Experimental trauma models: An update

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Frink, Michael ^a   Andruszkow, Hagen ^a   Zeckey, Christian ^a   Krettek, Christian ^a   Hildebrand, Frank ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; BLUNT TRAUMA; DISEASE MODEL; DISEASE SIMULATION; FATALITY; FEMUR OSTEOTOMY; FRACTURE; FRACTURE EXTERNAL FIXATION; HEMORRHAGIC SHOCK; LUNG INJURY; MORTALITY; MOUSE STRAIN; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; NONHUMAN; OSTEOSYNTHESIS; PATHOPHYSIOLOGY; PLATE FIXATION; PROCESS OPTIMIZATION; REVIEW; RODENT; SWINE; THORAX INJURY; TRAUMATIC BRAIN INJURY; ANIMAL; HUMAN; INJURY;

ANIMALIA;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; WOUNDS AND INJURIES;

EID: 79953269511     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/797383     Document Type: Review

References (165)

1. Nast-Kolb D., Aufmkolk M., Rucholtz S., Obertacke U., Waydhas C., Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma Journal of Trauma 2001 51 5 835 842 (Pubitemid 33117443)
2. Shapiro M. B., Jenkins D. H., Schwab C. W., Rotondo M. F., Damage control: collective review Journal of Trauma 2000 49 5 969 978
3. Keel M., Trentz O., Pathophysiology of polytrauma Injury 2005 36 6 691 709 (Pubitemid 40732303)
4. Tsukamoto T., Pape H. C., Animal models for trauma research: what are the options? Shock 2009 31 1 3 10
5. Hauser C. J., Zhou X., Joshi P., Cuchens M. A., Kregor P., Devidas M., Kennedy R. J., Poole G. V., Hughes J. L., The immune microenvironment of human fracture/soft-tissue hematomas and its relationship to systemic immunity Journal of Trauma 1997 42 5 895 904 (Pubitemid 27258321)
6. Hauser C. J., Preclinical models of traumatic, hemorrhagic shock Shock 2005 24 1, supplement 24 32
7. Rotstein O. D., Modeling the two-hit hypothesis for evaluating strategies to prevent organ injury after shock/resuscitation Journal of Trauma 2003 54 5, supplement S203 S206
8. Bone R. C., Sir Isaac Newton, sepsis, SIRS, and CARS Critical Care Medicine 1996 24 7 1125 1126 (Pubitemid 26249361)
9. Hietbrink F., Koenderman L., Rijkers G. T., Leenen L. P. H., Trauma: the role of the innate immune system World Journal of Emergency Surgery 2006 1 1, article 15
10. Spruijt N. E., Visser T., Leenen L. P.H., A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients Critical Care 2010 14 4 R150
11. Durham R. M., Moran J. J., Mazuski J. E., Shapiro M. J., Baue A. E., Flint L. M., Multiple organ failure in trauma patients Journal of Trauma 2003 55 4 608 616 (Pubitemid 37322595)
12. Hildebrand F., Giannoudis P., Kretteck C., Pape H. C., Damage control: extremities Injury 2004 35 7 678 689 (Pubitemid 38760168)
13. Redl H., Bahrami S., Large animal models: baboons for trauma, shock, and sepsis studies Shock 2005 24 supplement 1 88 93
14. Deitch E. A., Animal models of sepsis and shock: a review and lessons learned Shock 1998 9 1 1 11 (Pubitemid 128463868)
15. Waterston R. H., Lindblad-Toh K., Birney E., Rogers J., Abril J. F., Agarwal P., Agarwala R., Ainscough R., Alexandersson M., An P., Antonarakis S. E., Attwood J., Baertsch R., Bailey J., Barlow K., Beck S., Berry E., Birren B., Bloom T., Bork P., Botcherby M., Bray N., Brent M. R., Brown D. G., Brown S. D., Bult C., Burton J., Butler J., Campbell R. D., Carninci P., Cawley S., Chiaromonte F., Chinwalla A. T., Church D. M., Clamp M., Clee C., Collins F. S., Cook L. L., Copley R. R., Coulson A., Couronne O., Cuff J., Curwen V., Cutts T., Daly M., David R., Davies J., Delehaunty K. D., Deri J., Dermitzakis E. T., Dewey C., Dickens N. J., Diekhans M., Dodge S., Dubchak I., Dunn D. M., Eddy S. R., Elnitski L., Emes R. D., Eswara P., Eyras E., Felsenfeld A., Fewell G. A., Flicek P., Foley K., Frankel W. N., Fulton L. A., Fulton R. S., Furey T. S., Gage D., Gibbs R. A., Glusman G., Gnerre S., Goldman N., Goodstadt L., Grafham D., Graves T. A., Green E. D., Gregory S., Guigo R., Guyer M., Hardison R. C., Haussler D., Hayashizaki Y., Hillier L. W., Hinrichs A., Hlavina W., Holzer T., Hsu F., Hua A., Hubbard T., Hunt A., Jackson I., Jaffe D. B., Steven Johnson L., Jones M., Jones T. A., Joy A., Kamal M., Initial sequencing and comparative analysis of the mouse genome Nature 2002 420 6915 520 562 (Pubitemid 35477048)
16. Lomas-Niera J. L., Perl M., Chung C. S., Ayala A., Shock and hemorrhage: an overview of animal models Shock 2005 24 supplement 1 33 39
17. Hsieh C. H., Nickel E. A., Hsu J. T., Schwacha M. G., Bland K. I., Chaudry I. H., Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1 and phosphoinositide 3-kinase/akt activation Annals of Surgery 2009 250 6 995 1001
