Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: Implications for diabetes-induced impaired neovascularization in ischemic limb muscles

Circulation Research

Volumn 103, Issue 2, 2008, Pages

  Caporali, Andrea ^a   Pani, Elisabetta ^a,b   Horrevoets, Anton J G ^c   Kraenkel, Nicolle ^a   Oikawa, Atsuhiko ^a   Sala Newby, Graciela B ^a   Meloni, Marco ^a   Cristofaro, Brunella ^a   Graiani, Gallia ^d   Leroyer, Aurelie S ^e   Boulanger, Chantal M ^e   Spinetti, Gaia ^b   Yoon, Sung Ok ^f   Madeddu, Paolo ^a   Emanueli, Costanza ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b IRCCS MULTIMEDICA   (Italy)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF PARMA   (Italy)

^e HÔPITAL LARIBOISIÈRE   (France)

^f OHIO STATE UNIVERSITY   (United States)

Author keywords

Limb ischemia; Neurotrophins; P75NTR; Reparative neovascularization; VEGF A

Indexed keywords

BETA1 INTEGRIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; NEUROTROPHIN RECEPTOR P75; NITRIC OXIDE; PROTEIN KINASE B; SECURIN; SURVIVIN; VASCULOTROPIN A; NERVE GROWTH FACTOR RECEPTOR; NITRIC OXIDE SYNTHASE; STREPTOZOCIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD FLOW; CELL ADHESION; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; LIMB ISCHEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; ANIMAL; DIABETIC ANGIOPATHY; DISEASE MODEL; EXPERIMENTAL DIABETES MELLITUS; GENETIC TRANSFECTION; GENETICS; ISCHEMIA; METABOLISM; MOUSE STRAIN; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HUMANS; ISCHEMIA; MALE; MICE; MICE, INBRED STRAINS; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; STREPTOZOCIN; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 48849107004     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.177386     Document Type: Article

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