Negative selection during the peripheral immune response to antigen

Journal of Experimental Medicine

Volumn 193, Issue 1, 2001, Pages 1-11

  Anderton, S M ^a   Radu, C G ^a   Lowrey, P A ^a   Ward, E S ^a   Wraith, D C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Apoptosis; Autoimmunity; Encephalomyelitis; Repertoire selection; T cells

Indexed keywords

ANTIGEN; MYELIN BASIC PROTEIN; PEPTIDE DERIVATIVE; T LYMPHOCYTE RECEPTOR; VACCINE;

ALLERGIC ENCEPHALITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ANTIGENICITY; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CELL INTERACTION; CLONOGENESIS; CONTROLLED STUDY; DRUG DESIGN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOTHERAPY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS; AUTOIMMUNITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNIZATION; IMMUNODOMINANT EPITOPES; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; T-LYMPHOCYTES;

EID: 0035176638     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.1.1     Document Type: Article

References (65)

1. Selecting and maintaining a diverse T-cell repertoire
2. Low avidity recognition of self-antigen by T cells permits escape from central tolerance
3. Selection of the T cell repertoire
4. Tolerating the nervous system: A delicate balance
5. + T cells, but affect their long-term life span
6. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells
7. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
8. The organization of mature T-cell pools
9. + T cells in lymphopenic hosts
10. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
11. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide: Self-MHC complex recognition
12. A very high level of crossreactivity is an essential feature of the T-cell receptor
13. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis
14. T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S
15. Myelin basic protein peptide complexes with the class II MHC molecules I-Au and I-Ak form and dissociate rapidly at neutral pH
16. Quantitative analysis of peptides from myelin basic protein binding to the MHC class II protein, I-Au, which confers susceptibility to experimental allergic encephalomyelitis
17. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy
18. Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity
19. Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: Implications in induction of autoimmunity
20. Modulation of the immune response with T-cell epitopes: The ultimate goal for specific immunotherapy of autoimmune disease
21. Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft
22. A small number of residues in the class II molecule I-Au confer the ability to bind the myelin basic protein peptide Ac1-11
23. An autoantigenic T cell epitope forms unstable complexes with class II MHC: A novel route for escape from tolerance induction
24. Fine specificity of the myelin-reactive T cell repertoire: Implications for TCR antagonism in autoimmunity
25. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition
26. MHC-binding peptides for immunotherapy of experimental autoimmune disease
27. Determination of lymphocyte division by flow cytometry
28. u mice using peptide-MHC multimers
29. A kinetic basis for T cell receptor repertoire selection during an immune response
30. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis
31. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
32. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
33. + T cell responses in vivo and in vitro
34. Adaptive cellular interactions in the immune system: The tunable activation threshold and the significance of subthreshold responses
35. Tuning of activation thresholds explains flexibility in the selection and development oft cells in the thymus
36. T-cell-receptor affinity and thymocyte positive selection
37. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein
38. Endogenous myelin basic protein inactivates the high avidity T cell repertoire
39. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
40. Quantitative analysis of T cell activation: Role of TCR/ligand density and TCR affinity
41. Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity, for the major histocompatibility complex in self-reactive T cell receptor transgenic mice
42. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire
43. Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues
44. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope
45. Dominance and crypticity of T cell antigenic determinants
46. The nature of cryptic epitopes within the self-antigen myelin basic protein
47. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis
48. Dissecting the multifunctional causes of immunodominance in class I-restricted T cell responses to viruses
49. A single naturally processed measles virus peptide fully dominates the HLA-A*0201-associated peptide display and is mutated at its anchor position in persistent viral strains
50. Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines
51. Effector T-cell induction and T-cell memory versus peripheral deletion of T cells
52. Mature T lymphocyte apoptosis - Immune regulation in a dynamic and unpredictable antigenic environment
53. Tuning T cell activation threshold and effector function with cross-reactive peptide ligands
54. T cell antigen receptor signal transduction pathways
55. Ikaros sets thresholds for T cell activation and regulates chromosome propagation
56. Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice - Implications for autoimmunity
57. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
58. Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms
59. Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis
60. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
61. Molecular mimicry and immunemediated diseases
62. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis
63. Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
64. Genetic models of abnormal apoptosis in lymphocytes
65. Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity