Experimental traumatic brain injury

Experimental and Translational Stroke Medicine

Volumn 2, Issue 1, 2010, Pages

  Albert Weissenberger, Christiane ^a   Sirén, Anna Leena ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APNEA; ASTROCYTE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; BRAIN CONTUSION; BRAIN CORTEX; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN TISSUE; CELL ACTIVATION; CELL CULTURE MODEL; CONTROLLED CORTICAL IMPACT INJURY MODEL; CONTUSION; CRANIOTOMY; CRYOGENIC INJURY MODEL; DISEASE COURSE; DISEASE SEVERITY; DURA MATER; EXPERIMENTAL MODEL; FALLING; FLUID PERCUSSION INJURY MODEL; GRAVITY; HUMAN; MICROGLIA; NERVE CELL NECROSIS; NERVOUS SYSTEM INJURY; NONHUMAN; PATHOLOGY; PATHOPHYSIOLOGY; PERCUSSION; PRIORITY JOURNAL; REVIEW; RODENT; SKULL; TRAUMATIC BRAIN INJURY; TRAUMATIC EPILEPSY; WEIGHT DROP MODEL;

EID: 79951676626     PISSN: None     EISSN: 20407378     Source Type: Journal    
DOI: 10.1186/2040-7378-2-16     Document Type: Review

References (127)

1. Gaetz M. The neurophysiology of brain injury. Clin Neurophysiol 2004, 115:4-18. 10.1016/S1388-2457(03)00258-X, 14706464.
2. Division of Injury Response, National Center for Injury Prevention and Control Centers for Disease Control and Prevention, U.S Department of Health and Human Services Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations, and Deaths, 2002-2006, Atlanta 2010, Division of Injury Response, National Center for Injury Prevention and Control Centers for Disease Control and Prevention, U.S Department of Health and Human Services.
3. Maegele M, Engel D, Bouillon B, Lefering R, Fach H, Raum M, Buchheister B, Schaefer U, Klug N, Neugebauer E. Incidence and outcome of traumatic brain injury in an urban area in Western Europe over 10 years. Eur Surg Res 2007, 39:372-379. 10.1159/000107097, 17690556.
4. Mock C, Joshipura M, Goosen J, Lormand JD, Maier R. Strengthening trauma systems globally: the Essential Trauma Care Project. J Trauma 2005, 59:1243-1246. 10.1097/01.ta.0000197290.02807.de, 16385310.
5. Yattoo G, Tabish A. The profile of head injuries and traumatic brain injury deaths in Kashmir. J Trauma Manag Outcomes 2008, 2:5. 10.1186/1752-2897-2-5, 2464577, 18570674.
6. Chiu WT, Huang SJ, Tsai SH, Lin JW, Tsai MD, Lin TJ, Huang WC. The impact of time, legislation, and geography on the epidemiology of traumatic brain injury. J Clin Neurosci 2007, 14:930-935. 10.1016/j.jocn.2006.08.004, 17646104.
7. Martins ET, Linhares MN, Sousa DS, Schroeder HK, Meinerz J, Rigo LA, Bertotti MM, Gullo J, Hohl A, Dal-Pizzol F, Walz R. Mortality in severe traumatic brain injury: a multivariated analysis of 748 Brazilian patients from Florianopolis City. J Trauma 2009, 67:85-90. 10.1097/TA.0b013e318187acee, 19590314.
8. Xiong Y, Mahmood A, Chopp M. Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs 2009, 14:67-84. 10.1517/14728210902769601, 2773142, 19249984.
9. Doppenberg EM, Choi SC, Bullock R. Clinical trials in traumatic brain injury: lessons for the future. J Neurosurg Anesthesiol 2004, 16:87-94. 10.1097/00008506-200401000-00019, 14676577.
10. Maas AI. Neuroprotective agents in traumatic brain injury. Expert Opin Investig Drugs 2001, 10:753-767. 10.1517/13543784.10.4.753, 11281824.
11. Faden AI. Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr Opin Neurol 2002, 15:707-712. 10.1097/00019052-200212000-00008, 12447109.
12. Statler KD, Jenkins LW, Dixon CE, Clark RS, Marion DW, Kochanek PM. The simple model versus the super model: translating experimental traumatic brain injury research to the bedside. J Neurotrauma 2001, 18:1195-1206. 10.1089/089771501317095232, 11721738.
