NGF and heart: Is there a role in heart disease?

Pharmacological Research

Volumn 63, Issue 4, 2011, Pages 266-277

  Govoni, Stefano ^a   Pascale, Alessia ^a   Amadio, Marialaura ^a   Calvillo, Laura ^b   D'Elia, Emilia ^c   Cereda, Cristina ^d   Fantucci, Piercarlo ^e   Ceroni, Mauro ^a,d   Vanoli, Emilio ^a,c,f  

^a UNIVERSITY OF PAVIA   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c Istituto di Oncologia Policlinico di Monza   (Italy)

^d C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

^e UNIVERSITY OF MILANO BICOCCA   (Italy)

^f UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Arrhythmias; Catecholamine; Heart; Myocardial injury; Nerve sprouting; NGF

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; NORADRENALIN;

ARRHYTHMOGENESIS; ARTICLE; BIOLOGICAL ACTIVITY; DOWN REGULATION; GENE EXPRESSION; HEART DISEASE; HEART FAILURE; HEART HEMODYNAMICS; HEART MUSCLE INJURY; HUMAN; INNATE IMMUNITY; NERVE SPROUTING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TISSUE LEVEL; UPREGULATION;

EID: 79951811414     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.12.017     Document Type: Review

References (147)

1. W.C. Randal Nervous control of cardiovascular function 1985 Oxford University Press New York
2. P.J. Schwartz, G.E. Billman, and H.L. Stone Autonomic mechanisms in ventricular fibrillation induced by myocardial ischemia during exercise in dogs with a healed myocardial infarction. An experimental preparation for sudden cardiac death Circulation 69 1984 790 800 (Pubitemid 14125661)
3. M. Stramba-Badiale, E. Vanoli, G.M. De Ferrari, D. Cerati, R.D. Foreman, and P.J. Schwartz Sympathetic-parasympathetic interaction and accentuated antagonism in conscious dogs Am J Physiol 260 1991 335 340
4. M. Ieda, K. Kimura, H. Kanazawa, and K. Fukuda Regulation of cardiac nerves: a new paradigm in the management of sudden cardiac death? Curr Med Chem 15 2008 1731 1736
5. M. Ieda, and K. Fukuda New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: the regulatory mechanisms of cardiac innervation and their critical roles in cardiac performance J Pharmacol Sci 109 2009 348 353
6. A. Rodriguez-Tébar, G. Dechant, and Y.A. Barde Binding of brain-derived neurotrophic factor to the nerve growth factor receptor Neuron 4 1990 487 492 (Pubitemid 20160838)
7. S. Zhou, L.S. Chen, Y. Miyauchi, M. Miyauchi, S. Kar, and S. Kangavari Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs Circ Res 95 2004 76 83 (Pubitemid 38931838)
8. J.M. Cao, L.S. Chen, B.H. KenKnight, T. Ohara, M.H. Lee, and J. Tsai Nerve sprouting and sudden cardiac death Circ Res 86 2000 816 821 (Pubitemid 30217832)
9. A. Hassankhani, M.E. Steinhelper, M.H. Soonpaa, E.B. Katz, D.A. Taylor, and A. Andrade-Rozental Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells Dev Biol 169 1995 309 321
10. J.O. Hiltunen, A. Laurikainen, A. Väkevä, S. Meri, and M. Saarma Nerve growth factor and brain-derived neurotrophic factor mRNAs are regulated in distinct cell populations of rat heart after ischaemia and reperfusion J Pathol 194 2001 247 253
11. L. Lorgis, S. Amoureux, C. Vergely, M. Zeller, Y. Cottin, and L. Rochette Brain-derived neurotrophic factor (BDNF): role of this neurotrophin in cardiovascular physiopathology Ann Cardiol Angeiol (Paris) 58 2009 99 103
12. Y.S. Oh, A.Y. Jong, D.T. Kim, H. Li, C. Wang, and A. Zemljic-Harpf Spatial distribution of nerve sprouting after myocardial infarction in mice Heart Rhythm 3 2006 728 736 (Pubitemid 43785828)
