메뉴 건너뛰기




Volumn 68, Issue 7, 2011, Pages 1207-1214

Technologies of directed protein evolution in vivo

Author keywords

Cell culture based systems; Directed evolution; Gene conversion; Mutator strain; Protein engineering; Somatic hypermutation

Indexed keywords

BACILLUS ANTHRACIS; BIOTECHNOLOGY; CAPILLOVIRUS; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; EUKARYOTE; GENETIC VARIABILITY; HUMAN; IMMUNOCOMPETENT CELL; IN VIVO STUDY; LACTOBACILLUS GASSERI; MUTATOR GENE; NONHUMAN; PROKARYOTE; PSEUDOMONAS FLUORESCENS; REVIEW; SOMATIC HYPERMUTATION; TRANSGENE;

EID: 79953674772     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0610-5     Document Type: Review
Times cited : (10)

References (66)
  • 1
    • 33750006508 scopus 로고    scopus 로고
    • Directed evolution: An approach to engineer enzymes
    • DOI 10.1080/07388550600851423, PII K72L7J0440112P3K
    • J Kaur R Sharma 2006 Directed evolution: an approach to engineer enzymes Crit Rev Biotechnol 26 3 165 199 10.1080/07388550600851423 16923533 10.1080/07388550600851423 1:CAS:528:DC%2BD28XhtVaku7fI (Pubitemid 44567665)
    • (2006) Critical Reviews in Biotechnology , vol.26 , Issue.3 , pp. 165-199
    • Kaur, J.1    Sharma, R.2
  • 2
    • 48249098990 scopus 로고    scopus 로고
    • Protein design by directed evolution
    • 10.1146/annurev.biophys.37.032807.125832 18573077 10.1146/annurev. biophys.37.032807.125832 1:CAS:528:DC%2BD1cXnsVGltbg%3D
    • C Jackel P Kast D Hilvert 2008 Protein design by directed evolution Annu Rev Biophys 37 153 173 10.1146/annurev.biophys.37.032807.125832 18573077 10.1146/annurev.biophys.37.032807.125832 1:CAS:528:DC%2BD1cXnsVGltbg%3D
    • (2008) Annu Rev Biophys , vol.37 , pp. 153-173
    • Jackel, C.1    Kast, P.2    Hilvert, D.3
  • 3
    • 77952885870 scopus 로고    scopus 로고
    • Protein engineering of microbial enzymes
    • S1369-5274(10)00015-9 [pii]
    • Bottcher D, Bornscheuer UT Protein engineering of microbial enzymes. Curr Opin Microbiol 13 (3):274-282. S1369-5274(10)00015-9 [pii]
    • Curr Opin Microbiol , vol.13 , Issue.3 , pp. 274-282
    • Bottcher, D.1    Bornscheuer, U.T.2
  • 4
    • 70349774561 scopus 로고    scopus 로고
    • Directed evolution: New parts and optimized function
    • 10.1016/j.copbio.2009.08.005 19720520 10.1016/j.copbio.2009.08.005 1:CAS:528:DC%2BD1MXht1OrtLfI
    • MJ Dougherty FH Arnold 2009 Directed evolution: new parts and optimized function Curr Opin Biotechnol 20 4 486 491 10.1016/j.copbio.2009.08.005 19720520 10.1016/j.copbio.2009.08.005 1:CAS:528:DC%2BD1MXht1OrtLfI
    • (2009) Curr Opin Biotechnol , vol.20 , Issue.4 , pp. 486-491
    • Dougherty, M.J.1    Arnold, F.H.2
  • 5
    • 0028050350 scopus 로고
    • Rapid evolution of a protein in vitro by DNA shuffling
    • DOI 10.1038/370389a0
    • WP Stemmer 1994 Rapid evolution of a protein in vitro by DNA shuffling Nature 370 6488 389 391 10.1038/370389a0 8047147 10.1038/370389a0 1:CAS:528:DyaK2cXlvFOjsrs%3D (Pubitemid 24259765)
    • (1994) Nature , vol.370 , Issue.6488 , pp. 389-391
    • Stemmer, W.P.C.1
  • 7
    • 0032007562 scopus 로고    scopus 로고
    • Artificial evolution by DNA shuffling
    • DOI 10.1016/S0167-7799(97)01158-X, PII S016777999701158X
    • S Harayama 1998 Artificial evolution by DNA shuffling Trends Biotechnol 16 2 76 82 9487735 10.1016/S0167-7799(97)01158-X 1:CAS:528:DyaK1cXht1Snsr8%3D S0167-7799(97)01158-X [pii] (Pubitemid 28055476)
    • (1998) Trends in Biotechnology , vol.16 , Issue.2 , pp. 76-82
    • Harayama, S.1
  • 8
    • 1842868489 scopus 로고    scopus 로고
    • PCR approaches to DNA mutagenesis and recombination. An overview
    • 10.1385/1-59259-177-9:167 12494649 1:CAS:528:DC%2BD38XjtFOmsbg%3D
    • B Shen 2002 PCR approaches to DNA mutagenesis and recombination. An overview Methods Mol Biol 192 167 174 10.1385/1-59259-177-9:167 12494649 1:CAS:528:DC%2BD38XjtFOmsbg%3D