13. Shohami E, Shapira Y, Cotev S. Experimental closed head injury in rats: prostaglandin production in a noninjured zone. Neurosurgery 1988, 22:859-863. 10.1227/00006123-198805000-00009, 3164097.
14. Shapira Y, Shohami E, Sidi A, Soffer D, Freeman S, Cotev S. Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties. Crit Care Med 1988, 16:258-265. 10.1097/00003246-198803000-00010, 3277783.
15. Flierl MA, Stahel PF, Beauchamp KM, Morgan SJ, Smith WR, Shohami E. Mouse closed head injury model induced by a weight-drop device. Nat Protoc 2009, 4:1328-1337. 10.1038/nprot.2009.148, 19713954.
16. Foda MA, Marmarou A. A new model of diffuse brain injury in rats. Part II: Morphological characterization. J Neurosurg 1994, 80:301-313. 10.3171/jns.1994.80.2.0301, 8283270.
17. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 1994, 80:291-300. 10.3171/jns.1994.80.2.0291, 8283269.
18. Blaha M, Schwab J, Vajnerova O, Bednar M, Vajner L, Michal T. Intracranial pressure and experimental model of diffuse brain injury in rats. J Korean Neurosurg Soc 2010, 47:7-10. 10.3340/jkns.2010.47.1.7, 2817521, 20157371.
19. Adelson PD, Robichaud P, Hamilton RL, Kochanek PM. A model of diffuse traumatic brain injury in the immature rat. J Neurosurg 1996, 85:877-884. 10.3171/jns.1996.85.5.0877, 8893727.
20. Chen Y, Constantini S, Trembovler V, Weinstock M, Shohami E. An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits. J Neurotrauma 1996, 13:557-568. 10.1089/neu.1996.13.755, 8915907.
21. Dail WG, Feeney DM, Murray HM, Linn RT, Boyeson MG. Responses to cortical injury: II. Widespread depression of the activity of an enzyme in cortex remote from a focal injury. Brain Res 1981, 211:79-89. 10.1016/0006-8993(81)90068-8, 6784887.
22. Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 1981, 211:67-77. 10.1016/0006-8993(81)90067-6, 7225844.
23. Morales DM, Marklund N, Lebold D, Thompson HJ, Pitkanen A, Maxwell WL, Longhi L, Laurer H, Maegele M, Neugebauer E, Graham DJ, Stocchetti N, McIntosh TK. Experimental models of traumatic brain injury: do we really need to build a better mousetrap?. Neuroscience 2005, 136:971-989. 10.1016/j.neuroscience.2005.08.030, 16242846.
24. Mikawa S, Kinouchi H, Kamii H, Gobbel GT, Chen SF, Carlson E, Epstein CJ, Chan PH. Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice. J Neurosurg 1996, 85:885-891. 10.3171/jns.1996.85.5.0885, 8893728.
25. Bellander BM, von Holst H, Fredman P, Svensson M. Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat. J Neurosurg 1996, 85:468-475. 10.3171/jns.1996.85.3.0468, 8751634.
26. Cernak I. Animal models of head trauma. NeuroRx 2005, 2:410-422. 10.1602/neurorx.2.3.410, 1144485, 16389305.
27. Isaksson J, Hillered L, Olsson Y. Cognitive and histopathological outcome after weight-drop brain injury in the rat: influence of systemic administration of monoclonal antibodies to ICAM-1. Acta Neuropathol 2001, 102:246-256.
28. Allen GV, Gerami D, Esser MJ. Conditioning effects of repetitive mild neurotrauma on motor function in an animal model of focal brain injury. Neuroscience 2000, 99:93-105. 10.1016/S0306-4522(00)00185-8, 10924955.
29. Uhl MW, Biagas KV, Grundl PD, Barmada MA, Schiding JK, Nemoto EM, Kochanek PM. Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats. J Neurotrauma 1994, 11:303-315. 10.1089/neu.1994.11.303, 7996584.
30. DeKosky ST, Goss JR, Miller PD, Styren SD, Kochanek PM, Marion D. Upregulation of nerve growth factor following cortical trauma. Exp Neurol 1994, 130:173-177. 10.1006/exnr.1994.1196, 7867748.
