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Volumn 126, Issue 2, 2009, Pages 165-176

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

Author keywords

Agonists; Antagonists; Binding affinity; Coreceptors; Dissociation rate; Major histocompatibility complex; Peptide specificity; Peptide major histocompatibility complex; Serial triggering; T cell receptor; T cell receptor clustering

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

EID: 58149280299     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.03015.x     Document Type: Review
Times cited : (293)

References (106)
  • 5
    • 0031283279 scopus 로고    scopus 로고
    • Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization
    • Garcia KC, Tallquist MD, Pease LR et al. Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. Proc Natl Acad Sci USA 1997 94 : 13838 43.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13838-43
    • Garcia, K.C.1    Tallquist, M.D.2    Pease, L.R.3
  • 6
    • 0033082989 scopus 로고    scopus 로고
    • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands
    • Alam SM, Davies GM, Lin CM et al. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity 1999 10 : 227 37.
    • (1999) Immunity , vol.10 , pp. 227-37
    • Alam, S.M.1    Davies, G.M.2    Lin, C.M.3
  • 7
    • 0034903068 scopus 로고    scopus 로고
    • The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model
    • Rosette C, Werlen G, Daniels MA et al. The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity 2001 15 : 59 70.
    • (2001) Immunity , vol.15 , pp. 59-70
    • Rosette, C.1    Werlen, G.2    Daniels, M.A.3
  • 8
    • 56749129719 scopus 로고    scopus 로고
    • Distinct CDR3 conformations in T cell receptors determine the level of cross-reactivity for diverse antigens, but not the docking orientation
    • Jones LL, Colf LA, Stone JD, Garcia KC, Kranz DM. Distinct CDR3 conformations in T cell receptors determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J Immunol 2008 181 : 6255 64.
    • (2008) J Immunol , vol.181 , pp. 6255-64
    • Jones, L.L.1    Colf, L.A.2    Stone, J.D.3    Garcia, K.C.4    Kranz, D.M.5
  • 9
    • 0037218840 scopus 로고    scopus 로고
    • High affinity xenoreactive TCR:MHC interaction recruits CD8 in absence of binding to MHC
    • Buslepp J, Kerry SE, Loftus D, Frelinger JA, Appella E, Collins EJ. High affinity xenoreactive TCR:MHC interaction recruits CD8 in absence of binding to MHC. J Immunol 2003 170 : 373 83.
    • (2003) J Immunol , vol.170 , pp. 373-83
    • Buslepp, J.1    Kerry, S.E.2    Loftus, D.3    Frelinger, J.A.4    Appella, E.5    Collins, E.J.6
  • 10
    • 12544253697 scopus 로고    scopus 로고
    • Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand
    • Davis-Harrison RL, Armstrong KM, Baker BM. Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand. J Mol Biol 2005 346 : 533 50.
    • (2005) J Mol Biol , vol.346 , pp. 533-50
    • Davis-Harrison, R.L.1    Armstrong, K.M.2    Baker, B.M.3
  • 11
    • 10644239910 scopus 로고    scopus 로고
    • T cell cross-reactivity and conformational changes during TCR engagement
    • Lee JK, Stewart-Jones G, Dong T et al. T cell cross-reactivity and conformational changes during TCR engagement. J Exp Med 2004 200 : 1455 66.
    • (2004) J Exp Med , vol.200 , pp. 1455-66
    • Lee, J.K.1    Stewart-Jones, G.2    Dong, T.3
  • 12
    • 34247605947 scopus 로고    scopus 로고
    • Human TCR-binding affinity is governed by MHC class restriction
    • Cole DK, Pumphrey NJ, Boulter JM et al. Human TCR-binding affinity is governed by MHC class restriction. J Immunol 2007 178 : 5727 34.
    • (2007) J Immunol , vol.178 , pp. 5727-34
    • Cole, D.K.1    Pumphrey, N.J.2    Boulter, J.M.3
  • 13
    • 38949100462 scopus 로고    scopus 로고
    • The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain
    • Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY. The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain. Immunity 2008 28 : 171 82.
    • (2008) Immunity , vol.28 , pp. 171-82
    • Ishizuka, J.1    Stewart-Jones, G.B.2    Van Der Merwe, A.3    Bell, J.I.4    McMichael, A.J.5    Jones, E.Y.6
  • 15
    • 20944445641 scopus 로고    scopus 로고
    • Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection
    • Ely LK, Green KJ, Beddoe T et al. Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection. J Immunol 2005 174 : 5593 601.
