Can rhBMP-2 containing collagen sponges enhance bone repair in ovariectomized rats?: A preliminary study

Clinical Orthopaedics and Related Research

Volumn 467, Issue 12, 2009, Pages 3113-3120

  Sarban, Sezgin ^a   Senkoylu, Alparslan ^b   Isikan, U Erdem ^a   Korkusuz, Petek ^c   Korkusuz, Feza ^d  

^a HARRAN UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

^d MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN SPONGE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BIOMECHANICS; BONE MARROW; BONE REMODELING; CALLUS; CLINICAL ASSESSMENT; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FRACTURE HEALING; HISTOLOGY; IMPLANTATION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RANGE OF MOTION; RAT; SCORING SYSTEM; SHAM PROCEDURE; TIBIA FRACTURE; TIBIA OSTEOTOMY; X RAY FILM;

EID: 70449533085     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-009-1004-6     Document Type: Conference Paper

References (33)

1. O Akkus F Korkusuz S Akin N Akkas 1998 Relation between mechanical stiffness and vibration transmission of fracture callus: an experimental study on rabbit tibia Proc Instn Mech Eng. 212 327 336 10.1243/0954411981534105 1:STN:280:DyaK1M%2FhvF2qsQ%3D%3D
2. A Alanay C Chen S Lee SS Murray EJ Brochmann M Miyazaki A Napoli JC Wang 2008 The adjunctive effect of a binding peptide on bone morphogenetic protein enhanced bone healing in a rodent model of spinal fusion Spine. 33 1709 1713 10.1097/BRS.0b013e31817e9dfd 18580546
3. An YH, Friedman RJ. Animal models of bone defect repair. In: An YH, Friedman RJ, eds. Animal Models in Orthopedic Research. Boca Raton, FL: CRC Press LLC; 1999:241-260.
4. OS Atik 2008 FRAX™ and Turkey: osteoporotic fracture risk assessment Joint Dis Relat Surg. 19 100
5. OS Atik I Gunal F Korkusuz 2006 Burden of osteoporosis Clin Orthop Relat Res 443 19 24 10.1097/01.blo.0000200248.34876.fe 16462421 (Pubitemid 44324928)
6. JG Blythe HJ Buchsbaum 1976 Fracture healing in estrogen-treated and castrated rats Obstet Gynecol 48 351 352 1:STN:280:DyaE283ktlakug%3D%3D 948380
7. M Bostrom J Lane E Tomin M Browne W Berberian T Turek J Smith J Wozney T Schildhauer 1996 Use of bone morphogenetic protein-2 in the rabbit ulna nonunion model Clin Orthop Rel Res. 327 272 282 10.1097/00003086-199606000-00034
8. EY Chao N Inoue TK Koo YH Kim 2004 Biomechanical considerations of fracture treatment and bone quality maintenance in elderly patients and patients with osteoporosis Clin Orthop Relat Res 425 12 25 10.1097/01.blo.0000132263. 14046.0c 15292783
9. TM Chu SJ Warden CH Turner RL Stewart 2007 Segmental bone repair using a load-bearing biodegradable carrier of bone morphogenetic protein-2 Biomaterials. 28 459 467 10.1016/j.biomaterials.2006.09.004 1:CAS:528:DC%2BD28XhtFeiu7rK 16996588 (Pubitemid 44602234)
10. M Egermann AW Baltzer S Adamaszek C Evans P Robbins E Schneider CA Lill 2006 Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep Hum Gene Ther 17 507 517 10.1089/hum.2006.17.507 1:CAS:528:DC%2BD28XkslKis7s%3D 16716108 (Pubitemid 43794490)
11. M Egermann E Schneider CH Evans AW Baltzer 2005 The potential of gene therapy for fracture healing in osteoporosis Osteoporos Int 16 Suppl 2 S120 S128 10.1007/s00198-004-1817-9 15654580 (Pubitemid 46232129)
12. P Giannoudis C Tzioupis T Almalki R Buckley 2007 Fracture healing in osteoporotic fractures: is it really different? A basic science perspective Injury 38 Suppl 1 S90 S99 10.1016/j.injury.2007.02.014 17383490 (Pubitemid 46440934)
13. L Gürkan A Ekeland KM Gautvik N Langeland H Rønningen LF Solheim 1986 Bone changes after castration in rats. A model for osteoporosis Acta Orthop Scand 57 67 70 3962636
14. JO Hollinger AO Onikepe J MacKrell T Einhorn G Bradica S Lynch CE Hart 2008 Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix J Orthop Res 26 83 90 10.1002/jor.20453 1:CAS:528:DC%2BD1cXhtleksbs%3D 17676626
15. KD Johnson KE Frierson TS Keller C Cook R Scheinberg J Zerwekh L Meyers MF Sciadini 1996 Porous ceramics as bone graft substitutes in long bone defects: a biomechanical, histological, and radiographic analysis J Orthop Res 14 351 369 10.1002/jor.1100140304 1:STN:280:DyaK283ot1GhtA%3D%3D 8676247 (Pubitemid 26199823)
