Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse lewy body disease is associated with irregular α-synuclein/phospholipase C (PLCβ1) interactions

Brain Pathology

Volumn 14, Issue 4, 2004, Pages 388-398

  Dalfo E ^a   Albasanz, J L ^c   Martin M ^c   Ferrer, I ^a,b  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b Facultad de Medicina   (Spain)

^c UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; METABOTROPIC RECEPTOR; PHOSPHOLIPASE C; PROTEIN G;

ADULT; AGED; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 8744241629     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2004.tb00082.x     Document Type: Article

References (75)

1. Ahn BH, Rhim H, Kim SY, Sung YM, Lee MY, Choi JY, Wolozin B, Chang JS, Lee YH, Kwon TK, Chung KC, Yoon SH, Hahn SJ, Kim MS, Jo YH, Min DS (2002) α-synuclein interacts with phospholipase D isozymes and inhibits pervadanate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem 277:12334-12342.
2. Albasanz JL, Leon D, Ruiz MA, Fernandez M, Martin M (2002) Adenosine A1 receptor agonist treatment up-regulates rat brain metabotropic glutamate receptors. Biochim Biophys Acta 1593:69-75.
3. Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VMY, Trojanowski JQ, Iwatsubo T (1998) Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152:879-884.
4. Böhm D, Schwegler H, Kotthaus L, Nayernia K, Rickmann M, Köhler M, Rosenbusch J, Engel W, Flügge G, Burfeind P (2002) Disruption of PLCβ1-mediated signal transduction in mutant mice causes age-dependent hippocampal mossy fiber sprouting and neurodegeneration. Mol Cell Neurosci 21:584-601.
5. Braak H, Braak E (1999) Temporal sequence of Alzheimer's disease-related pathology. In: Cerebral cortex vol 14: Neurodegenerative and age-related changes in structure and function of cerebral cortex. Peters A, Morrison JH (eds.), pp 475-512, Kluwer Academic/Plenum Press: New York, Boston, Dordrecht, London, Moscow.
6. Bradley SR, Marino MJ, Wittmann M, Rouse ST, Awad H, Levey AI, Conn.PJ (2000) Activation of group II metabotropic glutamate receptors inhibit synaptic excitation of the substantia nigra pars reticulata. J Neurosci 20:3085-3094.
7. Breysse N, Baunez C, Spooren W, Gasparini F, Amalric M (2002) Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism. J Neurosci 22:5669-5678.
8. Campbell BC, Li QX, Culvenor JG, Jakala P, Cappai R, Beyreuther K, Masters CL, McLean CA (2000) Accumulation of insoluble α-synuclein in dementia with Lewy bodies. Neurobiol Dis 7:192-200.
9. Cha JHJ, Farrell LA, Ahmed SF, Frey A, Hsiao-Ashe KK, Young AB, Penney JB, Locascio JJ, Hyman BT, Irizarry MC (2001) Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein. Neurobiol Dis 8:90-102.
10. Churchyard A, Lees AJ (1997) The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease. Neurology 49:1570-1576.
11. Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, Bar-Sagi D, Morris AJ, Frohman MA (1997) Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 7:191-201.
12. Conn P, Pin JP (1997) Pharmacology and functions of metabotropic glutamate receptors. Ann Rev Pharmacol Toxicol 37:205-237.
13. Cowburn RF, O'Neill C, Bonkale WL, Ohm TG, Fatbom J (2001) Receptor-G-protein signalling in Alzheimer's disease. Biochem Soc Symp 67:163-175.
14. Dalfó E, Barrachina M, Rosa JL, Ambrosio S, Ferrer I (2004) Abnormal α-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease. Neurobiol Dis 16:92-97.
15. Dalfó E, Gómez-Isla T, Rosa JL, Nieto Bodelón M, Cuadrado Tejedor M, Barrachina M, Ambrosio S, Ferrer I (2004) Abnormal synuclein interactions with Rab proteins in synuclein A30P transgenic mice. J Neuropathol Exp Neurol 63:302-313.
16. Dewar D, Chalmers DT, Graham DI, McCulloch J (1991) Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: An autoradiographic study of the hippocampus. Brain Res 553:58-64.
17. Duda JE, Giasson BI, Chen Q, Gur TL, Hurtig HI, Stern MB, Gollomp SM, Ischiropoulos H, Lee VMY, Trojanowski JQ (2000) Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. Am J Pathol 157:1439-1445.
18. Duda JE, Giasson BI, Mabon ME, Lee VMY, Trojanowski JQ (2002) Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol 52:205-210.
19. Duda JE, Lee VMY, Trojanowski JQ (2000) Neuropathology of synuclein aggregates: new insights into mechanisms of neurodegenerative diseases. J Neurosci Res 61:121-127.
20. Feeley Kearney JA, Albin RL (2003) mGluRs: a target for pharmacotherapy in Parkinson's disease. Exp Neurol 184, suppl 1:S30-36.
