Role of 2C T cell receptor residues in the binding of self- and allo- major histocompatibility complexes

Journal of Experimental Medicine

Volumn 191, Issue 8, 2000, Pages 1355-1364

  Lee, Peter U Y ^a   Churchill, Hywyn R O ^a   Daniels, Mark ^b   Jameson, Stephen C ^b   Kranz, David M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Alloantigen; Antigen recognition; Complementarity determining region; Peptide major histocompatibility complex; T cell receptor

Indexed keywords

ALLOANTIGEN; T LYMPHOCYTE RECEPTOR; AUTOANTIGEN; HISTOCOMPATIBILITY ANTIGEN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; RECOMBINANT PROTEIN;

ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CELL CLONE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; MUTAGENESIS; PROTEIN QUATERNARY STRUCTURE; T LYMPHOCYTE; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BINDING SITES; CLONE CELLS; HISTOCOMPATIBILITY ANTIGENS; HUMANS; ISOANTIGENS; LIGANDS; MICE; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; T-LYMPHOCYTES; THERMODYNAMICS;

EID: 0034678142     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.8.1355     Document Type: Article

References (50)

1. Garcia, K.C., M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, and I.A. Wilson. 1996. An αβ T cell receptor structure at 2.5 angstrom and its orientation in the TCR-MHC complex. Science. 274:209-219.
2. Garboczi, D.N., P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, and D.C. Wiley. 1996. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature. 384:131-141.
3. Teng, M.K., A. Smolyar, A.G. Tse, J.H. Liu, J. Liu, R.E. Hussey, S.G. Nathenson, H.C., Chang, E.L. Reinherz, and J.H. Wang. 1998. Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes. Curr. Biol. 8:409-412.
4. Garcia, K.C., M. Degano, L.R. Pease, M. Huang, P. Peterson, L. Teyton, and I.A. Wilson. 1998. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science. 279:1166-1172.
5. Ding, Y.H., K.J. Smith, D.N. Garboczi, U. Utz, W.E. Biddison, and D.C. Wiley. 1998. Two different T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity. 8:403-411.
6. Ding, Y.H., B.M. Baker, D.N. Garboczi, W.E. Biddison, and D.C. Wiley. 1999. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity. 11:45-56.
7. Alam, S.M., P.J. Travers, J.L. Wung, W. Nasholds, S. Redpath, S.C. Jameson, and R.J. Gascoigne. 1996. T cell receptor affinity and thymocyte positive selection. Nature. 381:616-620.
8. Davis, M.M., J.J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien. 1998. Ligand recognition by alpha beta T cell receptors. Annu. Rev. Immunol. 16:523-544.
9. Manning, T.C., and D.M. Kranz. 1999. Binding energetics of T-cell receptors: correlation with immunological consequences. Immunol. Today. 20:417-122.
10. Sloan-Lancaster, J., and P.M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1-27.
11. Mason, D. 1998. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today. 19: 395-404.
12. Wells, J. 1991. Systematic mutational analyses of protein-protein interfaces. Methods Enzymol. 202:390-411.
13. Kranz, D.M., D.H. Sherman, M.V. Sitkovsky, M.S. Pasternack, and H.N. Eisen. 1984. Immunoprecipitation of cell surface structure of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc. Natl. Acad. Sci. USA. 81:573-577.
14. Sykulev, Y., A. Brunmark, T.J. Tsomides, S. Kageyama, M. Jackson, P.A. Peterson, and H.N. Eisen. 1994. High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA. 91:11487-11491.
15. Tallquist, M.D., T.J. Yun, and L.R. Pease. 1996. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity. J. Exp. Med. 184:1017-1026.
16. Udaka, K., K. Wiesmuller, S. Kienle, G. Jung, and P. Walden. 1996. Self-MHC-restricted peptides recognized by an alloreactive T-lymphocyte clone. J. Immunol. 157:670-678.
17. Manning, T.C., C.J. Schlueter, T.C. Brodnicki, E.A. Parke, J.A. Speir, K.C. Garcia, L. Teyton, I.A. Wilson, and D.M. Kranz. 1998. Alanine scanning mutagenesis of an αβ T cell receptor: mapping the energy of antigen recognition. Immunity. 8:413-425.
18. Manning, T.C., E.A. Parke, L. Teyton, and D.M. Kranz. 1999. Effects of complementarity determining region mutations on the affinity of an αβ T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing. J. Exp. Med. 189:461-470.
19. Altman, J.D., P.A.H. Moss, P.J.R. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMicheal, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
20. Hare, B.J., D.F. Wyss, M.S. Osburne, P.S. Kern, E.L. Reinherz, and G. Wagner. 1999. Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat. Struct. Biol. 6:574-581.
