Probucol attenuates atrial autonomic remodeling in a canine model of atrial fibrillation produced by prolonged atrial pacing

Chinese Medical Journal

Volumn 122, Issue 1, 2009, Pages 74-82

  Gong, Yong Tai ^a   Li, Wei Min ^a   Li, Yue ^a   Yang, Shu Sen ^a   Sheng, Li ^a   Yang, Ning ^a   Shan, Hong Bo ^a   Xue, Hong Jie ^a   Liu, Wei ^a   Yang, Bao Feng ^a   Dong, De Li ^a   Li, Bao Xin ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Atrial fibrillation; Autonomic nervous system; Inflammation; Nerve growth factor; Oxidative stress

Indexed keywords

C REACTIVE PROTEIN; MESSENGER RNA; NERVE GROWTH FACTOR BETA SUBUNIT; NORADRENALIN; PROBUCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; DISEASE MARKER; DOG; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEART ATRIUM FIBRILLATION; HEART ATRIUM FUNCTION; HEART ATRIUM PACING; HEART HEMODYNAMICS; HEART LEFT ATRIUM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOLECULAR MECHANICS; NERVE SPROUTING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPATHETIC INNERVATION; SYMPATHETIC NERVE; TISSUE LEVEL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; ATRIAL FIBRILLATION; BLOTTING, WESTERN; C-REACTIVE PROTEIN; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; DOGS; ELECTROCARDIOGRAPHY; FEMALE; HEART ATRIA; IMMUNOHISTOCHEMISTRY; MALE; NERVE GROWTH FACTOR; NOREPINEPHRINE; PROBUCOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 60649087382     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.01.014     Document Type: Article

References (41)

