Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala

Molecular Pharmacology

Volumn 76, Issue 2, 2009, Pages 369-378

  Mao, Sheng Chun ^a   Lin, Hui Ching ^a   Gean, Po Wu ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLYCINE TRANSPORTER; N [3 (4 FLUOROPHENYL) 3 (4' PHENYLPHENOXY)]PROPYLSARCOSINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN INHIBITOR; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONDITIONING; CONTROLLED STUDY; DRUG ANTAGONISM; ENDOCYTOSIS; FEAR; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYGDALA; ANIMALS; CONDITIONING (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; EXTINCTION, PSYCHOLOGICAL; FEAR; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; INFUSIONS, INTRAVENOUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MODELS, NEUROLOGICAL; N-METHYLASPARTATE; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SARCOSINE; STARTLE REACTION; TIME FACTORS;

EID: 67650831204     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.053728     Document Type: Article

References (42)

1. Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y, Lu J, Wong TP, Sheng M, and Wang YT (2004) Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. EMBO J 23:1040-1050. (Pubitemid 38436869)
2. Aubrey KR and Vandenberg RJ (2001) N[3-(4′-Fluorophenyl)-3- (4′-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. Br J Pharmacol 134:1429-1436.
3. Barad M (2006) Is extinction of fear erasure or inhibition? Why both, of course. Learn Mem 13:108-109.
4. Beattie EC, Carroll RC, Yu X, Morishita W, Yasuda H, von Zastrow M, and Malenka RC (2000) Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci 3:1291-1300. (Pubitemid 30951644)
5. Beique JC and Andrade R (2003) PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex. J Physiol 546:859-867. (Pubitemid 36204519)
6. Bergeron R, Meyer TM, Coyle JT, and Greene RW (1998) Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A 95:15730-15734. (Pubitemid 29018768)
7. Brebner K, Wong TP, Liu L, Liu Y, Campsall P, Gray S, Phelps L, Phillips AG, and Wang YT (2005) Nucleus accumbens long-term depression and the expression of behavioral sensitization. Science 310:1340-1343. (Pubitemid 41698868)
8. Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, and Nicoll RA (2000) Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408:936-943. (Pubitemid 32101633)
9. Chhatwal JP, Myers KM, Ressler KJ, and Davis M (2005) Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction. J Neurosci 25:502-506.
10. Dalton GL, Wang YT, Floresco SB, and Phillips AG (2008) Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear. Neuropsychopharmacology 33:2416-2426.
11. Davis M, Ressler K, Rothbaum BO, and Richardson R (2006) Effects of D-cycloserine on extinction: translation from preclinical to clinical work. Biol Psychiatry 60:369-375. (Pubitemid 44215855)
12. Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, Wei Y, Wang Y, Blumenthal R, Machado-Vieira R. et al. (2008) The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. J Neurosci 28:68-79.
13. El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, and Bredt DS (2002) Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108:849-863. (Pubitemid 34327535)
14. Falls WA, Miserendino MJ, and Davis M (1992) Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J Neurosci 12:854-863.
15. Gomez LL, Alam S, Smith KE, Horne E, and Dell'Acqua ML (2002) Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J Neurosci 22:7027-7044. (Pubitemid 35379160)
16. Hermans D, Craske MG, Mineka S, and Lovibond PF (2006) Extinction in human fear conditioning. Biol Psychiatry 60:361-368.
17. Johnson JW and Ascher P (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325:529-531. (Pubitemid 17056733)
18. Kim J, Lee S, Park K, Hong I, Song B, Son G, Park H, Kim WR, Park E, Choe HK, et al. (2007) Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A 104:20955-20960.
19. Ledgerwood L, Richardson R, and Cranney J (2003) Effects of D-cycloserine on the extinction of conditioned freezing. Behav Neurosci 117:341-349. (Pubitemid 36384252)
20. Ledgerwood L, Richardson R, and Cranney J (2004) D-Cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement. Behav Neurosci 118:505-513. (Pubitemid 38685318)
21. Lee H and Kim JJ (1998) Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J Neurosci 18:8444-8454. (Pubitemid 28465019)
22. Lee HK, Kameyama K, Huganir RL, and Bear MF (1998) NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21:1151-1162. (Pubitemid 29018084)
23. Lin CH, Yeh SH, Lu HY, and Gean PW (2003) The similarities and diversities of signal pathways leading to consolidation and extinction of fear memory. J Neurosci 23:8310-8317.
24. Man HY, Sekine-Aizawa Y, and Huganir RL (2007) Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit. Proc Natl Acad Sci U S A 104:3579-3584. (Pubitemid 46364201)
25. Maren S and Quirk GJ (2004) Neuronal signalling of fear memory. Nat Rev Neurosci 5:844-852.
26. McBain CJ, Kleckner NW, Wyrick S, and Dingledine R (1989) Structural requirements for activation of the glycine coagonist site of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol Pharmacol 36:556-565. (Pubitemid 19273831)
27. Moita MA, Lamprecht R, Nader K, and LeDoux JE (2002) A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nature Neurosci 5:837-838. (Pubitemid 34976645)
28. Myers KM and Davis M (2002) Behavioral and neural analysis of extinction. Neuron 36:567-584.
29. Quirk GJ, Likhtik E, Pelletier JG, and Paré D (2003) Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J Neurosci 23:8800-8807. (Pubitemid 37176661)
30. Quirk GJ, Russo GK, Barron JL, and Lebron K (2000) The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci 20:6225-6231.
31. Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, Hodges L, and Davis M (2004) Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry 61:1136-1144. (Pubitemid 39463415)
32. Rumbaugh G, Sia GM, Garner CC, and Huganir RL (2003) Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons. J Neurosci 23:4567-4576. (Pubitemid 36706187)
33. Schlüter OM, Xu W, and Malenka RC (2006) Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function. Neuron 51:99-111. (Pubitemid 43963332)
34. Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, and Nicoll RA (2002) Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A 99:13902-13907. (Pubitemid 35215478)
35. Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, and Bear MF (2005) Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression. J Biol Chem 280:16962-16968. (Pubitemid 41389157)
36. Taylor S, Thordarson DS, Maxfield L, Fedoroff IC, Lovell K, and Ogrodniczuk J (2003) Comparative efficacy, speed, and adverse effects of three PTSD treatments: exposure therapy, EMDR, and relaxation training. J Consult Clin Psychol 71:330-338. (Pubitemid 36323937)
37. Thomson AM, Walker VE, and Flynn DM (1989) Glycine enhances NMDA receptormediated synaptic potentials in neocortical slices. Nature 338:422-424.
38. Ungless MA, Whistler JL, Malenka RC, and Bonci A (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411:583-587.
39. Walker DL, Ressler KJ, Lu KT, and Davis M (2002) Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci 22:2343-2351.
40. Westergren I, Nyström B, Hamberger A, Nordborg C, and Johansson BB (1994) Concentrations of amino acids in extracellular fluid after opening of the bloodbrain barrier by intracarotid infusion of protamine sulfate. J Neurochem 62:159-165. (Pubitemid 24010635)
41. Wright CI, Fischer H, Whalen PJ, McInerney SC, Shin LM, and Rauch SL (2001) Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli. Neuroreport 12:379-383. (Pubitemid 32114384)
42. Yehuda R (2002) Post-traumatic stress disorder. N Engl J Med 346:108-114.