21. Willcox, B.E., G.F. Gao, J.R. Wyer, J.E. Ladbury, J.I. Bell, B.K. Jakobsen, and P.A. van der Merwe. 1999. TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity. 10:357-365.
22. Schodin, B.A., C.J. Schlueter, and D.M. Kranz. 1996. Binding properties and solubility of single-chain T cell receptors expressed in E. coli. Mol. Immunol. 33:819-829.
23. Staerz, U.D., H.G. Rammensee, J.D. Benedetto, and M.J. Bevan. 1985. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J. Immunol. 134:3994-4000.
24. Kranz, D.M., S. Tonegawa, and H.N. Eisen. 1984. Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA. 81:7922-7926.
25. Dal Porto, J., T.E. Johansen, B. Catipovic, D.J. Parfiit, D. Tuveson, U. Gether, S. Kozlowski, D.T. Fearon, and J.P. Schneck. 1993. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc. Natl. Acad. Sci. USA. 90:6671-6675.
26. O'Herrin, S.M., M.S. Lebowitz, J.G. Bieler, B.K. al-Ramadi, U. Utz, A.L. Bothwell, and J.P. Schneck. 1997. Analysis of the expression of peptide-major histocompatibility complexes using high affinity soluble divalent T cell receptors. J. Exp. Med. 186:1333-1345.
27. Sim, B.C., D. Lo, and N.R.J. Gascoigne. 1998. Preferential expression of TCR Vα regions in CD4/CD8 subsets: class discrimination or co-receptor recognition? Immunol. Today. 19:276-282.
28. Sim, B.-C., L. Zerva, M.I. Greene, and N.R.J. Gascoigne. 1996. Control of MHC restriction by TCR Vα CDR1 and CDR2. Science. 273:963-966.
29. Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella, and E. Robey. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183:731-741.
30. Matechak, E.O., N. Killeen, S.M. Hedrick, and B.J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity. 4:337-347.
31. hi thymocytes does not require T cell receptor-major histocompatibility complex contact. J. Exp. Med. 190:757-764.
32. Messaoudi, I., J. LeMaoult, and J. Nikolic-Zugic. 1999. The mode of ligand recognition by two peptide:MHC class I-specific monoclonal antibodies. J. Immunol. 163:3286-3294.
33. d peptide complexes. Immunity. 8:553-562.
34. Blackman, M., J. Kappler, and P. Marrack. 1990. The role of the T cell receptor in positive and negative selection of developing T cells. Science. 248:1335-1341.
35. Saito, T., J.L. Sussman, J.D. Ashwell, and R.N. Germain. 1989. Marked differences in the efficiency of expression of distinct alpha beta T cell receptor heterodimers. J. Immunol. 143:3379-3384.
36. Ignatowicz, L., W. Rees, R. Pacholczyk, H. Ignatowicz, E. Kushnir, J. Kappler, and P. Marrack. 1997. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity. 7:179-186.
37. Bevan, M.J. 1997. In thymic selection, peptide diversity gives and takes away. Immunity. 7:175-178.
38. b molecule. Immunity. 3:573-582.
39. Hornell, T.M., J.C. Solheim, N.B. Myers, W.E. Gillanders, G.K. Balendiran, T.H. Hansen, and J.M. Connolly. 1999. Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues. J. Immunol. 163:3217-3225.
40. Zerrahn, J., W. Held, and D.H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell. 88:627-636.
41. Kieke, M.C., E.V. Shusta, E.T. Boder, L. Teyton, K.D. Wittrup, and D.M. Kranz. 1999. Selection of functional T cell receptor mutants from a yeast surface-display library. Proc. Natl. Acad. Sci. USA. 96:5651-5656.
42. Shusta, E.V., M.C. Kieke, E. Parke, D.M. Kranz, and K.D. Wittrup. 1999. Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. J. Mol. Biol. 292:949-950.
43. Alam, S.M., G.M. Davies, C.M. Lin, T. Zal, W. Nasholds, S.C. Jameson, K.A. Hogquist, N.R. Gascoigne, and P.J. Travers. 1999. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity. 10:227-237.
44. d and the T cell receptor. J. Immunol. 157: 4478-4485.
45. Eisen, H.N., Y. Sykulev, and T.J. Tsomides. 1996. Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex (MHC) proteins. Adv. Protein Chem. 49:1-56.
46. Foote, J., and C. Milstein. 1994. Conformational isomerism and the diversity of antibodies. Proc. Natl. Acad. Sci. USA. 91: 10370-10374.
47. Wedemayer, G.J., P.A. Patten, L.H. Wang, P.G. Schultz, and R.C. Stevens. 1997. Structural insights into the evolution of an antibody combining site. Science. 276:1665-1669.
48. Boniface, J.J., Z. Reich, D.S. Lyons, and M.M. Davis. 1999. Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning. Proc. Natl. Acad. Sci. USA. 96:11446-11451.
49. Daniel, C., S. Horvath, and P.M. Allen. 1998. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity. 8:543-552.
50. Daniel, C., S. Horvath, and P.M. Allen. 1998. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity. 8:543-552.