    • (2002) Methods Mol Biol , vol.192 , pp. 167-174
    • Shen, B.1
  • 9
    • 33748478328 scopus 로고    scopus 로고
    • In vitro evolution of proteins
    • DOI 10.1263/jbb.101.449, PII S1389172306706090
    • T Matsuura T Yomo 2006 In vitro evolution of proteins J Biosci Bioeng 101 6 449 456 10.1263/jbb.101.449 16935245 10.1263/jbb.101.449 1:CAS:528: DC%2BD28Xotlaktrw%3D (Pubitemid 44355025)
    • (2006) Journal of Bioscience and Bioengineering , vol.101 , Issue.6 , pp. 449-456
    • Matsuura, T.1    Yomo, T.2
  • 10
    • 3142685154 scopus 로고    scopus 로고
    • In-vitro protein evolution by ribosome display and mRNA display
    • DOI 10.1016/j.jim.2004.04.008, PII S0022175904001309
    • D Lipovsek A Pluckthun 2004 In vitro protein evolution by ribosome display and mRNA display J Immunol Methods 290 1-2 51 67 10.1016/j.jim.2004.04. 008 15261571 10.1016/j.jim.2004.04.008 1:CAS:528:DC%2BD2cXlslyhurw%3D (Pubitemid 38917130)
    • (2004) Journal of Immunological Methods , vol.290 , Issue.1-2 , pp. 51-67
    • Lipovsek, D.1    Pluckthun, A.2
  • 11
    • 0346982051 scopus 로고    scopus 로고
    • Phage display
    • GP Smith VA Petrenko 1997 Phage display Chem Rev 97 2 391 410 11848876 10.1021/cr960065d 1:CAS:528:DyaK2sXhslamtb8%3D (Pubitemid 127659250)
    • (1997) Chemical Reviews , vol.97 , Issue.2 , pp. 391-410
    • Smith, G.P.1    Petrenko, V.A.2
  • 12
    • 77950164392 scopus 로고    scopus 로고
    • Random mutagenesis methods for in vitro directed enzyme evolution
    • Labrou NE (2010) Random mutagenesis methods for in vitro directed enzyme evolution. Curr Protein Pept Sci 11(1):91-100
    • (2010) Curr Protein Pept Sci , vol.11 , Issue.1 , pp. 91-100
    • Labrou, N.E.1
  • 13
    • 0028110130 scopus 로고
    • DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution
    • DOI 10.1073/pnas.91.22.10747
    • WP Stemmer 1994 DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution Proc Natl Acad Sci USA 91 22 10747 10751 7938023 10.1073/pnas.91.22.10747 1:CAS:528:DyaK2MXhsleltLw%3D (Pubitemid 24329076)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.22 , pp. 10747-10751
    • Stemmer, W.P.C.1
  • 14
    • 3042784274 scopus 로고    scopus 로고
    • Generating mutant libraries using error-prone PCR
    • 10.1385/1-59259-395-X:3 12824595 1:CAS:528:DC%2BD3sXkt1Ggtb8%3D
    • PC Cirino KM Mayer D Umeno 2003 Generating mutant libraries using error-prone PCR Methods Mol Biol 231 3 9 10.1385/1-59259-395-X:3 12824595 1:CAS:528:DC%2BD3sXkt1Ggtb8%3D
    • (2003) Methods Mol Biol , vol.231 , pp. 3-9
    • Cirino, P.C.1    Mayer, K.M.2    Umeno, D.3
  • 15
    • 54449087770 scopus 로고    scopus 로고
    • Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity
    • 10.1073/pnas.0803103105 18812512 10.1073/pnas.0803103105 1:CAS:528:DC%2BD1cXht1aqtbbP
    • CA Sarkar I Dodevski M Kenig S Dudli A Mohr E Hermans A Pluckthun 2008 Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity Proc Natl Acad Sci USA 105 39 14808 14813 10.1073/pnas.0803103105 18812512 10.1073/pnas.0803103105 1:CAS:528: DC%2BD1cXht1aqtbbP
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.39 , pp. 14808-14813
    • Sarkar, C.A.1    Dodevski, I.2    Kenig, M.3    Dudli, S.4    Mohr, A.5    Hermans, E.6    Pluckthun, A.7
  • 16
    • 0033643217 scopus 로고    scopus 로고
    • [19] Optimized synthesis of RNA-protein fusions for in vitro protein selection
    • R Liu JE Barrick JW Szostak RW Roberts 2000 Optimized synthesis of RNA-protein fusions for in vitro protein selection Methods Enzymol 318 268 293 10889994 10.1016/S0076-6879(00)18058-9 1:CAS:528:DC%2BD3cXltFSrsbY%3D (Pubitemid 30421654)
    • (2000) Methods in Enzymology , vol.318 , pp. 268-293
    • Liu, R.1    Barrick, J.E.2    Szostak, J.W.3    Roberts, R.W.4
