Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone

Journal of Experimental Medicine

Volumn 185, Issue 9, 1997, Pages 1651-1659

  Hemmer, Bernhard ^a   Fleckenstein, Burkhard T ^b   Vergelli, Marco ^a   Jung, Günther ^b   McFarland, Henry ^a   Martin, Roland ^a,b,c   Wiesmüller, Karl Heinz ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CROSS REACTION; ENZYME SPECIFICITY; GENE MAPPING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; T LYMPHOCYTE SUBPOPULATION;

EID: 0030925578     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.9.1651     Document Type: Article

References (31)

1. Janeway, C.A., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell. 76:275-285.
2. Anderson, D.C., W.C.A. Van Schooten, M.E. Barry, A.A.M. Janson, T.M. Buchanan, and R.R.P. De Vries. 1988. A Mycobacterium leprae-specific human T cell epitope crossreacts with an HLA-DR2 peptide. Science (Wash. DC). 242:259-261.
3. Fujinami, R.S., and M.B.A. Oldstone. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science (Wash. DC). 230:1043-1045.
4. Wraith, D.C., B. Brunn, and P.J. Fairchild. 1992. Cross-reactive antigen recognition by an encephalitogenic T cell receptor: implication for T cell biology and autoimmunity. J. Immunol. 149:3765-3770.
5. Evavold, B.D., J. Sloan-Lancaster, K.J. Wilson, J.B. Rothbard, and P.M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for endogenous ligands. Immunity. 2:655-663.
6. Bhardwaj, V., V. Kumar, H.M. Geysen, and E.E. Sercarz. 1993. Degenerate recognition of a dissimilar antigenic peptide by mylein-basic protein-reactive T cells. J. Immunol. 151: 5000-5010.
7. Wucherpfennig, K.W., and J.L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
8. de Koster, H.K., R. Amons, W.E. Benckhuijsen, M. Feijlbrief, G.A. Schellekens, and J.W. Drijfhout. 1995. The use of dedicated peptide libraries permits the discovery of high affinity binding peptides. J. Immunol. Methods. 187:179-188.
9. Songyang, Z., S.E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W.G. Haser, F. King, T. Roberts, S. Ratnofsky, R.J. Lechleider et al. 1993. Sh2 domains recognize specific phosphopeptide sequences. Cell. 72:767-778.
10. Kupke, T., C. Kempter, G. Jung, and F. Götz. 1995. Oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD. J. Biol. Chem. 270:11282-11289.
11. b J. Biol. Chem. 270:24130-24134.
12. Fleckenstein, B., H. Kalbacher, C.P. Muller, D. Stoll, T. Halder, G. Jung, and K.-H. Wiesmüller. 1996. New ligands binding to HLA class II molecule DRB1*0101 designed from the activity pattern of an unadecapeptide library. Brit. J. Pharmacol. 240:71-77.
13. Blake, J., J.V. Johnston, K.E. Hellström, H. Marquardt, and L. Chen. 1996. Use of combinatorial libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes. J. Exp. Med. 184: 121-130.
14. Gundlach, B.R., K.-H. Wiesmüller, T. Junt, S. Kienle, G. Jung, and P. Walden. 1996. Specificity and Degeneracy of minor Histocompatibility antigen-specific MHC-restricted CTL. J. Immunol. 156:3645-3651.
15. Udaka, K., K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1996. Self-MHC-restriceted peptides recognized by alloreactive T lymphocyte clone. J. Immunol. 157:670-678.
16. Udaka, K., K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1995. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries. J. Exp. Med. 181: 2097-2108.
17. Pinilla, C., J.R. Appel, P. Blanc, and R.A. Houghton. 1992. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries. Biotechniqnes. 13:901-905.
18. Houghten, R.A., C. Pinilla, S.E. Blondelle, J.R. Appel, C.T. Dooley, and J.H. Cuervo. 1991. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature (Lond). 354:84-86.
19. Wiesmüller, K.-H., S. Feiertag, B. Fleckenstein, S. Kienle, D. Stoll, M. Herrmann, and G. Jung. 1996. Automated procedures for the production and analysis of complex peptide libraries. In Combinatorial Peptide and Nonpeptide Libraries. G. Jung, editor. Verlag Chemie, Weinheim. 203-246.
20. Jung, G., and A.G. Beck-Sickinger. 1992. Multiple peptide synthesis methods and their applications. Angew. Chem. Int. Ed. Engl. 31:367-383.
21. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148:1359-1366.
22. Vergelli, M., B. Hemmer, U. Utz, A. Vogt, M. Kalbus, L. Tranquill, P. Conlon, N. Ling, L. Steinman, H.F. McFarland, and R. Martin. 1996. Differential T cell activation by altered peptide ligands derived from myelin basic protein peptide (87-99). Eur. J. Immunol. 26:2624-2634.
23. Martin, R., M.D. Howell, D. Jaraquemada, M. Flerlage, J. Richert, S. Brostoff, E.O. Long, D.E. McFarlin, and H.F. McFarland. 1991. A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J. Exp. Med. 173:19-24.
24. Vogt, A.B., H. Kropshofer, H. Kalbacher, M. Kalbus, H.-G. Rammensee, J.E. Coligan, and R. Martin. 1994. Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides. J. Immunol. 153:1665-1673.
25. Wucherpfennig, K.W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J.L. Strominger, and D.A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279-290.
26. Ghosh, P., M. Amaya, E. Mellins, and D.E. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature (Lond.). 378:457-462.
27. Stern, L.J., J.H. Brown, T.S. Jardetzky, J.C. Gorga, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza peptide. Nature (Lond.). 368:215-221.
28. Garcia, K.C., M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, and I.A. Wilson. 1996. An α/β T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Nature (Lond.). 274: 209-219.
29. Vergelli, M., B. Hemmer, M. Kalbus, A. Vogt, N. Ling, P. Conlon, J.E. Coligan, H.F. McFarland, and R. Martin. 1997. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells. J. Immunol. 158:3746-3752.
30. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 84:521-529.
31. Pawlowski, T.J., M.D. Singleton, D.Y. Loh, R. Berg, and U.D. Staerz. 1996. Permissive recognition during positive selection. Eur. J. Immunol. 26:851-857.