Regulation of nerve growth factor in the heart: The role of the calcineurin-NFAT pathway

Journal of Molecular and Cellular Cardiology

Volumn 46, Issue 4, 2009, Pages 568-578

  Rana, Obaida R ^a   Saygili, Erol ^a   Meyer, Christian ^a   Gemein, Christopher ^a   Krüttgen, Alexander ^a   Andrzejewski, Michael G ^a   Ludwig, Andreas ^a   Schotten, Ulrich ^b   Schwinger, Robert H G ^c   Weber, Christian ^a   Weis, Joachim ^a   Mischke, Karl ^a   Rassaf, Tienush ^a   Kelm, Malte ^a   Schauerte, Patrick ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c Klinikum Weiden   (Germany)

Author keywords

Calcineurin; Heart failure; Mechanical stretch; Myocardial infarction; NFAT; NGF

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; CALCINEURIN; CYCLOSPORIN A; LOSARTAN; NERVE GROWTH FACTOR; TACROLIMUS; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; GENE EXPRESSION; HEART VENTRICLE; MUSCLE CELL; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

ANIMALS; APOPTOSIS; CALCINEURIN; DOWN-REGULATION; MYOCARDIUM; MYOCYTES, CARDIAC; NERVE GROWTH FACTOR; NEURITES; NFATC TRANSCRIPTION FACTORS; ORGAN SPECIFICITY; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ADRENERGIC, ALPHA-1; STRESS, MECHANICAL; SYMPATHETIC NERVOUS SYSTEM; TRANSFECTION;

RATTUS;

EID: 61449124037     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2008.12.006     Document Type: Article

References (34)

