Polyphenol contents and antioxidant properties of medlar (Mespilus germanica L.)

Records of Natural Products

Volumn 5, Issue 3, 2011, Pages 158-175

  Gülçin, Ilhami ^a,b   Topal, Fevzi ^a   Sarikaya, S Beyza Öztürk ^c   Bursal, Ercan ^d   Bilsel, Gökhan ^e   Gören, Ahmet C ^e  

^a ATATÜRK UNIVERSITY   (Turkey)

^b AGRI IBRAHIM CECEN UNIVERSITY   (Turkey)

^c GUMUSHANE UNIVERSITY   (Turkey)

^d MU ALPARSLAN UNIVERSITY   (Turkey)

^e NATIONAL METROLOGY INSTITUTE   (Turkey)

Author keywords

Antioxidant activity; Medlar; Mespilus germanica; Radical scavenging; Trolox equivalent

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 4 HYDROXYBENZOIC ACID; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CAFFEIC ACID; CUPRIC ION; ELLAGIC ACID; FERRIC ION; FERROUS ION; FERULIC ACID; FLAVONOID; GALLIC ACID; HYDROGEN PEROXIDE; MESPILUS GERMANICA EXTRACT; N,N DIMETHYL 1,4 PHENYLENEDIAMINE; PARA COUMARIC ACID; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOL; PYROGALLOL; QUERCETIN; SCAVENGER; SUPEROXIDE; SYRINGIC ACID; TROLOX C; UNCLASSIFIED DRUG; VANILLIN;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MESPILUS GERMANICA; ROSACEAE; SUBSPECIES; TANDEM MASS SPECTROMETRY;

MESPILUS GERMANICA; ROSACEAE;

