 (Pubitemid 40469985)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.4 , pp. 312-324
    • Lewis, D.A.1    Hashimoto, T.2    Volk, D.W.3
  • 4
    • 57349167353 scopus 로고    scopus 로고
    • Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia
    • D.A. Lewis, R.Y. Cho, C.S. Carter, K. Eklund, S. Forster, and M.A. Kelly Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia Am J Psychiatry 165 2008 1585 1593
    • (2008) Am J Psychiatry , vol.165 , pp. 1585-1593
    • Lewis, D.A.1    Cho, R.Y.2    Carter, C.S.3    Eklund, K.4    Forster, S.5    Kelly, M.A.6
  • 5
    • 33847402548 scopus 로고    scopus 로고
    • Deciphering the disease process of schizophrenia: The contribution of cortical GABA neurons
    • D.A. Lewis, and T. Hashimoto Deciphering the disease process of schizophrenia: the contribution of cortical GABA neurons Int Rev Neurobiol 78 2007 109 131
    • (2007) Int Rev Neurobiol , vol.78 , pp. 109-131
    • Lewis, D.A.1    Hashimoto, T.2
  • 6
    • 0023082787 scopus 로고
    • Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia
    • D.C. Javitt Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia Hillside J Clin Psychiatry 9 1987 12 35
    • (1987) Hillside J Clin Psychiatry , vol.9 , pp. 12-35
    • Javitt, D.C.1
  • 7
    • 77953188782 scopus 로고    scopus 로고
    • Glutamatergic theories of schizophrenia
    • D.C. Javitt Glutamatergic theories of schizophrenia Isr J Psychiatry Relat Sci 47 2010 4 16
    • (2010) Isr J Psychiatry Relat Sci , vol.47 , pp. 4-16
    • Javitt, D.C.1
  • 8
    • 0032694066 scopus 로고    scopus 로고
    • NMDA receptor hypofunction model of schizophrenia
    • J.W. Olney, J.W. Newcomer, and N.B. Farber NMDA receptor hypofunction model of schizophrenia J Psychiatr Res 33 1999 523 533
    • (1999) J Psychiatr Res , vol.33 , pp. 523-533
    • Olney, J.W.1    Newcomer, J.W.2    Farber, N.B.3
  • 9
    • 0345830623 scopus 로고    scopus 로고
    • The NMDA Receptor Hypofunction Model of Psychosis
    • DOI 10.1196/annals.1300.008
    • N.B. Farber The NMDA receptor hypofunction model of psychosis Ann NY Acad Sci 1003 2003 119 130 (Pubitemid 38083050)
    • (2003) Annals of the New York Academy of Sciences , vol.1003 , pp. 119-130
    • Farber, N.B.1
  • 10
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • DOI 10.1038/361031a0
    • T.V. Bliss, and G.L. Collingridge A synaptic model of memory: long-term potentiation in the hippocampus Nature 361 1993 31 39 (Pubitemid 23020772)
    • (1993) Nature , vol.361 , Issue.6407 , pp. 31-39
    • Bliss, T.V.P.1    Collingridge, G.L.2
  • 12
    • 77956393566 scopus 로고    scopus 로고
    • Alterations of cortical GABA neurons and network oscillations in schizophrenia
    • G. Gonzalez-Burgos, T. Hashimoto, and D.A. Lewis Alterations of cortical GABA neurons and network oscillations in schizophrenia Curr Psychiatry Rep 12 2010 335 344
    • (2010) Curr Psychiatry Rep , vol.12 , pp. 335-344
    • Gonzalez-Burgos, G.1    Hashimoto, T.2    Lewis, D.A.3
  • 13
    • 54149109208 scopus 로고    scopus 로고
    • GABA neurons and the mechanisms of network oscillations: Implications for understanding cortical dysfunction in schizophrenia
    • G. Gonzalez-Burgos, and D.A. Lewis GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia Schizophr Bull 34 2008 944 961
    • (2008) Schizophr Bull , vol.34 , pp. 944-961
    • Gonzalez-Burgos, G.1    Lewis, D.A.2
  • 14
    • 0036784474 scopus 로고    scopus 로고
    • Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia
    • D.W. Volk, J.N. Pierri, J.M. Fritschy, S. Auh, A.R. Sampson, and D.A. Lewis Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia Cereb Cortex 12 2002 1063 1070
    • (2002) Cereb Cortex , vol.12 , pp. 1063-1070
    • Volk, D.W.1    Pierri, J.N.2    Fritschy, J.M.3    Auh, S.4    Sampson, A.R.5    Lewis, D.A.6
  • 15
    • 33749074397 scopus 로고    scopus 로고
    • Glutamate and schizophrenia: Beyond the dopamine hypothesis
    • J.T. Coyle Glutamate and schizophrenia: beyond the dopamine hypothesis Cell Mol Neurobiol 26 2006 365 384
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 365-384
    • Coyle, J.T.1
  • 16
    • 77149138329 scopus 로고    scopus 로고
    • Glutamatergic (N-methyl-d-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain?
    • G.J. Marek, B. Behl, A.Y. Bespalov, G. Gross, Y. Lee, and H. Schoemaker Glutamatergic (N-methyl-d-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain? Mol Pharmacol 77 2010 317 326
    • (2010) Mol Pharmacol , vol.77 , pp. 317-326
    • Marek, G.J.1    Behl, B.2    Bespalov, A.Y.3    Gross, G.4    Lee, Y.5    Schoemaker, H.6
  • 17
    • 36849005064 scopus 로고    scopus 로고
    • Glycine Transport Inhibitors and the Treatment of Schizophrenia
    • DOI 10.1016/j.biopsych.2007.09.017, PII S0006322307008918, Schizophrenia: From Genetics to Treatment
    • D.C. Javitt Glycine transport inhibitors and the treatment of schizophrenia Biol Psychiatry 63 2008 6 8 (Pubitemid 350234898)
    • (2008) Biological Psychiatry , vol.63 , Issue.1 , pp. 6-8
    • Javitt, D.C.1
  • 18
    • 35748969317 scopus 로고    scopus 로고
    • The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • DOI 10.1176/appi.ajp.2007.06081358
    • R.W. Buchanan, D.C. Javitt, S.R. Marder, N.R. Schooler, J.M. Gold, and R.P. McMahon The cognitive and negative symptoms in Schizophrenia trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments Am J Psychiatry 164 2007 1593 1602 (Pubitemid 350069740)
    • (2007) American Journal of Psychiatry , vol.164 , Issue.10 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3    Schooler, N.R.4    Gold, J.M.5    McMahon, R.P.6    Heresco-Levy, U.7    Carpenter, W.T.8
  • 21
    • 27744529018 scopus 로고    scopus 로고
    • Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: A randomized, double-blind, placebo-controlled study
    • DOI 10.1001/archpsyc.62.11.1196
    • H.Y. Lane, Y.C. Chang, Y.C. Liu, C.C. Chiu, and G.E. Tsai Sarcosine or d-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study Arch Gen Psychiatry 62 2005 1196 1204 (Pubitemid 41586919)
    • (2005) Archives of General Psychiatry , vol.62 , Issue.11 , pp. 1196-1204
    • Lane, H.-Y.1    Chang, Y.-C.2    Liu, Y.-C.3    Chiu, C.-C.4    Tsai, G.E.5
  • 22
    • 33748751382 scopus 로고    scopus 로고
    • Glycine transporter i inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia
    • H.Y. Lane, C.L. Huang, P.L. Wu, Y.C. Liu, Y.C. Chang, and P.Y. Lin Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia Biol Psychiatry 160 2006 645 649
    • (2006) Biol Psychiatry , vol.160 , pp. 645-649
    • Lane, H.Y.1    Huang, C.L.2    Wu, P.L.3    Liu, Y.C.4    Chang, Y.C.5    Lin, P.Y.6
  • 23
    • 77953545879 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and d-serine add-on treatment for schizophrenia
    • H.Y. Lane, C.H. Lin, Y.J. Huang, C.H. Liao, Y.C. Chang, and G.E. Tsai A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and d-serine add-on treatment for schizophrenia Int J Neuropsychopharmacol 13 2010 451 460