  • 18
    • 4644269746 scopus 로고    scopus 로고
    • High-throughput cell-free systems for synthesis of functionally active proteins
    • DOI 10.1016/j.tibtech.2004.08.012, PII S0167779904002343
    • AS Spirin 2004 High-throughput cell-free systems for synthesis of functionally active proteins Trends Biotechnol 22 10 538 545 10.1016/j.tibtech.2004.08.012 15450748 10.1016/j.tibtech.2004.08.012 1:CAS:528:DC%2BD2cXnvVOhsbw%3D (Pubitemid 39265186)
    • (2004) Trends in Biotechnology , vol.22 , Issue.10 , pp. 538-545
    • Spirin, A.S.1
  • 19
    • 0029680681 scopus 로고    scopus 로고
    • An efficient random mutagenesis technique using an E. coli mutator strain
    • 10.1385/0-89603-332-5:375 8850023 1:CAS:528:DyaK28Xhs12jtbc%3D
    • A Greener M Callahan B Jerpseth 1996 An efficient random mutagenesis technique using an E. coli mutator strain Methods Mol Biol 57 375 385 10.1385/0-89603-332-5:375 8850023 1:CAS:528:DyaK28Xhs12jtbc%3D
    • (1996) Methods Mol Biol , vol.57 , pp. 375-385
    • Greener, A.1    Callahan, M.2    Jerpseth, B.3
  • 20
    • 3242673654 scopus 로고    scopus 로고
    • Random mutagenesis strategies for construction of large and diverse clone libraries of mutated DNA fragments
    • 10.1385/1-59259-793-9:319 15153637 1:CAS:528:DC%2BD2cXlvVGrtr4%3D
    • S Chusacultanachai Y Yuthavong 2004 Random mutagenesis strategies for construction of large and diverse clone libraries of mutated DNA fragments Methods Mol Biol 270 319 334 10.1385/1-59259-793-9:319 15153637 1:CAS:528:DC%2BD2cXlvVGrtr4%3D
    • (2004) Methods Mol Biol , vol.270 , pp. 319-334
    • Chusacultanachai, S.1    Yuthavong, Y.2
  • 21
    • 0032486517 scopus 로고    scopus 로고
    • Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones
    • DOI 10.1002/(SICI)1097-0290(19980605)58:5<554::AID-BIT12>3.0.CO;2-B
    • UT Bornscheuer J Altenbuchner HH Meyer 1998 Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones Biotechnol Bioeng 58 5 554 559 10.1002/(SICI)1097- 0290(19980605)58:5<554::AID-BIT12>3.0.CO;2-B 10099292 10.1002/(SICI)1097- 0290(19980605)58:5<554::AID-BIT12>3.0.CO;2-B 1:CAS:528:DyaK1cXisVeqsrc%3D (Pubitemid 28178258)
    • (1998) Biotechnology and Bioengineering , vol.58 , Issue.5 , pp. 554-559
    • Bornscheuer, U.T.1    Altenbuchner, J.2    Meyer, H.H.3
  • 22
    • 0032828603 scopus 로고    scopus 로고
    • Directed evolution of an esterase: Screening of enzyme libraries based on pH-Indicators and a growth assay
    • DOI 10.1016/S0968-0896(99)00147-9, PII S0968089699001479
    • UT Bornscheuer J Altenbuchner HH Meyer 1999 Directed evolution of an esterase: screening of enzyme libraries based on pH indicators and a growth assay Bioorg Med Chem 7 10 2169 2173 10579522 10.1016/S0968-0896(99)00147-9 1:CAS:528:DyaK1MXmsFWqs70%3D S0968-0896(99)00147-9 [pii] (Pubitemid 29486576)
    • (1999) Bioorganic and Medicinal Chemistry , vol.7 , Issue.10 , pp. 2169-2173
    • Bornscheuer, U.T.1    Altenbuchner, J.2    Meyer, H.H.3
  • 23
    • 33846575680 scopus 로고    scopus 로고
    • Modification of Lactobacillus β-glucuronidase activity by random mutagenesis
    • DOI 10.1016/j.gene.2006.10.022, PII S0378111906006809
    • MJ Callanan WM Russell TR Klaenhammer 2007 Modification of Lactobacillus beta-glucuronidase activity by random mutagenesis Gene 389 2 122 127 10.1016/j.gene.2006.10.022 17174482 10.1016/j.gene.2006.10.022 1:CAS:528:DC%2BD2sXht1Gjtr8%3D (Pubitemid 46186781)
    • (2007) Gene , vol.389 , Issue.2 , pp. 122-127
    • Callanan, M.J.1    Russell, W.M.2    Klaenhammer, T.R.3
  • 24
    • 0035013599 scopus 로고    scopus 로고
    • Random mutagenesis in a plant viral genome using a DNA repair-deficient mutator Escherichia coli strain
    • DOI 10.1016/S0166-0934(01)00270-1, PII S0166093401002701