31. Holmin S, Schalling M, Hojeberg B, Nordqvist AC, Skeftruna AK, Mathiesen T. Delayed cytokine expression in rat brain following experimental contusion. J Neurosurg 1997, 86:493-504. 10.3171/jns.1997.86.3.0493, 9046307.
32. Nilsson P, Gazelius B, Carlson H, Hillered L. Continuous measurement of changes in regional cerebral blood flow following cortical compression contusion trauma in the rat. J Neurotrauma 1996, 13:201-207.
33. Lindh C, Wennersten A, Arnberg F, Holmin S, Mathiesen T. Differences in cell death between high and low energy brain injury in adult rats. Acta Neurochir (Wien) 2008, 150:1269-1275. 10.1007/s00701-008-0147-7, 19015811.
34. Umschwief G, Shein NA, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E. Heat acclimation provides sustained improvement in functional recovery and attenuates apoptosis after traumatic brain injury. J Cereb Blood Flow Metab 2010, 30:616-627. 10.1038/jcbfm.2009.234, 19904288.
35. Shohami E, Novikov M, Horowitz M. Long term exposure to heat reduces edema formation after closed head injury in the rat. Acta Neurochir Suppl (Wien) 1994, 60:443-445.
36. Leinhase I, Rozanski M, Harhausen D, Thurman JM, Schmidt OI, Hossini AM, Taha ME, Rittirsch D, Ward PA, Holers VM, Ertel W, Stahel PF. Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. J Neuroinflammation 2007, 4:13. 10.1186/1742-2094-4-13, 1867808, 17474994.
37. Leinhase I, Holers VM, Thurman JM, Harhausen D, Schmidt OI, Pietzcker M, Taha ME, Rittirsch D, Huber-Lang M, Smith WR, Ward PA, Stahel PF. Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC Neurosci 2006, 7:55. 10.1186/1471-2202-7-55, 1540436, 16842619.
38. Tweedie D, Milman A, Holloway HW, Li Y, Harvey BK, Shen H, Pistell PJ, Lahiri DK, Hoffer BJ, Wang Y, Pick CG, Greig NH. Apoptotic and behavioral sequelae of mild brain trauma in mice. J Neurosci Res 2007, 85:805-815. 10.1002/jnr.21160, 17243171.
39. Zohar O, Schreiber S, Getslev V, Schwartz JP, Mullins PG, Pick CG. Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice. Neuroscience 2003, 118:949-955. 10.1016/S0306-4522(03)00048-4, 12732240.
40. Tashlykov V, Katz Y, Gazit V, Zohar O, Schreiber S, Pick CG. Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice. Brain Res 2007, 1130:197-205. 10.1016/j.brainres.2006.10.032, 17174280.
41. Israelsson C, Wang Y, Kylberg A, Pick CG, Hoffer B, Ebendal T. Closed head injury in a mouse model results in molecular changes indicating inflammatory responses. J Neurotrauma 2009, 26:1307-1314. 10.1089/neu.2008.0676, 2989856, 19317611.
42. Ding JY, Kreipke CW, Speirs SL, Schafer P, Schafer S, Rafols JA. Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injury. Neurosci Lett 2009, 453:68-72. 10.1016/j.neulet.2009.01.077, 2703426, 19429018.
43. Nawashiro H, Messing A, Azzam N, Brenner M. Mice lacking GFAP are hypersensitive to traumatic cerebrospinal injury. Neuroreport 1998, 9:1691-1696. 10.1097/00001756-199806010-00004, 9665584.
44. Levasseur JE, Patterson JL, Ghatak NR, Kontos HA, Choi SC. Combined effect of respirator-induced ventilation and superoxide dismutase in experimental brain injury. J Neurosurg 1989, 71:573-577. 10.3171/jns.1989.71.4.0573, 2795176.
45. Yamaki T, Murakami N, Iwamoto Y, Sakakibara T, Kobori N, Ueda S, Kikuchi T, Uwahodo Y. Evaluation of learning and memory dysfunction and histological findings in rats with chronic stage contusion and diffuse axonal injury. Brain Res 1997, 752:151-160. 10.1016/S0006-8993(96)01469-2, 9106451.