EID: 79953123799     PISSN: None     EISSN: 13076167     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. K. Browicz and L. Mespilus (1972). In Davis PH. (Ed.). Flora of Turkey and the East Aegean Islands, Vol. 4, pp. 128-129, Edinburgh: Edinburgh University Press.
2. C. Bignami (2000). Il nespolo comune. L'Informace Agrario, 25, 43-46.
3. R. Baird and JW. (1989). Thieret The medlar (Mespilus germanica, Rosaceae) from antiquity to obscurity. Economic Botany 3.
4. Bassi E 1932. Frutticoltura. In Nuova Enciclopedia Agraria Italiana, Parte quinta. Unione Tipografica Torinese, Torino.
5. T. Baytop (1999). Therapy with medicinal plants in Turkey-past and present, 2nd, Nobel Tip Basimevi, p. 299, Çapa-Istanbul.
6. R.H. Glew, F.A. Ayaz, C. Sanz, D.J. VanderJagt, H.S. Huang, L.T. Chuang and M. Strnad (2003). Changes in sugars, organic acids and amino acids in medlar (Mespilus germanica L.) during fruit development, Food Chem. 83, 363-369.
7. R.H. Glew, F.A. Ayaz, C. Sanz, D.J. VanderJagt, H.S. Huang, L.T. Chuang and S. Miroslav (2003). Effect of postharvest period on sugar, organic acid and fatty acid compositions in commercially sold medlar (Mespilus germanica 'Dutch') fruit, Eur. Food Sci. Technol. 216, 390-394.
8. F.A. Ayaz, O. Demir, H. Torun, Y. Kolcuoglu and A. Colak (2008). Characterization of polyphenoloxidase (PPO) and total phenolic contents in medlar (Mespilus germanica L.) fruit during ripening and over ripening, Food Chem. 106, 291-298.
9. R.H. Glew, F.A. Ayaz, D.J. VanderJagt, M. Millson, R. Dris and R. Niskanen (2003). A Research note mineral composition of medlar (Mespilus germanica) fruit at different stages of maturity, J. Food Qual. 26, 441-447.
10. S.M. Pourmortazavia, M. Ghadirib, S.S. (2005). Hajimirsadegh Supercritical fluid extraction of volatile components from Bunium persicum Boiss. (Black cumin) and Mespilus germanica L. (medlar) seeds, J. Food Comp. Anal. 18, 439-446.
11. H. Haci{dotless}seferogullari{dotless}, M. Ozcan, M.H. Sonmete and O. Ozbek. (2005). Some physical and chemical parameters of wild medlar (Mespilus germanica L.) fruit grown in Turkey, J. Food Eng. 69, 1-7.
12. M. Oktay, İ. Gülçin and Ö. İ. Küfrevioǧlu, (2003). Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts, Lebensm. Wissen Technol. 36, 263-271.
13. L.O. Dragsted, M. Strube and J.C. Larsen (1993). Cancer-protective factors in fruits and vegetables: biochemical and biological background. Pharmacol. Toxicol. 72, 116-135
14. H.E. Poulsen, H. Prieme, S. Loft (1998). Role of oxidative DNA damage in cancer initiation and promotion, Eur. J. Cancer. Prevent. 7, 9-16.
15. İ. Gülçin, V. Mshvildadze, A. Gepdiremen and R. Elias, (2004). Antioxidant activity of saponins isolated from ivy: a-Hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside F, Planta Med. 70, 561-563.
16. İ. Gülçin, E. Bursal, H.M. Şehitoǧlu, M. Bilsel and A.C. Gören (2010). Polyphenol contents and antioxidant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey, Food Chem. Toxicol. 48, 2227-2238.
17. U. Ş. Harput, Y. Genç, N. Khan and İ. Saracoglu, (2011). Radical scavenging effects of different Veronica species, Rec. Nat. Prod. 5 100-107.
18. G.E. Pantelidis, M. Vasilakakis, G.A. Manganaris and G. Diamantidis (2007). Antioxidant capacity, phenol, anthocyanin and ascorbic acid contents in raspberries, blackberries, red currants, gooseberries and cornelian cherries, Food Chem. 102, 777-783.
19. N. Deighton, R. Brennan, C. Finn and HV. Davies (2000). Antioxidant properties of domesticated and wild Rubus species, J. Sci. Food Agric. 80, 1307-1313.
20. R.A. Moyer, K.E. Hummer, C.E. Finn, B. Frei and R.E. Wrolstad (2002). Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: vaccinium, rubus, and ribes, J. Agric. Food Chem. 50, 519-525.
21. D. Stewart, G.J. McDougall, J. Sungurtas, S. Verrall, J. Graham and I. Martinussen (2007). Metabolomic approach to identifying bioactive compounds in berries: Advances toward fruit nutritional enhancement, Mol. Nutr. Food Res. 51, 645-6451.
22. İ. Gülçin, Ş. Beydemir, İ.G. Şat and Ö. İ. Küfrevioǧlu (2005). Evaluation of antioxidant activity of cornelian cherry (Cornus mas L.), Acta Aliment. Hung. 34, 193-202.
23. İ. Gülçin, A.Z. Tel and E. Kirecci (2008). Antioxidant, antimicrobial, antifungal and antiradical activities of Cyclotrichium niveum (Boiss.) Manden and Scheng, Int. J. Food Propert. 11: 450-471.
24. İ. Gülçin, İ.G. Şat, Ş. Beydemir, M. Elmastaş and Ö. İ. Küfrevioǧlu (2004). Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.), Food Chem. 87, 393-400.
25. V.L. Singleton and J.L. Rossi (1965). Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents, Am. J. Enol. Viticult. 16, 144-148.