21. Ferrer I (2002) The neuropathological spectrum of Lewy body disorders. In: Neurodegenerative disorders associated with α-synuclein pathology, Tolosa E, Schulz JB, McKeith IG, Ferrer I (eds.), pp. 83-98, Ars Medica: Barcelona.
22. Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) α-synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biol 4:160-164.
23. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurrig HI, Ischiropoulos H, Trojanowski IQ, Lee VM (2000) Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions. Science 290:985-989.
24. Hamm HE (1998) The many faces of G protein signaling. J Biol Chem 273:669-672.
25. Hammond C (2003) Cellular and Molecular Neurobiology. Chapter 14: The metabotropic glutamate receptors, pp. 314-326, Academic Press: Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo.
26. Hansen LA, Daniel SE, Wilcock GK, Love S (1998) Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia. J Neurol Neurosurg Psychiatr 64:653-656.
27. Hansen LA, Samuel W (1997) Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies. Neurology 48:126-132.
28. Hashimoto M, Masliah E (1999) Alpha-synuclein in Lewy body disease and Alzheimer's disease. Brain Pathol 9:707-720.
29. Hölscher C (1998) Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis. Neurobiol Dis 5:129-141.
30. Hurtig HI, Trojanowski JQ, Galvin J, Ewbank D, Schmidt ML, Lee VM, Clark CM, Gloser G, Stern MB, Gollomp SM, Arnold SE (2000) α-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Neurology 54:1916-1921.
31. Ince PG, McKeith IG (2003) Dementia with Lewy bodies. In: Neurodegeneration: The molecular pathology of dementia and movement disorders, Dickson D (eds.), pp188-197, ISN Neuropath Press: Basel.
32. Ince PG, Perry EK, Morris CM (1998) Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome. Brain Pathol 8:299-324.
33. Iwatsubo T (2003) Aggregation of α-synuclein in the pathogenesis of Parkinson's disease. J Neurol 250 S3:11-14.
34. Jellinger K (1997) Morphological substrates of dementia in parkinsonism. A critical update. J Neural Transm 52:57-82.
35. Jellinger K, Mizuno Y (2003) Parkinson's disease. In: Neurodegeneration: The molecular pathology of dementia and movement disorders, Dickson D (eds.), pp 159-187, ISN Neuropath Press: Basel.
36. Jenko JM, Rawlingson A, Daniels B, Morris AJ (1998) Regulation of phospholipase D2: selective inhibition of phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 37:4901-4909.
37. Jolly-Tornetta C, Gao ZY, Lee V, Wolf BA (1998) Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons. J Biol Chem 273:14015-14021.
38. Kahle P, Haass C, Kretszchmar HA, Neumann M (2002) Sructure/function of α-synuclein in health and disease: rational development of animal models for Parkinson's disease and related disorders. J Neurochem 82:449-457.
39. Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonist. J Neurochem 52:1319-28.
40. Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, Ryu SH, Suh PG, Shin SH (1997) Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature 389:290-293.
41. + in primary astrocyte cultures. J Neurosci 9:1141-9.
42. Kolakowski LF (1994) GCRDb: a G-protein-coupled receptor database. Receptor Channels 2:1-7.
43. Kosaka K (1993) Dementia and neuropathology in Lewy body disease. Adv Neurol 60:456-463.
44. Kosaka K, Iseki E (1996) Diffuse Lewy body disease within the spectrum of Lewy body disease. In: Dementia with Lewy bodies, Perry RH, McKeith IG, Perry EK (eds.), pp. 238-247, Cambridge University Press: Cambridge.
45. Lee RK, Jimenez J, Cox AJ, Wurtman RJ (1996) Metabotropic glutamate receptors regulate APP processing in hippocampal neurons and cortical astrocytes derived from fetal rats. Ann NY Acad Sci 777:338-343.
46. Lennox G, Lowe J, Landon M, Byrne EJ, Mayer RJ, Godwin-Austen RB (1989) Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunohistochemistry. J Neurol Neurosurg Psychiatr 52:1236-1247.
47. Louzada PR, Paula Lima AC, de Mello FG, Ferreira ST (2001) Dual role of glutamatergic neurotransmission on amyloid beta (1-42) aggregation and neurotoxicity in embryonic avian retina. Neurosci Lett 301:59-63.
48. Marinissen MJ, Gutkind JS (2001) G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 22:368-376.
49. Martin M, Albasanz JL, Fernandez M, Ros M (1998) Cross-talk between beta-adrenergic and metabotropic glutamate receptors in rat C6 glioma cells. Biochem Biophys Acta 1393:186-192.
