메뉴 건너뛰기




Volumn 16, Issue 6, 2010, Pages 660-671

Senescence of the brain: Focus on cognitive kinases

Author keywords

Aging; CaM kinase; ELAV; Memory; Protein kinase A; Protein kinase C; Tyrosine kinase

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; 4 METHYLCATECHOL; ANIRACETAM; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRYOSTATIN 1; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CATALPOL; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOCOSAHEXAENOIC ACID; FORSKOLIN; GINKGO BILOBA EXTRACT; HU ANTIGEN; HUPERZINE A; INSULIN; ISOENZYME; LEVACECARNINE; MITOGEN ACTIVATED PROTEIN KINASE; NOBILETIN; OXIRACETAM; PENTOXIFYLLINE; PHOSPHATIDYLSERINE; PHOSPHOTRANSFERASE; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA 2; PROTEIN TYROSINE KINASE A; RESVERATROL; ROLIPRAM; SOMATOMEDIN RECEPTOR; UNCLASSIFIED DRUG; PROTEIN KINASE;

EID: 77950224240     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210790883732     Document Type: Review
Times cited : (45)

References (167)
  • 1
    • 33751213871 scopus 로고    scopus 로고
    • Ageing, hippocampal synaptic activity and magnesium
    • Billard JM. Ageing, hippocampal synaptic activity and magnesium. Magnes Res 2006; 19: 199-215.
    • (2006) Magnes Res , vol.19 , pp. 199-215
    • Billard, J.M.1
  • 2
    • 0023194609 scopus 로고
    • Human aging: Usual and successful
    • Rowe JW, Kahn RL. Human aging: usual and successful. Science 1987; 237: 143-149
    • (1987) Science , vol.237 , pp. 143-149
    • Rowe, J.W.1    Kahn, R.L.2
  • 3
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science 1997; 278: 412-419
    • (1997) Science , vol.278 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 4
    • 34548801253 scopus 로고    scopus 로고
    • Aging, plasticity and environmental enrichment: Structural changes and neurotransmitter dynamics in several areas of the brain
    • Mora F, Segovia G, del Arco A. Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain. Brain Res Rev 2007; 55: 78-88.
    • (2007) Brain Res Rev , vol.55 , pp. 78-88
    • Mora, F.1    Segovia, G.2    Del Arco, A.3
  • 5
    • 34250771556 scopus 로고    scopus 로고
    • The aging brain, a key target for the future: The protein kinase C involvement
    • Pascale A, Amadio M, Govoni S, Battaini F. The aging brain, a key target for the future: the protein kinase C involvement. Pharmacol Res 2007; 55: 560-569
    • (2007) Pharmacol Res , vol.55 , pp. 560-569
    • Pascale, A.1    Amadio, M.2    Govoni, S.3    Battaini, F.4
  • 6
    • 0032922388 scopus 로고    scopus 로고
    • Protein kinases: Which one is the memory molecule?
    • Micheau J, Riedel G. Protein kinases: which one is the memory molecule? Cell Mol Life Sci 1999; 55: 534-548
    • (1999) Cell Mol Life Sci , vol.55 , pp. 534-548
    • Micheau, J.1    Riedel, G.2
  • 7
    • 33748932680 scopus 로고    scopus 로고
    • Brain plasticity and mental processes: Cajal again
    • DeFelipe J. Brain plasticity and mental processes: Cajal again. Nat Rev Neurosci 2006; 7: 811-817
    • (2006) Nat Rev Neurosci , vol.7 , pp. 811-817
    • DeFelipe, J.1
  • 8
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function: Plasticity, network dynamics, and cognition
    • Rosenzweig ES, Barnes CA. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol 2003; 69: 143-179
    • (2003) Prog Neurobiol , vol.69 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 9
    • 0015799240 scopus 로고
    • Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
    • Bliss TV, Lømo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 1973; 232: 331-356
    • (1973) J Physiol , vol.232 , pp. 331-356
    • Bliss, T.V.1    Lømo, T.2
  • 10
    • 42249097894 scopus 로고    scopus 로고
    • The substrates of memory: Defects, treatments, and enhancement
    • Lynch G, Rex CS, Chen LY, Gall CM. The substrates of memory: defects, treatments, and enhancement. Eur J Pharmacol 2008; 585: 2-13.
    • (2008) Eur J Pharmacol , vol.585 , pp. 2-13
    • Lynch, G.1    Rex, C.S.2    Chen, L.Y.3    Gall, C.M.4
  • 11
    • 8444234659 scopus 로고    scopus 로고
    • Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: Role of secreted proteins tPA and BDNF
    • Pang PT, Lu B. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing Res Rev 2004; 3: 407-430
    • (2004) Ageing Res Rev , vol.3 , pp. 407-430
    • Pang, P.T.1    Lu, B.2
  • 12
    • 0036828992 scopus 로고    scopus 로고
    • Memory enhancement: The search for mechanism-based drugs
    • Lynch G. Memory enhancement: the search for mechanism-based drugs. Nat Neurosci 2002; 5: 1035-1038
    • (2002) Nat Neurosci , vol.5 , pp. 1035-1038
    • Lynch, G.1
  • 13
    • 34250731745 scopus 로고    scopus 로고
    • Happy birthday protein kinase C: Past, present and future of a superfamily
    • Battaini F, Mochly-Rosen D. Happy birthday protein kinase C: past, present and future of a superfamily. Pharmacol Res 2007; 55: 461-466
    • (2007) Pharmacol Res , vol.55 , pp. 461-466
    • Battaini, F.1    Mochly-Rosen, D.2
  • 14
    • 58149350128 scopus 로고    scopus 로고
    • Protein kinase C
    • Newton AC. Protein kinase C. IUBMB Life 2008; 60: 765-768
    • (2008) IUBMB Life , vol.60 , pp. 765-768
    • Newton, A.C.1
  • 15
    • 0028216874 scopus 로고
    • The protein kinase C family for neuronal signaling
    • Tanaka C, Nishizuka Y. The protein kinase C family for neuronal signaling. Annu Rev Neurosci 1994; 17: 551-567
    • (1994) Annu Rev Neurosci , vol.17 , pp. 551-567
    • Tanaka, C.1    Nishizuka, Y.2
  • 16
    • 66349096059 scopus 로고    scopus 로고
    • Lipid activation of protein kinases
    • Newton AC. Lipid activation of protein kinases. J Lipid Res 2009; 50: S266-S71.