    • X Lu H Hirata Y Yamaji M Ugaki S Namba 2001 Random mutagenesis in a plant viral genome using a DNA repair-deficient mutator Escherichia coli strain J Virol Methods 94 1-2 37 43 11337038 10.1016/S0166-0934(01)00270-1 1:CAS:528:DC%2BD3MXjtFGhsr8%3D S0166093401002701 [pii] (Pubitemid 32411476)
    • (2001) Journal of Virological Methods , vol.94 , Issue.1-2 , pp. 37-43
    • Lu, X.1    Hirata, H.2    Yamaji, Y.3    Ugaki, M.4    Namba, S.5
  • 25
    • 69849092387 scopus 로고    scopus 로고
    • Conditional gene silencing of multiple genes with antisense RNAs and generation of a mutator strain of Escherichia coli
    • 10.1093/nar/gkp498 19515932 10.1093/nar/gkp498
    • N Nakashima T Tamura 2009 Conditional gene silencing of multiple genes with antisense RNAs and generation of a mutator strain of Escherichia coli Nucleic Acids Res 37 15 e103 10.1093/nar/gkp498 19515932 10.1093/nar/gkp498
    • (2009) Nucleic Acids Res , vol.37 , Issue.15 , pp. 103
    • Nakashima, N.1    Tamura, T.2
  • 26
    • 39149115055 scopus 로고    scopus 로고
    • Deletion of dnaN1 generates a mutator phenotype in Bacillus anthracis
    • 10.1016/j.dnarep.2007.10.003 10.1016/j.dnarep.2007.10.003 1:CAS:528:DC%2BD1cXitVOktrc%3D
    • H Yang JH Miller 2008 Deletion of dnaN1 generates a mutator phenotype in Bacillus anthracis DNA Repair (Amst) 7 3 507 514 10.1016/j.dnarep.2007.10.003 10.1016/j.dnarep.2007.10.003 1:CAS:528:DC%2BD1cXitVOktrc%3D
    • (2008) DNA Repair (Amst) , vol.7 , Issue.3 , pp. 507-514
    • Yang, H.1    Miller, J.H.2
  • 28
    • 0018351517 scopus 로고
    • Initiation of replication of plasmid ColE1 DNA by RNA polymerase, ribonuclease H, and DNA polymerase I
    • T Itoh J Tomizawa 1979 Initiation of replication of plasmid ColE1 DNA by RNA polymerase, ribonuclease H, and DNA polymerase I Cold Spring Harb Symp Quant Biol 43 Pt 1 409 417 225109 1:CAS:528:DyaE1MXlsFCjtrY%3D (Pubitemid 9230216)
    • (1979) Cold Spring Harbor Symposia on Quantitative Biology , vol.43 , Issue.1 , pp. 409-417
    • Itoh, T.1    Tomizawa, J.2
  • 29
    • 68949161807 scopus 로고    scopus 로고
    • Programming cells by multiplex genome engineering and accelerated evolution
    • 10.1038/nature08187 19633652 10.1038/nature08187 1:CAS:528: DC%2BD1MXovFymtb4%3D
    • HH Wang FJ Isaacs PA Carr ZZ Sun G Xu CR Forest GM Church 2009 Programming cells by multiplex genome engineering and accelerated evolution Nature 460 7257 894 898 10.1038/nature08187 19633652 10.1038/nature08187 1:CAS:528:DC%2BD1MXovFymtb4%3D
    • (2009) Nature , vol.460 , Issue.7257 , pp. 894-898
    • Wang, H.H.1    Isaacs, F.J.2    Carr, P.A.3    Sun, Z.Z.4    Xu, G.5    Forest, C.R.6    Church, G.M.7
  • 30
    • 0035810938 scopus 로고    scopus 로고
    • High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides
    • DOI 10.1073/pnas.121164898
    • HM Ellis D Yu T DiTizio DL Court 2001 High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides Proc Natl Acad Sci USA 98 12 6742 6746 10.1073/pnas.121164898 11381128 10.1073/pnas.121164898 1:CAS:528:DC%2BD3MXksVOku74%3D (Pubitemid 32538287)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.12 , pp. 6742-6746
    • Ellis, H.M.1    Yu, D.2    DiTizio, T.3    Court, D.L.4
  • 31
    • 78649649132 scopus 로고    scopus 로고
    • PCR less library mutagenesis via oligonucleotide recombination in yeast
    • doi: 10.1002/pro.513
    • Pirakitikulr N, Ostrov N, Peralta-Yahya P, Cornish VW PCR less library mutagenesis via oligonucleotide recombination in yeast. Protein Sci 19(12):2336-2346. doi: 10.1002/pro.513
    • Protein Sci , vol.19 , Issue.12 , pp. 2336-2346
    • Pirakitikulr, N.1    Ostrov, N.2    Peralta-Yahya, P.3    Cornish, V.W.4
  • 32
    • 0014943022 scopus 로고
    • Variability in the lambda light chain sequences of mouse antibody
    • 5483159 10.1038/2281045a0 1:CAS:528:DyaE3MXnsVeitw%3D%3D
