Proliferation analysis of the growth plate after diaphyseal midshaft fracture by 5′-bromo-2′-deoxy-uridine

Virchows Archiv

Volumn 457, Issue 1, 2010, Pages 77-85

  Janezic, Gregor ^a   Widni, Eva Elisa ^a   Haxhija, Emir Q ^a   Stradner, Martin ^a   Fröhlich, Eleonore ^a   Weinberg, Annelie Martina ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

5 Bromo 2 deoxy uridine; Bone length discrepancy; Chondrocyte proliferation; Growth disturbance; Growth plate

Indexed keywords

BROXURIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; FRACTURE HEALING; GROWTH PLATE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LEG LENGTH INEQUALITY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPRAGUE DAWLEY RAT; TIBIA FRACTURE;

ANIMALS; BROMODEOXYURIDINE; CELL PROLIFERATION; CHONDROCYTES; DIAPHYSES; FRACTURE HEALING; FRACTURES, BONE; GROWTH PLATE; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 77954564473     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-010-0932-6     Document Type: Article

References (41)

1. Breitfuss H, Muhr G (1988) Can accelerated longitudinal growth be prevented following pediatric femur shaft fractures? Unfallchirurg 91:189194
2. Clement DA, Colton CL (1986) Overgrowth of the femur after fracture in childhood. An increased effect in boys. J Bone Jt Surg Br 68:534536
3. Reynolds DA (1981) Growth changes in fractured long-bones: a study of 126 children. J Bone Jt Surg Br 63-B:8388
4. Stephens MM, Hsu LC, Leong JC (1989) Leg length discrepancy after femoral shaft fractures in children. Review after skeletal maturity. J Bone Jt Surg Br 71:615618
5. Sulaiman AR, Joehaimy J, Iskandar MA et al (2006) Femoral overgrowth following plate fixation of the fractured femur in children. Singapore Med J 47:684687
6. Wallace ME, Hoffman EB (1992) Remodelling of angular deformity after femoral shaft fractures in children. J Bone Joint Surg Br 74:765769
7. Zimmermann R, Stoger A, Golser K et al (1999) Tibial growth after isolated femoral shaft fracture in the growth stage. Unfallchirurg 102:365370
8. Laer L, Herzog B (1978) Leg length differences and rotation defects after femoral shaft fractures in childhood. Therapeutic influence and spontaneous correction. Helv Chir Acta 45:1721
9. Aitken AP (1940) Overgrowth of the femoral shaft following fracture in children. Am J Surg 49:147148
10. Ogden JA (2000) Skeletal injury in the child. Springer-Verlag, New York
11. Pring M, Newton P, Rang M (2005) Femoral shaft. In: Rang M, Pring ME, Wenger DR (eds) Rang's children's fractures. Lippincott Williams & Wilkins, Philadelphia, PA, pp 181200
12. Rang M, Wenger DR (2005) Children are not just small adults. In: Rang M, Pring ME, Wenger DR (eds) Rang's children's fractures. Lippincott Williams & Wilkins, Philadelphia, PA, pp 110
13. Routt M Jr (1994) Fractures of the femoral shaft. In: Green N, Switontkowski M (eds) Skeletal trauma in children. WB Saunders Company, Philadelphia, pp 345368
14. Salter R (1983) Textbook of disorders and injuries of the musculoskeletal system. Williams & Wilkins, Baltimore, MD
15. Wirth T, Syed Ali MM, Rauer C et al (2001) The influence of local vascular regeneration on growth plate activity after defined growth plate lesions. Eur J Trauma 27:5865
16. Zionts LE, Harcke HT, Brooks KM et al (1987) Posttraumatic tibia valga: a case demonstrating asymmetric activity at the proximal growth plate on technetium bone scan. J Pediatr Orthop 7:458462
17. Etchebehere EC, Caron M, Pereira JA et al (2001) Activation of the growth plates on three-phase bone scintigraphy: the explanation for the overgrowth of fractured femurs. Eur J Nucl Med 28:7280