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 451-460
    • Lane, H.Y.1    Lin, C.H.2    Huang, Y.J.3    Liao, C.H.4    Chang, Y.C.5    Tsai, G.E.6
  • 24
    • 36849071470 scopus 로고    scopus 로고
    • Sarcosine (N-methylglycine) treatment for acute schizophrenia: A randomized, double-blind study
    • H.Y. Lane, Y.C. Liu, C.L. Huang, Y.C. Chang, C.H. Liau, and C.H. Perng Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study Biol Psychiatry 63 2008 9 12
    • (2008) Biol Psychiatry , vol.63 , pp. 9-12
    • Lane, H.Y.1    Liu, Y.C.2    Huang, C.L.3    Chang, Y.C.4    Liau, C.H.5    Perng, C.H.6
  • 25
    • 15944428993 scopus 로고    scopus 로고
    • Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: Implications for mechanisms of action
    • D.C. Javitt, L. Duncan, A. Balla, and H. Sershen Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action Mol Psychiatry 10 2005 275 287
    • (2005) Mol Psychiatry , vol.10 , pp. 275-287
    • Javitt, D.C.1    Duncan, L.2    Balla, A.3    Sershen, H.4
  • 26
    • 77949447469 scopus 로고    scopus 로고
    • Strategies to enhance N-methyl-d-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis
    • G.E. Tsai, and P.Y. Lin Strategies to enhance N-methyl-d-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis Curr Pharm Des 16 2010 522 537
    • (2010) Curr Pharm des , vol.16 , pp. 522-537
    • Tsai, G.E.1    Lin, P.Y.2
  • 27
    • 77953771657 scopus 로고    scopus 로고
    • Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia
    • E. Pinard, A. Alanine, D. Alberati, M. Bender, E. Borroni, and P. Bourdeaux Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia J Med Chem 53 2010 4603 4614
    • (2010) J Med Chem , vol.53 , pp. 4603-4614
    • Pinard, E.1    Alanine, A.2    Alberati, D.3    Bender, M.4    Borroni, E.5    Bourdeaux, P.6
  • 28
    • 10744221393 scopus 로고    scopus 로고
    • Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition
    • DOI 10.1016/S0896-6273(03)00672-X
    • J. Gomeza, S. Hulsmann, K. Ohno, V. Eulenburg, K. Szoke, and D. Richter Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition Neuron 40 2003 785 796 (Pubitemid 37431038)
    • (2003) Neuron , vol.40 , Issue.4 , pp. 785-796
    • Gomeza, J.1    Hulsmann, S.2    Ohno, K.3    Eulenburg, V.4    Szoke, K.5    Richter, D.6    Betz, H.7
  • 29
    • 0242544067 scopus 로고    scopus 로고
    • Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality
    • DOI 10.1016/S0896-6273(03)00673-1
    • J. Gomeza, K. Ohno, S. Hulsmann, W. Armsen, V. Eulenburg, and D.W. Richter Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality Neuron 40 2003 797 806 (Pubitemid 37431039)
    • (2003) Neuron , vol.40 , Issue.4 , pp. 797-806
    • Gomeza, J.1    Ohno, K.2    Hulsmann, S.3    Armsen, W.4    Eulenburg, V.5    Richter, D.W.6    Laube, B.7    Betz, H.8
  • 30
    • 15844362335 scopus 로고    scopus 로고
    • Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice
    • DOI 10.1113/jphysiol.2004.080655
    • M.M.E. Martina, B.T. Halman, S. Tsai, G. Tiberi, M. Tiberi, and J.T. Coyle Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice J Physiol 563 2005 777 793 (Pubitemid 40425594)
    • (2005) Journal of Physiology , vol.563 , Issue.3 , pp. 777-793
    • Martina, M.1    Turcotte, M.-E.B.2    Halman, S.3    Tsai, G.4    Tiberi, M.5    Coyle, J.T.6    Bergeron, R.7
  • 33
    • 33645214436 scopus 로고    scopus 로고
    • Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile
    • B.K. Yee, E. Balic, P. Singer, C. Schwerdel, T. Grampp, and L. Gabernet Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile J Neurosci 26 2006 3169 3181
    • (2006) J Neurosci , vol.26 , pp. 3169-3181
    • Yee, B.K.1    Balic, E.2    Singer, P.3    Schwerdel, C.4    Grampp, T.5    Gabernet, L.6
  • 34
    • 1942487359 scopus 로고    scopus 로고
    • Dorsal Telencephalon-Specific Expression of Cre Recombinase in PAC Transgenic Mice
    • DOI 10.1002/gene.20009
    • T. Iwasato, R. Nomura, R. Ando, T. Ikeda, M. Tanaka, and S. Itohara Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice Genesis 38 2004 130 138 (Pubitemid 38506850)
    • (2004) Genesis , vol.38 , Issue.3 , pp. 130-138
    • Iwasato, T.1    Nomura, R.2    Ando, R.3    Ikeda, T.4    Tanaka, M.5    Itohara, S.6
  • 35
    • 67349244893 scopus 로고    scopus 로고
    • Altered mnemonic functions and resistance to N-methyl-d-aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1
    • P. Singer, B.K. Yee, J. Feldon, T. Iwasato, S. Itohara, and T. Grampp Altered mnemonic functions and resistance to N-methyl-d-aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1 Neuroscience 161 2009 635 654
    • (2009) Neuroscience , vol.161 , pp. 635-654
    • Singer, P.1    Yee, B.K.2    Feldon, J.3    Iwasato, T.4    Itohara, S.5    Grampp, T.6
  • 36
    • 0035312367 scopus 로고    scopus 로고
    • Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain
    • DOI 10.1101/gad.862101
    • Y. Zhu, M.I. Romero, P. Ghosh, Z. Ye, P. Charnay, and E.J. Rushing Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain Genes Dev 15 2001 859 876 (Pubitemid 32295067)
    • (2001) Genes and Development , vol.15 , Issue.7 , pp. 859-876
    • Zhu, Y.1    Romero, M.I.2    Ghosh, P.3    Ye, Z.4    Charnay, P.5    Rushing, E.J.6    Marth, J.D.7    Parada, L.F.8
  • 37
    • 77954406611 scopus 로고    scopus 로고
    • Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice
    • V. Eulenburg, M. Retiounskaia, T. Papadopoulos, J. Gomeza, and H. Betz Glial glycine transporter 1 function is essential for early postnatal survival but dispensable in adult mice Glia 58 2010 1066 1073
    • (2010) Glia , vol.58 , pp. 1066-1073
    • Eulenburg, V.1    Retiounskaia, M.2    Papadopoulos, T.3    Gomeza, J.4    Betz, H.5
  • 38
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • S. Marino, M. Vooijs, H. van Der Gulden, J. Jonkers, and A. Berns Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum Genes Dev 14 2000 994 1004 (Pubitemid 30253007)
    • (2000) Genes and Development , vol.14 , Issue.8 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    Van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 39
    • 35748942594 scopus 로고    scopus 로고
    • Enhanced Recognition Memory Following Glycine Transporter 1 Deletion in Forebrain Neurons
    • DOI 10.1037/0735-7044.121.5.815, PII S0735704407605217
    • P. Singer, D. Boison, H. Möhler, J. Feldon, and B.K. Yee Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons Behav Neurosci 121 2007 815 825 (Pubitemid 350051286)
    • (2007) Behavioral Neuroscience , vol.121 , Issue.5 , pp. 815-825
    • Singer, P.1    Boison, D.2    Mohler, H.3    Feldon, J.4    Yee, B.K.5
  • 40
    • 70350121957 scopus 로고    scopus 로고
    • Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: Enhanced cognitive adaptability?