18. Hsieh C. H., Hsu J. T., Hsieh YA. C., Frink M., Raju R., Hubbard W. J., Bland K. I., Chaudry I. H., Suppression of activation and costimulatory signaling in splenic CD4+ T cells after trauma-hemorrhage reduces t-cell function: a mechanism of post-traumatic immune suppression American Journal of Pathology 2009 175 4 1504 1514
19. Kawasaki T., Suzuki T., Choudhry M. A., Bland K. I., Chaudry I. H., Salutary effects of 17 -estradiol on Peyer's patch T cell functions following trauma-hemorrhage Cytokine 2010 51 2 166 172
20. Suzuki T., Kawasaki T., Choudhry M. A., Chaudry I. H., Role of PPAR in the salutary effects of 17 -estradiol on kupffer cell cytokine production following trauma-hemorrhage Journal of Cellular Physiology 2011 226 1 205 211
21. Murao Y., Hata M., Ohnishi K., Okuchi K., Nakajima Y., Hiasa Y., Junger W. G., Hoyt D. B., Ohnishi T., Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock Shock 2003 20 1 23 28
22. Murao Y., Isayama K., Saito F., Hirakawa A., Nakatani T., Effect of hypertonic saline resuscitation on CD4+CD25+ regulatory T cells and gammadelta T cells after hemorrhagic shock and resuscitation in relation to apoptosis and iNOS The Journal of Trauma 2009 67 5 975 982
23. Claridge J. A., Weed A. C., Enelow R., Young J. S., Laparotomy potentiates cytokine release and impairs pulmonary function after hemorrhage and resuscitation in mice Journal of Trauma 2001 50 2 244 252 (Pubitemid 32230144)
24. Claridge J. A., Schulman A. M., Young J. S., Improved resuscitation minimizes respiratory dysfunction and blunts interleukin-6 and nuclear factor- B activation after traumatic hemorrhage Critical Care Medicine 2002 30 8 1815 1819 (Pubitemid 34879597)
25. Rajnik M., Salkowski C. A., Thomas K. E., Li Y. Y., Rollwagen F. M., Vogel S. N., Induction of early inflammatory gene expression in a murine model of nonresuscitated, fixed-volume hemorrhage Shock 2002 17 4 322 328
26. Barkhausen T., Probst C., Hildebrand F., Pape H. C., Krettek C., van Griensven M., Insulin therapy induces changes in the inflammatory response in a murine 2-hit model Injury 2009 40 8 806 814
27. Oberbeck R., Nickel E., Von Griensven M., Tschernig T., Wittwer T., Schmitz D., Pape H. C., The effect of dehydroepiandrosterone on hemorrhage-induced suppression of cellular immune function Intensive Care Medicine 2002 28 7 963 968 (Pubitemid 34762234)
28. Xiang M., Yin L., Li Y., Hemorrhagic shock activates lung endothelial NAD(P)H oxidase via neutrophil NADPH oxidase. American Journal of Respiratory Cell and Molecular Biology. In press
29. Cai B., Dong W., Sharpe S., Deitch E. A., Ulloa L., Survival and inflammatory responses in experimental models of hemorrhage. Journal of Surgical Research. In press
30. Jungner M., Grande P. O., Mattiasson G., Bentzer P., Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat Anesthesiology 2010 112 5 1194 1203
31. Kozlov A. V., Catharina Duvigneau J., Hyatt T. C., Raju R., Behling T., Hartl R. T., Staniek K., Miller I., Gregor W., Redl H., Chaudry I. H., Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension Molecular Medicine 2010 16 7-8 254 261
32. Troy B. P., Heslop D. J., Bandler R., Keay K. A., Haemodynamic response to haemorrhage: distinct contributions of midbrain and forebrain structures Autonomic Neuroscience 2003 108 1-2 1 11 (Pubitemid 37386257)
33. Yu H. P., Hwang T. L., Hwang T. L., Yen C. H., Lau Y. T., Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway Critical Care Medicine 2010 38 4 1147 1154
34. Doucet D., Badami C., Palange D., Bonitz R. P., Lu QI., Xu DA. Z., Kannan K. B., Colorado I., Feinman R., Deitch E. A., Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats PloS One 2010 5 2, article e9421
35. Fang Y., Li T., Fan X., Zhu YU., Liu L., Beneficial effects of activation of PKC on hemorrhagic shock in rats Journal of Trauma 2010 68 4 865 873
36. Diehl K. H., Hull R., Morton D., Pfister R., Rabemampianina Y., Smith D., Vidal J. M., Van De Vorstenbosch C., A good practice guide to the administration of substances and removal of blood, including routes and volumes Journal of Applied Toxicology 2001 21 1 15 23
37. Johnson R. A., Durante W., Craig T., Peyton K. J., Myers J. G., Stewart R. M., Johnson F. K., Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock Journal of Trauma 2010 69 2 384 391
38. Garner J., Watts S., Parry C., Bird J., Cooper G., Kirkman E., Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage Annals of Surgery 2010 251 6 1131 1139
39. George M. E., Mulier K. E., Beilman G. J., Hypothermia is associated with improved outcomes in a porcine model of hemorrhagic shock Journal of Trauma 2010 68 3 662 668
40. Namas R., Ghuma A., Torres A., Polanco P., Gomez H., Barclay D., Gordon L., Zenker S., Kim H. K., Hermus L., Zamora R., Rosengart M. R., Clermont G., Peitzman A., Billiar T. R., Ochoa J., Pinsky M. R., Puyana J. C., Vodovotz Y., An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage PloS One 2009 4 12, article e8406
41. Pehbck D., Wenzel V., Voelckel W., Jonsson K., Herff H., Mittlbck M., Nagele P., Effects of preoxygenation on desaturation time during hemorrhagic shock in pigs Anesthesiology 2010 113 3 593 599
42. Chiara O., Pelosi P., Brazzi L., Bottino N., Taccone P., Cimbanassi S., Segala M., Gattinoni L., Scalea T., Resuscitation from hemorrhagic shock: experimental model comparing normal saline, dextran, and hypertonic saline solutions Critical Care Medicine 2003 31 7 1915 1922 (Pubitemid 36900744)
43. Alam H. B., Stanton K., Koustova E., Burris D., Rich N., Rhee P., Effect of different resuscitation strategies on neutrophil activation in a swine model of hemorrhagic shock Resuscitation 2004 60 1 91 99 (Pubitemid 38251232)
44. Batchinsky A. I., Skinner J. E., Necsoiu C., Jordan B. S., Weiss D., Cancio L. C., New measures of heart-rate complexity: effect of chest trauma and hemorrhage Journal of Trauma 2010 68 5 1178 1185
45. Wade C. E., Prior exercise alters responses to hemorrhage Shock 2010 34 1 68 74
46. Englehart M. S., Allison C. E., Tieu B. H., Kiraly L. N., Underwood S. A., Muller P. J., Differding J. A., Sawai R. S., Karahan A., Schreiber M. A., Ketamine-based total intravenous anesthesia versus isoflurane anesthesia in a swine model of hemorrhagic shock Journal of Trauma 2008 65 4 901 909
47. York G. B., Eggers J. S., Smith D. L., Jenkins D. H., McNeil J. D., Mueller D., Josephs J. D., Kerby J. D., Low-volume resuscitation with a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) provides adequate tissue oxygenation for survival in a porcine model of controlled hemorrhage Journal of Trauma 2003 55 5 873 885 (Pubitemid 38004659)
48. Katz L. M., Manning J. E., McCurdy S., Sproule C., McGwin G., Moon-Massat P., Cairns C. B., Freilich D., Nitroglycerin attenuates vasoconstriction of HBOC-201 during hemorrhagic shock resuscitation Resuscitation 2010 81 4 481 487
49. Kheirabadi B. S., Scherer M. R., Estep J. S., Dubick M. A., Holcomb J. B., Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine The Journal of Trauma 2009 67 3 450 460
50. Kheirabadi B. S., Edens J. W., Terrazas I. B., Estep J. S., Klemcke H. G., Dubick M. A., Holcomb J. B., Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine The Journal of Trauma 2009 66 2 316 328
51. Velmahos G. C., Spaniolas K., Tabbara M., Duggan M., Li Y., De Moya M., Alam H. B., Abdominal insufflation decreases blood loss without worsening the inflammatory response: implications for prehospital control of internal bleeding American Surgeon 2008 74 4 297 301 (Pubitemid 351489589)
52. Carbonell W. S., Maris D. O., Mccall T., Grady M. S., Adaptation of the fluid percussion injury model to the mouse Journal of Neurotrauma 1998 15 3 217 229 (Pubitemid 28113581)
53. Dennis A. M., Haselkorn M. L., Vagni V. A., Garman R. H., Janesko-Feldman K., Bay H., Clark R. S. B., Jenkins L. W., Dixon C. E., Kochanek P. M., Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal death Journal of Neurotrauma 2009 26 6 889 899
54. Exo J. L., Shellington D. K., Bayir H., Vagni V. A., Janesco-Feldman K., Ma L., Hsia C. J., Clark R. S. B., Jenkins L. W., Dixon C. E., Kochanek P. M., Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated ringer's: effects on acute hemodynamics, survival, and neuronal death in mice Journal of Neurotrauma 2009 26 12 2403 2408
55. Israelsson C., Bengtsson H., Kylberg A., Kullander K., Lewn A., Hillered L., Ebendal T., Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury Journal of Neurotrauma 2008 25 8 959 974
56. Smith D. H., Soares H. D., Pierce J. S., Perlman K. G., Saatman K. E., Meaney D. F., Dixon C. E., McIntosh T. K., A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects Journal of Neurotrauma 1995 12 2 169 178
57. Bert-Weissenberger C., Siren A. L., Experimental traumatic brain injury Experimental and Translational Stroke Medicine 2010 2 1 16
58. Floyd C. L., Golden K. M., Black R. T., Hamm R. J., Lyeth B. G., Craniectomy position affects morris water maze performance and hippocampal cell loss after parasagittal fluid percussion Journal of Neurotrauma 2002 19 3 303 316 (Pubitemid 34246118)
59. Bansal V., Costantini T., Ryu S. Y., Peterson C., Loomis W., Putnam J., Elicieri B., Baird A., Coimbra R., Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury Journal of Trauma 2010 68 5 1059 1063
60. Flierl M. A., Stahel P. F., Beauchamp K. M., Morgan S. J., Smith W. R., Shohami E., Mouse closed head injury model induced by a weight-drop device Nature Protocols 2009 4 9 1328 1337