    • MG Weigert IM Cesari SJ Yonkovich M Cohn 1970 Variability in the lambda light chain sequences of mouse antibody Nature 228 5276 1045 1047 5483159 10.1038/2281045a0 1:CAS:528:DyaE3MXnsVeitw%3D%3D
    • (1970) Nature , vol.228 , Issue.5276 , pp. 1045-1047
    • Weigert, M.G.1    Cesari, I.M.2    Yonkovich, S.J.3    Cohn, M.4
  • 33
    • 0019847882 scopus 로고
    • Antibody diversity: Somatic hypermutation of rearranged V(H) genes
    • S Kim M Davis E Sinn P Patten L Hood 1981 Antibody diversity: somatic hypermutation of rearranged VH genes Cell 27 3 Pt 2 573 581 0092-8674(81)90399-8 6101208 10.1016/0092-8674(81)90399-8 1:CAS:528:DyaL38XhtFKku7w%3D (Pubitemid 12200794)
    • (1981) Cell , vol.27 , Issue.II3 , pp. 573-581
    • Kim, S.1    Davis, M.2    Sinn, E.3
  • 34
    • 0008476550 scopus 로고
    • Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
    • D McKean K Huppi M Bell L Staudt W Gerhard M Weigert 1984 Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin Proc Natl Acad Sci USA 81 10 3180 3184 6203114 10.1073/pnas.81.10.3180 1:CAS:528:DyaL2cXkslSluro%3D (Pubitemid 14110702)
    • (1984) Proceedings of the National Academy of Sciences of the United States of America , vol.81 , Issue.I10 , pp. 3180-3184
    • McKean, D.1    Huppi, K.2    Bell, M.3
  • 35
    • 0002341499 scopus 로고
    • The maturation of the antibody response
    • T. Honjo F. Alt (eds). Academic Press Limited London. 10.1016/B978-012053640-5/50006-9
    • Milstein C, Rada C (1995) The maturation of the antibody response. In: Honjo T, Alt F (eds) Immunoglobulin genes. Academic Press Limited, London, pp 57-83
    • (1995) Immunoglobulin Genes , pp. 57-83
    • Milstein, C.1    Rada, C.2
  • 36
    • 0036234455 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes: Merging mechanisms for genetic diversity
    • DOI 10.1016/S0092-8674(02)00706-7
    • FN Papavasiliou DG Schatz 2002 Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity Cell 109 Suppl S35 S44 11983151 10.1016/S0092-8674(02)00706-7 1:CAS:528:DC%2BD38Xjt1eqtbg%3D (Pubitemid 34457850)
    • (2002) Cell , vol.109 , Issue.2 SUPPL. 1
    • Papavasiliou F.Nina1    Schatz, D.G.2
  • 37
    • 0036674618 scopus 로고    scopus 로고
    • Aid and mismatch repair in antibody diversification
    • A Martin MD Scharff 2002 AID and mismatch repair in antibody diversification Nat Rev Immunol 2 8 605 614 10.1038/nri858 12154379 1:CAS:528:DC%2BD38XlslGqsr4%3D (Pubitemid 37328735)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.8 , pp. 605-614
    • Martin, A.1    Scharff, M.D.2
  • 38
    • 0038713344 scopus 로고    scopus 로고
    • Immunity through DNA deamination
    • DOI 10.1016/S0968-0004(03)00111-7
    • MS Neuberger RS Harris J Di Noia SK Petersen-Mahrt 2003 Immunity through DNA deamination Trends Biochem Sci 28 6 305 312 12826402 10.1016/S0968-0004(03) 00111-7 1:CAS:528:DC%2BD3sXkvVCnu7c%3D S0968000403001117 [pii] (Pubitemid 36776293)
    • (2003) Trends in Biochemical Sciences , vol.28 , Issue.6 , pp. 305-312
    • Neuberger, M.S.1    Harris, R.S.2    Di Noia, J.3    Petersen-Mahrt, S.K.4
  • 39
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of tghe antibody repertoire in the mouse
    • K Rajewsky I Forster A Cumano 1987 Evolutionary and somatic selection of the antibody repertoire in the mouse Science 238 4830 1088 1094 3317826 10.1126/science.3317826 1:CAS:528:DyaL1cXltlylsQ%3D%3D (Pubitemid 18011949)
    • (1987) Science , vol.238 , Issue.4830 , pp. 1088-1094
    • Rajewsky, K.1    Forster, I.2    Cumano, A.3
  • 40
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • 11007474 10.1016/S0092-8674(00)00078-7 1:CAS:528:DC%2BD3cXmsFWit7g%3D S0092-8674(00)00078-7 [pii]
    • M Muramatsu K Kinoshita S Fagarasan S Yamada Y Shinkai T Honjo 2000 Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 5 553 563 11007474 10.1016/S0092-8674(00)00078-7 1:CAS:528:DC%2BD3cXmsFWit7g%3D S0092-8674(00)00078-7 [pii]