26. M. Elmastaş, İ. Gülçin, Ş. Beydemir, Ö. İ. Küfrevioǧlu and H.Y. Aboul-Enein (2006). A study on the in vitro antioxidant activity of juniper (Juniperus communis L.) seeds extracts, Anal. Lett. 39, 47-65.
27. H. Serbetci Tohma and İ. Gülçin (2010). Antioxidant and radical scavenging activity of aerial parts and roots of Turkish liquorice (Glycyrrhiza glabra L.), Int. J. Food Propert. 13, 657-671.
28. E. Köksal, İ. Gülçin, S.B. Öztürk Sari{dotless}kaya and E. Bursal (2008). On the in vitro antioxidant activity of silymarin, J. Enzym. Inhib. Med. Chem. 24, 395-405.
29. A.A. Adedapo, F.O. Jimoh, A.J. Afolayan and P.J. Masika (2009). Antioxidant properties of the methanol extracts of the leaves and stems of Celtis Africana, Rec. Nat. Prod. 3, 23-31.
30. A.C. Gören, S. Çi{dotless}kri{dotless}kçi{dotless}, M. Çergel and G. Bilsel (2009). Rapid quantitation of curcumin in turmeric via NMR and LC-tandem mass spectrometry, Food Chem. 113, 1239-1242.
31. M. Oyaizu (1986). Studies on product of browning reaction prepared from glucose amine, Jpn. J. Nut. 44, 307-315.
32. T. Ak and İ. Gülçin (2008). Antioxidant and radical scavenging properties of curcumin, Chem. Biol. Interact. 174, 27-37.
33. G. Zengin, A. Aktumsek, G.O. Guler, Y.S. Cakmak and E. Yildiztugay (2011). Antioxidant properties of methanolic extract and fatty acid composition of Centaurea urvillei DC. subsp. hayekiana Wagenitz, Rec. Nat. Prod. 5, 123-132.
34. M.E. Büyükokuroǧlu, İ. Gülçin, M. Oktay and Ö. İ. Kufrevioǧlu (2001). In vitro antioxidant properties of dantrolene sodium, Pharmacol. Res. 44, 491-495.
35. H.T. Balaydi{dotless}n, İ. Gülçin, A. Menzek, S. Göksu and E. Şahin (2010). Synthesis and antioxidant properties of diphenylmethane derivative bromophenols including a natural product, J. Enzym. Inhib. Med. Chem. 25, 685-695.
36. R. Apak, K. Güçlü, M. Özyürek and S.E. Karademir (2004). A novel total antioxidant capacity index for dietary polyphenols, vitamin C and E, using their cupric ion reducing capability in the presence of neocuproine: The CUPRAC method, J. Agric. Food Chem. 52, 7970-7981.
37. R. Apak, K. Güçlü, M. Özyürek, S.E. Karademir and E. Erçal (2006). The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas, Int. J. Food Sci. Nut. 57, 292-304.
38. T.C.P. Dinis, V.M.C. Madeira and L.M. (1994). Almeida Action of phenolic derivates (acetoaminophen, salycilate, and 5-aminosalycilate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers, Arch. Biochem. Biophy. 315, 161-169.
39. İ. Gülçin, R. Elias, A. Gepdiremen and L. Boyer (2006). Antioxidant activity of lignans from fringe tree (Chionanthus virginicus L.), Eur. Food Res. Technol. 223, 759-767.
40. İ. Gülçin (2006). Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid), Toxicology 217, 213-220.
41. İ. Gülçin (2007). Comparison of in vitro antioxidant and antiradical activities of L-tyrosine and L-Dopa, Amino Acids 32, 431-438.
42. M.S. Blois (1958). Antioxidant determinations by the use of a stable free radical, Nature 26, 1199-1200.
43. M. Elmastas, İ. Türkekul, L. Öztürk, İ. Gülçin, Ö. Işi{dotless}ldak and H.Y. Aboul-Enein (2006). The antioxidant activity of two wild edible mushrooms (Morchella vulgaris and Morchella esculanta), Comb. Chem. High T. Scr. 9: 443-448.
44. İ. Gülçin (2006). Antioxidant and antiradical activities of L-Carnitine, Life Sci. 78, 803-811.
45. İ. Gülçin, E. Kirecci, E. Akkemik, F. Topal and O. Hisar (2010). Antioxidant and antimicrobial activities of an aquatic plant: Duckweed (Lemna minor L.), Turk. J. Biol. 34: 175-188.
46. İ. Gülçin, D. Berashvili and A. Gepdiremen (2005). Antiradical and antioxidant activity of total anthocyanins from Perilla pankinensis decne, J. Ethnopharmacol. 101, 287-293.
47. İ. Gülçin, M. Elmastas and H.Y. Aboul-Enein (2007). Determination of antioxidant and radical scavenging activity of basil (Ocimum basilicum) assayed by different methodologies, Phytother. Res. 21, 354-361.
48. İ. Gülçin, (2009). Antioxidant activity of L-Adrenaline: An activity-structure insight. Chem. Biol. Interact. 179, 71-80.
49. İ. Gülçin (2010). Antioxidant properties of resveratrol: A structure-activity insight, Innov. Food Sci. Emerg. 11, 210-218.
50. İ. Gülçin and A. Daştan (2007). Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities, J. Enzym. Inhib. Med. Chem. 22, 685-695.
51. O. Talaz, İ. Gülçin, S. Göksu and N. Saracoglu (2009). Antioxidant activity of 5, 10-dihydroindeno[1, 2-b]indoles containing substituents on dihydroindeno part, Bioorg. Med. Chem. 17, 6583-6589.
52. J. Zhishen, T. Mengcheng and W. Jianming (1999). The determination of flavonoid contents on mulberry and their scavenging effects on superoxide radical, Food Chem. 64: 555-559.