61. Bansal V., Costantini T., Kroll L., Peterson C., Loomis W., Eliceiri B., Baird A., Wolf P., Coimbra R., Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis Journal of Neurotrauma 2009 26 8 1353 1359
62. Thompson H. J., Lifshitz J., Marklund N., Grady M. S., Graham D. I., Hovda D. A., Mcintosh T. K., Lateral fluid percussion brain injury: a 15-year review and evaluation Journal of Neurotrauma 2005 22 1 42 75
63. Laurer H. L., McIntosh T. K., Experimental models of brain trauma Current Opinion in Neurology 1999 12 6 715 721 (Pubitemid 30072353)
64. Sell S. L., Avila M. A., Yu G., Vergara L., Prough D. S., Grady J. J., DeWitt D. S., Hypertonic resuscitation improves neuronal and behavioral outcomes after traumatic brain injury plus hemorrhage Anesthesiology 2008 108 5 873 881 (Pubitemid 351589483)
65. Stein S. C., Ganguly K., Belfield C. M., Xu X., Swanson E. W., Chen X. H., Browne K. D., Johnson V. E., Smith D. H., Lebold D. G., Cines D. B., Muzykhantov V. R., Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury Journal of Neurotrauma 2009 26 9 1585 1592
66. Kerby J. D., Sainz J. G., Zhang F., Hutchings A., Sprague S., Farrokhi F. R., Son M., Resuscitation from hemorrhagic shock with HBOC-201 in the setting of traumatic brain injury Shock 2007 27 6 652 656 (Pubitemid 46788165)
67. Wu H., Lu D., Jiang H., Xiong YE., Qu C., Li BO., Mahmood A., Zhou D., Chopp M., Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury Journal of Neurotrauma 2008 25 2 130 139 (Pubitemid 351252578)
68. Lahoud-Rahme M. S., Stezoski J., Kochanek P. M., Melick J., Tisherman S. A., Drabek T., Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation Resuscitation 2009 80 4 484 488
69. Geeraerts T., Ract C., Tardieu M., Fourcade O., Mazoit J. X., Benhamou D., Duranteau J., Vigue B., Changes in cerebral energy metabolites induced by impact-acceleration brain trauma and hypoxic-hypotensive injury in rats Journal of Neurotrauma 2006 23 7 1059 1071 (Pubitemid 44162711)
70. Signoretti S., Di Pietro V., Vagnozzi R., Lazzarino G., Amorini A. M., Belli A., D'Urso S., Tavazzi B., Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the rat Molecular and Cellular Biochemistry 2010 333 1-2 269 277
71. Biber N., Toklu H. Z., Solakoglu S., Gultomruk M., Hakan T., Berkman Z., Gul Dulger F., Cysteinyl-leukotriene receptor antagonist montelukast decreases blood-brain barrier permeability but does not prevent oedema formation in traumatic brain injury Brain Injury 2009 23 6 577 584
72. Salci K., Nilsson P., Goiny M., Contant C., Piper I., Enblad P., Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model Neurosurgery 2006 59 2 367 373 (Pubitemid 44325881)
73. Zink B. J., Stern S. A., McBeth B. D., Wang X., Mertz M., Effects of ethanol on limited resuscitation in a model of traumatic brain injury and hemorrhagic shock Journal of Neurosurgery 2006 105 6 884 893 (Pubitemid 44917392)
74. Feinstein A. J., Patel M. B., Sanui M., Cohn S. M., Majetschak M., Proctor K. G., Resuscitation with pressors after traumatic brain injury Journal of the American College of Surgeons 2005 201 4 536 545 (Pubitemid 41393074)
75. Gibson J. B., Maxwell R. A., Schweitzer J. B., Fabian T. C., Proctor K. G., Resuscitation from severe hemorrhagic shock after traumatic brain injury using saline, shed blood, or a blood substitute Shock 2002 17 3 234 244
76. Manley G. T., Rosenthal G., Lam M., Morabito D., Yan D., Derugin N., Bollen A., Knudson M. M., Panter S. S., Controlled cortical impact in swine: pathophysiology and biomechanics Journal of Neurotrauma 2006 23 2 128 139
77. Rosenthal G., Morabito D., Cohen M., Roeytenberg A., Derugin N., Panter S. S., Knudson M. M., Manley G., Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation Journal of Neurosurgery 2008 108 3 575 587 (Pubitemid 351357991)
78. Cheung K. M. C., Kaluarachi K., Andrew G., Lu W., Chan D., Cheah K. S. E., An externally fixed femoral fracture model for mice Journal of Orthopaedic Research 2003 21 4 685 690 (Pubitemid 36758212)
79. Hanratty B. M., Ryaby J. T., Pan X. H., Li G., Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model Journal of Orthopaedic Surgery and Research 2009 4 1, article 1
80. Holstein J. H., Garcia P., Histing T., Kristen A., Scheuer C., Menger M. D., Pohlemann T., Advances in the establishment of defined mouse models for the study of fracture healing and bone regeneration Journal of Orthopaedic Trauma 2009 23 supplement 5 S31 S38
81. Garcia P., Holstein J. H., Histing T., Burkhardt M., Culemann U., Pizanis A., Wirbel R. J., Pohlemann T., Menger M. D., A new technique for internal fixation of femoral fractures in mice: impact of stability on fracture healing Journal of Biomechanics 2008 41 8 1689 1696
