The glycine transporter 1 inhibitor SSR504734 enhances working memory performance in a continuous delayed alternation task in C57BL/6 mice

Psychopharmacology

Volumn 202, Issue 1-3, 2009, Pages 371-384

  Singer, Philipp ^a   Feldon, Joram ^a   Yee, Benjamin K ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Glycine transporter 1; Learning; Memory; NMDA receptor; Working memory

Indexed keywords

2 CHLORO N [ALPHA (2 PIPERIDINYL)BENZYL] 3 TRIFLUOROMETHYLBENZAMIDE; GLYCINE TRANSPORTER 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; FOOD DEPRIVATION; LEARNING; MALE; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; SOCIAL BEHAVIOR; TASK PERFORMANCE; WORKING MEMORY;

ANIMALS; BENZAMIDES; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD DEPRIVATION; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; MALE; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; PIPERIDINES; PSYCHOMOTOR PERFORMANCE;

EID: 59449096382     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1286-5     Document Type: Article

References (75)

1. JP Aggleton PR Hunt JNP Rawlins 1986 The effects of hippocampal lesions upon spatial and non-spatial tests of working memory Behav Brain Res 19 133 146
2. JP Aggleton AB Keith JN Rawlins PR Hunt A Sahgal 1992 Removal of the hippocampus and transection of the fornix produce comparable deficits on delayed non-matching to position by rats Behav Brain Res 52 61 71
3. C Aragon B Lopez-Corcuera 2005 Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion Trends Pharmacol Sci 26 283 286
4. D Attwell B Barbour M Szatkowski 1993 Nonvesicular release of neurotransmitter Neuron 11 401 407
5. DM Bannerman JN Rawlins MA Good 2006 The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory Psychopharmacology (Berl) 188 552 566
6. DM Bannerman B Niewoehner L Lyon C Romberg WB Schmitt A Taylor DJ Sanderson J Cottam R Sprengel PH Seeburg G Köhr JNP Rawlins 2008 NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory J Neurosci 28 3623 630
7. DM Barch 2004 Pharmacological manipulation of human working memory Psychopharmacology (Berl) 174 126 135
8. AJ Berger S Dieudonné P Ascher 1998 Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses J Neurophysiol 80 3336 3340
9. R Bergeron TM Meyer JT Coyle RW Greene 1998 Modulation of N-methyl-D-aspartate receptor function by glycine transport Proc Natl Acad Sci USA 95 15730 15734
10. H Betz B Laube 2006 Glycine receptors: recent insights into their structural organization and functional diversity J Neurochem 97 1600 1610
11. P Bitsios SG Giakoumaki K Theou S Frangou 2006 Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males Neuropsychologia 44 2494 2499
12. H Bräuner-Osborne J Egenbjerg E Nielsen U Madsen P Krogsgaard-Larsen 2000 Ligands for glutamate receptors: design and therapeutic prospects J Med Chem 43 2609 2645
13. L Chen M Muhlhauser CR Yang 2003 Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo J Neurophysiol 89 691 703
14. GL Collingridge TVP Bliss 1995 Memories of NMDA receptors and LTP Trends Neurosci 18 54 56
15. JT Coyle G Tsai 2004 NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia Int Rev Neurobiol 59 491 515
16. B Cubelos C Gimenez F Zafra 2005 Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain Cereb Cortex 15 448 459
17. B Cubelos IM Gonzales-Gonzales C Gimenez F Zafra 2005 The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalization J Neurochem 95 1047 1058
18. DC D'Souza R Gil K Cassello K Morrissey D Abi-Saab J White R Sturwold A Bennett LP Karper E Zuzarte 2000 IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans Biol Psychiat 47 450 462
19. W Danysz AC Parsons 1998 Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications Pharmacol Rev 50 597 664
20. W Danysz JT Wroblewski G Brooker E Costa 1987 Modulation of excitatory amino acid transmission by phencyclidine and glycine in the rat cerebellum in vivo Soc Neurosci Abstr 13 383
21. W Danysz JT Wroblewski G Brooker E Costa 1989 Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo Brain Res 479 270 276
