Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression

Journal of Clinical Investigation

Volumn 113, Issue 6, 2004, Pages 876-884

  Ieda, Masaki ^a   Fukuda, Keiichi ^a   Hisaka, Yasuyo ^a   Kimura, Kensuke ^a   Kawaguchi, Haruko ^a   Fujita, Jun ^a   Shimoda, Kouji ^a   Takeshita, Eiko ^a   Okano, Hideyuki ^a   Kurihara, Yukiko ^b   Kurihara, Hiroki ^b   Ishida, Junji ^c   Fukamizu, Akiyoshi ^c   Federoff, Howard J ^d   Ogawa, Satoshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSINOGEN; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN DELTA; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NORADRENALIN; PROTEIN; PROTEIN GIBETAGAMMA; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL STRAIN; CONTROLLED STUDY; EMBRYO; FEMALE; HEART INNERVATION; HEART MUSCLE CELL; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; RODENT; STELLATE GANGLION; SYMPATHETIC INNERVATION; UPREGULATION;

ANIMALS; APOPTOSIS; ENDOTHELIN-1; GENE EXPRESSION REGULATION; HEART; MICE; MYOCYTES, CARDIAC; NERVE GROWTH FACTOR; NEURONS; SYMPATHETIC NERVOUS SYSTEM;

EID: 11144356167     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200419480     Document Type: Article

References (33)

1. Loring, J.F., and Erickson, C.A. 1987. Neural crest cell migratory pathways in the trunk of the chick embryo. Dev. Biol. 121:220-236.
2. Snider, W.D. 1994. Functions of the neurotrophins during nervous system development; what the knockouts are teaching us. Cell. 77:627-638.
3. Lockhart, S.T., Turrigiano, G.G., and Birren, S.J. 1997. Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes. J. Neurosci. 17:9573-9582.
4. Heumann, R., Korsching, S., Scott, J., and Thoenen, H. 1984. Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues. EMBO J. 3:3183-3189.
5. Brennan, C., Rivas-Plata, K., and Landis, S.C. 1999. The p73 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo. Nat. Neurosci. 2:699-705.
6. Hassankhani, A., et al. 1995. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev. Biol. 169:309-321.
7. Cao, J.M., et al. 2000. Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation. 101:1960-1969.
8. Cao, J.M., et al. 2000. Nerve sprouting and sudden cardiac death. Circ. Res. 86:816-821.
9. Kanki, H., et al. 1999. Comparison of nerve growth factor mRNA expression in cardiac and skeletal muscle in streptozotocin-induced diabetic mice. Life Sci. 65:2305-2313.
10. Kaye, D.M., Vaddadi, G., Gruskin, S.L., Du, X.J., and Eslet, M.D. 2000. Reduced myocardial nerve growth factor expression in human and experimental heart failure. Circ. Res. 86:E80-E84.
11. Kurihara, Y., et al. 1994. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature. 368:703-710.
12. Kurihara, Y., et al. 1995. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J. Clin. Invest. 96:293-300.
13. Clouthier, D.E., et al. 1998. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 125:813-824.
14. Sano, M., et al. 2000. Interleukin-6 family of cytokines mediate angiotensin 11-induced cardiac hypertrophy in rodent cardiomyocytes. J. Biol. Chem. 275:29717-29723.
15. Akamatsu, W., et al. 1999. Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems. Proc. Natl. Acad. Sci. U. S. A. 96:9885-9890.
16. Nishida, M., et al. 2000. G alpha (i) and G alpha (o) are target proteins of reactive oxygen species. Nature. 408:492-495.
17. Zhan, Y., et al. 2003. Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression. Arterioscler. Thromb. Vasc. Biol. 23:795-801.
18. Colangelo, A.M., Johnson, P.F., and Mocchetti, I. 1998. Beta-adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT/enhancer-binding protein delta. Proc. Natl. Acad. Sci. U. S. A. 95:10920-10925.
19. Kodama, H., et al. 2003. Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation. Hypertension. 41:1372-1379.
20. Tanimoto, K., et al. 1994. Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269:31334-31337.
21. Nishimura, Y., Ito, T., Hoe, K., and Saavedra, J.M. 2000. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors. Brain Res. 871:29-38.
22. Hjemdahl, P. 1984. Catecholamine measurements by high-performance liquid chromatography. Am. J. Physiol. 247:E13-E20.
23. Kawasaki, T., et al. 2002. Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system. Development. 129:671-680.
24. Francis, N., et al. 1999. NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors. Dev. Biol. 210:411-427.
25. Selby, M.J., Edwards, R., Sharp, F., and Rutter, W.J. 1987. Mouse nerve growth factor gene: structures and expression. Mol. Cell. Biol. 7:3057-3064.
26. Chiloeches, A., et al. 1999. Regulation of Ras. GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras. J. Biol. Chem. 274:19762-19770.
27. Sugden, P.H., and Clerk, A. 1997. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell. Signal. 9:337-351.
28. Story, G.M., et al. 2000. Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits. Physiol. Genomics. 27:129-136.
29. Zou, Y., et al. 1998. Cell type-specific angiotensin 11-evoked signal transduction pathways. Circ. Res. 82:337-345.
30. Mocchetti, I., et al. 1989. Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma calls: a potential role of c-Fos protein. Proc. Natl. Acad. Sci. U. S. A. 86:3891-3895.
31. Clegg, D.O., Large, T.H., Bodary, S.C., and Reichardt, L.F. 1989. Regulation of nerve growth factor mRNA levels in developing rat heart ventricle is not altered by sympathectomy. Dev. Biol. 134:30-37.
32. Sakai, S., et al. 1996. Inhibition of myocardial endothelin pathway improves long term survival in heart failure. Nature. 384:353-355.
33. Matsumoto, Y., et al. 2002. Long-term endothelin a receptor blockade inhibits electrical remodeling in cardiomyopathic hamsters. Circulation. 106:613-619.