Role of platelet-rich plasma in acceleration of bone fracture healing

Annals of Plastic Surgery

Volumn 61, Issue 3, 2008, Pages 337-344

  Simman, Richard ^a,c   Hoffmann, Andrea ^a   Bohinc, R Jordan ^a   Peterson, Wylan C ^a   Russ, Andrew J ^b  

^a WRIGHT STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c KETTERING MEDICAL CENTER   (United States)

Author keywords

Growth factors TGF beta1 and BMP 2; Immunohistomorphometry; Long bone fracture healing; Platelet rich plasma; Radiographic analysis; Three point load bearing

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; SODIUM CHLORIDE; THROMBIN; TRANSFORMING GROWTH FACTOR BETA1; BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE RADIOGRAPHY; BONE STRENGTH; CALLUS; CONTROLLED STUDY; CORTICAL BONE; FEMUR FRACTURE; FRACTURE HEALING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LEWIS RAT; LONG BONE; MALE; NONHUMAN; OPEN FRACTURE; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THROMBOCYTE RICH PLASMA; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; BLOOD TRANSFUSION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOGRAPHY; WEIGHT BEARING;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD TRANSFUSION; BONE MORPHOGENETIC PROTEINS; BONY CALLUS; FEMORAL FRACTURES; FRACTURE HEALING; MALE; PLATELET-RICH PLASMA; RATS; RATS, INBRED LEW; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; WEIGHT-BEARING;

EID: 53149135842     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/SAP.0b013e318157a185     Document Type: Article

References (28)

1. Roldan JC, Jepsen S, Miller J, et al. Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7. Bone. 2004;34: 80-90.
2. Sanchez AR, Sheridan PJ, Kupp LI. Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants. 2003;18:93-103.
3. Tischler M. Platelet rich plasma. The use of autologous growth factors to enhance bone and soft tissue grafts. NY State Dent J. 2002;68:22-24.
4. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14:529-535.
5. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638-646.
6. Kim CS, Kim JI, Kim J, et al. Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers. Biomaterials. 2005;26:2501-2507.
7. Xu SW, Yu R, Zhao GF, et al. Early period of fracture healing in ovariectomized rats. Chin J Traumatol. 2003;6:160-166.
8. Lowery GL, Kulkarni S, Pennisi AE. Use of autologous growth factors in lumbar spinal fusion. Bone. 1999;25:47S-50S.
9. Stover EP, Siegel LC, Hood PA, et al. Platelet-rich plasma sequestration, with therapeutic platelet yields, reduces allogeneic transfusion in complex cardiac surgery. Anesth Analg. 2000;90:509-516.
10. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114:1502-1508.
11. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc. 2003;69:664.
12. Sano H, Uhthoff HK, Backman DS, et al. Correlation of radiographic measurements with biomechanical test results. Clin Orthop Relat Res. 1999;271-278.
13. Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone. 1993;14:595-608.
14. Andreassen TT, Seyer-Hansen K, Oxlund H. Biomechanical changes in connective tissues induced by experimental diabetes. Acta Endocrinol (Copenh). 1981;98:432-436.
15. Bak B, Jensen KS. Standardization of tibial fractures in the rat. Bone. 1992;13:289-295.
16. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1988;72:248-254.
17. Misugi E, Tojo SJ, Yasuda T, et al. Increased plasma P-selectin induced by intravenous administration of endotoxin in rats. Biochem Biophys Res Commun. 1998;246:414-417.
18. Amin HM, Ahmad S, Walenga JM, et al. Soluble P-selectin in human plasma: effect of anticoagulant matrix and its levels in patients with cardiovascular disorders. Clin Appl Thromb Hemost. 2000;6:71-76.
19. Onishi T, Ishidou Y, Nagamine T, et al. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats. Bone. 1998;22:605-612.
20. Zhang Y, Lu S, Wang J, et al. [Expression of BMP-2, TGF-beta, bFGF in guided bone regeneration]. Zhonghua Wai Ke Za Zhi. 1999;37:399-402.
21. Cao XS, Yang LJ, Wu XY, et al. [Changes of bone morphogenesis proteins and transforming growth factor-beta in hind-limb bones of 21 d tail-suspended rats]. Space Med Med Eng (Beijing). 2003;16:269-271.
22. Weibrich G, Hansen T, Kleis W, et al. Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone. 2004;34: 665-71.
23. Sarkar MR, Augat P, Shefelbine SJ, et al. Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold. Biomaterials. 2006;27:1817-1823.
24. Thorwarth M, Rupprecht S, Falk S, et al. Expression of bone matrix proteins during de novo bone formation using a bovine collagen and platelet-rich plasma (PRP)-an immunohistochemical analysis. Biomaterials. 2005;26:2575-2584.
25. Sipe JB, Zhang J, Waits C, et al. Localization of bone morphogenetic proteins (BMPs)-2, -4, and -6 within megakaryocytes and platelets. Bone. 2004;35:1316-1322.
26. Chakkalakal DA, Novak JR, Fritz ED, et al. Chronic ethanol consumption results in deficient bone repair in rats. Alcohol. 2002;37:13-20.
27. White AA 3rd, Panjabi MM, Southwick WO. The four biomechanical stages of fracture repair. J Bone Joint Surg Am. 1977;59:188-192.
28. Sakou T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone. 1998;22:591-603.