    • (2009) J Lipid Res , vol.50
    • Newton, A.C.1
  • 17
    • 0035204621 scopus 로고    scopus 로고
    • Protein kinase C isoforms as therapeutic targets in nervous system disease states
    • Battaini F. Protein kinase C isoforms as therapeutic targets in nervous system disease states. Pharmacol Res 2001; 44: 353-361
    • (2001) Pharmacol Res , vol.44 , pp. 353-361
    • Battaini, F.1
  • 19
    • 0030995406 scopus 로고    scopus 로고
    • Learning-induced alterations in hippocampal PKC-immunoreactivity: A review and hypothesis of its functional significance
    • Van der Zee EA, Luiten PG, Disterhoft JF. Learning-induced alterations in hippocampal PKC-immunoreactivity: a review and hypothesis of its functional significance. Prog Neuropsychopharmacol Biol Psychiatry 1997; 21: 531-572
    • (1997) Prog Neuropsychopharmacol Biol Psychiatry , vol.21 , pp. 531-572
    • Van Der Zee, E.A.1    Luiten, P.G.2    Disterhoft, J.F.3
  • 20
    • 0029002869 scopus 로고
    • Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice
    • Bowers BJ, Christensen SC, Pauley JR, Paylor R, Yuva L, Dunbar SE, et al. Protein and molecular characterization of hippocampal protein kinase C in C57BL/6 and DBA/2 mice. J Neurochem 1995; 64: 2737-2746
    • (1995) J Neurochem , vol.64 , pp. 2737-2746
    • Bowers, B.J.1    Christensen, S.C.2    Pauley, J.R.3    Paylor, R.4    Yuva, L.5    Dunbar, S.E.6
  • 21
    • 0027221644 scopus 로고
    • Associative learning potentiates protein kinase C activation in synaptosomes of the rabbit hippocampus
    • Sunayashiki-Kusuzaki K, Lester DS, Schreurs BG, Alkon DL. Associative learning potentiates protein kinase C activation in synaptosomes of the rabbit hippocampus. Proc Natl Acad Sci USA 1993; 90: 4286-4289
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4286-4289
    • Sunayashiki-Kusuzaki, K.1    Lester, D.S.2    Schreurs, B.G.3    Alkon, D.L.4
  • 22
    • 0033578855 scopus 로고    scopus 로고
    • Long-term potentiation-a decade of progress?
    • Malenka RC, Nicoll RA. Long-term potentiation-a decade of progress? Science 1999; 285: 1870-1874
    • (1999) Science , vol.285 , pp. 1870-1874
    • Malenka, R.C.1    Nicoll, R.A.2
  • 23
    • 0038518145 scopus 로고    scopus 로고
    • Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression
    • Chung HJ, Steinberg JP, Huganir RL, Linden DJ. Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 2003; 300: 1751-1755
    • (2003) Science , vol.300 , pp. 1751-1755
    • Chung, H.J.1    Steinberg, J.P.2    Huganir, R.L.3    Linden, D.J.4
  • 24
    • 41349089303 scopus 로고    scopus 로고
    • PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage
    • Sacktor TC. PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage. Prog Brain Res 2008; 169: 27-40.
