A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities

Biological Psychiatry

Volumn 59, Issue 8, 2006, Pages 721-729

  Rujescu, Dan ^a   Bender, Andreas ^a,b   Keck, Martin ^c   Hartmann, Annette M ^a   Ohl, Frauke ^c   Raeder, Hanna ^a   Giegling, Ina ^a   Genius, Just ^a   McCarley, Robert W ^d   Möller, Hans Jürgen ^a   Grunze, Heinz ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Animal model; Glutamate; Hippocampus; MK 801; NMDA; Psychosis

Indexed keywords

CALRETININ; DIZOCILPINE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PSYCHOSIS; PYRAMIDAL NERVE CELL; RAT; SCHIZOPHRENIA;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CHOICE BEHAVIOR; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; DNA, RECOMBINANT; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE POTENTIALS; MENTAL DISORDERS; MOTOR ACTIVITY; NEURAL NETWORKS (COMPUTER); NEURONS; PARVALBUMINS; PATCH-CLAMP TECHNIQUES; RATS; RATS, LONG-EVANS; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33645358358     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.08.029     Document Type: Article

References (64)

1. K.M. Abel, M.P. Allin, D.R. Hemsley, M.A. Geyer Low dose ketamine increases prepulse inhibition in healthy men Neuropharmacology 44 2003 729 737
2. Y. Aika, J.Q. Ren, K. Kosaka, T. Kosaka Quantitative analysis of GABA-like-immunoreactive and parvalbumin-containing neurons in the CA1 region of the rat hippocampus using a stereological method, the disector Exp Brain Res 99 1994 267 276
3. D.G. Amaral, M.P. Witter The three-dimensional organization of the hippocampal formation a review of anatomical data Neuroscience 31 1989 571 591
4. P. Andersen, J.C. Eccless, Y. Loyning Recurrent inhibition in the hippocampus with identification of the inhibitory cell and its synapses Nature 198 1963 540 542
5. S.E. Arnold The medial temporal lobe in schizophrenia J Neuropsychiatry Clin Neurosci 9 1997 460 470
6. C.L. Beasley, G.P. Reynolds Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics Schizophr Res 24 1997 349 355
7. F.M. Benes, S. Berretta GABAergic interneurons implications for understanding schizophrenia and bipolar disorder Neuropsychopharmacology 25 2001 1 27
8. F.M. Benes, E.W. Kwok, S.L. Vincent, M.S. Todtenkopf A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives Biol Psychiatry 44 1998 88 97
9. A. Bertolino, G. Esposito, J.H. Callicott, V.S. Mattay, J.D. Van Horn, J.A. Frank Specific relationship between prefrontal neuronal N-acetylaspartate and activation of the working memory cortical network in schizophrenia Am J Psychiatry 157 2000 26 33
10. G. Buzsaki, J.J. Chrobak Temporal structure in spatially organized neuronal ensembles a role for interneuronal networks Curr Opin Neurobiol 5 1995 504 510
11. G. Buzsaki, A. Draguhn Neuronal oscillations in cortical networks Science 304 2004 1926 1929
12. Q. Chen, C.L. Veenman, A. Reiner Cellular expression of ionotropic glutamate receptor subunits on specific striatal neuron types and its implication for striatal vulnerability in glutamate receptor-mediated excitotoxicity Neuroscience 73 1996 715 731
13. C. Constantinidis, P.S. Goldman-Rakic Correlated discharges among putative pyramidal neurons and interneurons in the primate prefrontal cortex J Neurophysiol 88 2002 3487 3497
14. M.R. del Rio, J. DeFelipe Colocalization of parvalbumin and calbindin D-28k in neurons including chandelier cells of the human temporal neocortex J Chem Neuroanat 12 1997 165 173
15. R. Dingledine, I.A. Langmoen Conductance changes and inhibitory actions of hippocampal recurrent IPSPs Brain Res 185 1980 277 287
16. M.F. Egan, D.R. Weinberger Neurobiology of schizophrenia Curr Opin Neurobiol 7 1997 701 707
17. M. Frotscher, J. Zimmer Commissural fibers terminate on nonpyramidal neurons in the guinea pig hippocampus-a combined Golgi/EM degeneration study Brain Res 265 1983 289 293
