Insulin therapy induces changes in the inflammatory response in a murine 2-hit model

Injury

Volumn 40, Issue 8, 2009, Pages 806-814

  Barkhausen, Tanja ^a   Probst, Christian ^a   Hildebrand, Frank ^a   Pape, Hans Christoph ^b   Krettek, Christian ^a   van Griensven, Martijn ^c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

Author keywords

Cytokines; Inflammation; Insulin; Neutrophils; Polytrauma; Sepsis

Indexed keywords

INSULIN; INTERLEUKIN 10; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CYTOKINE RELEASE; DRUG EFFECT; FEMUR FRACTURE; GENE EXPRESSION; HYPERGLYCEMIA; IMMUNOMODULATION; INFLAMMATION; INJURY; INSULIN TREATMENT; LEUKOCYTE ACTIVATION; MALE; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; POSTTRAUMATIC COMPLICATION; PRIORITY JOURNAL; SEPSIS;

ANIMALS; BLOOD GLUCOSE; FEMORAL FRACTURES; HYPOGLYCEMIC AGENTS; INSULIN; LIVER; LUNG; MALE; MICE; NEUTROPHIL INFILTRATION; SEPSIS; SURVIVAL RATE;

EID: 67650188910     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injury.2008.07.018     Document Type: Article

References (34)

1. Aljada A., and Dandona P. Effect of insulin on human aortic endothelial nitric oxide synthase. Metabolism 49 (2000) 147-150
2. Barkhausen T., Krettek C., and van Griensven M. L-selectin: adhesion, signalling and its importance in pathologic posttraumatic endotoxemia and non-septic inflammation. Exp Toxicol Pathol 57 (2005) 39-52
3. Bonnefont-Rousselot D. Glucose and reactive oxygen species. Curr Opin Clin Nutr Metab Care 5 (2002) 561-568
4. Bonnefont-Rousselot D., Bastard J.P., Jaudon M.C., and Delattre J. Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes Metab 26 (2000) 163-176
5. Brunkhorst F.M., Kuhnt E., Engel C., et al. Intensive insulin therapy in patients with severe sepsis and septic shock is associated with an increased rate of hypoglycaemia-results from randomised multicentre study (VISEP). Injury 33 (2005) 19
6. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332 (1995) 1351-1362
7. Dandona P., Aljada A., Mohanty P., et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?. J Clin Endocrinol Metab 86 (2001) 3257-3265
8. delaTorre A., Schroeder R.A., Punzalan C., and Kuo P.C. Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. J Immunol 162 (1999) 4101-4108
9. Gustavson S.M., Chu C.A., Nishizawa M., et al. Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog. Am J Physiol Endocrinol Metab 284 (2003) E695-707
10. Hack C.E., De Groot E.R., Felt-Bersma R.J., et al. Increased plasma levels of interleukin-6 in sepsis. Blood 74 (1989) 1704-1710
11. Hansen T.K., Thiel S., Wouters P.J., et al. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 88 (2003) 1082-1088
12. Inoguchi T., Li P., Umeda F., et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49 (2000) 1939-1945
13. Kemna E., Pickkers P., Nemeth E., et al. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106 (2005) 1864-1866
14. Khani S., and Tayek J.A. Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. Clin Sci (Lond) 101 (2001) 739-747
15. Lampugnani M.G., Caveda L., Breviario F., et al. Endothelial cell-to-cell junctions. Structural characteristics and functional role in the regulation of vascular permeability and leukocyte extravasation. Baillieres Clin Haematol 6 (1993) 539-558
16. Langouche L., Vanhorebeek I., Vlasselaers D., et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 115 (2005) 2277-2286
17. Levetan C.S., Passaro M., Jablonski K., et al. Unrecognized diabetes among hospitalized patients. Diabetes Care 21 (1998) 246-249
18. Maier R.V. Pathogenesis of multiple organ dysfunction syndrome-endotoxin, inflammatory cells, and their mediators: cytokines and reactive oxygen species. Surg Infect (Larchmt) 1 (2000) 197-204
19. Pachot A., Monneret G., Voirin N., et al. Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clin Immunol 114 (2005) 61-69
20. Radi Z.A., Kehrli Jr. M.E., and Ackermann M.R. Cell adhesion molecules, leukocyte trafficking, and strategies to reduce leukocyte infiltration. J Vet Intern Med 15 (2001) 516-529
21. Seekamp A., van Griensven M., Breyhan K., and Pohlmann T.H. The effect of fucoidin on the remote pulmonary injury in a two-hit trauma model in mice. Eur J Trauma 6 (2001) 317-326
22. Shinohara M., Thornalley P.J., Giardino I., et al. Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest 101 (1998) 1142-1147
23. Singh R., Barden A., Mori T., and Beilin L. Advanced glycation end-products: a review. Diabetologia 44 (2001) 129-146
24. Spiecker M., Peng H.B., and Liao J.K. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha. J Biol Chem 272 (1997) 30969-30974
25. Spittler A., Razenberger M., Kupper H., et al. Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production. Clin Infect Dis 31 (2000) 1338-1342
26. Su F., Wang Z., Bruhn A., et al. Euglycemic hyperinsulinemia in severe sepsis and septic shock. Eur Surg Res 38 (2006) 495-502
27. van den Berghe B.G., Wilmer A., Hermans G., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 354 (2006) 449-461
28. van den Berghe B.G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patient. N Engl J Med 345 (2001) 1359-1367
29. Vanhorebeek I., Langouche L., and van den Berghe B.G. Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?. Curr Opin Crit Care 11 (2005) 304-311
30. Venet F., Lepape A., Debard A.L., et al. The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock. Clin Immunol 113 (2004) 278-284
31. Viardot A., Grey S.T., Mackay F., and Chisholm D. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. Endocrinology 148 (2007) 346-353
32. Walley K.R., McDonald T.E., Higashimoto Y., and Hayashi S. Modulation of proinflammatory cytokines by nitric oxide in murine acute lung injury. Am J Respir Crit Care Med 160 (1999) 698-704
33. Watt M.J., Howlett K.F., Febbraio M.A., et al. Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. J Physiol 534 (2001) 269-278
34. Wulczyn F.G., Krappmann D., and Scheidereit C. The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation. J Mol Med 74 (1996) 749-769