    • (2005) J Immunol , vol.174 , pp. 5593-601
    • Ely, L.K.1    Green, K.J.2    Beddoe, T.3
  • 16
    • 38449104431 scopus 로고    scopus 로고
    • High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines
    • Zhao Y, Bennett AD, Zheng Z et al. High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. J Immunol 2007 179 : 5845 54.
    • (2007) J Immunol , vol.179 , pp. 5845-54
    • Zhao, Y.1    Bennett, A.D.2    Zheng, Z.3
  • 17
    • 0035811034 scopus 로고    scopus 로고
    • Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis
    • Garcia KC, Radu CG, Ho J, Ober RJ, Ward ES. Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2001 98 : 6818 23.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6818-23
    • Garcia, K.C.1    Radu, C.G.2    Ho, J.3    Ober, R.J.4    Ward, E.S.5
  • 18
    • 0032438551 scopus 로고    scopus 로고
    • High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling
    • Kersh GJ, Kersh EN, Fremont DH, Allen PM. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 1998 9 : 817 26.
    • (1998) Immunity , vol.9 , pp. 817-26
    • Kersh, G.J.1    Kersh, E.N.2    Fremont, D.H.3    Allen, P.M.4
  • 19
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan TW. Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci USA 1995 92 : 5042 6.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5042-6
    • McKeithan, T.W.1
  • 21
    • 0032563231 scopus 로고    scopus 로고
    • Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation
    • Kersh EN, Shaw AS, Allen PM. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation. Science 1998 281 : 572 5.
    • (1998) Science , vol.281 , pp. 572-5
    • Kersh, E.N.1    Shaw, A.S.2    Allen, P.M.3
  • 22
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 1995 375 : 148 51.
    • (1995) Nature , vol.375 , pp. 148-51
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 24
    • 34247519546 scopus 로고    scopus 로고
    • The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge
    • Carreno LJ, Bueno SM, Bull P, Nathenson SG, Kalergis AM. The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge. Immunology 2007 121 : 227 37.
    • (2007) Immunology , vol.121 , pp. 227-37
    • Carreno, L.J.1    Bueno, S.M.2    Bull, P.3    Nathenson, S.G.4    Kalergis, A.M.5
  • 25
    • 0037331525 scopus 로고    scopus 로고
    • Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
    • Holler PD, Kranz DM. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 2003 18 : 255 64.
    • (2003) Immunity , vol.18 , pp. 255-64
    • Holler, P.D.1    Kranz, D.M.2
  • 26
    • 21444445173 scopus 로고    scopus 로고
    • Directed evolution of human T-cell receptors with picomolar affinities by phage display
    • Li Y, Moysey R, Molloy PE et al. Directed evolution of human T-cell receptors with picomolar affinities by phage display. Nat Biotechnol 2005 23 : 349 54.
    • (2005) Nat Biotechnol , vol.23 , pp. 349-54
    • Li, Y.1    Moysey, R.2    Molloy, P.E.3
  • 27
    • 30044449525 scopus 로고    scopus 로고
    • Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function
    • Weber KS, Donermeyer DL, Allen PM, Kranz DM. Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci USA 2005 102 : 19033 8.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19033-8
    • Weber, K.S.1    Donermeyer, D.L.2    Allen, P.M.3    Kranz, D.M.4
  • 28
    • 0035887216 scopus 로고    scopus 로고
    • CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation
    • Holler PD, Lim AR, Cho BK, Rund LA, Kranz DM. CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation. J Exp Med 2001 194 : 1043 52.
    • (2001) J Exp Med , vol.194 , pp. 1043-52
    • Holler, P.D.1    Lim, A.R.2    Cho, B.K.3    Rund, L.A.4    Kranz, D.M.5
  • 29
    • 0037234768 scopus 로고    scopus 로고
    • TCRs with high affinity for foreign pMHC show self-reactivity
    • Holler PD, Chlewicki LK, Kranz DM. TCRs with high affinity for foreign pMHC show self-reactivity. Nat Immunol 2003 4 : 55 62.
    • (2003) Nat Immunol , vol.4 , pp. 55-62
    • Holler, P.D.1    Chlewicki, L.K.2    Kranz, D.M.3
  • 30
    • 38449086723 scopus 로고    scopus 로고
    • + T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate
    • + T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate. J Immunol 2007 179 : 2952 60.