    • P. Singer, D. Boison, H. Möhler, J. Feldon, and B.K. Yee Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability? Behav Neurosci 123 2009 1012 1027
    • (2009) Behav Neurosci , vol.123 , pp. 1012-1027
    • Singer, P.1    Boison, D.2    Möhler, H.3    Feldon, J.4    Yee, B.K.5
  • 41
    • 79953756501 scopus 로고    scopus 로고
    • Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice
    • in press (PMCID: PMC2980791)
    • Singer P, Boison D, Möhler H, Feldon J, Yee BK. Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice. Eur Neuropsychopharmacol; in press (PMCID: PMC2980791).
    • Eur Neuropsychopharmacol
    • Singer, P.B.1
  • 42
    • 78650109396 scopus 로고    scopus 로고
    • Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: Evidence for age-dependent phenotypes in Pavlovian learning
    • S. Dubroqua, P. Singer, D. Boison, J. Feldon, H. Mohler, and B.K. Yee Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning Behav Neurosci 124 2010 839 850
    • (2010) Behav Neurosci , vol.124 , pp. 839-850
    • Dubroqua, S.1    Singer, P.2    Boison, D.3    Feldon, J.4    Mohler, H.5    Yee, B.K.6
  • 43
    • 44749084727 scopus 로고    scopus 로고
    • The cognitive neuroscience of working memory: Relevance to CNTRICS and schizophrenia
    • D.M. Barch, and E. Smith The cognitive neuroscience of working memory: relevance to CNTRICS and schizophrenia Biol Psychiatry 64 2008 11 17
    • (2008) Biol Psychiatry , vol.64 , pp. 11-17
    • Barch, D.M.1    Smith, E.2
  • 44
    • 71749101289 scopus 로고    scopus 로고
    • Working memory and long-term memory deficits in schizophrenia: Is there a common substrate?
    • J.X. Van Snellenberg Working memory and long-term memory deficits in schizophrenia: is there a common substrate? Psychiatry Res 174 2009 89 96
    • (2009) Psychiatry Res , vol.174 , pp. 89-96
    • Van Snellenberg, J.X.1
  • 47
    • 0025190458 scopus 로고    scopus 로고
    • Sensorimotor gating and schizophrenia: Human and animal model studies
    • D. Braff, M.A. Geyer, and N.R. Swerdlow Sensorimotor gating and schizophrenia: human and animal model studies Arch Gen Psychiatry 47 2001 181 188
    • (2001) Arch Gen Psychiatry , vol.47 , pp. 181-188
    • Braff, D.1    Geyer, M.A.2    Swerdlow, N.R.3
  • 48
    • 0026581360 scopus 로고
    • Gating and habituation of the startle reflex in schizophrenic patients
    • Braff Dl, C. Grillon, and M.A. Geyer Gating and habituation of the startle reflex in schizophrenic patients Arch Gen Psychiatry 49 1992 206 215
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 206-215
    • Dl, B.1    Grillon, C.2    Geyer, M.A.3
  • 49
    • 0026960330 scopus 로고
    • Abolition of latent inhibition in acute, but not chronic, schizophrenics
    • N.S. Gray, D.R. Hemsley, and J.A. Gray Abolition of latent inhibition in acute, but not chronic, schizophrenics Neurol Psychiatry Brain Res 1 1992 83 89 (Pubitemid 24025553)
    • (1992) Neurology Psychiatry and Brain Research , vol.1 , Issue.2 , pp. 83-89
    • Gray, N.S.1    Hemsley, D.R.2    Gray, J.A.3
  • 51
    • 0028371468 scopus 로고
    • Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients
    • N.R. Swerdlow, D.L. Braff, N. Taaid, and M.A. Geyer Assessing the validity of an animal model of deficient sensorimotor gating inschizophrenia patients Arch Gen Psychiatry 51 1994 139 154 (Pubitemid 24985903)
    • (1994) Archives of General Psychiatry , vol.51 , Issue.2 , pp. 139-154
    • Swerdlow, N.R.1    Braff, D.L.2    Taaid, N.3    Geyer, M.A.4
  • 53
    • 33845870142 scopus 로고    scopus 로고
    • Neurophysiological endophenotypes of schizophrenia: The viability of selected candidate measures
    • DOI 10.1093/schbul/sbl060
    • B.I. Turetsky, M.E. Calkins, G.A. Light, A. Olincy, A.D. Radant, and N.R. Swerdlow Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures Schizophr Bull 33 2007 69 94 (Pubitemid 46026260)
    • (2007) Schizophrenia Bulletin , vol.33 , Issue.1 , pp. 69-94
    • Turetsky, B.I.1    Calkins, M.E.2    Light, G.A.3    Olincy, A.4    Radant, A.D.5    Swerdlow, N.R.6
  • 54
    • 33644876567 scopus 로고    scopus 로고
    • Reduced prepulse inhibition in unaffected siblings of schizophrenia patients
    • DOI 10.1111/j.1469-8986.2005.00346.x
    • V. Kumari, M. Das, E. Zachariah, U. Ettinger, and T. Sharma Reduced prepulse inhibition in unaffected siblings of schizophrenia patients Psychophysiology 42 2005 588 594 (Pubitemid 43942839)
    • (2005) Psychophysiology , vol.42 , Issue.5 , pp. 588-594
    • Kumari, V.1    Das, M.2    Zachariah, E.3    Ettinger, U.4    Sharma, T.5
  • 55
    • 0034917841 scopus 로고    scopus 로고
    • Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: A decade in review
    • DOI 10.1007/s002130100811
    • M.A. Geyer, K. Krebs-Thomson, D.L. Braff, and N.R. Swerdlow Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review Psychopharmacology (Berl) 156 2001 117 154 (Pubitemid 32702206)
    • (2001) Psychopharmacology , vol.156 , Issue.2-3 , pp. 117-154
    • Geyer, M.A.1    Krebs-Thomson, K.2    Braff, D.L.3    Swerdlow, N.R.4
  • 56
    • 46649110318 scopus 로고    scopus 로고
    • Realistic expectations of prepulse inhibition in translational models for schizophrenia research
    • N.R. Swerdlow, M. Weber, Y. Qu, G.A. Light, and D.L. Braff Realistic expectations of prepulse inhibition in translational models for schizophrenia research Psychopharmacology (Berl) 9 2008 331 388
    • (2008) Psychopharmacology (Berl) , vol.9 , pp. 331-388
    • Swerdlow, N.R.1    Weber, M.2    Qu, Y.3    Light, G.A.4    Braff, D.L.5
  • 57
    • 69249215243 scopus 로고    scopus 로고
    • Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment
    • I. Weiner, and M. Arad Using the pharmacology of latent inhibition to model domains of pathology in schizophrenia and their treatment Behav Brain Res 204 2009 369 386
    • (2009) Behav Brain Res , vol.204 , pp. 369-386
    • Weiner, I.1    Arad, M.2
  • 58
    • 0014388970 scopus 로고
    • Latent inhibition: The effect of nonreinforced preexposure to the conditional stimulus
    • R.E. Lubow, and A.U. Moore Latent inhibition: the effect of nonreinforced preexposure to the conditional stimulus J Comp Physiol Psychol 66 1959 688 694
    • (1959) J Comp Physiol Psychol , vol.66 , pp. 688-694