18. X.M. Gao, K. Sakai, R.C. Roberts, R.R. Conley, B. Dean, C.A. Tamminga Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus effects of schizophrenia Am J Psychiatry 157 2000 1141 1149
19. P.S. Goldman-Rakic Refional and cellular fractionation of working memory Proc Nat Acad Sci 93 1996 13473 13480
20. H. Grunze, J. Gallinat, C. Haag, U. Hegerl Psychopathological and auditory evoked potential correlates of ketamine psychosis-a single case report Schizophr Res 41 2000 386 388
21. H.C. Grunze, D.G. Rainnie, M.E. Hasselmo, E. Barkai, E.F. Hearn, R.W. McCarley NMDA-dependent modulation of CA1 local circuit inhibition J Neurosci 16 1996 2034 2043
22. A.I. Gulyas, N. Hajos, T.F. Freund Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus J Neurosci 16 1996 3397 3411
23. P.J. Harrison The neuropathology of schizophrenia A critical review of the data and their interpretation Brain 122 Pt 4 1999 593 624
24. P.J. Harrison, D.R. Weinberger Schizophrenia genes, gene expression, and neuropathology on the matter of their convergence Mol Psychiatry 10 2005 40 68
25. S. Heckers Neuroimaging studies of the hippocampus in schizophrenia Hippocampus 11 2001 520 528
26. C. Ikonomidou, J.L. Mosinger, K.S. Salles, J. Labruyere, J.W. Olney Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity J Neurosci 9 1989 2809 2818
27. C. Ikonomidou, F. Bosch, M. Miksa, P. Bittigau, J. Vockler, K. Dikranian Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain Science 283 1999 70 74
28. D.C. Javitt, A.M. Shelley, G. Silipo, J.A. Lieberman Deficits in auditory and visual context-dependent processing in schizophrenia defining the pattern Arch Gen Psychiatry 57 2000 1131 1137
29. G. Keilhoff, A. Becker, G. Grecksch, G. Wolf, H.G. Bernstein Repeated application of ketamine to rats induces changes in the hippocampal expression of parvalbumin, neuronal nitric oxide synthase and cFOS similar to those found in human schizophrenia Neuroscience 126 2004 591 598
30. M.B. Knable, B.M. Barci, M.J. Webster, J. Meador-Woodruff, E.F. Torrey Molecular abnormalities of the hippocampus in severe psychiatric illness postmortem findings from the Stanley Neuropathology Consortium Mol Psychiatry 9 2004 609 620
31. J.H. Krystal, L.P. Karper, J.P. Seibyl, G.K. Freeman, R. Delaney, J.D. Bremner Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans Psychotomimetic, perceptual, cognitive, and neuroendocrine responses Arch Gen Psychiatry 51 1994 199 214
32. A.C. Lahti, B. Koffel, D. LaPorte, C.A. Tamminga Subanesthetic doses of ketamine stimulate psychosis in schizophrenia Neuropsychopharmacology 13 1995 9 19
33. A.C. Lahti, M.A. Weiler, B.A. Tamara Michaelidis, A. Parwani, C.A. Tamminga Effects of ketamine in normal and schizophrenic volunteers Neuropsychopharmacology 25 2001 455 467
34. X.G. Li, P. Somogyi, A. Ylinen, G. Buzsaki The hippocampal CA3 network an in vivo intracellular labeling study J Comp Neurol 339 1994 181 208
35. W. Lukas, K.A. Jones Cortical neurons containing calretinin are selectively resistant to calcium overload and excitotoxicity in vitro Neuroscience 61 1994 307 316
36. A.K. Malhotra, D.A. Pinals, C.M. Adler, I. Elman, A. Clifton, D. Pickar Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics Neuropsychopharmacology 17 1997 141 150
37. R.W. McCarley, C.G. Wible, M. Frumin, Y. Hirayasu, J.J. Levitt, I.A. Fischer MRI anatomy of schizophrenia Biol Psychiatry 45 1999 1099 1119
38. A. Mechri, M. Saoud, G. Khiari, T. D'Amato, J. Dalery, L. Gaha Glutaminergic hypothesis of schizophrenia clinical research studies with ketamine Encephale 27 2001 53 59
39. Y. Miyamoto, K. Yamada, Y. Noda, H. Mori, M. Mishina, T. Nabeshima Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit J Neurosci 21 2001 750 757
40. B. Moghaddam, B. Adams, A. Verma, D. Daly Activation of glutamatergic neurotransmission by ketamine a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex J Neurosci 17 1997 2921 2927
41. A.R. Mohn, R.R. Gainetdinov, M.G. Caron, B.H. Koller Mice with reduced NMDA receptor expression display behaviors related to schizophrenia Cell 98 1999 427 436