46. McIntosh TK, Noble L, Andrews B, Faden AI. Traumatic brain injury in the rat: characterization of a midline fluid-percussion model. Cent Nerv Syst Trauma 1987, 4:119-134.
47. Dixon CE, Lyeth BG, Povlishock JT, Findling RL, Hamm RJ, Marmarou A, Young HF, Hayes RL. A fluid percussion model of experimental brain injury in the rat. J Neurosurg 1987, 67:110-119. 10.3171/jns.1987.67.1.0110, 3598659.
48. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL. Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 1989, 28:233-244. 10.1016/0306-4522(89)90247-9, 2761692.
49. Carbonell WS, Maris DO, McCall T, Grady MS. Adaptation of the fluid percussion injury model to the mouse. J Neurotrauma 1998, 15:217-229. 10.1089/neu.1998.15.217, 9528921.
50. Yamaki T, Murakami N, Iwamoto Y, Yoshino E, Nakagawa Y, Ueda S, Horikawa J, Tsujii T. A modified fluid percussion device. J Neurotrauma 1994, 11:613-622. 10.1089/neu.1994.11.613, 7861452.
51. Thompson HJ, Lifshitz J, Marklund N, Grady MS, Graham DI, Hovda DA, McIntosh TK. Lateral fluid percussion brain injury: a 15-year review and evaluation. J Neurotrauma 2005, 22:42-75. 10.1089/neu.2005.22.42, 15665602.
52. Keeling KL, Hicks RR, Mahesh J, Billings BB, Kotwal GJ. Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system. J Neuroimmunol 2000, 105:20-30. 10.1016/S0165-5728(00)00183-1, 10713360.
53. Kelley BJ, Lifshitz J, Povlishock JT. Neuroinflammatory responses after experimental diffuse traumatic brain injury. J Neuropathol Exp Neurol 2007, 66:989-1001. 10.1097/NEN.0b013e3181588245, 17984681.
54. Rogatsky GG, Sonn J, Kamenir Y, Zarchin N, Mayevsky A. Relationship between intracranial pressure and cortical spreading depression following fluid percussion brain injury in rats. J Neurotrauma 2003, 20:1315-1325. 10.1089/089771503322686111, 14748980.
55. Yamaki T, Murakami N, Iwamoto Y, Sakakibara T, Kobori N, Ueda S, Uwahodo Y, Kikuchi T. Cognitive dysfunction and histological findings in rats with chronic-stage contusion and diffuse axonal injury. Brain Res Brain Res Protoc 1998, 3:100-106. 10.1016/S1385-299X(98)00030-0, 9767137.
56. McGinn MJ, Kelley BJ, Akinyi L, Oli MW, Liu MC, Hayes RL, Wang KK, Povlishock JT. Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusion. J Neuropathol Exp Neurol 2009, 68:241-249. 10.1097/NEN.0b013e3181996bfe, 2779123, 19225412.
57. Hall KD, Lifshitz J. Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses. Brain Res 2010, 1323:161-173. 10.1016/j.brainres.2010.01.067, 20122903.
58. McNamara KC, Lisembee AM, Lifshitz J. The Whisker Nuisance Task Identifies a Late Onset, Persistent Sensory Sensitivity in Diffuse Brain-Injured Rats. J Neurotrauma 2010, 27:695-706. 10.1089/neu.2009.1237, 20067394.
59. Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain 2006, 129:2761-2772. 10.1093/brain/awl165, 16825202.
60. Murakami N, Yamaki T, Iwamoto Y, Sakakibara T, Kobori N, Fushiki S, Ueda S. Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus. J Neurotrauma 1998, 15:993-1003. 10.1089/neu.1998.15.993, 9840772.
61. Hoshino S, Tamaoka A, Takahashi M, Kobayashi S, Furukawa T, Oaki Y, Mori O, Matsuno S, Shoji S, Inomata M, Teramoto A. Emergence of immunoreactivities for phosphorylated tau and amyloid-beta protein in chronic stage of fluid percussion injury in rat brain. Neuroreport 1998, 9:1879-1883. 10.1097/00001756-199806010-00039, 9665619.
62. Miyazaki S, Katayama Y, Lyeth BG, Jenkins LW, DeWitt DS, Goldberg SJ, Newlon PG, Hayes RL. Enduring suppression of hippocampal long-term potentiation following traumatic brain injury in rat. Brain Res 1992, 585:335-339. 10.1016/0006-8993(92)91232-4, 1511317.