    • (2000) Cell , vol.102 , Issue.5 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 41
  • 42
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • DOI 10.1038/nature01760
    • P Pham R Bransteitter J Petruska MF Goodman 2003 Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation Nature 424 6944 103 107 10.1038/nature01760 12819663 10.1038/nature01760 1:CAS:528:DC%2BD3sXltVelsbs%3D (Pubitemid 36834850)
    • (2003) Nature , vol.424 , Issue.6944 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 43
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • DOI 10.1016/S1074-7613(00)80298-8
    • A Peters U Storb 1996 Somatic hypermutation of immunoglobulin genes is linked to transcription initiation Immunity 4 1 57 65 S1074-7613(00)80298-8 8574852 10.1016/S1074-7613(00)80298-8 1:CAS:528:DyaK28Xos1Klug%3D%3D (Pubitemid 26054936)
    • (1996) Immunity , vol.4 , Issue.1 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 44
    • 0032549125 scopus 로고    scopus 로고
    • Mismatch repair co-opted by hypermutation
    • DOI 10.1126/science.279.5354.1207
    • M Cascalho J Wong C Steinberg M Wabl 1998 Mismatch repair co-opted by hypermutation Science 279 5354 1207 1210 9469811 10.1126/science.279.5354.1207 1:CAS:528:DyaK1cXhtlSis74%3D (Pubitemid 28164372)
    • (1998) Science , vol.279 , Issue.5354 , pp. 1207-1210
    • Cascalho, M.1    Wong, J.2    Steinberg, C.3    Wabl, M.4
  • 45
    • 0037026482 scopus 로고    scopus 로고
    • Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
    • DOI 10.1038/nature00981
    • J Di Noia MS Neuberger 2002 Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase Nature 419 6902 43 48 10.1038/nature00981 12214226 10.1038/nature00981 1:CAS:528:DC%2BD38Xmslahtbk%3D (Pubitemid 34987864)
    • (2002) Nature , vol.419 , Issue.6902 , pp. 43-48
    • Di Noia, J.1    Neuberger, M.S.2
  • 46
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • DOI 10.1038/nature00862
    • SK Petersen-Mahrt RS Harris MS Neuberger 2002 AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification Nature 418 6893 99 103 10.1038/nature00862 12097915 10.1038/nature00862 1:CAS:528:DC%2BD38XltVantr0%3D (Pubitemid 34742579)
    • (2002) Nature , vol.418 , Issue.6893 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 47
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in place of the v segment by somatic hypermutation
    • 10.1038/376225a0 7617031 10.1038/376225a0 1:CAS:528:DyaK2MXntFSmuro%3D
    • J Yelamos N Klix B Goyenechea F Lozano YL Chui A Gonzalez Fernandez R Pannell MS Neuberger C Milstein 1995 Targeting of non-Ig sequences in place of the V segment by somatic hypermutation Nature 376 6537 225 229 10.1038/376225a0 7617031 10.1038/376225a0 1:CAS:528:DyaK2MXntFSmuro%3D
    • (1995) Nature , vol.376 , Issue.6537 , pp. 225-229
    • Yelamos, J.1    Klix, N.2    Goyenechea, B.3    Lozano, F.4    Chui, Y.L.5    Gonzalez Fernandez, A.6    Pannell, R.7    Neuberger, M.S.8    Milstein, C.9
  • 48
    • 0035871625 scopus 로고    scopus 로고
    • Increased transcription levels induce higher mutation rates in a hypermutating cell line
    • J Bachl C Carlson V Gray-Schopfer M Dessing C Olsson 2001 Increased transcription levels induce higher mutation rates in a hypermutating cell line J Immunol 166 8 5051 5057 11290786 1:STN:280:DC%2BD3MzmvFOguw%3D%3D (Pubitemid 32280718)
    • (2001) Journal of Immunology , vol.166 , Issue.8 , pp. 5051-5057
    • Bachl, J.1    Carlson, C.2    Gray-Schopfer, V.3    Dessing, M.4    Olsson, C.5
  • 49
    • 0037076967 scopus 로고    scopus 로고
    • AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
    • DOI 10.1126/science.1071556