    • (2007) J Immunol , vol.179 , pp. 2952-60
    • Tian, S.1    Maile, R.2    Collins, E.J.3    Frelinger, J.A.4
  • 31
    • 0348047600 scopus 로고    scopus 로고
    • Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation
    • Krogsgaard M, Prado N, Adams EJ, He XL, Chow DC, Wilson DB, Garcia KC, Davis MM. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell 2003 12 : 1367 78.
    • (2003) Mol Cell , vol.12 , pp. 1367-78
    • Krogsgaard, M.1    Prado, N.2    Adams, E.J.3    He, X.L.4    Chow, D.C.5    Wilson, D.B.6    Garcia, K.C.7    Davis, M.M.8
  • 32
    • 47649130715 scopus 로고    scopus 로고
    • Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities
    • Armstrong KM, Insaidoo FK, Baker BM. Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities. J Mol Recognit 2008 21 : 275 87.
    • (2008) J Mol Recognit , vol.21 , pp. 275-87
    • Armstrong, K.M.1    Insaidoo, F.K.2    Baker, B.M.3
  • 34
    • 26644468528 scopus 로고    scopus 로고
    • Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule
    • Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. Embo J 2005 24 : 2968 79.
    • (2005) Embo J , vol.24 , pp. 2968-79
    • Li, Y.1    Huang, Y.2    Lue, J.3    Quandt, J.A.4    Martin, R.5    Mariuzza, R.A.6
  • 35
    • 0033952004 scopus 로고    scopus 로고
    • Characterizing the functionality of recombinant T-cell receptors in vitro: a pMHC tetramer based approach
    • Tissot AC, Pecorari F, Pluckthun A. Characterizing the functionality of recombinant T-cell receptors in vitro: a pMHC tetramer based approach. J Immunol Methods 2000 2 : 147 65.
    • (2000) J Immunol Methods , vol.2 , pp. 147-65
    • Tissot, A.C.1    Pecorari, F.2    Pluckthun, A.3
  • 37
    • 38649128150 scopus 로고    scopus 로고
    • Class II major histocompatibility complex tetramer staining: progress, problems, and prospects
    • Vollers SS, Stern LJ. Class II major histocompatibility complex tetramer staining: progress, problems, and prospects. Immunology 2008 123 : 305 13.
    • (2008) Immunology , vol.123 , pp. 305-13
    • Vollers, S.S.1    Stern, L.J.2
  • 38
    • 33845607123 scopus 로고    scopus 로고
    • Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
    • Daniels MA, Teixeiro E, Gill J et al. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 2006 444 : 724 9.
    • (2006) Nature , vol.444 , pp. 724-9
    • Daniels, M.A.1    Teixeiro, E.2    Gill, J.3
  • 39
    • 0041929446 scopus 로고    scopus 로고
    • TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR
    • Holmberg K, Mariathasan S, Ohteki T, Ohashi PS, Gascoigne NR. TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol 2003 171 : 2427 34.
    • (2003) J Immunol , vol.171 , pp. 2427-34
    • Holmberg, K.1    Mariathasan, S.2    Ohteki, T.3    Ohashi, P.S.4    Gascoigne, N.R.5
  • 40
    • 0019454791 scopus 로고
    • Receptor clustering on a cell surface III. Theory of receptor cross-linking by multivalent ligands: description by ligand states
    • Perelson AS. Receptor clustering on a cell surface III. Theory of receptor cross-linking by multivalent ligands: description by ligand states. Math Biosci 1981 53 : 1 39.
    • (1981) Math Biosci , vol.53 , pp. 1-39
    • Perelson, A.S.1
  • 41
    • 0034753172 scopus 로고    scopus 로고
    • T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model
    • Stone JD, Cochran JR, Stern LJ. T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model. Biophys J 2001 81 : 2547 57.
    • (2001) Biophys J , vol.81 , pp. 2547-57
    • Stone, J.D.1    Cochran, J.R.2    Stern, L.J.3
  • 42
    • 0035108309 scopus 로고    scopus 로고
    • Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen
    • Fahmy TM, Bieler JG, Edidin M, Schneck JP. Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen. Immunity 2001 14 : 135 43.