13. M. Nian, P. Lee, N. Khaper, and P. Liu Inflammatory cytokines and postmyocardial infarction remodeling Circ Res 94 2004 1543 1553 (Pubitemid 38856961)
14. P.S. Chen, L.S. Chen, J.M. Cao, B. Sharifi, H.S. Karagueuzian, and M.C. Fishbein Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death Cardiovasc Res 50 2001 409 416 (Pubitemid 32382168)
15. R. Vracko, D. Thorning, and R.G. Frederickson Nerve fibers in human myocardial scars Hum Pathol 22 1991 138 146
16. J.M. Cao, M.C. Fishbein, J.B. Han, W.W. Lai, A.C. Lai, and T.J. Wu Relationship between regional cardiac hyperinnervation and ventricular arrhythmia Circulation 101 2000 1960 1969 (Pubitemid 30225278)
17. D.M. Kaye, G. Vaddadi, S.L. Gruskin, X.J. Du, and M.D. Esler Reduced myocardial nerve growth factor expression in human and experimental heart failure Circ Res 86 2000 80 84
18. M. Meloni, A. Caporali, G. Graiani, C. Lagrasta, R. Katare, and S. Van Linthout Nerve growth factor promotes repair following myocardial infarction Circ Res 106 2010 1275 1284
19. C. Lanni, S. Stanga, M. Racchi, and S. Govoni The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders Curr Pharm Des 16 2010 698 717
20. W.D. Snider Functions of the neurotrophins during nervous system development: what the knockouts are teaching us Cell 77 1994 627 638 (Pubitemid 24175600)
21. R. Lee, P. Kermani, K.K. Teng, and B.L. Hempstead Regulation of cell survival by secreted proneurotrophins Science 294 2001 1945 1948 (Pubitemid 33101595)
22. S.D. Skaper The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors CNS Neurol Disord Drug Targets 7 2008 46 62 (Pubitemid 351516216)
23. A. Blöchl, and R. Blöchl A cell-biological model of p75NTR signaling J Neurochem 102 2007 289 305
24. J.M. Frade, and Y.A. Barde Nerve growth factor: two receptors, multiple functions Bioassays 20 1998 137 145 (Pubitemid 28132109)
25. M.L. Cotrina, M. González-Hoyuela, J.A. Barbas, and A. Rodríguez-Tébar Programmed cell death in the developing somites is promoted by nerve growth factor via its p75(NTR) receptor Dev Biol 228 2000 326 336 (Pubitemid 32011995)
26. W.J. Friedman Neurotrophins induce death of hippocampal neurons via the p75 receptor J Neurosci 20 2000 6340 6346
27. L.F. Reichardt Neurotrophin-regulated signalling pathways Philos Trans R Soc Lond B Biol Sci 361 2006 1545 1564 (Pubitemid 44450210)
28. S. Cohen, R. Levi-Montalcini, and V. Hamburger A nerve growth-stimulating factor isolated from sarcom as 37 and 180 Proc Natl Acad Sci U S A 40 1954 1014 1018
29. R. Levi-Montalcini, and V. Hamburger Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo J Exp Zool 116 1951 321 361
30. R.B. Campenot Local control of neurite development by nerve growth factor Proc Natl Acad Sci U S A 74 1977 4516 4519 (Pubitemid 8225155)
31. A. Caporali, and C. Emanueli Cardiovascular actions of neurotrophins Physiol Rev 89 2009 279 308
32. E.J. Huang, and L.F. Reichardt Trk receptors: roles in neuronal signal transduction Annu Rev Biochem 72 2003 609 642 (Pubitemid 36930455)
33. R.A. Segal, and M.E. Greenberg Intracellular signaling pathways activated by neurotrophic factors Annu Rev Neurosci 19 1996 463 489 (Pubitemid 26080836)
34. S. Govoni, M. Amadio, F. Battaini, and A. Pascale Senescence of the brain: focus on cognitive kinases Curr Pharm Des 16 2010 660 671
35. R. Levi-Montalcini The nerve growth factor 35 years later Science 237 1987 1154 1162 (Pubitemid 17124912)