42. B.J. Morris, S.M. Cochran, J.A. Pratt PCP from pharmacology to modeling schizophrenia Curr Opin Pharmacol 5 2005 101 106
43. M.D. Nelson, A.J. Saykin, L.A. Flashman, H.J. Riordan Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging a meta-analytic study Arch Gen Psychiatry 55 1998 433 440
44. P.G. Nestor, M.E. Shenton, R.W. McCarley, J. Haimson, R.S. Smith, B. O'Donnell Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia Am J Psychiatry 150 1993 1849 1855
45. L.T. Niemi, J.M. Suvisaari, A. Tuulio-Henriksson, J.K. Lonnqvist Childhood developmental abnormalities in schizophrenia evidence from high-risk studies Schizophr Res 60 2003 239 258
46. S. Oh, Y.H. Kim, H.J. Hann, H.L. Lee, H.S. Choi, H.S. Kim, I.K. Ho Modulation of the levels of NMDA receptor subunit mRNA and the bindings of [3H]MK-801 in rat brain by chronic infusion of subtoxic dose of MK-801 Neurochem Res 26 2001 559 565
47. F. Ohl, F. Holsboer, R. Landgraf The modified hole board as a differential screen for behavior in rodents Behav Res Methods Instrum Comput 33 2001 392 397
48. J.W. Olney, J. Labruyere, G. Wang, D.F. Wozniak, M.T. Price, M.A. Sesma NMDA antagonist neurotoxicity mechanism and prevention Science 254 1991 1515 1518
49. G. Paxinos, C.R. Watson, P.C. Emson AChE-stained horizontal sections of the rat brain in stereotaxic coordinates J Neurosci Methods 3 1980 129 149
50. F. Pouille, M. Scanziani Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition Science 293 2001 1159 1163
51. S.G. Rao, G.V. Williams, P.S. Goldman-Rakic Destruction and creation of spatial tuning by disinhibition GABA(A) blockade of prefrontal cortical neurons engaged by working memory J Neurosci 20 2000 485 494
52. G.P. Reynolds, C.L. Beasley, Z.J. Zhang Understanding the neurotransmitter pathology of schizophrenia selective deficits of subtypes of cortical GABAergic neurons J Neural Transm 109 2002 881 889
53. R. Ritz, T.J. Sejnowski Synchronous oscillatory activity in sensory systems new vistas on mechanisms Curr Opin Neurobiol 7 1997 536 546
54. J.M. Rodriguez-Paz, V. Anantharam, S.N. Treistman Block of the N-methyl-D-aspartate receptor by phencyclidine-like drugs is influenced by alternative splicing Neurosci Lett 190 1995 147 150
55. A.F. Sadikot, R. Sasseville Neurogenesis in the mammalian neostriatum and nucleus accumbens parvalbumin-immunoreactive GABAergic interneurons J Comp Neurol 389 1997 193 211
56. A.F. Sadikot, A.M. Burhan, M.C. Belanger, R. Sasseville NMDA receptor antagonists influence early development of GABAergic interneurons in the mammalian striatum Brain Res Dev Brain Res 105 1998 35 42
57. T. Schiffelholz, D. Hinze-Selch, J.B. Aldenhoff Perinatal MK-801 treatment affects age-related changes in locomotor activity from childhood to later adulthood in rats Neurosci Lett 360 2004 157 160
58. W.A. Spencer, E.R. Kandel Cellular and integrative properties of the hippocampal pyramidal cell and the comparative electrophysiology of cortical neurons Int J Neurol 6 1968 266 296
59. E.F. Torrey, B.M. Barci, M.J. Webster, J.J. Bartko, J.H. Meador-Woodruff, M.B. Knable Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains Biol Psych 57 2005 252 260
60. G. Tsai, J.T. Coyle Glutamatergic mechanisms in schizophrenia Annu Rev Pharmacol Toxicol 42 2002 165 179
61. C. von der Malsburg Binding in models of perception and brain function Curr Opin Neurobiol 5 1995 520 526
62. H.J. Waldvogel, R.L. Faull, M.N. Williams, M. Dragunow Differential sensitivity of calbindin and parvalbumin immunoreactive cells in the striatum to excitotoxins Brain Res 546 1991 329 335
63. Z.J. Zhang, G.P. Reynolds A selective decrease in the relative density of parvalbumin-immunoreactive neurons in the hippocampus in schizophrenia Schizophr Res 55 2002 1 10
64. R.S. Zukin, M.V. Bennett Alternatively spliced isoforms of the NMDARI receptor subunit Trends Neurosci 18 1995 306 313