50. Martin M, Sanz JM, Cubero A (1993) Characterization of metabotropic glutamate receptors coupled to a pertussis toxin sensitive G-protein in bovine brain coated vesicles. FEBS Lett 316:191-196.
51. Martin-Ruiz C, Lawrence S, Piggott M, Kuryatov A, Lindstrom J, Gotti C, Cookson MR, Perry RH, Jaros E, Perry EK, Court JA (2002) Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression. Neurosci Lett 335:134-138.
52. Mattila PM, Rinne JO, Helenius H, Dickson DW, Roytta M (2000) synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol 100:285-290.
53. McKeith IG, Ballard CG, Pery RH, Ince PG, O'Brien JT, Neill D, Lowery K, Jaros E, Barber R, Thompson P, Swann A, Fairbairn AF, Perry EK (2000) Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology 54:1050-1058.
54. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lenox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47:1113-1124.
55. Michaelis EK (1998) Molecular biology of glutamate receptors in the central nervous system and their role in excitoxicity, oxidative stress and aging. Progr Neurobiol 54:369-415.
56. Ossowska K, Wardas J, Pietraszek M, Konieczny J, Wolfarth S (2003) The striatopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats. Neurosci Lett 342:21-24.
57. Ozawa S, Kamiya H, Tsuzuki K (1998) Glutamate receptors in the mammalian central nervous system. Progr Neurobiol 54:518-618.
58. Perry EK, Marshall E, Kerwin J, Smith CJ, Jabeen S, Cheng AV, Perry RH (1990) Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia. J Neurochem 55:1454-1456.
59. Perry EK, Marshall E, Perry RH, Irving D, Smith CJ, Blessed G, Fairbain AF (1990) Cholinergic and dopaminergic activities in senile dementia of the Lewy body type. Alzheimer's Dis Assoc Dis 4:87-95.
60. Perry EK, Marshall E, Thompson P, McKeith IG, Collerton D, Fairbain AF, Ferrier IN, Irving D, Perry RH (1993) Monoaminergic activities in Lewy body dementia: relation to hallucinations and extrapyramidal features. J Neural Transm 6:167-177.
61. Pimlott SL, Piggott M, Owens J, Greally E, Court JA, Jaros E, Perry RH, Perry EK, Wyper D (2004) Nicotinic acetylcholine receptor distribution in Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and vascular dementia: in vitro binding study using 5-[(125)i]-a-85380. Neuropsychopharmacology 29:108-116.
62. Pin JP, Acher F (2002) The metabotropic glutamate receptors: structure, activation, mechanisms and pharmacology. Curr Drug Target CNS Neural Disord 1:297-317.
63. Pisani A, Bonsi P, Centonze D, Gubellini P, Bernardi G, Calabresi P (2003) Targeting striatal cholinergic interneurons in parkinson's disease. Focus on metabotropic glutamate receptors. Neuropharmacology 45:45-56.
64. Pronin AN, Morris AJ, Surgunchov A, Benovic JL (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 275:26515-26522.
65. Rebecchi MJ, Pentyala SN (2000) Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 80:1291-1335.
66. Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70:281-312.
67. Samuel W, Galasko D, Masliah E, Hansen LA (1996) Neocortical Lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease. J Neuropathol Exp Neurol 55:44-52.
68. Sharma N, McLean P, Kawamata H, Irizarry MC, Hyman BT (2001) Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with uqbiquitin in Lewy bodies. Acta Neuropathol 102:329-334.
69. Smith Y, Charara A, Hanson JE, Paquet M, Levey AI (2000) GABA (B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates. J Anat 196:555-576.
70. Sweet RA, Hamilton RL, Healy MT, Wisniewski SR, Henteleff R, Pollock BG, Lewis DA, DeKosky ST (2001) Alterations of striatal dopamine receptor binding in Alzheimer's disease are associated with Lewy body pathology and antemortem psychosis. Arch Neurol 58:466-472.
71. Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E (1998) Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative diseases. Am J Pathol 152:367-72.
72. Tiger G, Bjorklund PE, Cowburn RF, Garlind A, O'Neill C, Wiehager B, Fowler CJ (1990) Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex. Eur J Pharmacol 188:51-62.
73. Valenti O, Marino MJ, Wittmann M, Lis E, DiLella AG, Kinnery GG, Conn PJ (2003) Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse. J Neurosci 23:7218-7226.
74. α1 in dorsal prefrontal cortex. Mol Brain Res 66:188-190.
75. Yuzaki M (2003) The delta2 glutamate receptor: 10 years later. Neurosci Res 46:11-22.