Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union

Journal of Biomechanics

Volumn 42, Issue 13, 2009, Pages 2089-2096

  Gröngröft, Ina ^a   Heil, Petra ^a   Matthys, Romano ^b   Lezuo, Patrick ^a   Tami, Andrea ^a   Perren, Stephan ^a,b   Montavon, Pierre ^d   Ito, Keita ^a,c  

^a AO RESEARCH INSTITUTE   (Switzerland)

^b AO Development Institute   (Switzerland)

^c EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Delayed union; Endochondral ossification; Fracture healing; Intramembranous ossification; Mice

Indexed keywords

DELAYED UNION; ENDOCHONDRAL OSSIFICATION; FRACTURE HEALING; INTRAMEMBRANOUS OSSIFICATION; MICE;

BENDING TESTS; BIOCHEMISTRY; CARTILAGE; FRACTURE; MOLECULAR BIOLOGY; RADIOGRAPHY;

BONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE PLATE; BONE RADIOGRAPHY; BONE SCREW; CONTROLLED STUDY; FEMALE; FRACTURE FIXATION; FRACTURE HEALING; FRACTURE NONUNION; HISTOLOGY; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOTOMY; PRIORITY JOURNAL; RIGIDITY;

ANIMALS; BONE PLATES; BONE SCREWS; DISEASE MODELS, ANIMAL; ELASTIC MODULUS; EQUIPMENT FAILURE ANALYSIS; FEMALE; FEMORAL FRACTURES; FRACTURE FIXATION, INTERNAL; FRACTURE HEALING; HUMANS; MICE; MICE, INBRED C57BL; OSTEOTOMY; PROSTHESIS DESIGN;

EID: 69449084918     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2009.06.004     Document Type: Article

References (31)

1. Cheung K.M., Kaluarachi K., et al. An externally fixed femoral fracture model for mice. J. Orthop. Res. 21 4 (2003) 685-690
2. Claes L., Augat P., et al. Influence of size and stability of the osteotomy gap on the success of fracture healing. J. Orthop. Res. 15 4 (1997) 577-584
3. Colnot C., Thompson Z., et al. Altered fracture repair in the absence of MMP9. Development 130 17 (2003) 4123-4133
4. Einhorn T.A. The cell and molecular biology of fracture healing. Clin. Orthop. Relat. Res. 355 Suppl (1998) S7-S21
5. Einhorn T.A., Majeska R.J., et al. The expression of cytokine activity by fracture callus. J. Bone Miner. Res. 10 8 (1995) 1272-1281
6. Ferguson C., Alpern E., et al. Does adult fracture repair recapitulate embryonic skeletal formation?. Mech. Dev. 87 1-2 (1999) 57-66
7. Gabet Y., Muller R., et al. Osteogenic growth peptide modulates fracture callus structural and mechanical properties. Bone 35 1 (2004) 65-73
8. Gerstenfeld L.C., Cullinane D.M., et al. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J. Cell. Biochem. 88 5 (2003) 873-884
9. Gerstenfeld L.C., Thiede M., et al. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J. Orthop. Res. 21 4 (2003) 670-675
10. Goldhahn S., Moser R., et al. Treatment methods and outcomes of tibial shaft fractures in Switzerland. A prospective multicenter study of the Swiss AO. Swiss Surg. 6 6 (2000) 315-322
11. Hayda R.A., Brighton C.T., et al. Pathophysiology of delayed healing. Clin. Orthop. Relat. Res. 355 Suppl. (1998) S31-S40
12. Hente R., Cordey J., et al. In vivo measurement of bending stiffness in fracture healing. Biomed. Eng. Online 2 (2003) 8
13. Hiltunen A., Vuorio E., et al. A standardized experimental fracture in the mouse tibia. J. Orthop. Res. 11 2 (1993) 305-312
14. Horner K., Loeffler K., et al. Comparison of the histologic structure of the compact bone of the long hollow bones of mouse, hamster, rat, guinea pig, rabbit, cat, and dog during development. Anat. Histol. Embryol. 26 4 (1997) 289-295
15. Ito K., Perren S.M., et al. Biology and Biomechanics in Bone Healing. AO Principals of Fracture Management (2007), AO Publishing, Davos pp. 9-33
16. Iwaki A., Jingushi S., et al. Localization and quantification of proliferating cells during rat fracture repair: detection of proliferating cell nuclear antigen by immunohistochemistry. J. Bone Miner. Res. 12 1 (1997) 96-102
17. Karladani A.H., Granhed H., et al. The influence of fracture etiology and type on fracture healing: a review of 104 consecutive tibial shaft fractures. Arch. Orthop. Trauma Surg. 121 6 (2001) 325-328
18. Le A.X., Miclau T., et al. Molecular aspects of healing in stabilized and non-stabilized fractures. J. Orthop. Res. 19 1 (2001) 78-84
19. Lu C., Miclau T., et al. Ischemia leads to delayed union during fracture healing: a mouse model. J. Orthop. Res. 25 1 (2007) 51-61
20. Matthys R., and Perren S.M. Internal fixator for use in the mouse. Injury (2008)
21. McKee M.D., Ocshner P.E., et al. Aseptic Nonunion. AO Principals of Fracture Management (2007), AO Publishing, Davos pp. 505-520
22. Nunamaker D.M. Experimental models of fracture repair. Clin. Orthop. Relat. Res. 355 Suppl (1998) S56-S65
23. Oetgen M.E., Merrell G.A., et al. Development of a femoral non-union model in the mouse. Injury 39 10 (2008) 1119-1126
24. Praemer A., Furner S., et al. Musculoskelelal Conditions in the United States (1992), American Academy of Orthopaedic Surgeons, Park Ridge, IL
25. Rahn B.A., and Sumner-Smith G. Bone Healing: Histologic and Physiologic Concepts. Bone in Clinical Orthopaedics (2001), AO Publishing, Davos pp.287-326
26. Schell H., Thompson M.S., et al. Mechanical induction of critically delayed bone healing in sheep: radiological and biomechanical results. J. Biomech. (2008)
27. Schindeler A., Morse A., et al. Models of tibial fracture healing in normal and Nf1-deficient mice. J. Orthop. Res. 26 8 (2008) 1053-1060
28. Tay B.K., Le A.X., et al. Histochemical and molecular analyses of distraction osteogenesis in a mouse model. J. Orthop. Res. 16 5 (1998) 636-642
29. Thompson Z., Miclau T., et al. A model for intramembranous ossification during fracture healing. J. Orthop. Res. 20 5 (2002) 1091-1098
30. Uhthoff H.K., Goto S., et al. Influence of stable fixation on trabecular bone healing: a morphologic assessment in dogs. J. Orthop. Res. 5 1 (1987) 14-22
31. Yukata K., Matsui Y., et al. Altered fracture callus formation in chondromodulin-I deficient mice. Bone 43 6 (2008) 1047-1056