    • Lubow, R.E.1    Moore, A.U.2
  • 59
    • 0016504948 scopus 로고
    • The more or less startling effects of weak prestimulation
    • F. Graham The more or less startling effects of weak prestimulation Psychophysiology 12 1975 238 248
    • (1975) Psychophysiology , vol.12 , pp. 238-248
    • Graham, F.1
  • 60
    • 0008808158 scopus 로고
    • Acoustic variables in the modification of startle reaction in the rat
    • H.S. Hoffman, and J.L. Searle Acoustic variables in the modification of startle reaction in the rat J Comp Physiol Psychol 60 1965 53 58
    • (1965) J Comp Physiol Psychol , vol.60 , pp. 53-58
    • Hoffman, H.S.1    Searle, J.L.2
  • 61
    • 0025520950 scopus 로고
    • Neural substrates of latent inhibition: The switching model
    • I. Weiner Neural substrates of latent inhibition: the switching model Psychol Bull 108 1990 442 461
    • (1990) Psychol Bull , vol.108 , pp. 442-461
    • Weiner, I.1
  • 62
    • 50349084472 scopus 로고    scopus 로고
    • 103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia
    • D. Boulay, P. Pichat, G. Dargazanli, G. Estenne-Bouhtou, J.P. Terranova, and N. Rogacki 103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia Pharmacol Biochem Behav 91 2008 47 58
    • (2008) Pharmacol Biochem Behav , vol.91 , pp. 47-58
    • Boulay, D.1    Pichat, P.2    Dargazanli, G.3    Estenne-Bouhtou, G.4    Terranova, J.P.5    Rogacki, N.6
  • 63
    • 0022725590 scopus 로고
    • Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
    • T.E. Robinson, and J.B. Becker Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis Brain Res 396 1986 157 159
    • (1986) Brain Res , vol.396 , pp. 157-159
    • Robinson, T.E.1    Becker, J.B.2
  • 64
    • 0034054794 scopus 로고    scopus 로고
    • The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies
    • M. Laruelle The role of endogenous sensitization in the pathophysiology of schizophrenia: implications from recent brain imaging studies Brain Res Brain Res Rev 31 2000 371 378
    • (2000) Brain Res Brain Res Rev , vol.31 , pp. 371-378
    • Laruelle, M.1
  • 65
    • 40349106017 scopus 로고    scopus 로고
    • Modelling prefrontal cortex deficits in schizophrenia: Implications for treatment
    • J.A. Pratt, C. Winchester, A. Egerton, S.M. Cochran, and B.J. Morris Modelling prefrontal cortex deficits in schizophrenia: implications for treatment Br J Pharmacol 153 March (Suppl. 1) 2008 S465 S470
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Pratt, J.A.1    Winchester, C.2    Egerton, A.3    Cochran, S.M.4    Morris, B.J.5
  • 66
    • 3142661662 scopus 로고    scopus 로고
    • Animal models of working memory: Insights for targeting cognitive dysfunction in schizophrenia
    • Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia. Psychopharmacology 2004;174:111-25.
    • (2004) Psychopharmacology , vol.174 , pp. 111-125
  • 67
    • 23244437953 scopus 로고    scopus 로고
    • Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
    • DOI 10.1016/j.neubiorev.2004.10.012, PII S0149763405000813, Festschrift in Honour of Jeffrey Gray - Issue 2: Schizophrenia and Consciousness
    • U. Meyer, J. Feldon, M. Schedlowski, and B.K. Yee Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia Neurosci Biobehav Rev 29 2005 913 947 (Pubitemid 41097394)
    • (2005) Neuroscience and Biobehavioral Reviews , vol.29 , Issue.6 , pp. 913-947
    • Meyer, U.1    Feldon, J.2    Schedlowski, M.3    Yee, B.K.4
  • 68
    • 69249107681 scopus 로고    scopus 로고
    • A review of the fetal brain cytokine imbalance hypothesis of schizophrenia
    • U. Meyer, J. Feldon, and B.K. Yee A review of the fetal brain cytokine imbalance hypothesis of schizophrenia Schizophr Bull 35 2009 959 967
    • (2009) Schizophr Bull , vol.35 , pp. 959-967
    • Meyer, U.1    Feldon, J.2    Yee, B.K.3
  • 69
    • 41849084434 scopus 로고    scopus 로고
    • The postweaning social isolation in C57BL/6 mice: Preferential vulnerability in the male sex
    • S. Pietropaolo, P. Singer, J. Feldon, and B.K. Yee The postweaning social isolation in C57BL/6 mice: preferential vulnerability in the male sex Psychopharmacology 197 2008 613 628
    • (2008) Psychopharmacology , vol.197 , pp. 613-628
    • Pietropaolo, S.1    Singer, P.2    Feldon, J.3    Yee, B.K.4
  • 70
    • 79960357927 scopus 로고    scopus 로고
    • Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders
    • M. Niwa, Y. Matsumoto, A. Mouri, N. Ozaki, and T. Nabeshima Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders Int J Neuropsychopharmacol 18 2010 1 19
    • (2010) Int J Neuropsychopharmacol , vol.18 , pp. 1-19
    • Niwa, M.1    Matsumoto, Y.2    Mouri, A.3    Ozaki, N.4    Nabeshima, T.5
  • 71
    • 0030811293 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide
    • DOI 10.1016/S0893-133X(97)00047-X
    • D.C. Javitt, H. Sershen, A. Hashim, and A. Lajtha Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide Neuropsychopharmacology 17 1997 202 204 (Pubitemid 27365961)
    • (1997) Neuropsychopharmacology , vol.17 , Issue.3 , pp. 202-204
    • Javitt, D.C.1    Sershen, H.2    Hashim, A.3    Lajtha, A.4
  • 72
    • 0031024622 scopus 로고    scopus 로고
    • Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: Implications for schizophrenia and substance abuse
    • DOI 10.1007/s002130050168
    • D.C. Javitt, and M. Frusciante Glycyldodecylamide, a phencyclidine behavioural antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse Psychopharmacology (Berl) 129 1997 96 98 (Pubitemid 27037457)
    • (1997) Psychopharmacology , vol.129 , Issue.1 , pp. 96-98
    • Javitt, D.C.1    Frusciante, M.2
  • 73
    • 57349094379 scopus 로고    scopus 로고
    • Design of potent GlyT1 inhibitors: In vitro and in vivo profiles
    • T.M. Bridges, R. Williams, and C.W. Lindsley Design of potent GlyT1 inhibitors: in vitro and in vivo profiles Curr Opin Mol Ther 10 2008 591 601
    • (2008) Curr Opin Mol Ther , vol.10 , pp. 591-601
    • Bridges, T.M.1    Williams, R.2    Lindsley, C.W.3
  • 74
    • 33745119671 scopus 로고    scopus 로고
    • Glycine transporter inhibitors as therapeutic agents for schizophrenia
    • K. Hashimoto Glycine transporter inhibitors as therapeutic agents for schizophrenia Recent Pat CNS Drug Discov 1 2006 43 53
    • (2006) Recent Pat CNS Drug Discov , vol.1 , pp. 43-53