18. Lee SH, Szoke G, Simpson H (2001) Response of the physis to leg lengthening. J Pediatr Orthop B 10:339343
19. Garces GL, Garcia-Castellano JM, Nogales J (1997) Longitudinal overgrowth of bone after osteotomy in young rats: influence of bone stability. Calcif Tissue Int 60:391393
20. Gerstenfeld LC, Cullinane DM, Barnes GL et al (2003) Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88:873884
21. Kaya AE (1986) Growth plate stimulation by diaphyseal fracture. Autoradiography of DNA synthesis in rats. Acta Orthop Scand 57:135137
22. Standring S, Ellis H, Healy JC et al (2005) Gray's anatomy: the anatomical basis of clinical practice. Elsevier Churchill Livingstone, Edinburgh
23. Ballock RT, O'Keefe RJ (2003) The biology of the growth plate. J Bone Jt Surg Am 85-A:715726
24. Forriol F, Shapiro F (2005) Bone development: interaction of molecular components and biophysical forces. Clin Orthop Relat Res 432:1433
25. Rauch F (2005) Bone growth in length and width: the Yin and Yang of bone stability. J Musculoskelet Neuronal Interact 5:194201
26. Meyer U, Wiesmann HP (2006) Bone and cartilage engineering. Springer-Verlag, Berlin
27. Abad V, Meyers JL, Weise M et al (2002) The role of the resting zone in growth plate chondrogenesis. Endocrinology 143:1851 1857
28. Bonnarens F, Einhorn TA (1984) Production of a standard closed fracture in laboratory animal bone. J Orthop Res 2:97101
29. Landry PS, Marino AA, Sadasivan KK et al (1996) Bone injury response. An animal model for testing theories of regulation. Clin Orthop Relat Res 332:260273
30. Morini S, Continenza MA, Ricciardi G et al (2004) Development of the microcirculation of the secondary ossification center in rat humeral head. Anat Rec A Discov Mol Cell Evol Biol 278:419427
31. Murakami S, Noda M (2000) Expression of Indian hedgehog during fracture healing in adult rat femora. Calcif Tissue Int 66:272276
32. Ashraf N, Meyer MH, Frick S et al (2007) Evidence for overgrowth after midfemoral fracture via increased RNA for mitosis. Clin Orthop Relat Res 454:214222
33. Okafuji N, Liu ZJ, King GJ (2006) Assessment of cell proliferation during mandibular distraction osteogenesis in the maturing rat. Am J Orthod Dentofacial Orthop 130:612621
34. Sato C, Muramoto T, Soma K (2006) Functional lateral deviation of the mandible and its positional recovery on the rat condylar cartilage during the growth period. Angle Orthod 76:591597
35. Sekine J, Sano K, Inokuchi T (1995) Effect of aging on the rat condylar fracture model evaluated by bromodeoxyuridine immunohistochemistry. J Oral Maxillofac Surg 53:13171321
36. Taylor JH, Woods PS, Hughes WL (1957) The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labeled thymidinee. Proc Natl Acad Sci USA 43:122128
37. Xiang Z, Markel MD (1995) Bromodeoxyuridine immunohistochemistry of epon-embedded undecalcified bone in a canine fracture healing model. J Histochem Cytochem 43:629635
38. Haxhija EQ, Yang H, Spencer AU et al (2006) Influence of the site of small bowel resection on intestinal epithelial cell apoptosis. Pediatr Surg Int 22:3742
39. Cho TJ, Gerstenfeld LC, Einhorn TA (2002) Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 17:513520
40. Einhorn TA (2005) The science of fracture healing. J Orthop Trauma 19:S4S6
41. Gerstenfeld LC, Einhorn TA (2003) Developmental aspects of fracture healing and the use of pharmacological agents to alter healing. J Musculoskelet Neuronal Interact 3:297303