Simvastatin reduces mortality and hepatic injury after hemorrhage/ resuscitation in rats

Shock

Volumn 34, Issue 1, 2010, Pages 46-54

  Relja, Borna ^a   Lehnert, Mark ^a   Seyboth, Korbinian ^a   Bormann, Fabian ^a   Höhn, Christoph ^a   Czerny, Christoph ^a   Henrich, Dirk ^a   Marzi, Ingo ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

cytoskeleton; hemorrhagic shock; in vivo; inflammation; liver; NOS; Simvastatin

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ACTIN; ALANINE AMINOTRANSFERASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE 1; INTERLEUKIN 6; MYOSIN; PLACEBO; RHO KINASE; SIMVASTATIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSKELETON; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FEMALE; HISTOPATHOLOGY; INFLAMMATION; LEWIS RAT; LIVER INJURY; LIVER NECROSIS; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MORTALITY; NEUTROPHIL; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RESUSCITATION; SELF EXAMINATION; SURVIVAL RATE;

ACTINS; ALDEHYDES; ANIMALS; APOPTOSIS; CYTOSKELETON; DNA FRAGMENTATION; HEMODYNAMICS; HEMORRHAGE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-6; LIPID PEROXIDATION; LIVER; MALE; NEUTROPHILS; NITRIC OXIDE SYNTHASE TYPE III; RATS; RESUSCITATION; SIMVASTATIN; TYROSINE;

EID: 77953909003     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181cd8d05     Document Type: Article

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