    • Hashimoto, K.1
  • 75
    • 67649989298 scopus 로고    scopus 로고
    • Glycine transport inhibitors for the treatment of schizophrenia: Symptom and disease modification
    • D.C. Javitt Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification Curr Opin Drug Discov Dev 12 2009 468 478
    • (2009) Curr Opin Drug Discov Dev , vol.12 , pp. 468-478
    • Javitt, D.C.1
  • 76
    • 37349109630 scopus 로고    scopus 로고
    • Interference of glycine transporter 1: Modulation of cognitive functions via activation of glycine-B site of the NMDA receptor
    • DOI 10.2174/187152407783220841
    • P. Singer, J. Feldon, and B.K. Yee Interference of glycine transporter 1: modulation of cognitive functions via activation of glycine-B site of the NMDA receptor CNS Agents Med Chem 7 2007 259 268 (Pubitemid 350291651)
    • (2007) Central Nervous System Agents in Medicinal Chemistry , vol.7 , Issue.4 , pp. 259-268
    • Singer, P.1    Feldon, J.2    Yee, B.K.3
  • 79
    • 0037320805 scopus 로고    scopus 로고
    • Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo
    • DOI 10.1152/jn.00680.2002
    • L. Chen, M. Muhlhauser, and C.R. Yang Glycine transporter-1blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo J Neurophysiol 89 2003 691 703 (Pubitemid 36206118)
    • (2003) Journal of Neurophysiology , vol.89 , Issue.2 , pp. 691-703
    • Chen, L.1    Muhlhauser, M.2    Yang, C.R.3
  • 80
    • 0041920952 scopus 로고    scopus 로고
    • The glycine transporter type 1 inhibitor N-[3-(4′-fluorophenyl)-3- (4′-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior
    • G.G. Kinney, C. Sur, M. Burno, P.J. Mallorga, J.B. Williams, and D.J. Figueroa The glycine transporter type 1 inhibitor N-[3-(4′-fluorophenyl)- 3-(4′-phenylphenoxy) propyl] sarcosine potentiates NMDA receptor-mediated resposes in vivo and produces an antipsychotic profile in rodent behaviour J Neurosci 23 2003 7586 7591 (Pubitemid 37034075)
    • (2003) Journal of Neuroscience , vol.23 , Issue.20 , pp. 7586-7591
    • Kinney, G.G.1    Sur, C.2    Burno, M.3    Mallorga, P.J.4    Williams, J.B.5    Figueroa, D.J.6    Wittmann, M.7    Lemaire, W.8    Conn, P.J.9
  • 81
    • 77957821700 scopus 로고    scopus 로고
    • Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential
    • D. Alberati, J.L. Moreau, R. Mory, E. Pinard, and J.G. Wettstein Pharmacological evaluation of a novel assay for detecting glycine transporter 1 inhibitors and their antipsychotic potential Pharmacol Biochem Behav 97 2010 185 191
    • (2010) Pharmacol Biochem Behav , vol.97 , pp. 185-191
    • Alberati, D.1    Moreau, J.L.2    Mory, R.3    Pinard, E.4    Wettstein, J.G.5
  • 82
    • 26444512148 scopus 로고    scopus 로고
    • Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives
    • DOI 10.1176/appi.ajp.162.10.1963
    • M.E. Calkins, R.C. Gur, J.D. Ragland, and R.E. Gur Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives Am J Psychiatry 162 2005 1963 1966 (Pubitemid 41428629)
    • (2005) American Journal of Psychiatry , vol.162 , Issue.10 , pp. 1963-1966
    • Calkins, M.E.1    Gur, R.C.2    Ragland, J.D.3    Gur, R.E.4
  • 83
    • 77953289841 scopus 로고    scopus 로고
    • D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats
    • T. Shimazaki, A. Kaku, and S. Chaki d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats Psychopharmacology (Berl) 209 2010 263 270
    • (2010) Psychopharmacology (Berl) , vol.209 , pp. 263-270
    • Shimazaki, T.1    Kaku, A.2    Chaki, S.3
  • 84
    • 59449096382 scopus 로고    scopus 로고
    • The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice
    • P. Singer, J. Feldon, and B.K. Yee The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice Psychopharmacology (Berl) 202 2009 371 384
    • (2009) Psychopharmacology (Berl) , vol.202 , pp. 371-384
    • Singer, P.1    Feldon, J.2    Yee, B.K.3
  • 85
    • 67650831204 scopus 로고    scopus 로고
    • Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala
    • S.C. Mao, H.C. Lin, and P.W. Gean Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala Mol Pharmacol 76 2009 369 378
    • (2009) Mol Pharmacol , vol.76 , pp. 369-378
    • Mao, S.C.1    Lin, H.C.2    Gean, P.W.3
  • 86
    • 67349167781 scopus 로고    scopus 로고
    • Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour
    • P. Singer, J. Feldon, and B.K. Yee Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour Eur Neuropsychopharmacol 19 2009 571 580
    • (2009) Eur Neuropsychopharmacol , vol.19 , pp. 571-580
    • Singer, P.1    Feldon, J.2    Yee, B.K.3
  • 87
    • 77955981325 scopus 로고    scopus 로고
    • A glycine transporter-1 inhibitor, attenuates acquisition and expression of contextual conditioned fear in rats
    • H. Nishikawa, T. Inoue, T. Izumi, S. Nakagawa, and T. Koyama A glycine transporter-1 inhibitor, attenuates acquisition and expression of contextual conditioned fear in rats Behav Pharmacol 21 2010 576 579 SSR504734
    • (2010) Behav Pharmacol , vol.21 , pp. 576-579
    • Nishikawa, H.1    Inoue, T.2    Izumi, T.3    Nakagawa, S.4    Koyama, T.5
  • 89
    • 53149130964 scopus 로고    scopus 로고
    • Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1)
    • D. Manahan-Vaughan, V. Wildförster, and C. Thomsen Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1) Eur J Neurosci 28 2008 1342 1350
    • (2008) Eur J Neurosci , vol.28 , pp. 1342-1350
    • Manahan-Vaughan, D.1    Wildförster, V.2    Thomsen, C.3
  • 90
    • 34249888474 scopus 로고    scopus 로고
    • Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment
    • DOI 10.1007/s00213-007-0742-y
    • S. Harich, G. Gross, and A. Bespalov Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment Psychopharmacology (Berl) 192 2007 511 519 (Pubitemid 46870746)
    • (2007) Psychopharmacology , vol.192 , Issue.4 , pp. 511-519
    • Harich, S.1    Gross, G.2    Bespalov, A.3
  • 91
    • 36049021794 scopus 로고    scopus 로고
    • D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats
    • DOI 10.1016/j.bbr.2007.07.033, PII S0166432807003920
    • J. Karasawa, K. Hashimoto, and S. Chaki d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats Behav Brain Res 186 2008 78 83 (Pubitemid 350100896)
    • (2008) Behavioural Brain Research , vol.186 , Issue.1 , pp. 78-83
    • Karasawa, J.-i.1    Hashimoto, K.2    Chaki, S.3