    • K Yoshikawa IM Okazaki T Eto K Kinoshita M Muramatsu H Nagaoka T Honjo 2002 AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts Science 296 5575 2033 2036 10.1126/science.1071556 12065838 10.1126/science.1071556 1:CAS:528:DC%2BD38Xks1eqtbw%3D (Pubitemid 34627527)
    • (2002) Science , vol.296 , Issue.5575 , pp. 2033-2036
    • Yoshikawa, K.1    Okazaki, I.-M.2    Eto, T.3    Kinoshita, K.4    Muramatsu, M.5    Nagaoka, H.6    Honjo, T.7
  • 51
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • DOI 10.1016/S1074-7613(00)80651-2
    • JE Sale MS Neuberger 1998 TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line Immunity 9 6 859 869 9881976 10.1016/S1074-7613(00)80651-2 1:CAS:528:DyaK1MXms1CqsA%3D%3D S1074-7613(00)80651-2 [pii] (Pubitemid 29024465)
    • (1998) Immunity , vol.9 , Issue.6 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 53
    • 0037083364 scopus 로고    scopus 로고
    • Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
    • DOI 10.1126/science.1067308
    • H Arakawa J Hauschild JM Buerstedde 2002 Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion Science 295 5558 1301 1306 10.1126/science.1067308 11847344 10.1126/science. 1067308 1:CAS:528:DC%2BD38XhsVGhsb8%3D (Pubitemid 34157623)
    • (2002) Science , vol.295 , Issue.5558 , pp. 1301-1306
    • Arakawa, H.1    HauschiLd, J.2    Buerstedde, J.-M.3
  • 54
    • 19344367559 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate
    • DOI 10.1371/journal.pbio.0020179
    • H Arakawa H Saribasak JM Buerstedde 2004 Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate PLoS Biol 2 7 E179 10.1371/journal.pbio.0020179 15252444 10.1371/journal.pbio.0020179 (Pubitemid 39234410)
    • (2004) PLoS Biology , vol.2 , Issue.7
    • Arakawa, H.1    Saribasak, H.2    Buerstedde, J.-M.3
  • 55
    • 0025936509 scopus 로고
    • Increased ratio of targeted to random integration after transfection of chicken B cell lines
    • JM Buerstedde S Takeda 1991 Increased ratio of targeted to random integration after transfection of chicken B cell lines Cell 67 1 179 188 0092-8674(91)90581-I 1913816 10.1016/0092-8674(91)90581-I 1:CAS:528: DyaK3MXmslams74%3D (Pubitemid 121001434)
    • (1991) Cell , vol.67 , Issue.1 , pp. 179-188
    • Buerstedde, J.-M.1    Takeda, S.2
  • 56
    • 24944494926 scopus 로고    scopus 로고
    • Rapid generation of specific antibodies by enhanced homologous recombination
    • DOI 10.1038/nbt1092
    • H Seo M Masuoka H Murofushi S Takeda T Shibata K Ohta 2005 Rapid generation of specific antibodies by enhanced homologous recombination Nat Biotechnol 23 6 731 735 10.1038/nbt1092 15924134 10.1038/nbt1092 1:CAS:528:DC%2BD2MXkvVShsrk%3D (Pubitemid 41716364)
    • (2005) Nature Biotechnology , vol.23 , Issue.6 , pp. 731-735
    • Seo, H.1    Masuoka, M.2    Murofushi, H.3    Takeda, S.4    Shibata, T.5    Ohta, K.6
  • 57
    • 34347250889 scopus 로고    scopus 로고
    • An ex vivo method for rapid generation of monoclonal antibodies (ADLib system)
    • 10.1038/nprot.2006.248 17406441 10.1038/nprot.2006.248 1:CAS:528:DC%2BD28Xht1eitL%2FO
    • H Seo S Hashimoto K Tsuchiya W Lin T Shibata K Ohta 2006 An ex vivo method for rapid generation of monoclonal antibodies (ADLib system) Nat Protoc 1 3 1502 1506 10.1038/nprot.2006.248 17406441 10.1038/nprot.2006.248 1:CAS:528:DC%2BD28Xht1eitL%2FO
    • (2006) Nat Protoc , vol.1 , Issue.3 , pp. 1502-1506
    • Seo, H.1    Hashimoto, S.2    Tsuchiya, K.3    Lin, W.4    Shibata, T.5    Ohta, K.6
  • 58
    • 35748970498 scopus 로고    scopus 로고
    • Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering
    • H Seo T Yamada S Hashimoto W Lin K Ohta 2007 Modulation of immunoglobulin gene conversion in chicken DT40 by enhancing histone acetylation, and its application to antibody engineering Biotechnol Genet Eng Rev 24 179 193 18059633 1:CAS:528:DC%2BD2sXhtlKiurjE (Pubitemid 350041418)