    • (2001) Immunity , vol.14 , pp. 135-43
    • Fahmy, T.M.1    Bieler, J.G.2    Edidin, M.3    Schneck, J.P.4
  • 43
    • 33645892299 scopus 로고    scopus 로고
    • A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex
    • Schamel WW, Risueno RM, Minguet S, Ortiz AR, Alarcon B. A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex. Trends Immunol 2006 27 : 176 82.
    • (2006) Trends Immunol , vol.27 , pp. 176-82
    • Schamel, W.W.1    Risueno, R.M.2    Minguet, S.3    Ortiz, A.R.4    Alarcon, B.5
  • 44
    • 23044469067 scopus 로고    scopus 로고
    • Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
    • Wooldridge L, van den Berg HA, Glick M et al. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem 2005 280 : 27491 501.
    • (2005) J Biol Chem , vol.280 , pp. 27491-501
    • Wooldridge, L.1    Van Den Berg, H.A.2    Glick, M.3
  • 47
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for T cell receptor repertoire selection during an immune response
    • Savage PA, Boniface JJ, Davis MM. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 1999 10 : 485 92.
    • (1999) Immunity , vol.10 , pp. 485-92
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 48
    • 0032192469 scopus 로고    scopus 로고
    • Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]
    • Boniface JJ, Rabinowitz JD, Wulfing C et al. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. Immunity 1998 9 : 459 66.
    • (1998) Immunity , vol.9 , pp. 459-66
    • Boniface, J.J.1    Rabinowitz, J.D.2    Wulfing, C.3
  • 49
    • 0033710093 scopus 로고    scopus 로고
    • The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
    • Cochran JR, Cameron TO, Stern LJ. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 2000 12 : 241 50.
    • (2000) Immunity , vol.12 , pp. 241-50
    • Cochran, J.R.1    Cameron, T.O.2    Stern, L.J.3
  • 50
    • 33846224785 scopus 로고    scopus 로고
    • Full activation of the T cell receptor requires both clustering and conformational changes at CD3
    • Minguet S, Swamy M, Alarcon B, Luescher IF, Schamel WW. Full activation of the T cell receptor requires both clustering and conformational changes at CD3. Immunity 2007 26 : 43 54.
    • (2007) Immunity , vol.26 , pp. 43-54
    • Minguet, S.1    Swamy, M.2    Alarcon, B.3    Luescher, I.F.4    Schamel, W.W.5
  • 51
    • 31144479383 scopus 로고    scopus 로고
    • CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement
    • Stone JD, Stern LJ. CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement. J Immunol 2006 176 : 1498 505.
    • (2006) J Immunol , vol.176 , pp. 1498-505
    • Stone, J.D.1    Stern, L.J.2
  • 52
    • 28744431910 scopus 로고    scopus 로고
    • Loss of CD8 and TCR binding to class I MHC ligands following T cell activation
    • Kao C, Daniels MA, Jameson SC. Loss of CD8 and TCR binding to class I MHC ligands following T cell activation. Int Immunol 2005 17 : 607 17.
    • (2005) Int Immunol , vol.17 , pp. 607-17
    • Kao, C.1    Daniels, M.A.2    Jameson, S.C.3
  • 53
    • 0037184955 scopus 로고    scopus 로고
    • The organizing principle in the formation of the T cell receptor-CD3 complex
    • Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 2002 111 : 967 79.
    • (2002) Cell , vol.111 , pp. 967-79
    • Call, M.E.1    Pyrdol, J.2    Wiedmann, M.3    Wucherpfennig, K.W.4
  • 54
    • 0029122018 scopus 로고
    • Evidence for multivalent structure of T-cell antigen receptor complex
    • Exley M, Wileman T, Mueller B, Terhorst C. Evidence for multivalent structure of T-cell antigen receptor complex. Mol Immunol 1995 32 : 829 39.
    • (1995) Mol Immunol , vol.32 , pp. 829-39
    • Exley, M.1    Wileman, T.2    Mueller, B.3    Terhorst, C.4
  • 57
    • 27544441784 scopus 로고    scopus 로고
    • Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    • Campi G, Varma R, Dustin ML. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med 2005 202 : 1031 6.
    • (2005) J Exp Med , vol.202 , pp. 1031-6
    • Campi, G.1    Varma, R.2    Dustin, M.L.3
  • 59
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    • Varma R, Campi G, Yokosuka T, Saito T, Dustin ML. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 2006 25 : 117 27.