22. R Depoortère G Estenne-Bouhtou A Coste C Lanneau 2005 Neurochemical, electrophysiological and pharmalogical profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic Neuropsychopharmacology 30 1963 1985
23. SB Dunnett 1993
24. SB Dunnett AT Wareham EM Morres 1990 Cholinergic blockade in prefrontal cortex and hippocampus disrupts short-term memory in rats Neuroreport 1 61 64
25. S Duffy V Labrie JC Roder 2008 D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning Neuropsychopharmacology 33 1004 1018
26. SG Giakoumaki P Bitsios S Frangou 2006 The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing Brain Res 1078 168 170
27. FK Graham 1975 The more or less startling effects of weak prestimulation Psychophysiology 12 238 248
28. S Harich G Gross A Bespalov 2007 Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment Psychopharmacology (Berl) 192 511 519
29. U Heresco-Levy 2000 N-Methyl-D-aspartate (NMDA) receptor-based treatment approaches in schizophrenia: the first decade Int J Neuropsychopharmacol 3 243 258
30. U Heresco-Levy DC Javitt M Ermilov Mor C del A Horowitz D Kelly 1996 Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia Br J Psychiat 169 610 617
31. U Heresco-Levy DC Javitt M Ermilov C Mordel G Silipo M Lichtenstein 1999 Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia Arch Gen Psychiat 56 29 36
32. U Heresco-Levy M Ermilov P Lichtenberg G Bar DC Javitt 2004 High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia Biol Psychiat 55 165 171
33. WK Honig 1978
34. DC Javitt P Doneshka I Zylberman W Ritter HG Vaughan Jr 1993 Impairment of early cortical processing in schizophrenia: an event-related potential confirmation study Biol Psychiat 33 513 519
35. DC Javitt G Silipo A Cienfuegos AM Shelley N Bark M Park JP Lindenmayer R Suckow SR Zukin 2001 Adjunctive high dose glycine in the treatment of schizophrenia Int J Neuropsychopharmacol 4 385 391
36. J Jonides DE Nee 2006 Brain mechanisms of proactive interference in working memory Neuroscience 139 181 193
37. GG Kinney C Sur 2005 Glycine site modulators and transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia Curr Neuropharmacol 3 35 43
38. GG Kinney C Sur M Burno PJ Mallorga JB Williams DJ Figueroa M Wittmann W Lemaire PJ Conn 2003 The glycine transporter type 1 inhibitor N-[3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior J Neurosci 23 7586 7591
39. HY Lane YC Chang YC Liu CC Chiu GE Tsai 2005 Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study Arch Gen Psychiat 62 1196 1204
40. B Laube G Maksay R Schemm H Betz 2002 Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol Sci 23 519 527
41. SM Lechner 2006 Glutamate-based therapeutic approaches: inhibitors of glycine transport Curr Opin Pharmacol 6 75 81
42. M Leonetti C Desvignes I Bougault J Souilhac F Oury-Donat R Steinberg 2006 2-Chloro-N-[(S)-phenyl [(2S)-piperidin-2-yl] methyl]-3-trifluoromethyl benzamide, monohydrochloride, an inhibitor of the glycine transporter type 1, increases evoked-dopamine release in the rat nucleus accumbens in vivo via an enhanced glutamatergic neurotransmission Neuroscience 137 555 564
43. S Leung RJ Croft BV O'Neill PJ Nathan 2008 Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls Psychopharmacology (Berl) 196 451 460
44. JP Marquis MC Audet FY Doré S Goulet 2007 Delayed alteration performance following subchronic phencyclidine administration in rats depends on task parameters Prog Neuropsychopharmacol Biol Psychiatry 31 1108 1112
45. M Martina Y Gorfinkel S Halma JA Lowe P Periyalwar P CJ Lowe R Bergeron 2004 Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels J Physiol 557 489 500
46. CJ McBain ML Mayer 1994 N-Methyl-D-aspartic acid receptor structure and function Physiol Rev 74 723 760
47. SB McHugh B Niewoehner JNP Rawlins DM Bannerman 2008 Dorsal hippocampal N-methyl-D-aspartate receptors underlie spatial working memory performance during non-matching to place testing on the T-maze Behav Brain Res 186 41 47
48. MA Mehta WJ Riedel 2006 Dopaminergic enhancement of cognitive function Current Pharmaceutical Design 12 2487 2500