1. Schwartz P.J., Vanoli E., Zaza A., and Zuanetti G. The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. Am. Heart J. 109 (1985) 937-948
2. Himura Y., Felten S.Y., Kashiki M., Lewandowski T.J., Delehanty J.M., and Liang C.S. Cardiac noradrenergic nerve terminal abnormality in dogs with experimental congestive heart failure. Circulation 88 (1993) 1299-1309
3. Oh Y.S., Jong A.Y., Kim D.T., Li H., Wang C., Zemljic-Harpf A., et al. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm 3 6 (2006) 728-736
4. Cao J.M., Fishbein M.C., Han J.B., Lai W.W., Lai A.C., Wu T.J., et al. Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation 101 16 (2000) 1960-1969
5. Cao J.M., Chen L.S., KenKnight B.H., Ohara T., Lee M.H., Tsai J., et al. Nerve sprouting and sudden cardiac death. Circ. Res. 86 7 (2000) 816-821
6. Jiang H., Lu Z., Yu Y., Zhao D., Yang B., and Huang C. Relationship between sympathetic nerve sprouting and repolarization dispersion at peri-infarct zone after myocardial infarction. Auton. Neurosci. 134 1-2 (2007) 18-25
7. Levi-Montalcini R. The nerve growth factor: its role in growth, differentiation and function of the sympathetic adrenergic neuron. Prog. Brain Res. 45 (1976) 235-258
8. Snider W.D. Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77 (1994) 627-638
9. Hassankhani A., Steinhelper M.E., Soonpaa M.H., Katz E.B., Taylor D.A., Andrade-Rozental A., et al. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev. Biol. 169 (1995) 309-321
10. Hasan W., Jama A., Donohue T., Wernli G., Onyszchuk G., Al-Hafez B., et al. Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats. Brain Res. 1124 1 (2006) 142-154
11. Qin F., Vulapalli R.S., Stevens S.Y., and Liang C.S. Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF. Am. J. Physiol. Heart Circ. Physiol. Physiol. 282 1 (2002) H363-371
12. Kaye D.M., Vaddadi G., Gruskin S.L., Du X.J., and Esler M.D. Reduced myocardial nerve growth factor expression in human and experimental heart failure. Circ. Res. 86 (2000) E80-84
13. Caporali A., Sala-Newby G.B., Meloni M., Graiani G., Pani E., Cristofaro B., et al. Identification of the prosurvival activity of nerve growth factor on cardiac myocytes. Cell Death Differ. 15 2 (2008) 299-311
14. Hilfiker-Kleiner D., Kaminski K., Kaminska A., Fuchs M., Klein G., Podewski E., et al. Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation. Circulation 109 18 (2004) 2227-2233
15. Agnoletti G., Cornacchiari A., Panzali A.F., Ghielmi S., De Giuli F., and Ferrari R. Effect of congestive heart failure on rate of atrial natriuretic factor release in response to stretch and isoprenaline. Cardiovasc. Res. 24 11 (1990) 938-945
16. Ruwhof C., van Wamel J.T., Noordzij L.A., Aydin S., Harper J.C., and van der Laarse A. Mechanical stress stimulates phospholipase C activity and intracellular calcium ion levels in neonatal rat cardiomyocytes. Cell Calcium 29 2 (2001) 73-83
17. Molkentin J.D. Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovasc. Res. 63 3 (2004) 467-475
18. Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93 (1998) 215-228
19. Rana O.R., Zobel C., Saygili E., Brixius K., Gramley F., Schimpf T., et al. A simple device to apply equibiaxial strain to cells cultured on flexible membranes. Am. J. Physiol. Heart Circ. Physiol. 294 1 (2008) H532-540
20. Zobel C., Rana O.R., Saygili E., Bolck B., Saygili E., Diedrichs H., et al. Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy. Cardiology 107 4 (2007) 281-290
21. Saygili E., Rana O.R., Saygili E., Reuter H., Frank K., Schwinger R.H., et al. Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Am. J. Physiol. Heart Circ. Physiol. Physiol 292 6 (2007) H2898-2905
22. Oka T., Dai Y., and Molkentin J.D. Regulation of calcineurin through transcriptional induction of the calcineurin Aβ promoter in vitro and in vivo. Mol. Cell. Biol. (2005) 6649-6659
23. Sheehan J., Eischeid A., Saunders R., and Pouratian N. Potentiation of neurite outgrowth and reduction of apoptosis by immunosuppressive agents: implications for neuronal injury and transplantation. Neurosurg. Focus 20 5 (2006) E9
24. Sadoshima J., Xu Y., Slayter H.S., and Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75 5 (1993) 977-984
25. Rana Z.A., Gundersen K., and Buonanno A. Activity-dependent repression of muscle genes by NFAT. Proc. Natl. Acad. Sci. U. S. A. 105 15 (2008) 5921-5926
26. Carvalho L.D., Teixeira L.K., Carrossini N., Caldeira A.T., Ansel K.M., Rao A., et al. The NFAT1 transcription factor is a repressor of cyclin A2 gene expression. Cell Cycle 6 14 (2007) 1789-1795
27. Groth R.D., Coicou L.G., Mermelstein P.G., and Seybold V.S. Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes. J Neurochem 102 4 (2007) 1162-1174
28. Baines C.P., and Molkentin J.D. STRESS signaling pathways that modulate cardiac myocyte apoptosis. J. Mol. Cell. Cardiol. 38 (2005) 47-62
29. Lotem J., Kama R., and Sachs L. Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 12016-12020
30. 2+-induced apoptosis through calcineurin dephosphorylation of Bad. Science 284 (1999) 339-343
31. Zhao Y., Tozawa Y., Iseki R., Mukai M., and Iwata M. Calcineurin activation protects T cells from glucocorticoid-induced apoptosis. J. Immunol. 154 (1995) 6346-6354
32. De Windt L.J., Lim H.W., Taigen T., Wencker D., Condorelli G., Dorn 2nd G.W., et al. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis independent model of dilated heart failure. Circ. Res. 86 (2000) 255-263
33. Saito S., Hiroi Y., Zou Y., Aikawa R., Toko H., Shibasaki F., et al. Beta-adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J. Biol. Chem. 275 (2000) 34528-34533
34. Kreusser M.M., Buss S.J., Krebs J., Kinscherf R., Metz J., Katus H.A., et al. Differential expression of cardiac neurotrophic factors and sympathetic nerve ending abnormalities within the failing heart. J. Mol. Cell. Cardiol. 44 2 (2008) 380-387