82. Holstein J. H., Matthys R., Histing T., Becker S. C., Fiedler M., Garcia P., Meier C., Pohlemann T., Menger M. D., Development of a stable closed femoral fracture model in mice Journal of Surgical Research 2009 153 1 71 75
83. Colburn N. T., Zaal K. J. M., Wang F., Tuan R. S., A role for / T cells in a mouse model of fracture healing Arthritis and Rheumatism 2009 60 6 1694 1703
84. Hiltunen A., Vuorio E., Aro H. T., A standardized experimental fracture in the mouse tibia Journal of Orthopaedic Research 1993 11 2 305 312 (Pubitemid 23159359)
85. Connolly C. K., Li G., Bunn J. R., Mushipe M., Dickson G. R., Marsh D. R., A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals Journal of Orthopaedic Research 2003 21 5 843 849 (Pubitemid 37045562)
86. Holstein J. H., Menger M. D., Culemann U., Meier C., Pohlemann T., Development of a locking femur nail for mice Journal of Biomechanics 2007 40 1 215 219 (Pubitemid 44848333)
87. Bonnarens F., Einhorn T. A., Production of a standard closed fracture in laboratory animal bone Journal of Orthopaedic Research 1984 2 1 97 101 (Pubitemid 14034681)
88. Manigrasso M. B., O'Connor J. P., Characterization of a closed femur fracture model in mice Journal of Orthopaedic Trauma 2004 18 10 687 695 (Pubitemid 40533068)
89. Grongroft I., Heil P., Matthys R., Lezuo P., Tami A., Perren S., Montavon P., Ito K., Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union Journal of Biomechanics 2009 42 13 2089 2096
90. Matthys R., Perren S. M., Internal fixator for use in the mouse Injury 2009 40 4 S103 S109
91. Claes L., Blakytny R., Gockelmann M., Schoen M., Ignatius A., Willie B., Early dynamization by reduced fixation stiffness does not improve fracture healing in a rat femoral osteotomy model Journal of Orthopaedic Research 2009 27 1 22 27
92. Simman R., Hoffmann A., Bohinc R. J., Peterson W. C., Russ A. J., Role of platelet-rich plasma in acceleration of bone fracture healing Annals of Plastic Surgery 2008 61 3 337 344
93. Li J., Ahmed M., Bergstrom J., Ackermann P., Stark A., Kreicbergs A., Occurrence of substance P in bone repair under different load comparison of straight and angulated fracture in rat tibia Journal of Orthopaedic Research 2010 28 12 1643 1650
94. Janezic G., Widni E.-E., Haxhija E. Q., Stradner M., Frhlich E., Weinberg A.-M., Proliferation analysis of the growth plate after diaphyseal midshaft fracture by 5′ -bromo- 2′ -deoxy-uridine Virchows Archiv 2010 457 1 77 85
95. Cottrell J. A., O'Connor J. P., Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing Journal of Bone and Joint Surgery. Series A 2009 91 11 2653 2665
96. Cottrell J. A., Meyenhofer M., Medicherla S., Higgins L., O'Connor J. P., Analgesic effects of p38 kinase inhibitor treatment on bone fracture healing Pain 2009 142 1-2 116 126
97. Gilley R. S., Wallace L. J., Bourgeault C. A., Kidder L. S., Bechtold J. E., OP-1 augments glucocorticoid-inhibited fracture healing in a rat fracture model Clinical Orthopaedics and Related Research 2009 467 12 3104 3112
98. Utvag S. E., Korsnes L., Rindal D. B., Reikers O., Influence of flexible nailing in the later phase of fracture healing: strength and mineralization in rat femora Journal of Orthopaedic Science 2001 6 6 576 584 (Pubitemid 34019568)
99. Schoen M., Rotter R., Schattner S., Mittlmeier T., Claes L., Vollmar B., Gradl G., Introduction of a new interlocked intramedullary nailing device for stabilization of critically sized femoral defects in the rat: a combined biomechanical and animal experimental study Journal of Orthopaedic Research 2008 26 2 184 189 (Pubitemid 351220136)
100. Kolios L., Hoerster A. K., Sehmisch S., Malcherek M. C., Rack T., Tezval M., Seidlova-Wuttke D., Wuttke W., Stuermer K. M., Stuermer E. K., Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis? Calcified Tissue International 2010 86 1 23 32
101. Sarban S., Senkoylu A., Isikan U. E., Korkusuz P., Korkusuz F., Can rhBMP-2 containing collagen sponges enhance bone repair in ovariectomized rats? A preliminary study Clinical Orthopaedics and Related Research 2009 467 12 3113 3120
102. Kokubu T., Hak D. J., Hazelwood S. J., Reddi A. H., Development of an atrophic nonunion model and comparison to a closed healing fracture in rat femur Journal of Orthopaedic Research 2003 21 3 503 510 (Pubitemid 36546817)
103. Bergenstock M., Min W., Simon A. M., Sabatino C., O'Connor J. P., A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats Journal of Orthopaedic Trauma 2005 19 10 717 723 (Pubitemid 44378210)
104. Hughes M. S., Kazmier P., Burd T. A., Anglen J., Stoker A. M., Kuroki K., Carson W. L., Cook J. L., Enhanced fracture and soft-tissue healing by means of anabolic dietary supplementation Journal of Bone and Joint Surgery. Series A 2006 88 11 2386 2394 (Pubitemid 44713825)
105. Habermann B., Kafchitsas K., Olender G., Augat P., Kurth A., Strontium ranelate enhances callus strength more than PTH 134 in an osteoporotic rat model of fracture healing Calcified Tissue International 2010 86 1 82 89
106. Heiner D. E., Meyer M. H., Frick S. L., Kellam J. F., Fiechtl J., Meyer R. A., Gene expression during fracture healing in rats comparing intramedullary fixation to plate fixation by DNA microarray Journal of Orthopaedic Trauma 2006 20 1 27 38 (Pubitemid 44378191)
107. Schmidhammer R., Zandieh S., Mittermayr R., Pelinka L. E., Leixnering M., Hopf R., Kroepfl A., Redl H., Assessment of bone union/nonunion in an experimental model using microcomputed technology Journal of Trauma 2006 61 1 199 205 (Pubitemid 44098345)
108. Betz O. B., Betz V. M., Nazarian A., Pilapil C. G., Vrahas M. S., Bouxsein M. L., Gerstenfeld L. C., Einhorn T. A., Evans C. H., Direct percutaneous gene delivery to enhance healing of segmental bone defects Journal of Bone and Joint Surgery. Series A 2006 88 2 355 365 (Pubitemid 43185138)
109. Mark H., Bergholm J., Nilsson A., Rydevik B., Strmberg L., An external fixation method and device to study fracture healing in rats Acta Orthopaedica Scandinavica 2003 74 4 476 482 (Pubitemid 37108470)
110. Komrakova M., Werner C., Wicke M., Nguyen BA. T., Sehmisch S., Tezval M., Stuermer K. M., Stuermer E. K., Effect of daidzein, 4-methylbenzylidene camphor or estrogen on gastrocnemius muscle of osteoporotic rats undergoing tibia healing period Journal of Endocrinology 2009 201 2 253 262
111. Garces G. L., Garcia-Castellano J. M., Nogales J., Longitudinal overgrowth of bone after osteotomy in young rats: influence of bone stability Calcified Tissue International 1997 60 4 391 393 (Pubitemid 27143456)
112. Alam H. B., Shuja F., Butt M. U., Duggan M., Li Y., Zacharias N., Fukudome E. Y., Liu B., deMoya M., Velmahos G. C., Surviving blood loss without blood transfusion in a swine poly-trauma model Surgery 2009 146 2 325 333
113. Cho S. D., Holcomb J. B., Tieu B. H., Englehart M. S., Morris M. S., Karahan Z. A., Underwood S. A., Muller P. J., Prince M. D., Medina L., Sondeen J., Shults C., Duggan M., Tabbara M., Alam H. B., Schreiber M. A., Reproducibility of an animal model simulating complex combat-related injury in a multiple-institution format Shock 2009 31 1 87 96
114. Girolami A., Little R. A., Fox B. A., Dark P. M., Hemodynamic responses to fluid resuscitation after blunt trauma Critical Care Medicine 2002 30 2 385 392 (Pubitemid 34158124)
115. Majetschak M., Cohn S. M., Obertacke U., Proctor K. G., Therapeutic potential of exogenous ubiquitin during resuscitation from severe trauma The Journal of Trauma 2004 56 5 991 999
116. Van Der Elst M., Dijkema A. R. A., Klein C. P. A. T., Patka P., Haarman H. J., Tissue reaction on PLLA versus stainless steel interlocking nails for fracture fixation: an animal study Biomaterials 1995 16 2 103 106
117. Zellweger R., Ayala A., Zhu X. L., Holme K. R., DeMaso C. M., Chaudry I. H., A novel nonanticoagulant heparin improves splenocyte and peritoneal macrophage immune function after trauma-hemorrhage and resuscitation Journal of Surgical Research 1995 59 1 211 218
118. Hewitt P. M., Armstrong N., Bowrey P., Cherian M., Morris D. L., Cimetidine prevents suppression of delayed hypersensitivity in an animal model of haemorrhagic shock Injury 2002 33 8 673 678
119. Oberbeck R., Van Griensven M., Nickel E., Tschernig T., Wittwer T., Pape H. C., Influence of -adrenoceptor antagonists on hemorrhage-induced cellular immune suppression Shock 2002 18 4 331 335
120. Hildebrand F., Van Griensven M., Giannoudis P., Luerig A., Harwood P., Harms O., Fehr M., Krettek C., Pape H. C., Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma Cytokine 2005 31 5 382 393 (Pubitemid 41188060)
121. Frink M., Hsieh YA. C., Hu S., Hsieh C. H., Pape H. C., Choudhry M. A., Schwacha M. G., Bland K. I., Chaudry I. H., Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis Annals of Surgery 2007 246 5 836 843 (Pubitemid 350035661)
122. Hildebrand F., Thobe B. M., Hubbard W. J., Choudhry M. A., Pape H.-C., Chaudry I. H., Effects of 17 -estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage Cytokine 2006 36 3-4 107 114 (Pubitemid 46290697)
123. Hildebrand F., Hubbard W. J., Choudhry M. A., Frink M., Pape H.-C., Kunkel S. L., Chaudry I. H., Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage American Journal of Pathology 2006 169 3 784 794 (Pubitemid 44411946)
