Recognition of cytoplasmic RNA results in cathepsin-dependent inflammasome activation and apoptosis in human macrophages

Journal of Immunology

Volumn 186, Issue 5, 2011, Pages 3085-3092

  Rintahaka, Johanna ^a   Lietzén, Niina ^b   Öhman, Tiina ^b   Nyman, Tuula A ^b   Matikainen, Sampsa ^a  

^a FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN D; CATHEPSIN INHIBITOR; CYSTATIN; DOUBLE STRANDED RNA; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; LYSOSOME ENZYME; PEPTIDES AND PROTEINS; PROTEIN INHIBITOR; PROTEINASE; SECRETOME; SMALL CYTOPLASMIC RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENCEPHALOMYOCARDITIS VIRUS; ENZYME ACTIVATION; EXOSOME; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INNATE IMMUNITY; MACROPHAGE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEOMICS; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; WESTERN BLOTTING;

APOPTOSIS; CATHEPSINS; CELLS, CULTURED; CYTOPLASM; ENCEPHALOMYOCARDITIS VIRUS; HUMANS; INFLAMMASOMES; MACROPHAGES; MOLECULAR MIMICRY; POLY I-C; RNA, DOUBLE-STRANDED; RNA, VIRAL; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS INDIANA VIRUS;

EID: 79952771710     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002051     Document Type: Article

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