    • (2006) Immunity , vol.25 , pp. 117-27
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 60
    • 0034714184 scopus 로고    scopus 로고
    • Differential clustering of CD4 and CD3zeta during T cell recognition
    • Krummel MF, Sjaastad MD, Wulfing C, Davis MM. Differential clustering of CD4 and CD3zeta during T cell recognition. Science 2000 289 : 1349 52.
    • (2000) Science , vol.289 , pp. 1349-52
    • Krummel, M.F.1    Sjaastad, M.D.2    Wulfing, C.3    Davis, M.M.4
  • 61
    • 0035693584 scopus 로고    scopus 로고
    • CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation
    • Daniels MA, Devine L, Miller JD et al. CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Immunity 2001 15 : 1051 61.
    • (2001) Immunity , vol.15 , pp. 1051-61
    • Daniels, M.A.1    Devine, L.2    Miller, J.D.3
  • 62
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
    • Demetriou M, Granovsky M, Quaggin S, Dennis JW. Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 2001 409 : 733 9.
    • (2001) Nature , vol.409 , pp. 733-9
    • Demetriou, M.1    Granovsky, M.2    Quaggin, S.3    Dennis, J.W.4
  • 63
    • 10344249912 scopus 로고    scopus 로고
    • N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells
    • Morgan R, Gao G, Pawling J, Dennis JW, Demetriou M, Li B. N-acetylglucosaminyltransferase V (Mgat5)-mediated N-glycosylation negatively regulates Th1 cytokine production by T cells. J Immunol 2004 173 : 7200 8.
    • (2004) J Immunol , vol.173 , pp. 7200-8
    • Morgan, R.1    Gao, G.2    Pawling, J.3    Dennis, J.W.4    Demetriou, M.5    Li, B.6
  • 65
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998 395 : 82 6.
    • (1998) Nature , vol.395 , pp. 82-6
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 66
    • 38949197102 scopus 로고    scopus 로고
    • T-cell activation through immunological synapses and kinapses
    • Dustin ML. T-cell activation through immunological synapses and kinapses. Immunol Rev 2008 221 : 77 89.
    • (2008) Immunol Rev , vol.221 , pp. 77-89
    • Dustin, M.L.1
  • 68
    • 2442651482 scopus 로고    scopus 로고
    • T cell killing does not require the formation of a stable mature immunological synapse
    • Purbhoo MA, Irvine DJ, Huppa JB, Davis MM. T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol 2004 5 : 524 30.
    • (2004) Nat Immunol , vol.5 , pp. 524-30
    • Purbhoo, M.A.1    Irvine, D.J.2    Huppa, J.B.3    Davis, M.M.4
  • 69
    • 51349131307 scopus 로고    scopus 로고
    • The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality
    • Cemerski S, Das J, Giurisato E, Markiewicz MA, Allen PM, Chakraborty AK, Shaw AS. The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity 2008 29 : 414 22.
    • (2008) Immunity , vol.29 , pp. 414-22
    • Cemerski, S.1    Das, J.2    Giurisato, E.3    Markiewicz, M.A.4    Allen, P.M.5    Chakraborty, A.K.6    Shaw, A.S.7
  • 70
    • 33947189706 scopus 로고    scopus 로고
    • The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse
    • Cemerski S, Das J, Locasale J et al. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity 2007 26 : 345 55.
    • (2007) Immunity , vol.26 , pp. 345-55
    • Cemerski, S.1    Das, J.2    Locasale, J.3
  • 71
    • 0242497659 scopus 로고    scopus 로고
    • The immunological synapse balances T cell receptor signaling and degradation
    • Lee KH, Dinner AR, Tu C et al. The immunological synapse balances T cell receptor signaling and degradation. Science 2003 302 : 1218 22.
    • (2003) Science , vol.302 , pp. 1218-22
    • Lee, K.H.1    Dinner, A.R.2    Tu, C.3
  • 73
    • 0030176270 scopus 로고    scopus 로고
    • Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
    • Sykulev Y, Joo M, Vturina I, Tsomides TJ, Eisen HN. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 1996 4 : 565 71.
    • (1996) Immunity , vol.4 , pp. 565-71
    • Sykulev, Y.1    Joo, M.2    Vturina, I.3    Tsomides, T.J.4    Eisen, H.N.5
  • 75
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • Krogsgaard M, Li QJ, Sumen C, Huppa JB, Huse M, Davis MM. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 2005 434 : 238 43.