124. Hildebrand F., Hubbard W. J., Choudhry M. A., Thobe B. M., Pape H. C., Chaudry I. H., Effects of 17 -estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females Journal of Leukocyte Biology 2006 80 4 759 765 (Pubitemid 44835894)
125. Perl M., Chung C. S., Perl U., Thakkar R., Lomas-Neira J., Ayala A., Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury Critical Care Medicine 2010 38 4 1179 1186
126. Morrison A. M., Wang P., Chaudry I. H., A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis Shock 1996 6 1 46 51 (Pubitemid 126727727)
127. Wang P., Ba Z. F., Reich S. S., Zhou M., Holme K. R., Chaudry I. H., Effects of nonanticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock American Journal of Physiology 1996 270 4 H1294 H1302
128. Kim H., Chen J., Zinn K. R., Hubbard W. J., Fineberg N. S., Chaudry I. H., Single photon emission computed tomography demonstrated efficacy of 17 -estradiol therapy in male rats after trauma-hemorrhage and extended hypotension The Journal of Trauma 2010 69 5 1266 1273
129. Arora T. K., Malhotra A. K., Ivatury R., Mangino M. J., l-Arginine infusion during resuscitation for hemorrhagic shock: impact and mechanism. The Journal of Trauma. In press
130. Relja B., Lehnert M., Seyboth K., Bormann F., Hhn C., Czerny C., Henrich D., Marzi I., Simvastatin reduces mortality and hepatic injury after hemorrhage/resuscitation in rats Shock 2010 34 1 46 54
131. Dickneite G., Dorr B., Kaspereit F., Tanaka K. A., Prothrombin complex concentrate versus recombinant factor vIIa for reversal of hemodilutional coagulopathy in a porcine trauma model Journal of Trauma 2010 68 5 1151 1157
132. Regel G., Lobenhoffer P., Grotz M., Pape H. C., Lehmann U., Tscherne H., Treatment results of patients with multiple trauma: an analysis of 3406 cases treated between 1972 and 1991 at a German Level I Trauma Center Journal of Trauma 1995 38 1 70 78
133. Thibault K. L., Margulies S. S., Age-dependent material properties of the porcine cerebrumml: effect on pediatric inertial head injury criteria Journal of Biomechanics 1998 31 12 1119 1126 (Pubitemid 29005180)
134. Finnie J. W., Blumbergs P. C., Traumatic brain injury Veterinary Pathology 2002 39 6 679 689
135. Hildebrand F., Giannoudis P. V., Griensven M. V., Zelle B., Ulmer B., Krettek C., Bellamy M. C., Pape H. C., Management of polytraumatized patients with associated blunt chest trauma: a comparison of two European countries Injury 2005 36 2 293 302 (Pubitemid 40138673)
136. Cohn S. M., Pulmonary contusion: review of the clinical entity Journal of Trauma 1997 42 5 973 979 (Pubitemid 27258333)
137. Knferl M. W., Liener U. C., Seitz D. H., Perl M., Bruckner U. B., Kinzl L., Gebhard F., Cardiopulmonary, histological, and inflammatory alterations
138. Satoh Y., Sato S., Saitoh D., Tokuno S., Hatano B., Shimokawaji T., Kobayashi H., Takishima K., Pulmonary blast injury in mice: a novel model for studying blast injury in the laboratory using laser-induced stress waves Lasers in Surgery and Medicine 2010 42 4 313 318
139. Majetschak M., Sorell L. T., Patricelli T., Seitz D. H., Knoferl M. W., Detection and possible role of proteasomes in the bronchoalveolar space of the injured lung Physiological Research 2009 58 3 363 372
140. Aydin M. D., Eroglu A., Gundogdu C., Turkyilmaz A., Altas S., Aydin N., The preventive role of thoracic duct ligation on cerebral fat embolism in lung injury: an experimental study Medical Science Monitor 2008 14 11 BR256 BR260
141. Raghavendran K., Davidson B. A., Helinski J. D., Marschke C. J., Manderscheid P., Woytash J. A., Notter R. H., Knight P. R., A rat model for isolated bilateral lung contusion from blunt chest trauma Anesthesia and Analgesia 2005 101 5 1482 1489 (Pubitemid 41531892)
142. Raghavendran K., Davidson B. A., Huebschmann J. C., Helinski J. D., Hutson A. D., Dayton M. T., Notter R. H., Knight P. R., Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion Journal of Surgical Research 2009 155 2 273 282
143. Hoth J. J., Hudson W. P., Brownlee N. A., Yoza B. K., Hiltbold E. M., Meredith J. W., McCall C. E., Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion Shock 2007 28 4 447 452 (Pubitemid 47415256)
144. Davis K. A., Fabian T. C., Ragsdale D. N., Trenthem L. L., Proctor K. G., Endogenous adenosine and secondary injury after chest trauma Journal of Trauma 2000 49 5 892 898
145. Moomey C. B. Jr., Fabian T. C., Croce M. A., Melton S. M., Proctor K. G., Cardiopulmonary function after pulmonary contusion and partial liquid ventilation Journal of Trauma 1998 45 2 283 290 (Pubitemid 28399718)
146. Fanelli V., Puntorieri V., Assenzio B., Martin E. L., Elia V., Bosco M., Delsedime L., Del Sorbo L., Ferrari A., Italiano S., Ghigo A., Slutsky A. S., Hirsch E., Ranieri V. M., Pulmonary-derived phosphoinositide 3-kinase gamma (PI3K ) contributes to ventilator-induced lung injury and edema Intensive Care Medicine 2010 36 11 1935 1945