63. Pitkanen A, Immonen RJ, Grohn OH, Kharatishvili I. From traumatic brain injury to posttraumatic epilepsy: what animal models tell us about the process and treatment options. Epilepsia 2009, 50(Suppl 2):21-29. 10.1111/j.1528-1167.2008.02007.x, 19187291.
64. Smith DH, Okiyama K, Thomas MJ, Claussen B, McIntosh TK. Evaluation of memory dysfunction following experimental brain injury using the Morris water maze. J Neurotrauma 1991, 8:259-269. 10.1089/neu.1991.8.259, 1803034.
65. Soares HD, Thomas M, Cloherty K, McIntosh TK. Development of prolonged focal cerebral edema and regional cation changes following experimental brain injury in the rat. J Neurochem 1992, 58:1845-1852. 10.1111/j.1471-4159.1992.tb10061.x, 1560237.
66. Pierce JE, Trojanowski JQ, Graham DI, Smith DH, McIntosh TK. Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat. J Neurosci 1996, 16:1083-1090.
67. Smith DH, Lowenstein DH, Gennarelli TA, McIntosh TK. Persistent memory dysfunction is associated with bilateral hippocampal damage following experimental brain injury. Neurosci Lett 1994, 168:151-154. 10.1016/0304-3940(94)90438-3, 8028769.
68. Vink R, Mullins PG, Temple MD, Bao W, Faden AI. Small shifts in craniotomy position in the lateral fluid percussion injury model are associated with differential lesion development. J Neurotrauma 2001, 18:839-847. 10.1089/089771501316919201, 11526990.
69. Floyd CL, Golden KM, Black RT, Hamm RJ, Lyeth BG. Craniectomy position affects morris water maze performance and hippocampal cell loss after parasagittal fluid percussion. J Neurotrauma 2002, 19:303-316. 10.1089/089771502753594873, 11939498.
70. Carbonell WS, Grady MS. Regional and temporal characterization of neuronal, glial, and axonal response after traumatic brain injury in the mouse. Acta Neuropathol 1999, 98:396-406. 10.1007/s004010051100, 10502046.
71. Spain A, Daumas S, Lifshitz J, Rhodes J, Andrews PJ, Horsburgh K, Fowler JH. Mild Fluid Percussion Injury in Mice Produces Evolving Selective Axonal Pathology and Cognitive Deficits Relevant to Human Brain Injury. J Neurotrauma 2010,
72. Dixon CE, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL. A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods 1991, 39:253-262. 10.1016/0165-0270(91)90104-8, 1787745.
73. Smith DH, Soares HD, Pierce JS, Perlman KG, Saatman KE, Meaney DF, Dixon CE, McIntosh TK. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J Neurotrauma 1995, 12:169-178. 10.1089/neu.1995.12.169, 7629863.
74. Dhillon HS, Donaldson D, Dempsey RJ, Prasad MR. Regional levels of free fatty acids and Evans blue extravasation after experimental brain injury. J Neurotrauma 1994, 11:405-415. 10.1089/neu.1994.11.405, 7837281.
75. Griesbach GS, Sutton RL, Hovda DA, Ying Z, Gomez-Pinilla F. Controlled contusion injury alters molecular systems associated with cognitive performance. J Neurosci Res 2009, 87:795-805. 10.1002/jnr.21893, 2747484, 18831070.
76. Adelson PD, Whalen MJ, Kochanek PM, Robichaud P, Carlos TM. Blood brain barrier permeability and acute inflammation in two models of traumatic brain injury in the immature rat: a preliminary report. Acta Neurochir Suppl 1998, 71:104-106.
77. von Baumgarten L, Trabold R, Thal S, Back T, Plesnila N. Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice. J Cereb Blood Flow Metab 2008, 28:1353-1360. 10.1038/jcbfm.2008.30, 18414497.
78. Hall ED, Bryant YD, Cho W, Sullivan PG. Evolution of post-traumatic neurodegeneration after controlled cortical impact traumatic brain injury in mice and rats as assessed by the de Olmos silver and fluorojade staining methods. J Neurotrauma 2008, 25:235-247. 10.1089/neu.2007.0383, 18352837.