    • (2007) Biotechnology and Genetic Engineering Reviews , vol.24 , pp. 179-193
    • Seo, H.1    Yamada, T.2    Hashimoto, S.-I.3    Lin, W.4    Ohta, K.5
  • 59
    • 32644480287 scopus 로고    scopus 로고
    • Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line
    • DOI 10.1093/nar/gnj013
    • N Kanayama K Todo S Takahashi M Magari H Ohmori 2006 Genetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell line Nucleic Acids Res 34 2 e10 16421270 10.1093/nar/gnj013 34/2/e10 [pii] (Pubitemid 43245432)
    • (2006) Nucleic Acids Research , vol.34 , Issue.2 , pp. 1-9
    • Kanayama, N.1    Todo, K.2    Takahashi, S.3    Magari, M.4    Ohmori, H.5
  • 61
    • 3042559648 scopus 로고    scopus 로고
    • Mutants IoxP vectors for selectable marker recycle and conditional knock-outs
    • DOI 10.1186/1472-6750-1-7
    • H Arakawa D Lodygin JM Buerstedde 2001 Mutant loxP vectors for selectable marker recycle and conditional knock-outs BMC Biotechnol 1 7 11591226 10.1186/1472-6750-1-7 1:STN:280:DC%2BD3srgs1Sgsg%3D%3D (Pubitemid 38846427)
    • (2001) BMC Biotechnology , vol.1 , pp. 7
    • Arakawa, H.1    Lodygin, D.2    Buerstedde, J.-M.3
  • 62
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • DOI 10.1016/0092-8674(94)90316-6
    • AG Betz C Milstein A Gonzalez-Fernandez R Pannell T Larson MS Neuberger 1994 Elements regulating somatic hypermutation of an immunoglobulin kappa gene: critical role for the intron enhancer/matrix attachment region Cell 77 2 239 248 8168132 10.1016/0092-8674(94)90316-6 1:CAS:528:DyaK2cXktVahurc%3D 0092-8674(94)90316-6 [pii] (Pubitemid 24138621)
    • (1994) Cell , vol.77 , Issue.2 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 63
    • 33746574474 scopus 로고    scopus 로고
    • Targeting of somatic hypermutation
    • DOI 10.1038/nri1896, PII NRI1896
    • VH Odegard DG Schatz 2006 Targeting of somatic hypermutation Nat Rev Immunol 6 8 573 583 10.1038/nri1896 16868548 10.1038/nri1896 1:CAS:528:DC%2BD28Xnt1yisLc%3D (Pubitemid 44134090)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.8 , pp. 573-583
    • Odegard, V.H.1    Schatz, D.G.2
  • 64
    • 42149132725 scopus 로고    scopus 로고
    • Cutting edge: A cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus
    • 18250404 1:CAS:528:DC%2BD1cXhsVShtrc%3D 180/4/2019 [pii]
    • N Kothapalli DD Norton SD Fugmann 2008 Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus J Immunol 180 4 2019 2023 18250404 1:CAS:528: DC%2BD1cXhsVShtrc%3D 180/4/2019 [pii]
    • (2008) J Immunol , vol.180 , Issue.4 , pp. 2019-2023
    • Kothapalli, N.1    Norton, D.D.2    Fugmann, S.D.3
  • 65
    • 59249094658 scopus 로고    scopus 로고
    • A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation
    • 10.1371/journal.pgen.1000332 19132090 10.1371/journal.pgen.1000332
    • A Blagodatski V Batrak S Schmidl U Schoetz RB Caldwell H Arakawa JM Buerstedde 2009 A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation PLoS Genet 5 1 e1000332 10.1371/journal.pgen.1000332 19132090 10.1371/journal.pgen.1000332
    • (2009) PLoS Genet , vol.5 , Issue.1 , pp. 1000332
    • Blagodatski, A.1    Batrak, V.2    Schmidl, S.3    Schoetz, U.4    Caldwell, R.B.5    Arakawa, H.6    Buerstedde, J.M.7
  • 66
    • 60049095326 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line
    • 10.1098/rstb.2008.0202 19008193 10.1098/rstb.2008.0202 1:CAS:528:DC%2BD1MXjs1WisbY%3D
    • H Arakawa JM Buerstedde 2009 Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line Philos Trans R Soc Lond B Biol Sci 364 1517 639 644 10.1098/rstb.2008.0202 19008193 10.1098/rstb.2008. 0202 1:CAS:528:DC%2BD1MXjs1WisbY%3D
    • (2009) Philos Trans R Soc Lond B Biol Sci , vol.364 , Issue.1517 , pp. 639-644
    • Arakawa, H.1    Buerstedde, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.