  • 92
    • 42749085595 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and d-serine
    • DOI 10.1016/j.euroneuro.2007.07.009, PII S0924977X07001563
    • K. Hashimoto, Y. Fujita, T. Ishima, S. Chaki, and M. Iyo Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and d-serine Eur Neuropsychopharmacol 18 2008 414 421 (Pubitemid 351608551)
    • (2008) European Neuropsychopharmacology , vol.18 , Issue.6 , pp. 414-421
    • Hashimoto, K.1    Fujita, Y.2    Ishima, T.3    Chaki, S.4    Iyo, M.5
  • 93
    • 0010411289 scopus 로고    scopus 로고
    • The role of preclinical models in the development of psychotropic drugs
    • M.A. Geyer, and A. Markou The role of preclinical models in the development of psychotropic drugs K.L. Davis, D. Charney, J.T. Coyle, C.B. Nemeroff, Neuropsychopharmacology: the fifth generation of progress 2002 Lippincott, Williams and Wilkins 445 455
    • (2002) Neuropsychopharmacology: The Fifth Generation of Progress , pp. 445-455
    • Geyer, M.A.1    Markou, A.2
  • 94
    • 0033938877 scopus 로고    scopus 로고
    • Animal models of deficient sensorimotor gating: What we know, what we think we know, and what we hope to know soon
    • N.R. Swerdlow, D.L. Braff, and M.A. Geyer Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon Behav Pharmacol 11 2000 185 204 (Pubitemid 30449750)
    • (2000) Behavioural Pharmacology , vol.11 , Issue.3-4 , pp. 185-204
    • Swerdlow, N.R.1    Braff, D.L.2    Geyer, M.A.3
  • 95
    • 17744372866 scopus 로고    scopus 로고
    • Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia
    • DOI 10.1007/s00213-005-2210-x
    • T. Lipina, V. Labrie, I. Weiner, and J. Roder Modulators of the glycine site on NMDA receptors, d-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia Psychopharmacology (Berl) 179 2005 54 67 (Pubitemid 40576692)
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 54-67
    • Lipina, T.1    Labrie, V.2    Weiner, I.3    Roder, J.4
  • 96
    • 0033594947 scopus 로고    scopus 로고
    • A hyperglycinergic rat model for the pathogenesis of schizophrenia: Preliminary findings
    • R. Waziri, and S. Baruah A hyperglycinergic rat model for the pathogenesis of schizophrenia: preliminary findings Schizophr Res 37 1999 205 225
    • (1999) Schizophr Res , vol.37 , pp. 205-225
    • Waziri, R.1    Baruah, S.2
  • 97
    • 33847256383 scopus 로고    scopus 로고
    • High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients
    • U. Heresco-Levy, G. Bar, R. Levin, M. Ermilov, R.P. Ebstein, and D.C. Javitt High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients Schizophr Res 91 2007 14 21
    • (2007) Schizophr Res , vol.91 , pp. 14-21
    • Heresco-Levy, U.1    Bar, G.2    Levin, R.3    Ermilov, M.4    Ebstein, R.P.5    Javitt, D.C.6
  • 98
    • 0030853211 scopus 로고    scopus 로고
    • The switching model of latent inhibition: An update of neural substrates
    • DOI 10.1016/S0166-4328(97)02314-0, PII S0166432897023140
    • I. Weiner, and J. Feldon The switching model of latent inhibition: an update of neural substrates Behav Brain Res 88 1997 11 25 (Pubitemid 27459688)
    • (1997) Behavioural Brain Research , vol.88 , Issue.1 , pp. 11-25
    • Weiner, I.1    Feldon, J.2
  • 99
    • 0000683636 scopus 로고
    • Animal models with construct validity for schizophrenia
    • B.A. Ellenbroek, and A.R. Cools Animal models with construct validity for schizophrenia Behav Pharmacol 1 1990 469 490
    • (1990) Behav Pharmacol , vol.1 , pp. 469-490
    • Ellenbroek, B.A.1    Cools, A.R.2
  • 101
    • 0033813572 scopus 로고    scopus 로고
    • The pharmacology of latent inhibition as an animal model of schizophrenia
    • P.C. Moser, J.M. Hitchcock, S. Lister, and P.M. Moran The pharmacology of latent inhibition as an animal model of schizophrenia Brain Res Rev 33 2000 275 307
    • (2000) Brain Res Rev , vol.33 , pp. 275-307
    • Moser, P.C.1    Hitchcock, J.M.2    Lister, S.3    Moran, P.M.4
  • 102
    • 0038624724 scopus 로고    scopus 로고
    • The "two-headed" latent inhibition model of schizophrenia: Modeling positive and negative symptoms and their treatment
    • DOI 10.1007/s00213-002-1313-x
    • I. Weiner The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment Psychopharmacology (Berl) 169 2003 257 297 (Pubitemid 37264944)
    • (2003) Psychopharmacology , vol.169 , Issue.3-4 , pp. 257-297
    • Weiner, I.1
  • 103
    • 59449086656 scopus 로고    scopus 로고
    • Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: Latent inhibition studies in the rat
    • M.D. Black, G.B. Varty, M. Arad, S. Barak, A. De Levie, and D. Boulay Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat Psychopharmacology (Berl) 202 2009 385 396
    • (2009) Psychopharmacology (Berl) , vol.202 , pp. 385-396
    • Black, M.D.1    Varty, G.B.2    Arad, M.3    Barak, S.4    De Levie, A.5    Boulay, D.6
  • 104
    • 0344430085 scopus 로고    scopus 로고
    • Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: Reversal by glycine and a glycine transporter inhibitor
    • DOI 10.1016/S0006-3223(03)00374-3
    • G. Le Pen, J. Kew, D. Alberati, E. Borroni, M.P. Heitz, and J.L. Moreau Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and a glycine transporter inhibitor Biol Psychiatry 54 2003 1162 1170 (Pubitemid 37464862)
    • (2003) Biological Psychiatry , vol.54 , Issue.11 , pp. 1162-1170
    • Le Pen, G.1    Kew, J.2    Alberati, D.3    Borroni, E.4    Heitz, M.-P.5    Moreau, J.-L.6
  • 105
    • 77953290416 scopus 로고    scopus 로고
    • The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice
    • H.H. Chen, A. Stoker, and A. Markou The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice Psychopharmacology (Berl) 209 2010 343 350
    • (2010) Psychopharmacology (Berl) , vol.209 , pp. 343-350
    • Chen, H.H.1    Stoker, A.2    Markou, A.3
  • 106
    • 77956650149 scopus 로고    scopus 로고
    • Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice
    • K. Kopec, D.G. Flood, M. Gasior, B.A. McKenna, E. Zuvich, and J. Schreiber Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice Biochem Pharmacol 80 2010 1407 1417
    • (2010) Biochem Pharmacol , vol.80 , pp. 1407-1417
    • Kopec, K.1    Flood, D.G.2    Gasior, M.3    McKenna, B.A.4    Zuvich, E.5    Schreiber, J.6
  • 107