36. D. Vaudry, Y. Chen, C.M. Hsu, and L.E. Eiden PC12 cells as a model to study the neurotrophic activities of PACAP Ann N Y Acad Sci 83 2002 1272 1284
37. D. Kunz, G. Walker, M. Bedoucha, U. Certa, P. März-Weiss, and B. Dimitriades-Schmutz Expression profiling and ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells BMC Genomics 24 2009 10:90
38. T.F. Dijkmans, L.W. van Hooijdonk, T.G. Schouten, J.T. Kamphorst, A.C. Vellinga, and J.H. Meerman Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation J Neurochem 105 2008 2388 2403 (Pubitemid 351782276)
39. J.M. Cosgaya, and A. Aranda Nerve growth factor regulates transforming growth factor-beta 1 gene expression by both transcriptional and posttranscriptional mechanisms in PC12 cells Neurochemistry 65 1995 2484 2490
40. N.H. Lee, and R.L. Malek Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity J Biol Chem 273 1998 22317 22325 (Pubitemid 28399791)
41. N.I. Perrone-Bizzozero, R.L. Neve, N. Irwin, S. Lewis, I. Fischer, and L.I. Benowitz Post-transcriptional regulation of GAP-43 mRNA levels during neuronal differentiation and nerve regeneration Mol Cell Neurosci 2 1991 402 409 (Pubitemid 121005704)
42. E. Alleva, and I. Branchi NGF: a social molecule Psychoneuroendocrinology 31 2006 295 296 (Pubitemid 43261647)
43. P. Luppi, R. Levi-Montalcini, L. Bracci-Laudiero, A. Bertolini, R. Arletti, and D. Tavernari NGF is released into plasma during human pregnancy: an oxytocin-mediated response? Neuroreport 4 1993 1063 1065 (Pubitemid 23242647)
44. M. Hadjiconstantinou, L. McGuire, A.M. Duchemin, B. Laskowski, J. Kiecolt-Glaser, and R. Glaser Changes in plasma nerve growth factor levels in older adults associated with chronic stress J Neuroimmunol 116 2001 102 106 (Pubitemid 32322644)
45. E. Emanuele, P. Politi, M. Bianchi, P. Minoretti, M. Bertona, and D. Geroldi Raised plasma nerve growth factor levels associated with early-stage romantic love Psychoneuroendocrinology 31 2006 288 294 (Pubitemid 43261646)
46. T. Serrano, L.C. Lorigados, and S. Armenteros Nerve growth factor levels in normal human sera Neuroreport 8 1996 179 181 (Pubitemid 126785554)
47. C. Missale, F. Boroni, S. Sigala, A. Buriani, M. Fabris, and A. Leon Nerve growth factor in the anterior pituitary: localization in mammotroph cells and cosecretion with prolactin by a dopamine-regulated mechanism Proc Natl Acad Sci U S A 93 1996 4240 4245 (Pubitemid 26144270)
48. J.W. Nam, J.W. Chung, H.S. Kho, S.C. Chung, and Y.K. Kim Nerve growth factor concentration in human saliva Oral Dis 13 2007 187 192
49. R. Mathison, J.S. Davison, and A.D. Befus Neuroendocrine regulation of inflammation and tissue repair by submandibular gland factors Immunol Today 15 1995 527 532 (Pubitemid 24327566)
50. C. Schäper, S. Gläser, D.A. Groneberg, G. Kunkel, R. Ewert, and O. Noga Nerve growth factor synthesis in human vascular smooth muscle cells and its regulation by dexamethasone Regul Pept 157 2009 3 7
51. E.J. Mufson, J.S. Kroin, T.J. Sendera, and T. Sobreviela Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases Prog Neurobiol 57 1999 451 484 (Pubitemid 29057112)
52. H. Thoenen Neurotrophins and neuronal plasticity Science 270 1995 593 598
53. A. Micera, A. Lambiase, L. Aloe, Bonini Se, F. Levi-Schaffer, and S.T. Bonini Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases Cytokine Growth Factor Rev 15 2004 411 417 (Pubitemid 39550452)
54. R.A. Rush Immunohistochemical localization of endogenous nerve growth factor Nature 312 1984 364 367 (Pubitemid 15209313)