79. Chen SF, Hsu CW, Huang WH, Wang JY. Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury. Br J Pharmacol 2008, 155:1279-1296. 10.1038/bjp.2008.345, 2607198, 18776918.
80. Sandhir R, Onyszchuk G, Berman NE. Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Exp Neurol 2008, 213:372-380. 10.1016/j.expneurol.2008.06.013, 2662478, 18692046.
81. Igarashi T, Potts MB, Noble-Haeusslein LJ. Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury. Exp Neurol 2007, 203:258-268. 10.1016/j.expneurol.2006.08.030, 17045589.
82. Koshinaga M, Katayama Y, Fukushima M, Oshima H, Suma T, Takahata T. Rapid and widespread microglial activation induced by traumatic brain injury in rat brain slices. J Neurotrauma 2000, 17:185-192. 10.1089/neu.2000.17.185, 10757324.
83. Elliott MB, Jallo JJ, Tuma RF. An investigation of cerebral edema and injury volume assessments for controlled cortical impact injury. J Neurosci Methods 2008, 168:320-324. 10.1016/j.jneumeth.2007.10.019, 18076998.
84. Schuhmann MU, Mokhtarzadeh M, Stichtenoth DO, Skardelly M, Klinge PM, Gutzki FM, Samii M, Brinker T. Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. Neurol Res 2003, 25:481-491. 10.1179/016164103101201896, 12866196.
85. Kiening KL, van Landeghem FK, Schreiber S, Thomale UW, von Deimling A, Unterberg AW, Stover JF. Decreased hemispheric Aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats. Neurosci Lett 2002, 324:105-108. 10.1016/S0304-3940(02)00180-5, 11988338.
86. Baskaya MK, Rao AM, Dogan A, Donaldson D, Dempsey RJ. The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci Lett 1997, 226:33-36. 10.1016/S0304-3940(97)00239-5, 9153635.
87. Baskaya MK, Dogan A, Temiz C, Dempsey RJ. Application of 2,3,5-triphenyltetrazolium chloride staining to evaluate injury volume after controlled cortical impact brain injury: role of brain edema in evolution of injury volume. J Neurotrauma 2000, 17:93-99. 10.1089/neu.2000.17.93, 10674761.
88. Stroop R, Thomale UW, Pauser S, Bernarding J, Vollmann W, Wolf KJ, Lanksch WR, Unterberg AW. Magnetic resonance imaging studies with cluster algorithm for characterization of brain edema after controlled cortical impact injury (CCII). Acta Neurochir Suppl 1998, 71:303-305.
89. Unterberg AW, Stroop R, Thomale UW, Kiening KL, Pauser S, Vollmann W. Characterisation of brain edema following "controlled cortical impact injury" in rats. Acta Neurochir Suppl 1997, 70:106-108.
90. Statler KD, Scheerlinck P, Pouliot W, Hamilton M, White HS, Dudek FE. A potential model of pediatric posttraumatic epilepsy. Epilepsy Res 2009, 86:221-223. 10.1016/j.eplepsyres.2009.05.006, 2702176, 19520549.
91. Hunt RF, Scheff SW, Smith BN. Posttraumatic epilepsy after controlled cortical impact injury in mice. Exp Neurol 2009, 215:243-252. 10.1016/j.expneurol.2008.10.005, 19013458.
92. Pappius HM. Local cerebral glucose utilization in thermally traumatized rat brain. Ann Neurol 1981, 9:484-491. 10.1002/ana.410090511, 7271242.
93. Tengvar C, Olsson Y. Uptake of macromolecules into neurons from a focal vasogenic cerebral edema and subsequent axonal spread to other brain regions. A preliminary study in the mouse with horseradish peroxidase as a tracer. Acta Neuropathol 1982, 57:233-235. 10.1007/BF00685395, 6181647.
94. Rakos G, Kis Z, Nagy D, Lur G, Farkas T, Hortobagyi T, Vecsei L, Toldi J. Evans Blue fluorescence permits the rapid visualization of non-intact cells in the perilesional rim of cold-injured rat brain. Acta Neurobiol Exp (Wars) 2007, 67:149-154.