49. MJ Milan 2002 N-Methyl-D-aspartate receptor-coupled glycine-B receptors in the pathogenesis and treatment of schizophrenia: a critical review Curr Drug Targets CNS Neurol Disord 1 191 213
50. A Molander HH Lidö E Löf M Eriscon B Söderpalm 2007 The glycine reuptake inhibitor Org 25935 decreases ethanol intake and preference in mal wistar rats Alcohol 42 11 18
51. JB Monahan GE Handelmann WF Hood AA Cordi 1989 D-Cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats Pharmacol Biochem Behav 34 649 653
52. RG Morris 1989 Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5 J Neurosci 19 3040 3057
53. Y Nong YQ Huang YT Wang MW Salter 2003 Glycine binding primes NMDA receptor internalization Nature 422 302 307
54. M Nunnink RA Davenport B Ortega TA Houpt 2007 D-Cycloserine enhances conditioned taste aversion learning in rats Pharmacol Biochem Behav 87 321 330
55. JW Olney NB Farber 1995 Glutamate receptor dysfunction and schizophrenia Arch Gen Psychiat 52 998 1007
56. DS Olton 1979 Mazes, maps, and memory Am Psychol 34 583 596
57. DS Olton JT Becker GE Handelmann 1979 Hippocampus, space and memory Behav Brain Sci 2 313 365
58. C Palmer KA Ellis BV O'Neill RJ Croft S Leung C Oliver KA Wesnes PJ Nathan 2008 The cognitive effects of modulating the glycine site of the NMDA receptor with high-dose glycine in healthy controls Hum Psychopharmacol 23 151 159
59. R Pussinen P Sirviö 1999 Effects of D-cycloserine, a positive modulator of N-methyl-D-aspartate receptors, and ST 587, a putative alpha-1 adrenergic agonist, individually and in combination, on the non-delayed and delayed foraging behaviour of rats assessed in the radial arm J Psychopharmacol 13 171 179
60. S Rajendra JW Lynch PR Schofield 1997 The glycine receptor Pharmacol Ther 73 121 146
61. JNP Rawlins E Tsaltas 1983 The hippocampus, time and working memory Behav Brain Res 10 233 262
62. B Sahakian S Morein-Zamir 2007 Professor's little helper Nature 450 1157 1159
63. DJ Sanderson A Gray A Simon AM Taylor RM Deacon PH Seeburg R Sprengel MA Good JN Rawlins DM Bannerman 2007 Deletion of Glutamate receptor-A (GluR-A) AMPA receptor sunbunits impairs one-trial spatial memory Behav Neurosci 121 559 569
64. S Shoham DC Javitt U Heresco-Levy 1999 High dose glycine nutrition affects glial cell morphology in rat hippocampus and cerebellum Int J Neuropsychopharmacol 2 35 40
65. P Singer D Boison H Möhler J Feldon BK Yee 2007 Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons Behav Neurosci 121 815 25
66. P Singer J Feldon BK Yee 2007 Interference of glycine transporter 1: modulation of cognitive functions via activation of glycine-B site of the NMDA receptor CNS Agents Med Chem 7 259 268
67. KJ Stanhope AP McLenachan CT Dourish 1995 Dissociation between cognitive and motor/motivational deficits in the delayed matching to position test: effects of scopolamine, 8-OH-DPAT and EAA antagonists Psychopharmacology (Berl) 122 268 280
68. NR Swerdlow DL Braff MA Geyer 2000 Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon Behav Pharmacol 11 185 204
69. YP Tang E Shimizu GR Dube C Rampon GA Kerchner M Zhuo G Liu JZ Tsien 1999 Genetic enhancement of learning and memory in mice Nature 401 63 69
70. G Tsai HY Lane P Yang MY Chong N Lange 2004 Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia Biol Psychiat 55 452 456
71. D Umbricht S Krljes 2005 Mismatch negativity in schizophrenia: a meta-analysis Schizophr Res 76 1 23
72. BK Yee JNP Rawlins 1994 The effects of hippocampal formation ablation or fimbria-fornix section on performance of a nonspatial radial arm maze task by rats J Neurosci 14 3766 3774
73. BK Yee JNP Rawlins 1998 A comparison between the effects of medial septal lesions and entorhinal cortex lesions on performance of nonspatial working memory tasks and reversal learning Behav Brain Res 94 281 300
74. BK Yee E Balic P Singer C Schwerdel T Grampp L Gabernet I Knuesel D Benke J Feldon H Mohler D Boison 2006 Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile J Neurosci 26 3169 3181
75. A Zlomuzica MA De Souza Silva JP Huston E Dere 2007 NMDA receptor modulation by D-cycloserine promotes episodic-like memory in mice Psychopharmacology (Berl) 193 503 509