    • (2005) Nature , vol.434 , pp. 238-43
    • Krogsgaard, M.1    Li, Q.J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 77
    • 0037452755 scopus 로고    scopus 로고
    • T-cell activation: the power of one
    • Germain RN. T-cell activation: the power of one. Curr Biol 2003 13 : R137 9.
    • (2003) Curr Biol , vol.13
    • Germain, R.N.1
  • 78
  • 79
    • 0033578825 scopus 로고    scopus 로고
    • Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers
    • Kern P, Hussey RE, Spoerl R, Reinherz EL, Chang HC. Expression, purification, and functional analysis of murine ectodomain fragments of CD8alphaalpha and CD8alphabeta dimers. J Biol Chem 1999 274 : 27237 43.
    • (1999) J Biol Chem , vol.274 , pp. 27237-43
    • Kern, P.1    Hussey, R.E.2    Spoerl, R.3    Reinherz, E.L.4    Chang, H.C.5
  • 81
    • 0034685884 scopus 로고    scopus 로고
    • Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha
    • Gao GF, Willcox BE, Wyer JR et al. Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha. J Biol Chem 2000 275 : 15232 8.
    • (2000) J Biol Chem , vol.275 , pp. 15232-8
    • Gao, G.F.1    Willcox, B.E.2    Wyer, J.R.3
  • 82
    • 0034517387 scopus 로고    scopus 로고
    • Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor
    • Gao GF, Jakobsen BK. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today 2000 21 : 630 6.
    • (2000) Immunol Today , vol.21 , pp. 630-6
    • Gao, G.F.1    Jakobsen, B.K.2
  • 83
    • 0036467498 scopus 로고    scopus 로고
    • Interactions between MHC molecules and co-receptors of the TCR
    • Konig R. Interactions between MHC molecules and co-receptors of the TCR. Curr Opin Immunol 2002 14 : 75 83.
    • (2002) Curr Opin Immunol , vol.14 , pp. 75-83
    • Konig, R.1
  • 85
    • 34548264739 scopus 로고    scopus 로고
    • Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
    • Laugel B, van den Berg HA, Gostick E et al. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. J Biol Chem 2007 282 : 23799 810.
    • (2007) J Biol Chem , vol.282 , pp. 23799-810
    • Laugel, B.1    Van Den Berg, H.A.2    Gostick, E.3
  • 86
    • 0023607034 scopus 로고
    • A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL
    • Potter TA, Bluestone JA, Rajan TV. A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL. J Exp Med 1987 166 : 956 66.
    • (1987) J Exp Med , vol.166 , pp. 956-66
    • Potter, T.A.1    Bluestone, J.A.2    Rajan, T.V.3
  • 87
    • 0024595609 scopus 로고
    • Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes
    • Potter TA, Rajan TV, Dick RF II., Bluestone JA. Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature 1989 337 : 73 5.
    • (1989) Nature , vol.337 , pp. 73-5
    • Potter, T.A.1    Rajan, T.V.2    Dick II., R.F.3    Bluestone, J.A.4
  • 88
    • 0025366452 scopus 로고
    • A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2
    • Salter RD, Benjamin RJ, Wesley PK et al. A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature 1990 345 : 41 6.
    • (1990) Nature , vol.345 , pp. 41-6
    • Salter, R.D.1    Benjamin, R.J.2    Wesley, P.K.3
  • 89
    • 0034677055 scopus 로고    scopus 로고
    • Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers
    • Daniels MA, Jameson SC. Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers. J Exp Med 2000 191 : 335 46.
    • (2000) J Exp Med , vol.191 , pp. 335-46
    • Daniels, M.A.1    Jameson, S.C.2
  • 90
    • 0035852736 scopus 로고    scopus 로고
    • Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor
    • Cho BK, Lian KC, Lee P, Brunmark A, McKinley C, Chen J, Kranz DM, Eisen HN. Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor. Proc Natl Acad Sci USA 2001 98 : 1723 7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1723-7
    • Cho, B.K.1    Lian, K.C.2    Lee, P.3    Brunmark, A.4    McKinley, C.5    Chen, J.6    Kranz, D.M.7    Eisen, H.N.8
  • 91
    • 19944434233 scopus 로고    scopus 로고
    • + T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR
    • + T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity 2005 22 : 117 29.
    • (2005) Immunity , vol.22 , pp. 117-29
    • Kuball, J.1    Schmitz, F.W.2    Voss, R.H.3
  • 92
    • 7244240852 scopus 로고    scopus 로고
    • Antibody specific for the peptide major histocompatibility complex. Is it T cell receptor-like?