1. Jayachandran JV, Sih HJ, Winkle W, Zipes DP, Hutchins GD, Olgin JE. Atrial fibrillation produced by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation. Circulation 2000; 101: 1185-1191.
2. Chang CM, Wu TJ, Zhou S, Doshi RN, Lee MH, Ohara T, et al. Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing. Circulation 2001; 103: 22-25.
3. Hamabe A, Chang CM, Zhou S, Chou CC, Yi J, Miyauchi Y, et al. Induction of atrial fibrillation and nerve sprouting by prolonged left atrial pacing in dogs. Pacing Clin Electrophysiol 2003; 26: 2247-2252.
4. Miyauchi Y, Zhou S, Okuyama Y, Miyauchi M, Hayashi H, Hamabe A, et al. Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: implications for atrial fibrillation. Circulation 2003; 108: 360-366.
5. Swissa M, Zhou S, Paz O, Fishbein MC, Chen LS, Chen PS. Canine model of paroxysmal atrial fibrillation and paroxysmal atrial tachycardia. Am J Physiol Heart Circ Physiol 2005; 289: H1851-H1857.
6. Liu YB, Wu CC, Lu LS, Su MJ, Lin CW, Lin SF, et al. Sympathetic nerve sprouting, electrical remodeling, and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits. Circ Res 2003; 92:1145-1152.
7. Hasan W, Jama A, Donohue T, Wernli G, Onyszchuk G, Al-Hafez B, et al. Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats. Brain Res 2006; 1124: 142-154.
8. Shiroshita-Takeshita A, Schram G, Lavoie J, Nattel S. Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs. Circulation 2004; 110: 2313-2319.
9. Shiroshita-Takeshita A, Brundel BJ, Lavoie J, Nattel S. Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs. Cardiovasc Res 2006; 69: 865-875.
10. Nakamura R, Egashira K, Machida Y, Hayashidani S, Takeya M, Utsumi H, et al. Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation. Circulation 2002; 106: 362-367.
11. Li Y, Li WM, Gong YT, Li BX, Liu W, Han W, et al. The effects of cilazapril and valsartan on the mRNA and protein expressions of atrial calpains and atrial structural remodeling in atrial fibrillation dogs. Basic Res Cardiol 2007; 102: 245-256.
12. Han W, Li WM, Xie BD, Li Y, Zhao JY, Huang YL. Effects of cilazapril on endothelial cell function and fibrinolysis system in atrial fibrillation. Chin Med J 2005; 118:1032-1035.
13. He MX, Ke J, Li ZG, Liu FZ. Effects of nimodipine on acute cerebral ischemia and reperfusion injury of rats. Acta Pharmacologica Sinica 1996; 17: 309-310.
14. Carnes CA, Chung MK, Nakayama T, Nakayama H, Baliga RS, Piao S, et al. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res 2001; 89: E32-E38.
15. de la Monte SM, Neely TR, Cannon J, Wands JR. Oxidative stress and hypoxia-like injury cause Alzheimer-type molecular abnormalities in central nervous system neurons. Cell Mol Life Sci 2000; 57: 1471-1481.
16. Craft JM, Watterson DM, Van Eldik LJ. Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia 2006; 53: 484-490.
17. Kaye MP, Wells DJ, Tyce GM. Nerve growth factor-enhanced reinnervation of surgically denervated canine heart. Am J Physiol 1979; 236: H624-H628.
18. Olivieri G, Otten U, Meier F, Baysang G, Dimitriades-Schmutz B, Müller-Spahn F, et al. Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells. Neurol Clin Neurophysiol 2002; 2: 2-10.
19. Abe Y, Akeda K, An HS, Aoki Y, Pichika R, Muehleman C, et al. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine 2007; 32: 635-642.
20. von Boyen GB, Steinkamp M, Reinshagen M, Schäfer KH, Adler G, Kirsch J. Nerve growth factor secretion in cultured enteric glia cells is modulated by proinflammatory cytokines. J Neuroendocrinol 2006; 18: 820-825.
21. Hiltunen JO, Arumäe U, Moshnyakov M, Saarma M. Expression of mRNAs for neurotrophins and their receptors in developing rat heart. Circ Res 1996; 79: 930-939.
22. 2+ channels in adult bullfrog sympathetic neurons by nerve growth factor. J Neurophysiol 1998; 80: 1352-1361.
23. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, et al. Nerve sprouting and sudden cardiac death. Circ Res 2000; 86: 816-821.
24. Zhou S, Chen LS, Miyauchi Y, Miyauchi M, Kar S, Kangavari S, et al. Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. Circ Res 2004; 95: 76-83.
25. El-Helou V, Proulx C, Gosselin H, Clement R, Mimee A, Villeneuve L, et al. Dexamethasone treatment of post-MI rats attenuates sympathetic innervation of the infarct region. J Appl Physiol 2008; 104:150-156.
26. Shelton DL, Reichardt LF. Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs. Proc Natl Acad Sci USA 1984; 81: 7951-7955.
27. Olgin JE, Sih HJ, Hanish S, Jayachandran JV, Wu J, Zheng QH, et al. Heterogeneous atrial denervation creates substrate for sustained atrial fibrillation. Circulation 1998; 98: 2608-2614.
28. Schuessler RB, Grayson TM, Bromberg BI, Cox JL, Boineau JP. Cholinergically mediated tachyarrhythmias induced by a single extrastimulus in the isolated canine right atrium. Circ Res 1992; 71: 1254-1267.
29. Kneller J, Zou R, Vigmond EJ, Wang Z, Leon LJ, Nattel S. Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties. Circ Res 2002; 90: E73-E87.
30. Sharifov OF, Fedorov VV, Beloshapko GG, Glukhov AV, Yushmanova AV, Rosenshtraukh LV. Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs. J Am Coll Cardiol 2004; 43: 483-490.
31. 2+ transient: an arrhythmia trigger within pulmonary veins. J Am Coll Cardiol 2006; 47: 1196-1206.
32. Yi Z, Zhang HC, Zhang P, Liu G, Lu P, Sun JL, et al. The relationship of paroxysmal atrial fibrillation and regional sympathetic innervations in the atria and pulmonary veins: experiment with dogs. Natl Med J China (Chin) 2007; 87: 3433-3435.
33. Nakamura R, Egashira K, Machida Y, Hayashidani S, Takeya M, Utsumi H, et al. Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation. Circulation 2002; 106: 362-367.
34. Sia YT, Lapointe N, Parker TG, Tsoporis JN, Deschepper CF, Calderone A, et al. Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation 2002; 105: 2549-2555.
35. Li Y, Li W, Yang B, Han W, Dong D, Xue J, et al. Effects of Cilazapril on atrial electrical, structural and functional remodeling in atrial fibrillation dogs. J Electrocardiol 2007; 40: 100.e1-e6.
36. Aimé-Sempé C, Folliguet T, Rücker-Martin C, Krajewska M, Krajewska S, Heimburger M, et al. Myocardial cell death in fibrillating and dilated human right atria. J Am Coll Cardiol 1999; 34: 1577-1586.
37. Polyakova V, Miyagawa S, Szalay Z, Risteli J, Kostin S. Atrial extracellular matrix remodelling in patients with atrial fibrillation. J Cell Mol Med 2008; 12: 189-208.
38. Shi Y, Ducharme A, Li D, Gaspo R, Nattel S, Tardif JC. Remodeling of atrial dimensions and emptying function in canine models of atrial fibrillation. Cardiovasc Res 2001; 52: 217-225.
39. Gould PA, Yii M, McLean C, Finch S, Marshall T, Lambert GW, et al. Evidence for increased atrial sympathetic innervation in persistent human atrial fibrillation. Pacing Clin Electrophysiol 2006; 29: 821-829.
40. Neuman RB, Bloom HL, Shukrullah I, Darrow LA, Kleinbaum D, Jones DP, et al. Oxidative stress markers are associated with persistent atrial fibrillation. Clin Chem 2007; 53: 1652-1657.
41. Engelmann MD, Svendsen JH. Inflammation in the genesis and perpetuation of atrial fibrillation. Eur Heart J 2005; 26: 2083-2092.