Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

Neuroscience Letters

Volumn 373, Issue 1, 2004, Pages 79-84

  Gabernet, Laetitia ^a   Pauly Evers, Meike ^b   Schwerdel, Cornelia ^a   Lentz, Michèle ^a   Bluethmann, Horst ^b   Vogt, Kaspar ^a   Alberati, Daniela ^c   Mohler, Hanns ^a,d   Boison, Detlev ^a,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d ETH ZURICH   (Switzerland)

Author keywords

AMPA receptor; Gene targeting; Glycine; Glycine transporter 1; NMDA receptor; Schizophrenia

Indexed keywords

CARRIER PROTEIN; GLYCINE TRANSPORTER 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

EID: 8844272671     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.09.064     Document Type: Article

References (18)

1. A.J. Berger, S. Dieudonne, and P. Ascher Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses J. Neurophysiol. 80 1998 3336 3340
2. R. Bergeron, T.M. Meyer, J.T. Coyle, and R.W. Greene Modulation of N-methyl-d-aspartate receptor function by glycine transport Proc. Natl. Acad. Sci. USA 95 1998 15730 15734
3. D. Boison, L. Scheurer, V. Zumsteg, T. Rülicke, P. Litynski, B. Fowler, S. Brandner, and H. Mohler Neonatal hepatic steatosis by disruption of the adenosine kinase gene Proc. Natl. Acad. Sci. USA 99 2002 6985 6990
4. B. Borowsky, and B.J. Hoffman Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure J. Biol. Chem. 44 1998 29077 29085
5. A. Carlsson, N. Waters, S. Holm-Waters, J. Tedroff, M. Nilsson, and M.L. Carlsson Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence Annu. Rev. Pharmacol. Toxicol. 41 2001 237 260
6. L. Chen, M. Muhlhauser, and C.R. Yang Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo J. Neurophysiol. 89 2003 691 703
7. J.T. Coyle, G. Tsai, and D. Goff Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia Ann. NY Acad. Sci. 1003 2003 318 327
8. W. Danysz, and A.C. Parsons Glycine and N-methyl-d-aspartate receptors: physiological significance and possible therapeutic applications Pharmacol. Rev. 50 1998 597 664
9. J. Gomeza, S. Hulsmann, K. Ohno, V. Eulenburg, K. Szoke, D. Richter, and H. Betz Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition Neuron 40 2003 785 796
10. G.G. Kinney, C. Sur, M. Burno, P.J. Mallorga, J.B. Williams, D.J. Figueroa, M. Wittmann, W. Lemaire, and P.J. Conn The glycine transporter type 1 inhibitor N-[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)propyl] sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior J. Neurosci. 23 2003 7586 7591
11. K.N. Kumar, N. Tilakaratne, P.S. Johnson, A.E. Allen, and E.K. Michaelis Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complex Nature 354 1991 70 73
12. M. Martina, Y. Gorfinkel, S. Halman, J.A. Lowe, P. Periyalwar, C.J. Schmidt, and R. Bergeron Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels J. Physiol. 557 2004 489 500
13. A.R. Mohn, R.R. Gainetdinov, M.G. Caron, and B.H. Koller Mice with reduced NMDA receptor expression display behaviours related to schizophrenia Cell 98 1999 427 436
14. K. Moriyoshi, M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, and S. Nakanishi Molecular cloning and characterization of the rat NMDA receptor Nature 354 1991 31 37
15. Y. Nong, Y.Q. Huang, W. Ju, L.V. Kalia, G. Ahmadian, Y.T. Wang, and M.W. Salter Glycine binding primes NMDA receptor internalization Nature 422 2003 302 307
16. T. Priestley, P. Laughton, J. Myers, B. Le Bourdelles, J. Kerby, and P.J. Whiting Pharmacological properties of recombinant human N-methyl-d-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells Mol. Pharmacol. 48 1995 841 848
17. G. Tsai, R.J. Ralph-Williams, M. Martina, R. Bergeron, J. Berger-Sweeney, K.S. Dunham, Z. Jiang, S.B. Caine, and J.T. Coyle Gene knockout of glycine transporter 1: characterization of the behavioral phenotype Proc. Natl. Acad. Sci. USA 101 2004 8485 8490
18. F. Zafra, C. Aragon, L. Olivares, N.C. Danbolt, C. Gimenez, and J. Storm-Mathisen Glycine transporters are differentially expressed among CNS cells J. Neurosci. 15 1995 3952 3969