    • (2008) Prog Brain Res , vol.169 , pp. 27-40
    • Sacktor, T.C.1
  • 26
    • 0027787664 scopus 로고
    • PKC γ mutant mice exhibit mild deficits in spatial and contextual learning
    • Abeliovich A, Paylor R, Chen C, Kim JJ, Wehner JM, Tonegawa S. PKC γ mutant mice exhibit mild deficits in spatial and contextual learning. Cell 1993; 75: 1263-1271
    • (1993) Cell , vol.75 , pp. 1263-1271
    • Abeliovich, A.1    Paylor, R.2    Chen, C.3    Kim, J.J.4    Wehner, J.M.5    Tonegawa, S.6
  • 27
    • 0029591742 scopus 로고
    • Impaired synapse elimination during cerebellar development in PKC γ mutant mice
    • Kano M, Hashimoto K, Chen C, Abeliovich A, Aiba A, Kurihara H, et al. Impaired synapse elimination during cerebellar development in PKC γ mutant mice. Cell 1995; 83: 1223-1231
    • (1995) Cell , vol.83 , pp. 1223-1231
    • Kano, M.1    Hashimoto, K.2    Chen, C.3    Abeliovich, A.4    Aiba, A.5    Kurihara, H.6
  • 28
    • 0029620817 scopus 로고
    • Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC γ mutant mice
    • Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, et al. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC γ mutant mice. Cell 1995; 83: 1233-1242
    • (1995) Cell , vol.83 , pp. 1233-1242
    • Chen, C.1    Kano, M.2    Abeliovich, A.3    Chen, L.4    Bao, S.5    Kim, J.J.6
  • 29
    • 24944578263 scopus 로고    scopus 로고
    • Genetic enhancement of visual learning by activation of protein kinase C pathways in small groups of rat cortical neurons
    • Zhang GR, Wang X, Kong L, Lu X, Lee B, Liu M, et al. Genetic enhancement of visual learning by activation of protein kinase C pathways in small groups of rat cortical neurons. J Neurosci 2005; 25: 8468-8481
    • (2005) J Neurosci , vol.25 , pp. 8468-8481
    • Zhang, G.R.1    Wang, X.2    Kong, L.3    Lu, X.4    Lee, B.5    Liu, M.6
  • 30
    • 0035975648 scopus 로고    scopus 로고
    • Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons
    • Neill JC, Sarkisian MR, Wang Y, Liu Z, Yu L, Tandon P, et al. Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons. Mol Brain Res 2001; 93: 127-136
    • (2001) Mol Brain Res , vol.93 , pp. 127-136
    • Neill, J.C.1    Sarkisian, M.R.2    Wang, Y.3    Liu, Z.4    Yu, L.5    Tandon, P.6
  • 31
    • 0027997694 scopus 로고
    • Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: "in vitro" and "in vivo" studies
    • Pascale A, Milano S, Corsico N, Lucchi L, Battaini F, Arrigoni E, et al. Protein kinase C activation and anti-amnesic effect of acetyl-L-carnitine: "in vitro" and "in vivo" studies. Eur J Pharmacol 1994; 265: 1-7.
    • (1994) Eur J Pharmacol , vol.265 , pp. 1-7
    • Pascale, A.1    Milano, S.2    Corsico, N.3    Lucchi, L.4    Battaini, F.5    Arrigoni, E.6
  • 32
    • 0027332653 scopus 로고
    • Cognition stimulating drugs modulate PKC activity in cerebral cortex and hippocampus of adult rats
    • Lucchi L, Pascale A, Battaini F, Govoni S, Trabucchi M. Cognition stimulating drugs modulate PKC activity in cerebral cortex and hippocampus of adult rats. Life Sci 1993; 53: 1821-1832
    • (1993) Life Sci , vol.53 , pp. 1821-1832
    • Lucchi, L.1    Pascale, A.2    Battaini, F.3    Govoni, S.4    Trabucchi, M.5
  • 33
    • 0036198571 scopus 로고    scopus 로고
    • Aniracetam improves contextual fear conditioning and increases hippocampal γ-PKC activation in DBA/2J mice
    • Smith AM, Wehner JM. Aniracetam improves contextual fear conditioning and increases hippocampal γ-PKC activation in DBA/2J mice. Hippocampus 2002; 12: 76-85.
    • (2002) Hippocampus , vol.12 , pp. 76-85
    • Smith, A.M.1    Wehner, J.M.2
  • 34
    • 0024500148 scopus 로고
    • Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release
    • Friedman E, Wang HY. Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release. J Neurochem 1989; 52: 187-192
    • (1989) J Neurochem , vol.52 , pp. 187-192
    • Friedman, E.1    Wang, H.Y.2
  • 35
    • 0025125366 scopus 로고
    • Regulation of phorbol ester binding and protein kinase C activity in aged rat brain
    • Battaini F, Del Vesco R, Govoni S, Trabucchi M. Regulation of phorbol ester binding and protein kinase C activity in aged rat brain. Neurobiol Aging 1990; 11: 563-566
    • (1990) Neurobiol Aging , vol.11 , pp. 563-566
    • Battaini, F.1    Del Vesco, R.2    Govoni, S.3    Trabucchi, M.4
  • 37
    • 0029851919 scopus 로고    scopus 로고
    • Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex
    • Pascale A, Fortino I, Govoni S, Trabucchi M, Wetsel WC, Battaini F. Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. J Neurochem 1996; 67: 2471-2477
    • (1996) J Neurochem , vol.67 , pp. 2471-2477
    • Pascale, A.1    Fortino, I.2    Govoni, S.3    Trabucchi, M.4    Wetsel, W.C.5    Battaini, F.6
  • 38
    • 0031444196 scopus 로고    scopus 로고
    • Spatial memory is related to hippocampal subcellular concentrations of calcium- Dependent protein kinase C isoforms in young and aged rats
    • Colombo PJ, Wetsel WC, Gallagher M. Spatial memory is related to hippocampal subcellular concentrations of calcium- dependent protein kinase C isoforms in young and aged rats. Proc Natl Acad Sci USA 1997; 94: 14195-14199
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14195-14199
    • Colombo, P.J.1    Wetsel, W.C.2    Gallagher, M.3
  • 39
    • 0036229301 scopus 로고    scopus 로고
    • Individual differences in spatial memory among aged rats are related to hippocampal PKC γ immunoreactivity
    • Colombo PJ, Gallagher M. Individual differences in spatial memory among aged rats are related to hippocampal PKC γ immunoreactivity. Hippocampus 2002; 12: 285-289
    • (2002) Hippocampus , vol.12 , pp. 285-289
    • Colombo, P.J.1    Gallagher, M.2
  • 40
    • 10044297404 scopus 로고    scopus 로고
    • Spatial memory in aged rats is related to PKCγ-dependent G-protein coupling of the M1 receptor
    • Rossi MA, Mash DC, deToledo-Morrell L. Spatial memory in aged rats is related to PKCγ-dependent G-protein coupling of the M1 receptor. Neurobiol Aging 2005; 26: 53-68.
    • (2005) Neurobiol Aging , vol.26 , pp. 53-68
    • Rossi, M.A.1    Mash, D.C.2    DeToledo-Morrell, L.3
  • 42
    • 0027177629 scopus 로고
    • Effects of aging on spatial learning and hippocampal protein kinase C in mice
    • Fordyce DE, Wehner JM. Effects of aging on spatial learning and hippocampal protein kinase C in mice. Neurobiol Aging 1993; 14: 309-317
    • (1993) Neurobiol Aging , vol.14 , pp. 309-317
    • Fordyce, D.E.1    Wehner, J.M.2
  • 44
    • 0031964645 scopus 로고    scopus 로고
    • Anchoring proteins for PKC: A means for isoenzyme selectivity
    • Mochly Rosen D, Gordon AS. Anchoring proteins for PKC: a means for isoenzyme selectivity. FASEB J 1998; 12: 35-42.
    • (1998) FASEB J , vol.12 , pp. 35-42
    • Mochly Rosen, D.1    Gordon, A.S.2
  • 45
    • 34250757608 scopus 로고    scopus 로고
    • Insight into intra- And inter-molecular interactions of PKC: Design of specific modulators of kinase function
    • Kheifets V, Mochly-Rosen D. Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacol Res 2007; 55: 467-476
    • (2007) Pharmacol Res , vol.55 , pp. 467-476
    • Kheifets, V.1    Mochly-Rosen, D.2
  • 46
    • 4444262821 scopus 로고    scopus 로고
    • Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs
    • Sanguino E, Roglans N, Alegret M, Sánchez RM, Vázquez- Carrera M, Laguna JC. Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs. Biochem Pharmacol 2004; 68: 1411-1421
    • (2004) Biochem Pharmacol , vol.68 , pp. 1411-1421
    • Sanguino, E.1    Roglans, N.2    Alegret, M.3    Sánchez, R.M.4    Vázquez-Carrera, M.5    Laguna, J.C.6
  • 47
    • 0030813899 scopus 로고    scopus 로고
    • The role of anchoring protein RACK1 in PKC activation in the ageing rat brain
    • Battaini F, Pascale A, Paoletti R, Govoni S. The role of anchoring protein RACK1 in PKC activation in the ageing rat brain. Trends Neurosci 1997; 20: 410-415
    • (1997) Trends Neurosci , vol.20 , pp. 410-415
    • Battaini, F.1    Pascale, A.2    Paoletti, R.3    Govoni, S.4
  • 48
    • 0035667276 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and the relationship with aging and memory: A possible link with protein kinase C functional machinery
    • Racchi M, Govoni S, Solerte SB, Galli CL, Corsini E. Dehydroepiandrosterone and the relationship with aging and memory: a possible link with protein kinase C functional machinery. Brain Res Brain Res Rev 2001; 37: 287-293
    • (2001) Brain Res Brain Res Rev , vol.37 , pp. 287-293
    • Racchi, M.1    Govoni, S.2    Solerte, S.B.3    Galli, C.L.4    Corsini, E.5
  • 49
    • 0028294993 scopus 로고
    • Inositol 1,4,5 trisphosphate receptor and ryanodine receptor in the aging brain of Wistar rats
    • Martini A, Battaini F, Govoni S, Volpe P. Inositol 1,4,5 trisphosphate receptor and ryanodine receptor in the aging brain of Wistar rats. Neurobiol Aging 1994; 15: 203-206
    • (1994) Neurobiol Aging , vol.15 , pp. 203-206
    • Martini, A.1    Battaini, F.2    Govoni, S.3    Volpe, P.4
  • 50
    • 0031853418 scopus 로고    scopus 로고
    • Age-related alteration of PKC, a key enzyme in memory processes: Physiological and pathological examples
    • Pascale A, Govoni S, Battaini F. Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples. Mol Neurobiol 1998; 16: 49-56
    • (1998) Mol Neurobiol , vol.16 , pp. 49-56
    • Pascale, A.1    Govoni, S.2    Battaini, F.3
  • 51
    • 0028339544 scopus 로고
    • Attenuated protein kinase C activity and translocation in Alzheimer's disease brain
    • Wang HY, Pisano MR, Friedman E. Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol Aging 1994; 15: 293-298
    • (1994) Neurobiol Aging , vol.15 , pp. 293-298
    • Wang, H.Y.1    Pisano, M.R.2    Friedman, E.3
  • 52
    • 0032865258 scopus 로고    scopus 로고
    • Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients
    • Battaini F, Pascale A, Lucchi L, Pasinetti GM, Govoni S. Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients. Exp Neurol 1999; 159: 559-564
    • (1999) Exp Neurol , vol.159 , pp. 559-564
    • Battaini, F.1    Pascale, A.2    Lucchi, L.3    Pasinetti, G.M.4    Govoni, S.5
  • 53
    • 66049123115 scopus 로고    scopus 로고
    • Improved spatial learning in aged rats by genetic activation of protein kinase C in small groups of hippocampal neurons
    • Zhang GR, Liu M, Cao H, Kong L, Wang X, O'Brien JA, et al. Improved spatial learning in aged rats by genetic activation of protein kinase C in small groups of hippocampal neurons. Hippocampus 2009; 19: 413-423
    • (2009) Hippocampus , vol.19 , pp. 413-423
    • Zhang, G.R.1    Liu, M.2    Cao, H.3    Kong, L.4    Wang, X.5    O'Brien, J.A.6
  • 54
    • 32244440146 scopus 로고    scopus 로고
    • Protein kinase C signal transduction regulation in physiological and pathological aging
    • Battaini F, Pascale A. Protein kinase C signal transduction regulation in physiological and pathological aging. Ann NY Acad Sci 2005; 1057: 177-192
    • (2005) Ann NY Acad Sci , vol.1057 , pp. 177-192
    • Battaini, F.1    Pascale, A.2
  • 55
    • 33751187120 scopus 로고    scopus 로고
    • Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats
    • Liu J, He QJ, Zou W, Wang HX, Bao YM, Liu YX, et al. Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats. Brain Res 2006; 1123: 68-79.
    • (2006) Brain Res , vol.1123 , pp. 68-79
    • Liu, J.1    He, Q.J.2    Zou, W.3    Wang, H.X.4    Bao, Y.M.5    Liu, Y.X.6
  • 56
    • 60349116815 scopus 로고    scopus 로고
    • Comparative neuroprotective properties of stilbene and catechin analogs: Action via a plasma membrane receptor site?
    • Bastianetto S, Dumont Y, Han Y, Quirion R. Comparative neuroprotective properties of stilbene and catechin analogs: action via a plasma membrane receptor site? CNS Neurosci Ther 2009; 15:76-83.
    • (2009) CNS Neurosci Ther , vol.15 , pp. 76-83
    • Bastianetto, S.1    Dumont, Y.2    Han, Y.3    Quirion, R.4
  • 58
    • 33744465230 scopus 로고    scopus 로고
    • PKC epsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
    • Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, et al. PKC epsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci USA 2006; 103: 8215-8220
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8215-8220
    • Choi, D.S.1    Wang, D.2    Yu, G.Q.3    Zhu, G.4    Kharazia, V.N.5    Paredes, J.P.6
  • 59
    • 0037736704 scopus 로고    scopus 로고
    • Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model
    • Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, et al. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 2003; 6: 153-162
    • (2003) Nutr Neurosci , vol.6 , pp. 153-162
    • Joseph, J.A.1    Denisova, N.A.2    Arendash, G.3    Gordon, M.4    Diamond, D.5    Shukitt-Hale, B.6
  • 60
    • 0031985192 scopus 로고    scopus 로고
    • Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease
    • Gasparini L, Racchi M, Binetti G, Trabucchi M, Solerte SB, Alkon D, et al. Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease. FASEB J 1998; 12: 17-34.
    • (1998) FASEB J , vol.12 , pp. 17-34
    • Gasparini, L.1    Racchi, M.2    Binetti, G.3    Trabucchi, M.4    Solerte, S.B.5    Alkon, D.6
  • 61
    • 0031820045 scopus 로고    scopus 로고
    • Increased natural killer cell cytotoxicity in Alzheimer's disease may involve protein kinase C dysregulation
    • Solerte SB, Fioravanti M, Pascale A, Ferrari E, Govoni S, Battaini F. Increased natural killer cell cytotoxicity in Alzheimer's disease may involve protein kinase C dysregulation. Neurobiol Aging 1998; 19: 191-199
    • (1998) Neurobiol Aging , vol.19 , pp. 191-199
    • Solerte, S.B.1    Fioravanti, M.2    Pascale, A.3    Ferrari, E.4    Govoni, S.5    Battaini, F.6
  • 63
    • 7444256727 scopus 로고    scopus 로고
    • Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
    • Birnbaum SG, Yuan PX, Wang M, Vijayraghvan S, Bloom AK, Davis DJ, et al. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science 2004; 306: 882-884
    • (2004) Science , vol.306 , pp. 882-884
    • Birnbaum, S.G.1    Yuan, P.X.2    Wang, M.3    Vijayraghvan, S.4    Bloom, A.K.5    Davis, D.J.6
  • 64
    • 34250703569 scopus 로고    scopus 로고
    • Classical PKC isoforms in cancer
    • Martiny-Baron G, Fabbro D. Classical PKC isoforms in cancer. Pharmacol Res 2007; 55: 477-486
    • (2007) Pharmacol Res , vol.55 , pp. 477-486
    • Martiny-Baron, G.1    Fabbro, D.2
  • 65
    • 33846528583 scopus 로고    scopus 로고
    • PKC signaling deficits: A mechanistic hypothesis for the origins of Alzheimer's disease
    • Alkon DL, Sun MK, Nelson TJ. PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease. Trends Pharmacol Sci 2007; 28: 51-60.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 51-60
    • Alkon, D.L.1    Sun, M.K.2    Nelson, T.J.3
  • 66
    • 33644685637 scopus 로고    scopus 로고
    • The role of protein kinase C in cerebral ischemic and reperfusion injury
    • Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke 2005; 36: 2781-2790
    • (2005) Stroke , vol.36 , pp. 2781-2790
    • Bright, R.1    Mochly-Rosen, D.2
  • 67
    • 0029880976 scopus 로고    scopus 로고
    • A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices
    • Nguyen PV, Kandel ER. A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. J Neurosci 1996; 16: 3189-3198
    • (1996) J Neurosci , vol.16 , pp. 3189-3198
    • Nguyen, P.V.1    Kandel, E.R.2
  • 68
    • 2542439651 scopus 로고    scopus 로고
    • Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
    • Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR. Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. Nat Neurosci 2004; 7: 635-642
    • (2004) Nat Neurosci , vol.7 , pp. 635-642
    • Wang, H.1    Ferguson, G.D.2    Pineda, V.V.3    Cundiff, P.E.4    Storm, D.R.5
  • 69
    • 0033180362 scopus 로고    scopus 로고
    • Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP
    • Wong ST, Athos J, Figueroa XA, Pineda VV, Schaefer ML, Chavkin CC, et al. Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 1999; 23: 787-798
    • (1999) Neuron , vol.23 , pp. 787-798
    • Wong, S.T.1    Athos, J.2    Figueroa, X.A.3    Pineda, V.V.4    Schaefer, M.L.5    Chavkin, C.C.6
  • 70
    • 0027203084 scopus 로고
    • Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
    • Frey U, Huang YY, Kandel ER. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 1993; 260: 1661-1664
    • (1993) Science , vol.260 , pp. 1661-1664
    • Frey, U.1    Huang, Y.Y.2    Kandel, E.R.3
  • 71
    • 0031196961 scopus 로고    scopus 로고
    • Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats
    • Bernabeu R, Cammarota M, Izquierdo I, Medina JH. Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats. Braz J Med Biol Res 1997; 30: 961-965
    • (1997) Braz J Med Biol Res , vol.30 , pp. 961-965
    • Bernabeu, R.1    Cammarota, M.2    Izquierdo, I.3    Medina, J.H.4
  • 72
    • 0032125869 scopus 로고    scopus 로고
    • Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala
    • Huang YY, Kandel ER. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron 1998; 21: 169-178
    • (1998) Neuron , vol.21 , pp. 169-178
    • Huang, Y.Y.1    Kandel, E.R.2
  • 74
    • 0032426667 scopus 로고    scopus 로고
    • Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
    • Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA 1998; 95: 15020-15025
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15020-15025
    • Barad, M.1    Bourtchouladze, R.2    Winder, D.G.3    Golan, H.4    Kandel, E.5
  • 75
    • 0034051217 scopus 로고    scopus 로고
    • Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism
    • Zhang HT, Crissman AM, Dorairaj NR, Chandler LJ, O'Donnell JM. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology 2000; 23: 198-204.
    • (2000) Neuropsychopharmacology , vol.23 , pp. 198-204
    • Zhang, H.T.1    Crissman, A.M.2    Dorairaj, N.R.3    Chandler, L.J.4    O'Donnell, J.M.5
  • 76
    • 0033922848 scopus 로고    scopus 로고
    • Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats
    • Berl
    • Zhang HT, O'Donnell JM. Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats. Psychopharmacology (Berl) 2000; 150: 311-316
    • (2000) Psychopharmacology , vol.150 , pp. 311-316
    • Zhang, H.T.1    O'Donnell, J.M.2
  • 78
    • 0242573351 scopus 로고    scopus 로고
    • Age-related memory impairment. Is the cure worse than the disease?
    • Baxter MG. Age-related memory impairment. Is the cure worse than the disease? Neuron 2003; 40: 669-670
    • (2003) Neuron , vol.40 , pp. 669-670
    • Baxter, M.G.1
  • 79
    • 0242460552 scopus 로고    scopus 로고
    • Dysregulation of protein kinase a signaling in the aged prefrontal cortex: New strategy for treating age-related cognitive decline
    • Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AF. Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Neuron 2003; 40: 835-845
    • (2003) Neuron , vol.40 , pp. 835-845
    • Ramos, B.P.1    Birnbaum, S.G.2    Lindenmayer, I.3    Newton, S.S.4    Duman, R.S.5    Arnsten, A.F.6
  • 80
    • 0033232469 scopus 로고    scopus 로고
    • A role for norepinephrine in stress-induced cognitive deficits: Alpha-1-adrenoceptor mediation in the prefrontal cortex
    • Birnbaum S, Gobeske KT, Auerbach J, Taylor JR, Arnsten AF. A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex. Biol Psychiatry 1999; 46: 1266-1274
    • (1999) Biol Psychiatry , vol.46 , pp. 1266-1274
    • Birnbaum, S.1    Gobeske, K.T.2    Auerbach, J.3    Taylor, J.R.4    Arnsten, A.F.5
  • 81
    • 0242689354 scopus 로고    scopus 로고
    • Activation of cAMP-dependent protein kinase a in prefrontal cortex impairs working memory performance
    • Taylor JR, Birnbaum S, Ubriani R, Arnsten AF. Activation of cAMP-dependent protein kinase A in prefrontal cortex impairs working memory performance. J Neurosci 1999; 19: RC23.
    • (1999) J Neurosci , vol.19
    • Taylor, J.R.1    Birnbaum, S.2    Ubriani, R.3    Arnsten, A.F.4
  • 83
    • 0029950182 scopus 로고    scopus 로고
    • CREB and the formation of long-term memory
    • Yin JC, Tully T. CREB and the formation of long-term memory. Curr Opin Neurobiol 1996; 6: 264-268
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 264-268
    • Yin, J.C.1    Tully, T.2
  • 84
    • 0030463470 scopus 로고    scopus 로고
    • CREB phosphorylation and dephosphorylation: A Ca(2+)- And stimulus duration-dependent switch for hippocampal gene expression
    • Bito H, Deisseroth K, Tsien RW. CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell 1996; 87: 1203-1214
    • (1996) Cell , vol.87 , pp. 1203-1214
    • Bito, H.1    Deisseroth, K.2    Tsien, R.W.3
  • 85
    • 0033493229 scopus 로고    scopus 로고
    • Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus
    • Lu YF, Kandel ER, Hawkins RD. Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus. J Neurosci 1999; 19: 10250-10261
    • (1999) J Neurosci , vol.19 , pp. 10250-10261
    • Lu, Y.F.1    Kandel, E.R.2    Hawkins, R.D.3
  • 87
    • 0037040402 scopus 로고    scopus 로고
    • Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture
    • Barco A, Alarcon JM, Kandel ER. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 2002; 108: 689-703.
    • (2002) Cell , vol.108 , pp. 689-703
    • Barco, A.1    Alarcon, J.M.2    Kandel, E.R.3
  • 88
    • 0031036208 scopus 로고    scopus 로고
    • Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein
    • Murphy DD, Segal M. Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein. Proc Natl Acad Sci USA 1997; 94: 1482-1487
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1482-1487
    • Murphy, D.D.1    Segal, M.2
  • 89
    • 0345118873 scopus 로고    scopus 로고
    • Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments
    • Brightwell JJ, Gallagher M, Colombo PJ. Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments. Neurobiol Learn Mem 2004; 81: 19-26.
    • (2004) Neurobiol Learn Mem , vol.81 , pp. 19-26
    • Brightwell, J.J.1    Gallagher, M.2    Colombo, P.J.3
  • 90
    • 33645226449 scopus 로고    scopus 로고
    • Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats
    • Mouravlev A, Dunning J, Young D, During MJ. Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats. Proc Natl Acad Sci USA 2006; 103: 4705-4710
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4705-4710
    • Mouravlev, A.1    Dunning, J.2    Young, D.3    During, M.J.4
  • 91
    • 0036968513 scopus 로고    scopus 로고
    • Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats
    • Nagakura A, Niimura M, Takeo S. Effects of a phosphodiesterase IV inhibitor rolipram on microsphere embolism-induced defects in memory function and cerebral cyclic AMP signal transduction system in rats. Br J Pharmacol 2002; 135: 1783-1793
    • (2002) Br J Pharmacol , vol.135 , pp. 1783-1793
    • Nagakura, A.1    Niimura, M.2    Takeo, S.3
  • 93
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci 2002; 25: 103-126
    • (2002) Annu Rev Neurosci , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 94
    • 0024461379 scopus 로고
    • Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP
    • Malinow R, Schulman H, Tsien RW. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science 1989; 245: 862-866
    • (1989) Science , vol.245 , pp. 862-866
    • Malinow, R.1    Schulman, H.2    Tsien, R.W.3
  • 95
    • 0026637195 scopus 로고
    • Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice
    • Silva AJ, Stevens CF, Tonegawa S, Wang Y. Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 1992; 257: 201-206
    • (1992) Science , vol.257 , pp. 201-206
    • Silva, A.J.1    Stevens, C.F.2    Tonegawa, S.3    Wang, Y.4
  • 96
    • 0028486257 scopus 로고
    • The role of calcium-calmodulin kinase II in three forms of synaptic plasticity
    • Stevens CF, Tonegawa S, Wang Y. The role of calcium-calmodulin kinase II in three forms of synaptic plasticity. Curr Biol 1994; 4:687-693
    • (1994) Curr Biol , vol.4 , pp. 687-693
    • Stevens, C.F.1    Tonegawa, S.2    Wang, Y.3
  • 97
    • 0028033340 scopus 로고
    • Spatial and temporal changes in signal transduction pathways during LTP
    • Thomas KL, Laroche S, Errington ML, Bliss TV, Hunt SP. Spatial and temporal changes in signal transduction pathways during LTP. Neuron 1994; 13: 737-745
    • (1994) Neuron , vol.13 , pp. 737-745
    • Thomas, K.L.1    Laroche, S.2    Errington, M.L.3    Bliss, T.V.4    Hunt, S.P.5
  • 98
    • 0033568865 scopus 로고    scopus 로고
    • Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons
    • Ouyang Y, Rosenstein A, Kreiman G, Schuman EM, Kennedy MB. Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J Neurosci 1999; 19: 7823-7833
    • (1999) J Neurosci , vol.19 , pp. 7823-7833
    • Ouyang, Y.1    Rosenstein, A.2    Kreiman, G.3    Schuman, E.M.4    Kennedy, M.B.5
  • 99
    • 0026742451 scopus 로고
    • Impaired spatial learning in α-calcium-calmodulin kinase II mutant mice
    • Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial learning in α-calcium-calmodulin kinase II mutant mice. Science 1992; 257: 206-211
    • (1992) Science , vol.257 , pp. 206-211
    • Silva, A.J.1    Paylor, R.2    Wehner, J.M.3    Tonegawa, S.4
  • 100
    • 23844454133 scopus 로고    scopus 로고
    • Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro
    • Ahmed T, Frey JU. Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro. Neuropharmacology 2005; 49: 477-492
    • (2005) Neuropharmacology , vol.49 , pp. 477-492
    • Ahmed, T.1    Frey, J.U.2
  • 101
    • 38749125113 scopus 로고    scopus 로고
    • Alpha calcium/calmodulin dependent protein kinase II in learning-dependent plasticity of mouse somatosensory cortex
    • Skibinska-Kijek A, Radwanska A, Kossut M. Alpha calcium/calmodulin dependent protein kinase II in learning-dependent plasticity of mouse somatosensory cortex. Neuroscience 2008; 151: 750-757
    • (2008) Neuroscience , vol.151 , pp. 750-757
    • Skibinska-Kijek, A.1    Radwanska, A.2    Kossut, M.3
  • 102
    • 60349108170 scopus 로고    scopus 로고
    • Age-related expression of calcium/calmodulin-dependent protein kinase II a in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs
    • Zhang GR, Cheng XR, Zhou WX, Zhang YX. Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs. Neuroscience 2009; 159: 308-315
    • (2009) Neuroscience , vol.159 , pp. 308-315
    • Zhang, G.R.1    Cheng, X.R.2    Zhou, W.X.3    Zhang, Y.X.4
  • 103
    • 0025014874 scopus 로고
    • Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase
    • McKee AC, Kosik KS, Kennedy MB, Kowall NW. Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase. J Neuropathol Exp Neurol 1990; 49: 49-63.