55. S. Korsching, and H. Thoenen Developmental changes of nerve growth factor levels in sympathetic ganglia and their target organs Dev Biol 126 1988 40 46 (Pubitemid 18077582)
56. S. Korsching, and H. Thoenen Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation Proc Natl Acad Sci U S A 80 1983 3513 3516 (Pubitemid 13060194)
57. A. Micera, A. Lambiase, B. Stampachiacchiere, S. Bonini, S. Bonini, and F. Levi-Schaffer Nerve growth factor and tissue repair remodeling: trkA (NGFR) and p75 (NTR), two receptors one fate Cytokine Growth Factor Rev 18 2007 245 256 (Pubitemid 46900902)
58. D.L. Shelton, and L.F. Reichardt Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs Proc Natl Acad Sci U S A 81 1984 7951 7955 (Pubitemid 15169180)
59. J.O. Hiltunen, U. Arumäe, M. Moshnyakov, and M. Saarma Expression of mRNAs for neurotrophins and their receptors in developing rat heart Circ Res 79 1996 930 939 (Pubitemid 26359234)
60. V. Freund, and N. Frossard Expression of nerve growth factor in the airways and its possible role in asthma Prog Brain Res 146 2004 335 346 (Pubitemid 37541392)
61. A. Lambiase, A. Micera, R. Sgrulletta, Bonini Se, and S.T. Bonini Nerve growth factor and the immune system: old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditions Curr Opin Allergy Clin Immunol 4 2004 425 430 (Pubitemid 39274085)
62. A. Leon, A. Buriani, R. dal Toso, M. Fabris, S. Romanello, and L. Aloe Mast cells synthesize, store, and release nerve growth factor Proc Natl Acad Sci U S A 9 1994 3739 3743 (Pubitemid 24139507)
63. R.D. Stanzel, S. Lourenssen, and M.G. Blennerhassett Inflammation causes expression of NGF in epithelial cells of the rat colon Exp Neurol 211 2008 203 213
64. L. Calz, L. Giardino, and L. Aloe NGF content and expression in the rat pituitary gland and regulation by thyroid hormone Brain Res Mol Brain Res 51 1997 60 68 (Pubitemid 27504032)
65. B.F. Van der Laan, J.L. Freeman, and S.L. Asa Expression of growth factors and growth factor receptors in normal and tumorous human thyroid tissues Thyroid 5 1995 67 73
66. C. Li, G. Watanabe, Q. Weng, W. Jin, C. Furuta, and A.K. Suzuki Expression of nerve growth factor (NGF), and its receptors TrkA and p75 in the reproductive organs of the adult male rats Zool Sci 22 2005 933 937 (Pubitemid 41360624)
67. F.G. Varol, A.M. Duchemin, N.H. Neff, and M. Hadjiconstantinou Nerve growth factor (NGF) and NGF mRNA change in rat uterus during pregnancy Neurosci Lett 294 2000 58 62
68. F. Miralles, P. Philippe, P. Czernichow, and R. Scharfmann Expression of nerve growth factor and its high-affinity receptor Trk-A in the rat pancreas during embryonic and fetal life J Endocrinol 156 1998 431 439 (Pubitemid 28131460)
69. R. Dal Toso, M.A. De Bernardi, G. Brooker, E. Costa, and I. Mocchetti Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells J Pharmacol Exp Ther 246 1998 1190 1193
70. Y. Furukawa, N. Tomioka, W. Sato, E. Satoyoshi, K. Hayashi, and S. Furukawa Catecholamines increase nerve growth factor mRNA content in both mouse astroglial cells and fibroblast cells FEBS 247 1989 463 467 (Pubitemid 19129298)
71. D. Creedon, and J.B. Tuttle Nerve growth factor synthesis in vascular smooth muscle Hypertension 18 1991 730 741
72. R. Hellweg, C.E. Bandtlow, R. Heumann, and S. Korsching Nerve growth factor synthesis in cultured rat iris: modulation by endogenous transmitter substances Exp Cell Res 179 1988 18 30
73. E. Nisoli, C. Tonello, M. Benarese, P. Liberini, and M.O. Carruba Expression of nerve growth factor in brown adipose tissue: implications for thermogenesis and obesity Endocrinology 137 1996 495 503 (Pubitemid 26043741)
74. F. Qin, R.S. Vulapalli, S.Y. Stevens, and C.S. Liang Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF Am J Physiol Heart Circ Physiol 282 2002 363 371
75. K. Kimura, H. Kanazawa, M. Ieda, H. Kawaguchi-Manabe, Y. Miyake, and T. Yagi Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure Auton Neurosci 156 2010 27 35
76. Y.T. Gong, W.M. Li, Y. Li, S.S. Yang, L. Sheng, and N. Yang Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing Chin Med J (Engl) 122 2009 74 82
77. S.S. Riaz, and D.R. Tomlinson Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and β-adrenoceptor 2 agonists Mol Brain Res 85 2000 179 188 (Pubitemid 32056249)
78. B. Hundle, T. McMahon, J. Dadgar, C.H. Chen, D. Mochly-Rosen, and R.O. Messing An inhibitory fragment derived from protein kinase C epsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters J Biol Chem 272 1997 15028 15035 (Pubitemid 27251780)
79. M. Ieda, K. Fukuda, Y. Hisaka, K. Kimura, H. Kawaguchi, and J. Fujita Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression J Clin Invest 113 2004 876 884 (Pubitemid 38544146)
80. S. Riaz, M. Malcangio, M. Miller, and D.R. Tomlinson A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats Diabetologia 42 1999 1308 1313 (Pubitemid 29500967)
81. E. Germani, E. Lesma, A.M. Di Giulio, and A. Gorio Progressive and selective changes in neurotrophic factor expression and substance p axonal transport induced by perinatal diabetes: protective action of antioxidant treatment J Neurosci Res 57 1999 521 528 (Pubitemid 29372926)
82. C. Crowley, S.D. Spencer, M.C. Nishimura, K.S. Chen, S. Pitts-Meek, and M.P. Armanini Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons Cell 76 1994 1001 1011 (Pubitemid 24106381)
83. R.J. Smeyne, R. Klein, A. Schnapp, L.K. Long, S. Bryant, and A. Lewin Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene Nature 368 1994 246 249 (Pubitemid 24108841)
84. U. Ernsberger Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia Cell Tissue Res 336 2009 349 384
85. T.D. Patel, A. Jackman, F.L. Rice, J. Kucera, and W.D. Snider Development of sensory neurons in the absence of NGF/TrkA signaling in vivo Neuron 25 2000 345 357
86. N.O. Glebova, and D.D. Ginty Heterogeneous requirement of NGF for sympathetic target innervation in vivo J Neurosci 24 2004 743 751 (Pubitemid 38166500)
87. G.D. Nicol, and M.R. Vasko Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks? Mol Interv 7 2007 26 41 (Pubitemid 46364322)
88. G. Terenghi Peripheral nerve regeneration and neurotrophic factors J Anat 194 1999 1 14 (Pubitemid 29126690)
89. U. Otten, J.L. Scully, P.B. Ehrhard, and R.A. Gadient Neurotrophins: signals between the nervous and immune systems Prog Brain Res 103 1994 293 305
90. K. Horigome, E.D. Pryor, E.M. Bullock, and E.M. Johnson Jr. Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation J Biol Chem 268 1993 14481 14487
91. A. Solomon, L. Aloe, J. Pe'er, J. Frucht-Pery, S. Bonini, and F. Levi-Schaffer Nerve growth factor is preformed in and activates human peripheral blood eosinophils J Allergy Clin Immunol 102 1998 454 460 (Pubitemid 28471508)
92. C. Pincelli, C. Sevignani, R. Manfredini, A. Grande, F. Fantini, and L. Bracci-Laudiero Expression and function of nerve growth factor and nerve growth factor receptor on cultured keratinocytes J Invest Dermatol 103 1994 13 18 (Pubitemid 24227562)
93. M. Yaar, M.S. Eller, P. DiBenedetto, W.R. Reenstra, S. Zhai, and T. McQuaid The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes J Clin Invest 94 1994 1550 1562
94. M. Polak, R. Scharfmann, B. Seilheimer, G. Eisenbarth, D. Dressler, and I.M. Verma Nerve growth factor induces neuron-like differentiation of an insulin-secreting pancreatic beta cell line Proc Natl Acad Sci U S A 90 1993 5781 5785 (Pubitemid 23176246)
95. V. Navarro-Tableros, T. Fiordelisio, A. Hernandez-Cruz, and M. Hiriart Nerve growth factor promotes development of glucose-induced insulin secretion in rat neonate pancreatic beta cells by modulating calcium channels Channels 1 2007 408 416
96. K. Raile, J. Klammt, A. Garten, S. Laue, M. Blüher, and S. Kralisch Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells Regul Pept 135 2006 30 38 (Pubitemid 43816096)
97. J.A. Vega, O. Garcia-Suarez, J. Hannestad, M. Perez-Perez, and A. Germana Neurotrophins and the immune system J Anat 203 2003 1 19 (Pubitemid 36889240)
98. B.A. Habecker, P. Bilimoria, C. Linick, K. Gritman, C.U. Lorentz, and W. Woodward Regulation of cardiac innervation and function via the p75 neurotrophin receptor Auton Neurosci 140 2008 40 48
99. A. Caporali, G.B. Sala-Newby, M. Meloni, G. Graiani, E. Pani, and B. Cristofaro Identification of the prosurvival activity of nerve growth factor on cardiac myocytes Cell Death Differ 15 2008 299 311
100. G. Cantarella, L. Lempereur, M. Presta, D. Ribatti, G. Lombardo, and P. Lazarovici Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo FASEB J 16 2002 1307 1309
101. A. Caporali, E. Pani, A.J.G. Horrevoets, N. Kraenkel, A. Oikawa, and G.B. Sala-Newby Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles Circ Res 103 2008 e15 26
102. L. Manni, A. Antonelli, N. Costa, and L. Aloe Stress alters vascular-endothelial growth factor expression in rat arteries: role of nerve growth factor Basic Res Cardiol 100 2005 121 130 (Pubitemid 40361604)
103. O.R. Rana, E. Saygili, C. Meyer, C. Gemein, A. Krüttgen, and M.G. Andrzejewski Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway J Mol Cell Cardiol 46 2009 568 578
104. B.D. Sachs, G.S. Baillie, J.R. McCall, M.A. Passino, C. Schachtrup, and D.A. Wallace p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway J Cell Biol 177 2007 1119 1132 (Pubitemid 46955714)
105. S. Wang, P. Bray, T. McCaffrey, K. March, B.L. Hempstead, and R. Kraemer p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells Am J Pathol 157 2000 1247 1258
106. S.T. Lockhart, J.N. Mead, J.M. Pisano, J.D. Slonimsky, and S.J. Birren Nerve growth factor collaborates with myocyte-derived factors to promote development of presynaptic sites in cultured sympathetic neurons J Neurobiol 42 2000 460 476 (Pubitemid 30127804)
107. S.T. Lockhart, G.G. Turrigiano, and S.J. Birren Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes J Neurosci 17 1997 9573 9582 (Pubitemid 28006401)
108. M.P. Kaye, D.J. Wells, and G.M. Tyce Nerve growth factor-enhanced reinnervation of surgically denervated canine heart Am J Physiol 236 1979 624 628
109. L.S. Chen, S. Zhou, M.C. Fishbein, and P.S. Chen New perspectives on the role of autonomic nervous system in the genesis of arrhythmias J Cardiovasc Electrophysiol 18 2007 123 127 (Pubitemid 44952760)
110. S. Zhou, O. Paz, J.M. Cao, K. Asotra, N.N. Chai, and C. Wang Differential beta-adrenoceptor expression induced by nerve growth factor infusion into the canine right and left stellate ganglia Heart Rhythm 2 2005 1347 1355 (Pubitemid 43055418)
111. H.J. Cheng, Z.S. Zhang, K. Onishi, T. Ukai, D.C. Sane, and C.P. Cheng Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium Circ Res 89 2001 599 606 (Pubitemid 32924214)
112. C. Gauthier, G. Tavernier, F. Charpentier, D. Langin, and H. Le Marec Functional beta3-adrenoceptor in the human heart J Clin Invest 98 1996 556 562
113. J.P. Giacobino Beta 3-adrenoceptor: an update Eur J Endocrinol 132 1995 377 385
114. C. Gauthier, D. Langin, and J.L. Balligand Beta3-adrenoceptors in the cardiovascular system Trends Pharmacol Sci 21 2000 426 431
115. R.F. Bosch, A.C. Schneck, J. Kiehn, W. Zhang, A. Hambrock, and B.W. Eigenberger Beta3-adrenergic regulation of an ion channel in the heart-inhibition of the slow delayed rectifier potassium current I(Ks) in guinea pig ventricular myocytes Cardiovasc Res 56 2002 393 403 (Pubitemid 35351561)
116. M.L. Entman, and C.W. Smith Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease Cardiovasc Res 28 1994 1301 1311 (Pubitemid 24300430)
117. H.K. Hawkins, M.L. Entman, J.Y. Zhu, K.A. Youker, K. Berens, and M. Doré Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody Am J Pathol 148 1996 1957 1969
118. K. Kawamoto, J. Aoki, A. Tanaka, A. Itakura, H. Hosono, and H. Arai Nerve growth factor activates mast cells through the collaborative interaction with lysophosphatidylserine expressed on the membrane surface of activated platelets J Immunol 168 2002 6412 6419 (Pubitemid 34620066)
119. N.G. Frangogiannis, K.A. Youker, R.D. Rossen, M. Gwechenberger, M.H. Lindsey, and L.H. Mendoza Cytokines and the microcirculation in ischemia and reperfusion J Mol Cell Cardiol 30 1998 2567 2576 (Pubitemid 29017498)
120. M.C. Caroleo, N. Costa, L. Bracci-Laudiero, and L. Aloe Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors J Neuroimmunol 113 2001 193 201 (Pubitemid 32112745)
121. Y. Susaki, S. Shimizu, K. Katakura, N. Watanabe, K. Kawamoto, and M. Matsumoto Functional properties of murine macrophages promoted by nerve growth factor Blood 88 1996 4630 4637 (Pubitemid 26419146)
122. R. Barouch, G. Kazimirsky, E. Appel, and C. Brodie Nerve growth factor regulates TNF-alpha production in mouse macrophages via MAP kinase activation J Leukoc Biol 69 2001 1019 1026 (Pubitemid 32577906)
123. G. Wernli, W. Hasan, A. Bhattacherjee, N. van Rooijen, and P.G. Smith Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction Basic Res Cardiol 104 6 2009 681 693
124. W. Hasan, A. Jama, T. Donohue, G. Wernli, G. Onyszchuk, and B. Al-Hafez Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats Brain Res 1124 2006 142 154 (Pubitemid 44779548)
125. F.M. Sheridan, P.G. Cole, and D. Ramage Leukocyte adhesion to the coronary microvasculature during ischemia and reperfusion in an in vivo canine model Circulation 93 1996 1784 1787 (Pubitemid 26154027)
126. Z.Q. Zhao, M. Nakamura, N.P. Wang, D.A. Velez, K.O. Hewan-Lowe, and R.A. Guyton Dynamic progression of contractile and endothelial dysfunction and infarct extension in the late phase of reperfusion J Surg Res 94 2000 133 144
127. W.J. Dreyer, L.H. Michael, M.S. West, C.W. Smith, R. Rothlein, and R.D. Rossen Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion Circulation 84 1991 400 411
128. S.J. Weiss Tissue destruction by neutrophils N Engl J Med 320 1989 365 376 (Pubitemid 19106873)
129. A.P. Gee, M.D. Boyle, K.L. Munger, M.J. Lawman, and M. Young Nerve growth factor: stimulation of polymorphonuclear leukocyte chemotaxis in vitro Proc Natl Acad Sci U S A 80 1983 7215 7218 (Pubitemid 14208829)
130. Y. Kannan, K. Usami, M. Okada, S. Shimizu, and H. Matsuda Nerve growth factor suppresses apoptosis of murine neutrophils Biochem Biophys Res Commun 186 1992 1050 1056
131. Y. Kannan, H. Ushio, H. Koyama, M. Okada, M. Oikawa, and T. Yoshihara 2.5S nerve growth factor enhances survival, phagocytosis, and superoxide production of murine neutrophils Blood 77 1991 1320 1325
132. S.D. Solomon, S. Zelenkofske, J.J. McMurray, P.V. Finn, E. Velazquez, and G. Ertl Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both N Engl J Med 352 2005 2581 2588 Erratum in: N Engl J Med 2005;353:744 (Pubitemid 41007844)
133. D.P. Zipes, M.J. Barber, N. Takahashi, and R.F. Gilmour Jr. Influence of the autonomic nervous system on the genesis of cardiac arrhythmias Pacing Clin Electrophysiol 6 1983 1210 1220
134. Z.F. Issa, J. Rosenberger, W.J. Groh, J.M. Miller, and D.P. Zipes Ischemic ventricular arrhythmias during heart failure: a canine model to replicate clinical events Heart Rhythm 2 2005 979 983 (Pubitemid 41372287)
135. D.T. Kim, D.J. Luthringer, A.C. Lai, G. Suh, L. Czer, and L.S. Chen Sympathetic nerve sprouting after orthotopic heart transplantation J Heart Lung Transplant 23 2004 1349 1358 (Pubitemid 40018156)
136. A. Malliani, P.J. Schwartz, and A. Zanchetti A sympathetic reflex elicide by experimental coronary occlusion Am J Physiol 217 1969 703 709
137. D. Cerati, and P.J. Schwartz Single cardiac vagal fiber activity, acute myocardial ischemia and risk of sudden death Circ Res 69 1991 1389 1401
138. P.J. Schwartz, E. Vanoli, L. Crotti, C. Spazzolini, C. Ferrandi, and A. Goosen Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome. A contributory role for common genetic variants J Am Coll Cardiol 51 2008 920 929 (Pubitemid 351282460)
139. E. Vanoli, G.M. De Ferrari, M. Stramba-Badiale, S.S. Hull Jr., R.D. Foreman, and P.J. Schwartz Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction Circ Res 68 1991 1471 1481
140. E. Vanoli, P.B. Adamson, S.S. Hull, R.D. Foreman, and P.J. Schwartz Prediction of unexpected sudden death among healthy dogs by a novel marker of autonomic neural activity Heart Rhythm 5 2008 300 305
141. A. Pascale, M. Amadio, and A. Quattrone Defining a neuron: neuronal ELAV proteins Cell Mol Life Sci 65 2008 128 140 (Pubitemid 351152226)
142. D. Rossi, M. Amadio, A. Carnevale Baraglia, O. Azzolina, A. Ratti, and S. Govoni Discovery of small peptides derived from embryonic lethal abnormal vision proteins structure showing RNA-stabilizing properties J Med Chem 52 2009 5017 5019
143. J. Gruenberg The endocytic pathway: a mosaic of domains Nat Rev Mol Cell Biol 2 2001 721 730 (Pubitemid 33679834)
144. P.P. Di Fiore, and P. De Camilli Endocytosis and signaling. An inseparable partnership Cell 106 2001 1 4
145. R. Kuruvilla, L.S. Zweifel, N.O. Glebova, B.E. Lonze, G. Valdez, and H. Ye A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling Cell 118 2004 243 255 (Pubitemid 38962579)
146. T. Moises, A. Dreier, S. Flohr, M. Esser, E. Brauers, and K. Reiss Tracking TrkA's trafficking: NGF receptor trafficking controls NGF receptor signaling Mol Neurobiol 35 2007 151 159 (Pubitemid 350131692)
147. P.A. Barker, N.K. Hussain, and P.S. McPherson Retrograde signaling by the neurotrophins follows a well-worn trk Trends Neurosci 25 2002 379 381 (Pubitemid 34804451)