95. Raslan F, Schwarz T, Meuth SG, Austinat M, Bader M, Renne T, Roosen K, Stoll G, Siren AL, Kleinschnitz C. Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. J Cereb Blood Flow Metab 2010, 30:1477-1486. 10.1038/jcbfm.2010.28, 20197781.
96. Pifarre P, Prado J, Giralt M, Molinero A, Hidalgo J, Garcia A. Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury. J Neurochem 2010, 112:807-817. 10.1111/j.1471-4159.2009.06518.x, 20002517.
97. Giralt M, Penkowa M, Lago N, Molinero A, Hidalgo J. Metallothionein-1+2 protect the CNS after a focal brain injury. Exp Neurol 2002, 173:114-128. 10.1006/exnr.2001.7772, 11771944.
98. Eriskat J, Furst M, Stoffel M, Baethmann A. Correlation of lesion volume and brain swelling from a focal brain trauma. Acta Neurochir Suppl 2003, 86:265-266.
99. Stoffel M, Blau C, Reinl H, Breidt J, Gersonde K, Baethmann A, Plesnila N. Identification of brain tissue necrosis by MRI: validation by histomorphometry. J Neurotrauma 2004, 21:733-740. 10.1089/0897715041269678, 15253801.
100. Bordey A, Hablitz JJ, Sontheimer H. Reactive astrocytes show enhanced inwardly rectifying K+ currents in situ. Neuroreport 2000, 11:3151-3155. 10.1097/00001756-200009280-00022, 11043540.
101. Penkowa M, Giralt M, Lago N, Camats J, Carrasco J, Hernandez J, Molinero A, Campbell IL, Hidalgo J. Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury. Exp Neurol 2003, 181:130-148. 10.1016/S0014-4886(02)00051-1, 12781987.
102. Penkowa M, Giralt M, Carrasco J, Hadberg H, Hidalgo J. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 2000, 32:271-285. 10.1002/1098-1136(200012)32:3<271::AID-GLIA70>3.0.CO;2-5, 11102968.
103. Quintana A, Giralt M, Rojas S, Penkowa M, Campbell IL, Hidalgo J, Molinero A. Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. J Neurosci Res 2005, 82:701-716. 10.1002/jnr.20680, 16267827.
104. Siren AL, Radyushkin K, Boretius S, Kammer D, Riechers CC, Natt O, Sargin D, Watanabe T, Sperling S, Michaelis T, Price J, Meyer B, Frahm J, Ehrenreich H. Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin. Brain 2006, 129:480-489. 10.1093/brain/awh703, 16339796.
105. Lewin E. The production of epileptogenic cortical foci in experimental animals by freezing. Purpura 1972, New York: Raven Press, Purpura DP, Perry JK, Tower DB, Woodbury DM, Walter R.
106. Coutinho-Netto J, Boyar MM, Abdul-Ghani AS, Bradford HF. In vivo inhibition of incorporation of [U-14C]glucose into proteins in experimental focal epilepsy. Epilepsia 1982, 23:383-389. 10.1111/j.1528-1157.1982.tb05424.x, 6807670.
107. Redecker C, Luhmann HJ, Hagemann G, Fritschy JM, Witte OW. Differential downregulation of GABAA receptor subunits in widespread brain regions in the freeze-lesion model of focal cortical malformations. J Neurosci 2000, 20:5045-5053.
108. Nilsson B, Ponten U. Exerimental head injury in the rat. Part 2: Regional brain energy metabolism in concussive trauma. J Neurosurg 1977, 47:252-261. 10.3171/jns.1977.47.2.0252, 874548.
109. Maruichi K, Kuroda S, Chiba Y, Hokari M, Shichinohe H, Hida K, Iwasaki Y. Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats. Neuropathology 2009, 29:132-139. 10.1111/j.1440-1789.2008.00956.x, 18702633.
110. Goldman H, Hodgson V, Morehead M, Hazlett J, Murphy S. Cerebrovascular changes in a rat model of moderate closed-head injury. J Neurotrauma 1991, 8:129-144. 10.1089/neu.1991.8.129, 1870136.
111. Shreiber DI, Bain AC, Ross DT, Smith DH, Gennarelli TA, McIntosh TK, Meaney DF. Experimental investigation of cerebral contusion: histopathological and immunohistochemical evaluation of dynamic cortical deformation. J Neuropathol Exp Neurol 1999, 58:153-164. 10.1097/00005072-199902000-00005, 10029098.
112. Fitch MT, Doller C, Combs CK, Landreth GE, Silver J. Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma. J Neurosci 1999, 19:8182-8198.
113. Mathew P, Bullock R, Graham DI, Maxwell WL, Teasdale GM, McCulloch J. A new experimental model of contusion in the rat. Histopathological analysis and temporal patterns of cerebral blood flow disturbances. J Neurosurg 1996, 85:860-870. 10.3171/jns.1996.85.5.0860, 8893725.
114. Mori S. Uptake of (3 H)thymidine by corpus callosum cells in rats following a stab wound of the brain. Brain Res 1972, 46:177-186. 10.1016/0006-8993(72)90014-5, 4635361.
115. Cernak I, Noble-Haeusslein LJ. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J Cereb Blood Flow Metab 2010, 30:255-266. 10.1038/jcbfm.2009.203, 19809467.
116. Richmond DR, Damon EG, Bowen IG, Fletcher ER, White CS. Air-blast studies with eight species of mammals. Techn Progr Rep DASA 1854. Fission Prod Inhal Proj 1967, 1-44.
117. Cernak I, Savic J, Malicevic Z, Zunic G, Radosevic P, Ivanovic I, Davidovic L. Involvement of the central nervous system in the general response to pulmonary blast injury. J Trauma 1996, 40:100-104.
118. Wang HC, Duan ZX, Wu FF, Xie L, Zhang H, Ma YB. A New Rat Model for Diffuse Axonal Injury Using a Combination of Linear Acceleration and Angular Acceleration. J Neurotrauma 2010, 27:707-719. 10.1089/neu.2009.1071, 20039778.
119. Kilbourne M, Kuehn R, Tosun C, Caridi J, Keledjian K, Bochicchio G, Scalea T, Gerzanich V, Simard JM. Novel model of frontal impact closed head injury in the rat. J Neurotrauma 2009, 26:2233-2243. 10.1089/neu.2009.0968, 2824220, 19929375.
120. Viano DC, Hamberger A, Bolouri H, Saljo A. Concussion in professional football: animal model of brain injury-part 15. Neurosurgery 2009, 64:1162-1173. 10.1227/01.NEU.0000345863.99099.C7, 19487897.
121. Ishige N, Pitts LH, Berry I, Carlson SG, Nishimura MC, Moseley ME, Weinstein PR. The effect of hypoxia on traumatic head injury in rats: alterations in neurologic function, brain edema, and cerebral blood flow. J Cereb Blood Flow Metab 1987, 7:759-767.
122. Tanno H, Nockels RP, Pitts LH, Noble LJ. Breakdown of the blood-brain barrier after fluid percussion brain injury in the rat: Part 2: Effect of hypoxia on permeability to plasma proteins. J Neurotrauma 1992, 9:335-347. 10.1089/neu.1992.9.335, 1291693.
123. Venturi L, Miranda M, Selmi V, Vitali L, Tani A, Margheri M, De Gaudio AR, Adembri C. Systemic sepsis exacerbates mild post-traumatic brain injury in the rat. J Neurotrauma 2009, 26:1547-1556. 10.1089/neu.2008.0723, 19257801.
124. Morrison B, Saatman KE, Meaney DF, McIntosh TK. In vitro central nervous system models of mechanically induced trauma: a review. J Neurotrauma 1998, 15:911-928. 10.1089/neu.1998.15.911, 9840765.
125. Morrison AL, King TM, Korell MA, Smialek JE, Troncoso JC. Acceleration-deceleration injuries to the brain in blunt force trauma. Am J Forensic Med Pathol 1998, 19:109-112. 10.1097/00000433-199806000-00002, 9662103.
126. Yanagida Y, Fujiwara S, Mizoi Y. Differences in the intracranial pressure caused by a 'blow' and/or a 'fall'-an experimental study using physical models of the head and neck. Forensic Sci Int 1989, 41:135-145. 10.1016/0379-0738(89)90245-4, 2767573.
127. McLean AJ. Brain injury without head impact?. J Neurotrauma 1995, 12:621-625. 10.1089/neu.1995.12.621, 8683613.