16. DS Keskin A Tezcaner P Korkusuz F Korkusuz V Hasirci 2005 Collagen-chondroitin sulfate-based PLLA-SAIB-coated rhBMP-2 delivery system for bone repair Biomaterials. 26 4023 4034 10.1016/j.biomaterials.2004.09.063 1:CAS:528:DC%2BD2MXisFWq 15626448 (Pubitemid 40038791)
17. C Kirker-Head V Karageorgiou S Hofmann R Fajardo O Betz HP Merkle M Hilbe B von Rechenberg J McCool L Abrahamsen A Nazarian E Cory M Curtis D Kaplan L Meinel 2007 BMP-silk composite matrices heal critically sized femoral defects Bone. 41 247 255 10.1016/j.bone.2007.04.186 1:CAS:528:DC%2BD2sXnsFKrsr4%3D 17553763 (Pubitemid 47001819)
18. TS Lindholm 1974 Studies of the skeletal mass and bone formation of tibial fracture callus and femoral bone in growing osteopenic rats Acta Chir Scand Suppl. 449 37 42 1:STN:280:DyaE2M7otVKqsw%3D%3D 4533568
19. H Maeda A Sano K Fujioka 2004 Controlled release of rhBMP-2 from collagen minipellet and the relationship between release profile and ectopic bone formation Int J Pharm. 275 109 122 10.1016/j.ijpharm.2004.01.040 1:CAS:528:DC%2BD2cXivFGktL0%3D 15081142 (Pubitemid 38481524)
20. G Melhus LB Solberg S Dimmen JE Madsen L Nordsletten FP Reinholt 2007 Experimental osteoporosis induced by ovariectomy and vitamin D deficiency does not markedly affect fracture healing in rats Acta Orthop. 78 393 403 10.1080/17453670710013988 17611855 (Pubitemid 47027149)
21. H Namkung-Matthai R Appleyard J Jansen J Hao Lin S Maastricht M Swain RS Mason GA Murrell AD Diwan T Diamond 2001 Osteoporosis influences the early period of fracture healing in a rat osteoporotic model Bone. 281 80 86 10.1016/S8756-3282(00)00414-2 (Pubitemid 32112065)
22. L Nordsletten JE Madsen 2006 The effect of bone morphogenetic proteins in fracture healing Scand J Surg. 95 91 94 1:STN:280:DC%2BD28vgt1WksQ%3D%3D 16821651
23. RN Rosier RJ O'Keefe DG Hicks 1998 The potential role of transforming growth factor beta in fracture healing Clin Orthop Relat Res 355 Suppl S294 S300 10.1097/00003086-199810001-00030 9917649
24. MA Royals SM Fujita GL Yevey J Rodriguez PC Schultheiss RL Dunn 1999 Biocompatibility of a biodegradable in situ forming implant system in Rhesus monkeys J Biomed Mater Res 45 231 239 10.1002/(SICI)1097-4636(19990605)45: 3<231::AID-JBM11>3.0.CO;2-H 1:CAS:528:DyaK1MXisVeqtbY%3D 10397981 (Pubitemid 29165939)
25. H Schliephake HA Weich C Dullin R Gruber S Frahse 2008 Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid-an experimental study in rats Biomaterials. 29 103 110 10.1016/j. biomaterials.2007.09.019 1:CAS:528:DC%2BD2sXht1Wqtb7O 17936352 (Pubitemid 47599661)
26. G Schmidmaier P Schwabe B Wildemann NP Haas 2007 Use of bone morphogenetic proteins for treatment of non-unions and future perspectives Injury. 38-S4 S35 S41 10.1016/S0020-1383(08)70007-X (Pubitemid 351162870)
27. MF Sciadini KD Johnson 2000 Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model J Orthop Res 18 289 302 10.1002/jor.1100180218 1:CAS:528: DC%2BD3cXjslSnur8%3D 10815831
28. M Sener V Onar C Kazimoglu S Yagdi 2009 Mortality and morbidity in elderly patients who underwent partial prosthesis replacement for proximal femoral fractures Joint Dis Relat Surg. 20 11 17
29. MF Swiontkowski HT Aro S Donell JL Esterhai J Goulet A Jones PJ Kregor L Nordsletten G Paiement A Patel 2006 Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies J Bone Joint Surg Am 88 1258 1265 10.2106/JBJS.E.00499 16757759 (Pubitemid 43837120)
30. Y Tang W Tang Y Lin J Long H Wang L Liu W Tian 2008 Combination of bone tissue engineering and BMP-2 gene transfection promotes bone healing in osteoporotic rats Cell Biol Int 32 1150 1157 10.1016/j.cellbi.2008.06.005 1:CAS:528:DC%2BD1cXhtVens7bM 18638562
31. JC Tou A Foley YV Yuan S Arnaud CE Wade M Brown JC Tou A Foley YV Yuan S Arnaud CE Wade M Brown 2008 The effect of ovariectomy combined with hindlimb unloading and reloading on the long bones of mature Sprague-Dawley rats Menopause. 15 494 502 10.1097/gme.0b013e318148bbad 18030174 (Pubitemid 351656755)
32. SW Xu R Yu GF Zhao JW Wang 2003 Early period of fracture healing in ovariectomized rats Chin J Traumatol. 6 160 166 12749788
33. CY Yang DJ Simmons R Lozano 1994 The healing of grafts combining freeze-dried and demineralized allogeneic bone in rabbits Clin Orthop Relat Res 298 286 295 8118989