147. Bueltmann M., Kong X., Mertens M., Yin N., Yin J., Liu Z., Koster A., Kuppe H., Kuebler W. M., Inhaled milrinone attenuates experimental acute lung injury Intensive Care Medicine 2009 35 1 171 178
148. Ulrich K., Stern M., Goddard M. E., Williams J., Zhu J., Dewar A., Painter H. A., Jeffery P. K., Gill D. R., Hyde S. C., Geddes D. M., Takata M., Alton E. W. F. W., Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury American Journal of Physiology 2005 288 6 L1179 L1192
149. Henderson W. R. Jr., Chi E. Y., Ye X., Nguyen C., Tien Y.-T., Zhou B., Borok Z., Knight D. A., Kahn M., Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis Proceedings of the National Academy of Sciences of the United States of America 2010 107 32 14309 14314
150. Melton S. M., Davis K. A., Moomey C. B. Jr., Fabian T. C., Proctor K. G., Mediator-dependent secondary injury after unilateral blunt thoracic trauma Shock 1999 11 6 396 402
151. Westphal M., Noshima S., Isago T., Fujioka K., Maybauer M. O., Maybauer D. M., Traber L. D., Flynn J. T., Westphal-Varghese B. B., Traber D. L., Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury Anesthesiology 2005 102 5 954 961 (Pubitemid 40586536)
152. Esechie A., Enkhbaatar P., Traber D. L., Jonkam C., Lange M., Hamahata A., Djukom C., Whorton E. B., Hawkins H. K., Traber L. D., Szabo C., Beneficial effect of a hydrogen sulphide donor (sodium sulphide) in an ovine model of burn- and smoke-induced acute lung injury British Journal of Pharmacology 2009 158 6 1442 1453
153. Saunders F. D., Westphal M., Enkhbaatar P., Wang J., Pazdrak K., Nakano Y., Hamahata A., Jonkam C. C., Lange M., Connelly R. L., Kulp G. A., Cox R. A., Hawkins H. K., Schmalstieg F. C., Horvath E., Szabo C., Traber L. D., Whorton E., Herndon D. N., Traber D. L., Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury American Journal of Physiology 2010 298 3 L427 L436
154. Ball M. K., Hillman N. H., Kallapur S. G., Polglase G. R., Jobe A. H., Pillow J. J., Body temperature effects on lung injury in ventilated preterm lambs Resuscitation 2010 81 6 749 754
155. Rixen D., Sauerland S., Oestern H.-J., Bouillon B., Management strategies in the first operative phase after long-bone injury of the lower extremity in multiple-injured patients. A systematic literature review Unfallchirurg 2005 108 10 829 842 (Pubitemid 41452744)
156. Lu C., Miclau T., Hu D., Hansen E., Tsui K., Puttlitz C., Marcucio R. S., Cellular basis for age-related changes in fracture repair Journal of Orthopaedic Research 2005 23 6 1300 1307 (Pubitemid 41554661)
157. Nunamaker D. M., Experimental models of fracture repair Clinical Orthopaedics and Related Research 1998 supplement 355 S56 S65
158. Marturano J. E., Cleveland B. C., Byrne M. A., O'Connell S. L., Wixted J. J., Billiar K. L., An improved murine femur fracture device for bone healing studies Journal of Biomechanics 2008 41 6 1222 1228
159. Barkhausen T., Hildebrand F., Krettek C., van Griensven M., DHEA-dependent and organ-specific regulation of TNF- mRNA expression in a murine polymicrobial sepsis and trauma model Critical Care 2009 13 4, article R114
160. Manabe T., Mori S., Mashiba T., Kaji Y., Iwata K., Komatsubara S., Seki A., Sun Y. X., Yamamoto T., Human parathyroid hormone (134) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys Bone 2007 40 6 1475 1482 (Pubitemid 46756411)
161. Lindsey B. A., Clovis N. B., Smith E. S., Salihu S., Hubbard D. F., An animal model for open femur fracture and osteomyelitispart I Journal of Orthopaedic Research 2010 28 1 38 42
162. Drosse I., Volkmer E., Seitz S., Seitz H., Penzkofer R., Zahn K., Matis U., Mutschler W., Augat P., Schieker M., Validation of a femoral critical size defect model for orthotopic evaluation of bone healing: a biomechanical, veterinary and trauma surgical perspective Tissue Engineering. Part C 2008 14 1 79 88 (Pubitemid 351522752)
163. Atesok K., Li R., Stewart D. J., Schemitsch E. H., Endothelial progenitor cells promote fracture healing in a segmental bone defect model Journal of Orthopaedic Research 2010 28 8 1007 1014
164. Flannery O. M., Britton J. R., O'reilly P., Mahony N., Prendergast P. J., Kenny P. J., The threshold force required for femoral impaction grafting in revision hip surgery Acta Orthopaedica 2010 81 3 303 307
165. Pierce M. C., Valdevit A., Anderson L., Inoue N., Hauser D. L., Biomechanical evaluation of dual-energy x-ray absorptiometry for predicting fracture loads of the infant femur for injury investigation: an in vitro porcine model Journal of Orthopaedic Trauma 2000 14 8 571 576