Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

EMBO Journal

Volumn 30, Issue 6, 2011, Pages 1137-1148

  Yin, Yiyuan ^a,b   Li, Yili ^a,c   Kerzic, Melissa C ^a,c   Martin, Roland ^d   Mariuzza, Roy A ^a,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c Bldg 142   (United States)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

autoimmunity; MHC class II; multiple sclerosis; structure; T cell receptor

Indexed keywords

HLA DR4 ANTIGEN; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; HUMAN; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AUTOANTIGENS; CRYSTALLOGRAPHY, X-RAY; HLA-DR4 ANTIGEN; HUMANS; MODELS, MOLECULAR; MYELIN BASIC PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, ANTIGEN, T-CELL; SURFACE PLASMON RESONANCE;

EID: 79952750632     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.21     Document Type: Article

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