53. İ. Gülçin, R. Elias, A. Gepdiremen, A. Chea and F. Topal (2010). Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: Cepharanthine and fangchinoline, J. Enzym. Inhib. Med. Chem. 25, 44-53.
54. E. Köksal and İ. Gülçin (2008). Antioxidant activity of cauliflower (Brassica oleracea L.), Turk. J. Agric. For. 32, 65-78.
55. İ. Gülçin, V. Mshvildadze, A. Gepdiremen and R. Elias (2006). Screening of antioxidant and antiradical activity of monodesmosides and crude extract from Leontice smirnowii Tuber, Phytomedicine 13, 343-351.
56. V. Fogliano, V. Verde, G. Randazzo and A. Ritieni (1999). Method for measuring antioxidant activity and its application to monitoring the antioxidant capacity of wines, J. Agric. Food Chem. 47, 1035-1040.
57. İ. Gülçin. (2008). Measurement of antioxidant ability of melatonin and serotonin by the DMPD and CUPRAC methods as trolox equivalent, J. Enzym. Inhib. Med. Chem. 23, 871-876.
58. K. Robards, P.D. Prenzler, G. Tucker, P. Swatsitang, W. Glover (1999). Phenolic compounds and their role in oxidative processes in fruits, Food Chem. 66, 401-436.
59. İ. Gülçin, R. Elias, A. Gepdiremen, K. Taoubi, and E. Köksal, (2009). Antioxidant secoiridoids from fringe tree (Chionanthus virginicus L.), Wood Sci. Technol. 43, 195-212.
60. V. Roginsky and E.A. Lissi (2005). Review of methods to determine chain-breaking antioxidant activity in food, Food Chem. 92, 235-254.
61. İ. Gülçin, H.A. Alici and M. Cesur, (2005). Determination of in vitro antioxidant and radical scavenging activities of propofol, Chem. Pharm. Bull. 53, 281-285.
62. İ. Gülçin, M.E. Büyükokuroǧlu, M. Oktay and Ö. İ. Küfrevioǧlu (2003). Antioxidant and analgesic activities of turpentine of Pinus nigra Arn. Subsp. pallsiana (Lamb.) Holmboe, J. Ethnopharmacol. 86, 51-58.
63. S. Karaman, E. Tütem, K.S. Baskan and R. Apak (2009). Comparison of total antioxidant capacity and phenolic composition of some apple juices with combined HPLC-CUPRAC assay, Food Chem. 120, 1201-1209.
64. A. Luximon-Ramma, T. Bahorun and A. Crozier (2003). Antioxidant actions and phenolic and vitamin C contents of common Mauritian exotic fruits, J. Sci. Food Agric. 83, 496-502.
65. R. Pulido, L. Bravo and F. Sauro-Calixto (2000). Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay, J. Agr. Food Chem. 48, 3396-3402.
66. F.Q. Schafer and G.R. Buettner (2001). Redox state of the cell as viewed through the glutathione disulfide/glutathione couple, Free Radic. Biol Med. 30, 1191-1212.
67. İ. Gülçin, Ş. Beydemir, H.A. Alici, M. Elmastaş and M.E. Büyükokuroǧlu (2004). In vitro antioxidant properties of morphine, Pharmacol. Res. 49. 59-66.
68. İ. Gülçin, V. Mshvildadze, A. Gepdiremen and R. Elias, (2006). Antioxidant activity of a triterpenoid glycoside isolated from the berries of Hedera colchica: 3-O-(β-D-glucopyranosyl)-hederagenin, Phytother. Res. 20, 130-134.
69. B. Halliwell and J.M.C. Gutteridge (1984). Oxygen toxicology, oxygen radicals, transition metals and diseas, Biochem. J. 219, 1-4.
70. İ. Gülçin, (2005). The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds, Int. J. Food Sci. Nut. 56, 491-499.
71. P.C. Chai, L.H. Long and B. Halliwell (2003). Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines, Biochem. Bioph. Res. Co. 304, 650-654.
72. B. Özcelik, J.H. Lee and D.B. Min. (2003). Effects of light, oxygen and pH on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method to evaluate antioxidants, J. Food Sci. 68, 487-490.
73. B. Matthäus (2002). Antioxidant activity of extracts obtained from residues of different oilseeds, J. Agric. Food Chem. 50, 3444-3452.
74. R. Amarowicz, R.B. Pegg, P. Rahimi-Moghaddam, B. Barl and J.A. Weil (2004). Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies, Food Chem. 84, 551-562.
75. B. Halliwell and S. Chirico (1993). Lipid peroxidation: its mechanism, measurement, and significance, Am. J. Clin. Nut. 57, 715-725.
76. İ. Gülçin, Ö. İ. Küfrevioǧlu, M. Oktay and Buyukokuroglu M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.), J. Ethnopharmacol. 90, 205-215.
77. A.P. Wickens (2001). Aging and the free radical theory, Resp. Physiol. 128, 379-391.
78. P.G. Pietta (2000). Flavonoids as antioxidants, J. Nat. Prod. 63, 1035-1042.
79. I. Parejo, F. Viladomat, J. Bastida, A. Rosas-Romero, N. Flerlage, J. Burillo and C. Codina (2002). Comparison between the radical scavenging activity and antioxidant activity of six distilled and nondistilled Mediterranean herbs and aromatic plants, J. Agric. Food Chem. 50, 6882-6890.
80. S.I. Liochev and I. Fridovich (1995). Superoxide from glucose oxidase or from nitroblue tetrazolium, Arch. Biochem. Biophys. 318, 408-410.
81. C. Beauchamp and I. Fridovich (1971). Superoxide dismutase: improved assays and an assay applicable to acrylamide gels, Anal. Biochem. 44, 276-287.