    • Mareeva T, Lebedeva T, Anikeeva N, Manser T, Sykulev Y. Antibody specific for the peptide major histocompatibility complex. Is it T cell receptor-like? J Biol Chem 2004 279 : 44243 9.
    • (2004) J Biol Chem , vol.279 , pp. 44243-9
    • Mareeva, T.1    Lebedeva, T.2    Anikeeva, N.3    Manser, T.4    Sykulev, Y.5
  • 93
    • 23944497170 scopus 로고    scopus 로고
    • Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse
    • Yachi PP, Ampudia J, Gascoigne NR, Zal T. Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol 2005 6 : 785 92.
    • (2005) Nat Immunol , vol.6 , pp. 785-92
    • Yachi, P.P.1    Ampudia, J.2    Gascoigne, N.R.3    Zal, T.4
  • 95
    • 0033199753 scopus 로고    scopus 로고
    • Binding energetics of T-cell receptors: correlation with immunological consequences
    • Manning TC, Kranz DM. Binding energetics of T-cell receptors: correlation with immunological consequences. Immunol Today 1999 20 : 417 22.
    • (1999) Immunol Today , vol.20 , pp. 417-22
    • Manning, T.C.1    Kranz, D.M.2
  • 96
    • 33750795840 scopus 로고    scopus 로고
    • The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy
    • Donermeyer DL, Weber KS, Kranz DM, Allen PM. The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy. J Immunol 2006 177 : 6911 9.
    • (2006) J Immunol , vol.177 , pp. 6911-9
    • Donermeyer, D.L.1    Weber, K.S.2    Kranz, D.M.3    Allen, P.M.4
  • 98
    • 0035554950 scopus 로고    scopus 로고
    • Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
    • Benoist C, Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2001 2 : 797 801.
    • (2001) Nat Immunol , vol.2 , pp. 797-801
    • Benoist, C.1    Mathis, D.2
  • 99
    • 0346103729 scopus 로고    scopus 로고
    • A role for TCR affinity in regulating naive T cell homeostasis
    • Kieper WC, Burghardt JT, Surh CD. A role for TCR affinity in regulating naive T cell homeostasis. J Immunol 2004 172 : 40 4.
    • (2004) J Immunol , vol.172 , pp. 40-4
    • Kieper, W.C.1    Burghardt, J.T.2    Surh, C.D.3
  • 100
    • 1242270587 scopus 로고    scopus 로고
    • Recognition and function in a degenerate immune system
    • Sercarz EE, Maverakis E. Recognition and function in a degenerate immune system. Mol Immunol 2004 15 : 1003 8.
    • (2004) Mol Immunol , vol.15 , pp. 1003-8
    • Sercarz, E.E.1    Maverakis, E.2
  • 101
    • 1242315566 scopus 로고    scopus 로고
    • T cell receptor crossreactivity as a general property of T cell recognition
    • Wucherpfennig KW. T cell receptor crossreactivity as a general property of T cell recognition. Mol Immunol 2004 15 : 1009 17.
    • (2004) Mol Immunol , vol.15 , pp. 1009-17
    • Wucherpfennig, K.W.1
  • 104
    • 0037470496 scopus 로고    scopus 로고
    • Antibody multispecificity mediated by conformational diversity
    • James LC, Roversi P, Tawfik DS. Antibody multispecificity mediated by conformational diversity. Science 2003 299 : 1362 7.
    • (2003) Science , vol.299 , pp. 1362-7
    • James, L.C.1    Roversi, P.2    Tawfik, D.S.3
  • 105
    • 2942659074 scopus 로고    scopus 로고
    • T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit
    • Gakamsky DM, Luescher IF, Pecht I. T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit. Proc Natl Acad Sci USA 2004 101 : 9063 6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9063-6
    • Gakamsky, D.M.1    Luescher, I.F.2    Pecht, I.3
  • 106
    • 1242270594 scopus 로고    scopus 로고
    • T cell receptors: affinities, cross-reactivities, and a conformer model
    • Holler PD, Kranz DM. T cell receptors: affinities, cross-reactivities, and a conformer model. Mol Immunol 2004 15 : 1027 31.
    • (2004) Mol Immunol , vol.15 , pp. 1027-31
    • Holler, P.D.1    Kranz, D.M.2


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