Predictive behavior within microbial genetic networks

Science

Volumn 320, Issue 5881, 2008, Pages 1313-1317

  Tagkopoulos, Ilias ^a,b   Liu, Yir Chung ^b   Tavazoie, Saeed ^b  

^a Princeton University   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

BACTERIUM; BEHAVIOR; BIOCHEMISTRY; ENVIRONMENTAL CHANGE; GASTROENTERITIS; GENETIC ANALYSIS; HOMEOSTASIS; LEARNING; METAZOAN; OXYGEN; PHYSIOLOGY;

ADAPTATION; ANTICIPATION; ARTICLE; COMPUTER MODEL; ENVIRONMENTAL CHANGE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ESCHERICHIA COLI; GASTROINTESTINAL TRACT; HABITAT; HOMEOSTASIS; NONHUMAN; OXYGEN SUPPLY; PREDICTION; PRIORITY JOURNAL; SIMULATION; STATE DEPENDENT LEARNING; TEMPERATURE SENSITIVITY; TRANSCRIPTION REGULATION; AEROBIC METABOLISM; ANAEROBIC GROWTH; BIOLOGICAL MODEL; COMPUTER SIMULATION; DIRECTED MOLECULAR EVOLUTION; DNA MICROARRAY; ECOSYSTEM; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; KINETICS; METABOLISM; MUTATION; PHYSIOLOGY; STATISTICAL MODEL; TEMPERATURE;

ESCHERICHIA COLI; MAMMALIA; METAZOA;

ADAPTATION, PHYSIOLOGICAL; AEROBIOSIS; ANAEROBIOSIS; COMPUTER SIMULATION; DIRECTED MOLECULAR EVOLUTION; ECOSYSTEM; ESCHERICHIA COLI; GENE REGULATORY NETWORKS; HOMEOSTASIS; KINETICS; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXYGEN; TEMPERATURE; TRANSCRIPTION, GENETIC;

EID: 45549085296     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1154456     Document Type: Article

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27. We thank the members of the Tavazoie laboratory for helpful comments on the manuscript, Princeton's CSES team for supercomputer support, and S. Tavazoie, M. Tavazoie, and G. Vassilakis for crucial feedback throughout the preparation of this manuscript. Supported by a Burroughs Wellcome fellowship (I.T.) and by grants from the NSF Faculty Early Career Development (CAREER) Program, Defense Advanced Research Projects Agency, National Human Genome Research Institute, and National Institute of General Medical Sciences (P50 GM071508) (S.T.). The microarray data are deposited at NCBI Gene Expression Omnibus with accession number GSE10855.