Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Doucet, Danielle ^a   Badami, Chirag ^a   Palange, David ^a   Bonitz, R Paul ^a   Lu, Qi ^a   Xu, Da Zhong ^a   Kannan, Kolenkode B ^a   Colorado, Iriana ^a   Feinman, Rena ^a   Deitch, Edwin A ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; DIARYLPROPIONITRILE; ESTRADIOL; ESTROGEN RECEPTOR BETA; EVANS BLUE; INDUCIBLE NITRIC OXIDE SYNTHASE; MYELOPEROXIDASE; ESTROGEN; ESTROGEN RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSLOCATION; CELL PROTECTION; CLINICAL ASSESSMENT; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INJURY; LUNG; LUNG INJURY; LUNG LAVAGE; MEMBRANE PERMEABILITY; NONHUMAN; OVARIECTOMY; PROTEIN BLOOD LEVEL; RAT; REPERFUSION; RESUSCITATION; SPRAGUE DAWLEY RAT; STOMACH INJURY; ANIMAL; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; INTESTINE; INTESTINE CELL; METABOLISM; MULTIPLE ORGAN FAILURE; PATHOPHYSIOLOGY; PHYSIOLOGY; TRAUMATIC SHOCK;

BACTERIA (MICROORGANISMS); RATTUS;

ANIMALS; ENTEROCYTES; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; ESTROUS CYCLE; FEMALE; IMMUNOHISTOCHEMISTRY; INTESTINES; LUNG INJURY; MULTIPLE ORGAN FAILURE; NITRIC OXIDE SYNTHASE TYPE II; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; SHOCK, HEMORRHAGIC; SHOCK, TRAUMATIC;

EID: 77949675487     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009421     Document Type: Article

References (47)

1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, et al. (1995) Epidemiology of trauma deaths: A reassessment. J Trauma 38: 185-193.
2. Anathakrishnan P, Deitch EA (2003) Gut orgin sepsis and MODS: The role of sex hormones in modulating intestinal and distant organ injury. XX vs XY 1: 108-117.
3. Magnotti LJ, Fischer PE, Zarzaur BI, Fabian TC, Croce MA (2008) Impact of gender on outcomes after blunt injury: A definitive analysis of more than 36,000 trauma patients. J Am Coll Surg 206: 984-922.
4. Deitch EA, Livingston DH, Lavery RF, Monaghan SF, Bongu A, et al. (2007) Hormonally active women tolerate shock-trauma better than do men: A propective study of over 4000 trauma patients. Ann Surg 246: 447-455.
5. Angele MK, Schwacha MG, Ayala AA, Chaudry IH (2000) Effect of gender and sex hormones on immune responses following shock: A review article. Shock 14: 81-90.
6. Deitch EA, Xu DZ, Qu L (2006) Gut lymph hypothesis of early shock and trauma-induced multiple organ dysfunction syndrome: A new look at gut-origin sepsis. J Organ Dysfunct 2: 70-79.
7. Deitch EA, Forsythe R, Anjaria D, Livingston DH, Lu Q, et al. (2004) The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock. Shock 22: 221-228.
8. Senthil M, Brown M, Xu Dz, Lu Q, Feketeova E, et al. (2006) Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple organ dysfunction syndrome: Validating studies in a porcine model. J Trauma 60: 958-967.
9. Jarrar D, Wang P, Knoferl MW, Kuebler JF, Cioffi WG, et al. (2000) Insight into the mechanisms by which estradiol improves organ functions after trauma-hemorrhage. Surgery 128: 246-252.
10. Adams CA, Magnotti LJ, Xu DZ, Lu Q, Deitch EA (2000) Acute lung injury after hemorrhagic shock is dependent on gut injury and gender. Am Surg 66: 905-913.
11. Deitch EA, Ananthakrishnan P, Cohen DB, Xu DZ, Feketeova E, et al. (2006) Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries. Am J Physiol Heart Circ Physiol 291: H1456-1465.
12. Caruso JM, Deitch EA, Xu DZ, Lu Q, Dayal SD (2003) Gut Injury and gut-induced lung injury after trauma hemorrhagic shock is gender and estrus cycle specific in the rat. J Trauma 55: 531-539.
13. Macheido GW, Zeats S, Berezina T, Xu DZ, Spolarics Z, et al. (2004) Red blood cell damage after trauma-hemorrhage is modulated by gender. J Trauma 56: 837-844.
14. Sifri ZC, Cohen D, Ananthakrishnan P, Wang L, Kaiser VL, et al. (2007) Sex hormones affect bone marrow dysfunction after trauma and hemorrhagic shock. Crit Care Med 35: 864-869.
15. Sifri ZC, Kaiser VL, Ananthakrishnan P, Wang L, Mohr AM, et al. (2006) Bone marrow failure in male rats following trauma/hemorrhagic shock is mediated by mesenteric lymph and modulated by castration. Shock 25: 12-16.
16. Szabo C (1995) Alteration in nitric oxide production in various forms of circulatory shock. New Horiz 3: 2-32.
17. Salzmann AL (1995) Nitric oxide in the gut. New Horizon 3: 33-45.
18. Ananthakrishnan P, Cohen DB, Xu DZ, Lu Q, Feketeova E, et al. (2005) Sex hormones modulated distant organ injury in both trauma/hemorrhagic shock model and a burn model. Surgery 137: 56-65.
19. Bjornstrom L, Sjoberg M (2005) Mechanisms of estrogen receptor signaling: Convergence of genomic and nongenomic actions on target cells. Mol Endocrinol 19: 833-842.
20. Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Hägglad J, et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138: 863-870.
21. Yu HP, Shimizu T, Hsieh YC, Suzuki T, Choudhry MA, et al. (2006) Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage. J Leuk Biol 79: 963-970.
22. Suzuki T, Shimizu T, Yu HP, Hsieh YC, Choudhry MA, et al. (2007) Tissue Compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage. J Appl Physiol 102: 163-8.
23. Myers MJ, Sun J, Carlso KE, Marriner GA, Katzenellenbogen BS, et al. (2001) Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44: 4230-4251.
24. Baker HJ, Lindsey JR, Weisbroth SH (1979) The Laboratory Rat, Volume 1, Biology and Diseases. New York: Academic Press. pp 54-156.
25. Baker JW, Deitch EA, Li M, Berg RD, Specian RD (1988) Hemorrhagic shock induces bacterial translocation from the gut. J Trauma 28: 896-906.
26. Magnotti LJ, Upperman JS, Xu DZ, Lu Q, Deitch EA (1998) Gut-derived mesenteric lymph but not portal blood increases endothelial cell permeability and promotes lung injury after hemorrhagic shock. Ann Surg 228: 518-527.
27. Raju R, Bland KI, Chaudry IH (2008) Estrogen: A novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations. Mol Med 14: 213-221.
28. Doucet DR, Bonitz P, Feinman R, Colorado I, Mahdury R, et al. (2010) Estrogenic hormone modulation abrogates changes in red blood cell deformability and neutrophil activation in trauma hemorrhagic shock. J Trauma 68: 35-41.
29. Yu HP, Shimazu T, Choudhry MA, Hsieh YC, Suzuki T, et al. (2006) Mechanism of cardioprotection following trauma-hemorrhagic-shock by selective estrogen receptor- β agonist: Up-regulation of cardiac heat shock factor-1 and heat shock proteins. J Mol Cell Card 40: 185-194.
30. Yu HP, Hsieh YC, Suzuki T, Shimizu T, Choudhry MA, et al. (2006) Salutary effects of estrogen receptor-β agonist on lung injury after trauma-hemorrhage. Am J Physiol Lung Cell Mol Physiol 290: L1004-1009.
31. Reilly PM, Wilkins KB, Fuh KC, Haglund U, Bulkley GB (2001) The mesenteric hemodynamic response to circulatory shock: An overview. Shock 15: 329-343.
32. Suzuki Y, Deitch EA, Mishima S, Lu Q, Xu DZ (2000) Inducible nitric oxide synthase gene knockout mice have increased resistance to gut injury and bacterial translocation after an intestinal ischemia-reperfusion injury. Crit Care Med 28: 3692-3696.
33. Thomas ML, Xu X, Norfleet AM, Watson CS (1993) The presence of functional estrogen receptors in intestinal epithelial cells. Endocrinology 132: 426-430.
34. Hendrickse CW, Jones CE, Donovan IA, Neoptolemos JP, Baker PR (1993) Oestrigen and progesterone receptors in colorectal cancer and human colonic cancer cell lines. Br J Surgery 80: 636-640.
35. Mendelsohn ME, Karas RH (1999) The protective effects of estrogen on the cardiovascular system. New Engl J Med 340: 1801-1811.
36. Kauser K, Sonnenberg D, Tse J, Rubanyi GM (1997) 17β-estradiol attenuates endotoxin-induced excessive nitric oxide production in ovariectomized rats in vivo. Am J Physiol 273: H506-H509.
37. Unno N, Menconi MJ, Smith M, Aguirre DE, Fink MP (1997) Hyperperme-ability of intestinal epithelial monolayers is induced by NO: effect of low extracellular pH. Am J Physiol 272: G923-G934.
38. Xu DZ, Lu Q, Deitch EA (2002) Nitric oxide directly impairs intestinal barrier function. Shock 17: 139-145.
39. Forsythe RM, Xu DZ, Lu Q, Deitch EA (2002) Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion. Shock 17: 180-184.
40. Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, et al. (1999) Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest 103: 401-406.
41. Deitch EA, Chu H, Xu DZ (2008) Organ blood flow and the central hemodynamic response are better preserved in female, as opposed to the male rats, after trauma-hemorrhagic shock. J Trauma 65: 566-572.
42. Ba ZF, Kuebler JF, Rue LW III, Bland KI, Wang P, et al. (2003) Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation; role of vascular endothelial cell function. Am J Physiol Heart Circ Physiol 284: H21262-21269.
43. Jarrar D, Wang P, Knoferl MW, Kuebler JF, Cioffi WG, et al. (2000) Insight into the mechanism by which estradiol improves organ functions after trauma-hemorrhage. Surgery 128: 246-252.
44. Proctor KG (2008) Gender differences in trauma theory vs practice. Am J Physiol Regul Integr Comp Physiol 294: R1822-1824.
45. Deitch EA (1998) Animal models of sepsis and shock: A review and lessons learned. Shock 9: 1-11.
46. Dossett LA, Swenson BR, Evans HL, Bonatti, H, Sawyer RG, et al. (2008) Serum estradiol concentration as a predictor of death in critically ill and injured adults. Surg Infec 9: 41-48.
47. Scheingraber S, Dobbert D, Schmiedel P, Seliger E, Dralle H (2005) Gender-specific differences in sex hormones and cytokines in patients undergoing major abdominal surgery. Surg Today 35: 846-854.