    • 72649084912 scopus 로고    scopus 로고
    • The effects of glycine transporter i inhibitor, N-methylglycine (sarcosine), on ketamine-induced alterations in sensorimotor gating and regional brain c-Fos expression in rats
    • S.Y. Yang, C.J. Hong, Y.H. Huang, and S.J. Tsai The effects of glycine transporter I inhibitor, N-methylglycine (sarcosine), on ketamine-induced alterations in sensorimotor gating and regional brain c-Fos expression in rats Neurosci Lett 469 2010 127 130
    • (2010) Neurosci Lett , vol.469 , pp. 127-130
    • Yang, S.Y.1    Hong, C.J.2    Huang, Y.H.3    Tsai, S.J.4
  • 108
    • 56049092225 scopus 로고    scopus 로고
    • Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia
    • C.R Yang, and K.A. Svensson Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: the therapeutic potentials for schizophrenia Pharmacol Ther 120 2008 317 332
    • (2008) Pharmacol Ther , vol.120 , pp. 317-332
    • Yang, C.R.1    Svensson, K.A.2
  • 109
    • 51049089047 scopus 로고    scopus 로고
    • Neurochemical and behavioural profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas
    • K.W. Perry, J.F. Falcone, M.J. Fell, J.W. Ryder, H. Yu, and P.L. Love Neurochemical and behavioural profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas Neuropharmacology 55 2008 743 754
    • (2008) Neuropharmacology , vol.55 , pp. 743-754
    • Perry, K.W.1    Falcone, J.F.2    Fell, M.J.3    Ryder, J.W.4    Yu, H.5    Love, P.L.6
  • 110
    • 38149075122 scopus 로고    scopus 로고
    • Glycine uptake regulates hippocampal network activity via glycine receptormediated tonic inhibition
    • L.H. Zhang, N. Gong, D. Fei, L. Xu, and T.L. Xu Glycine uptake regulates hippocampal network activity via glycine receptormediated tonic inhibition Neuropsychopharmacology 33 2008 701 711
    • (2008) Neuropsychopharmacology , vol.33 , pp. 701-711
    • Zhang, L.H.1    Gong, N.2    Fei, D.3    Xu, L.4    Xu, T.L.5
  • 111
    • 33645358358 scopus 로고    scopus 로고
    • A pharmacological model for psychosis based on N-methyl-d-aspartate receptor hypofunction: Molecular, cellular, functional and behavioural abnormalities
    • D. Rujescu, A. Bender, M. Keck, A.M. Hartmann, F. Ohl, and H. Raeder A pharmacological model for psychosis based on N-methyl-d-aspartate receptor hypofunction: molecular, cellular, functional and behavioural abnormalities Biol Psychiatry 59 2006 721 729
    • (2006) Biol Psychiatry , vol.59 , pp. 721-729
    • Rujescu, D.1    Bender, A.2    Keck, M.3    Hartmann, A.M.4    Ohl, F.5    Raeder, H.6
  • 112
    • 0031800004 scopus 로고    scopus 로고
    • Effects of continuous D-amphetamine and phencyclidine administration on social behaviour, stereotyped behaviour, and locomotor activity in rats
    • DOI 10.1016/S0893-133X(97)00200-5, PII S0893133X97002005
    • F Sams-Dodd Effects of continuous d-amphetamine and phencyclidine administration on social behaviour, stereotyped behaviour, and locomotor activity in rats Neuropsychopharmacology 19 1998 18 25 (Pubitemid 28255210)
    • (1998) Neuropsychopharmacology , vol.19 , Issue.1 , pp. 18-25
    • Sams-Dodd, F.1
  • 113
    • 33749063363 scopus 로고    scopus 로고
    • Modeling Madness in Mice: One Piece at a Time
    • DOI 10.1016/j.neuron.2006.09.023, PII S0896627306007306
    • P.A. Arguello, and J.A. Gogos Modeling madness in mice: one piece at a time Neuron 52 2006 179 196 (Pubitemid 44466363)
    • (2006) Neuron , vol.52 , Issue.1 , pp. 179-196
    • Arguello, P.A.1    Gogos, J.A.2
  • 114
    • 2942599183 scopus 로고    scopus 로고
    • Animal models relevant to schizophrenia disorders
    • M.A. Geyer, and B. Moghaddam Animal models relevant to schizophrenia disorders K.L. Davis, D.S. Charney, J.T. Coyle, C. Nemeroff, Neuropsychopharmacology: the fifth generation of progress 2002 Lippincott Williams and Wilkins Philadelphia 689 701
    • (2002) Neuropsychopharmacology: The Fifth Generation of Progress , pp. 689-701
    • Geyer, M.A.1    Moghaddam, B.2
  • 115
    • 29744432669 scopus 로고    scopus 로고
    • 2-Chloro-N-[(S)-phenyl [(2S)-piperidin-2-yl] methyl]-3-trifluoromethyl benzamide, monohydrochloride, an inhibitor of the glycine transporter type 1, increases evoked-dopamine release in the rat nucleus accumbens in vivo via an enhanced glutamatergic neurotransmission
    • DOI 10.1016/j.neuroscience.2005.09.003, PII S0306452205010316
    • M. Leonetti, C. Desvignes, I. Bougault, J. Souilhac, F. Oury-Donat, and R. Steinberg 2-Chloro-N-[(S)-phenyl [(2S)-piperidin-2-yl] methyl]-3- trifluoromethyl benzamide, monohydrochloride, an inhibitor of the glycine transporter type 1, increases evoked-dopamine release in the rat nucleus accumbens in vivo via an enhanced glutamatergic neurotransmission Neuroscience 137 2006 555 564 (Pubitemid 43031521)
    • (2006) Neuroscience , vol.137 , Issue.2 , pp. 555-564
    • Leonetti, M.1    Desvignes, C.2    Bougault, I.3    Souilhac, J.4    Oury-Donat, F.5    Steinberg, R.6
  • 116
    • 0020428675 scopus 로고
    • Partial improvement in negative schizophrenic symptoms after amphetamine
    • DOI 10.1007/BF00432248
    • B.M. Angrist, E. Peselow, M. Rubinstein, J. Corwin, and J. Rotrosen Partial improvement in negative schizophrenic symptoms after amphetamine Psychopharmacology (Berl) 78 1982 128 130 (Pubitemid 13234088)
    • (1982) Psychopharmacology , vol.78 , Issue.2 , pp. 128-130
    • Angrist, B.1    Peselow, E.2    Rubinstein, M.3
  • 117
    • 21844469260 scopus 로고    scopus 로고
    • Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers
    • DOI 10.1016/j.schres.2004.12.019, PII S092099640500006X
    • D.M. Barch, and C.S. Carter Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers Schizophr Res 77 2005 43 58 (Pubitemid 40957060)
    • (2005) Schizophrenia Research , vol.77 , Issue.1 , pp. 43-58
    • Barch, D.M.1    Carter, C.S.2
  • 119
    • 72449178338 scopus 로고    scopus 로고
    • The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice
    • D. Boulay, O. Bergis, P. Avenet, and G. Griebel The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice Neuropsychopharmacology 35 2010 416 427
    • (2010) Neuropsychopharmacology , vol.35 , pp. 416-427
    • Boulay, D.1    Bergis, O.2    Avenet, P.3    Griebel, G.4
  • 121
    • 33644875319 scopus 로고    scopus 로고
    • Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: Conceptual and treatment issues
    • H.J. Möller Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: conceptual and treatment issues World J Biol Psychiatry 6 2005 247 263
    • (2005) World J Biol Psychiatry , vol.6 , pp. 247-263
    • Möller, H.J.1
  • 122
    • 33846062865 scopus 로고    scopus 로고
    • The glycine reuptake inhibitor org 25935 decreases ethanol intake and preference in male Wistar rats
    • DOI 10.1093/alcalc/agl085, Special Issue on Pediatric Overweight
    • A. Molander, H.H. Lidö, E. Löf, M. Ericson, and B. Söderpalm The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in male wistar rats Alcohol Alcohol 42 2007 11 18 (Pubitemid 46062634)
    • (2007) Alcohol and Alcoholism , vol.42 , Issue.1 , pp. 11-18
    • Molander, A.1    Lido, H.H.2    Lof, E.3    Ericson, M.4    Soderpalm, B.5
  • 123
    • 77956158371 scopus 로고    scopus 로고
    • Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    • V. Vengeliene, F. Leonardi-Essmann, W.H. Sommer, M. Marston, and H. Spanagel R. Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats Biol Psychiatry 68 2010 704 711
    • (2010) Biol Psychiatry , vol.68 , pp. 704-711
    • Vengeliene, V.1    Leonardi-Essmann, F.2    Sommer, W.H.3    Marston, M.4    Spanagel, R.H.5
  • 124
    • 65749112372 scopus 로고    scopus 로고
    • Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain
    • T. Dohi, K. Morita, T. Kitayama, N. Motoyama, and N. Morioka Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain Pharmacol Ther 123 2009 54 79
    • (2009) Pharmacol Ther , vol.123 , pp. 54-79
    • Dohi, T.1    Morita, K.2    Kitayama, T.3    Motoyama, N.4    Morioka, N.5
  • 125
    • 53249120926 scopus 로고    scopus 로고
    • Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain
    • H. Hermanns, U. Muth-Selbach, R. Williams, S. Krug, P. Lipfert, and R. Werdehausen Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain Neurosci Lett 445 2008 214 219
    • (2008) Neurosci Lett , vol.445 , pp. 214-219
    • Hermanns, H.1    Muth-Selbach, U.2    Williams, R.3    Krug, S.4    Lipfert, P.5    Werdehausen, R.6
  • 126
    • 47949120019 scopus 로고    scopus 로고
    • Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice
    • K. Morita, N. Motoyama, T. Kitayama, N. Morioka, K. Kifune, and T. Dohi Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice J Pharmacol Exp Ther 326 2008 633 645
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 633-645
    • Morita, K.1    Motoyama, N.2    Kitayama, T.3    Morioka, N.4    Kifune, K.5    Dohi, T.6
  • 127
    • 42549154180 scopus 로고    scopus 로고
    • Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment
    • DOI 10.1097/ALN.0b013e31816c9044, PII 0000054220080500000022
    • M. Tanabe, K. Takasu, S. Yamaguchi, D. Kodama, and H. Ono Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment Anesthesiology 108 2008 929 937 (Pubitemid 351589490)
    • (2008) Anesthesiology , vol.108 , Issue.5 , pp. 929-937
    • Tanabe, M.1    Takasu, K.2    Yamaguchi, S.3    Kodama, D.4    Ono, H.5
  • 128
    • 77951297450 scopus 로고    scopus 로고
    • Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test
    • M. Kalinichev, K.R. Starr, S. Teague, A.M. Bradford, R.A. Porter, and H.J. Herdon Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test Brain Res 1331 2010 105 113
    • (2010) Brain Res , vol.1331 , pp. 105-113
    • Kalinichev, M.1    Starr, K.R.2    Teague, S.3    Bradford, A.M.4    Porter, R.A.5    Herdon, H.J.6
  • 129
    • 77953319320 scopus 로고    scopus 로고
    • Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models
    • K. Socała, D. Nieoczym, C. Rundfeldt, and P. Wlaź Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models Pharmacol Rep 62 2010 392 397
    • (2010) Pharmacol Rep , vol.62 , pp. 392-397
    • Socała, K.1    Nieoczym, D.2    Rundfeldt, C.3    Wlaź, P.4
  • 130
    • 0035340978 scopus 로고    scopus 로고
    • Glial transporters for glutamate, glycine, and GABA III. Glycine transporters
    • DOI 10.1002/jnr.1069
    • A. Gadea, and A.M. López-Colomé Glial transporters for glutamate, glycine, and GABA III. Glycine transporters J Neurosci Res 64 2001 218 222 (Pubitemid 32385689)
    • (2001) Journal of Neuroscience Research , vol.64 , Issue.3 , pp. 218-222
    • Gadea, A.1    Lpez-Colom, A.M.2
  • 131
    • 0035869714 scopus 로고    scopus 로고
    • Glial transporters for glutamate, glycine and GABA I. Glutamate transporters
    • DOI 10.1002/jnr.1039
    • A. Gadea, and A.M. López-Colomé Glial transporters for glutamate, glycine and GABA I Glutamate transporters J Neurosci Res 63 2001 453 460 (Pubitemid 32193702)
    • (2001) Journal of Neuroscience Research , vol.63 , Issue.6 , pp. 453-460
    • Gadea, A.1    Lopez-Colome, A.M.2
  • 132
    • 23044501819 scopus 로고    scopus 로고
    • Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission
    • DOI 10.1097/00001756-200508010-00019
    • T.X. Xu, N. Gong, and T.L. Xu Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission Neuroreport 16 2005 1227 1231 (Pubitemid 41058474)
    • (2005) NeuroReport , vol.16 , Issue.11 , pp. 1227-1231
    • Xu, T.-X.1    Gong, N.2    Xu, T.-L.3
  • 133
    • 33747083749 scopus 로고    scopus 로고
    • Effects of D-Cycloserine on Extinction: Translation From Preclinical to Clinical Work
    • DOI 10.1016/j.biopsych.2006.03.084, PII S0006322306007311
    • M. Davis, K. Ressler, B.O. Rothbaum, and R. Richardson Effects of d-cycloserine on extinction: translation from preclinical to clinical work Biol Psychiatry 60 2006 369 375 (Pubitemid 44215855)
    • (2006) Biological Psychiatry , vol.60 , Issue.4 , pp. 369-375
    • Davis, M.1    Ressler, K.2    Rothbaum, B.O.3    Richardson, R.4
  • 134
    • 0037088911 scopus 로고    scopus 로고
    • Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats
    • D.K. Walker, K.J. Ressler, K.-T. Lu, and M. Davis Facilitation of conditioned fear extinction by systemic administration or intra-amygdala Infusions of d-cycloserine as assessed with fear-potentiated startle in rats J Neurosci 22 2002 2343 2351 (Pubitemid 35386533)
    • (2002) Journal of Neuroscience , vol.22 , Issue.6 , pp. 2343-2351
    • Walker, D.L.1    Ressler, K.J.2    Lu, K.-T.3    Davis, M.4


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