    • (1990) J Neuropathol Exp Neurol , vol.49 , pp. 49-63
    • McKee, A.C.1    Kosik, K.S.2    Kennedy, M.B.3    Kowall, N.W.4
  • 104
    • 0028297574 scopus 로고
    • Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease
    • Murray KD, Gall CM, Jones EG, Isackson PJ. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience 1994; 60: 37-48.
    • (1994) Neuroscience , vol.60 , pp. 37-48
    • Murray, K.D.1    Gall, C.M.2    Jones, E.G.3    Isackson, P.J.4
  • 105
    • 0036293402 scopus 로고    scopus 로고
    • Injection of bradykinin or cyclosporine a to hippocampus induces Alzheimer-like phosphorylation of tau and abnormal behavior in rats
    • Engl
    • Wang Q, Wang J. Injection of bradykinin or cyclosporine A to hippocampus induces Alzheimer-like phosphorylation of tau and abnormal behavior in rats. Chin Med J (Engl) 2002; 115: 884-887
    • (2002) Chin Med J , vol.115 , pp. 884-887
    • Wang, Q.1    Wang, J.2
  • 106
    • 52049121528 scopus 로고    scopus 로고
    • Calmodulin-kinases: Modulators of neuronal development and plasticity
    • Wayman GA, Lee YS, Tokumitsu H, Silva A, Soderling TR. Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron 2008; 59: 914-931
    • (2008) Neuron , vol.59 , pp. 914-931
    • Wayman, G.A.1    Lee, Y.S.2    Tokumitsu, H.3    Silva, A.4    Soderling, T.R.5
  • 107
    • 54049107769 scopus 로고    scopus 로고
    • Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging
    • Fukushima H, Maeda R, Suzuki R, Suzuki A, Nomoto M, Toyoda H, et al. Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J Neurosci 2008; 28: 9910-9919
    • (2008) J Neurosci , vol.28 , pp. 9910-9919
    • Fukushima, H.1    Maeda, R.2    Suzuki, R.3    Suzuki, A.4    Nomoto, M.5    Toyoda, H.6
  • 108
    • 0034279245 scopus 로고    scopus 로고
    • Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice
    • Ho N, Liauw JA, Blaeser F, Wei F, Hanissian S, Muglia LM, et al. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci 2000; 20: 6459-6472
    • (2000) J Neurosci , vol.20 , pp. 6459-6472
    • Ho, N.1    Liauw, J.A.2    Blaeser, F.3    Wei, F.4    Hanissian, S.5    Muglia, L.M.6
  • 109
    • 0035929240 scopus 로고    scopus 로고
    • An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
    • Kang H, Sun LD, Atkins CM, Soderling TR, Wilson MA, Tonegawa S. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell 2001; 106: 771-783
    • (2001) Cell , vol.106 , pp. 771-783
    • Kang, H.1    Sun, L.D.2    Atkins, C.M.3    Soderling, T.R.4    Wilson, M.A.5    Tonegawa, S.6
  • 110
    • 0036270962 scopus 로고    scopus 로고
    • Calcium calmodulin-dependent protein kinase IV is required for fear memory
    • Wei F, Qiu CS, Liauw J, Robinson DA, Ho N, Chatila T, et al. Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat Neurosci 2002; 5: 573-579
    • (2002) Nat Neurosci , vol.5 , pp. 573-579
    • Wei, F.1    Qiu, C.S.2    Liauw, J.3    Robinson, D.A.4    Ho, N.5    Chatila, T.6
  • 111
    • 3042631024 scopus 로고    scopus 로고
    • Gene regulation and DNA damage in the ageing human brain
    • Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, et al. Gene regulation and DNA damage in the ageing human brain. Nature 2004; 429: 883-891
    • (2004) Nature , vol.429 , pp. 883-891
    • Lu, T.1    Pan, Y.2    Kao, S.Y.3    Li, C.4    Kohane, I.5    Chan, J.6
  • 113
    • 0032572613 scopus 로고    scopus 로고
    • Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: Effects of insulin treatment
    • Biessels GJ, Kamal A, Urban IJ, Spruijt BM, Erkelens DW, Gispen WH. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res 1998; 800: 125-135
    • (1998) Brain Res , vol.800 , pp. 125-135
    • Biessels, G.J.1    Kamal, A.2    Urban, I.J.3    Spruijt, B.M.4    Erkelens, D.W.5    Gispen, W.H.6
  • 114
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M, Mehta T, Selkoe DJ. Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 2007; 282: 33305-33312
    • (2007) J Biol Chem , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 115
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol 2001; 177: 125-134
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2
  • 116
    • 2942532719 scopus 로고    scopus 로고
    • Emerging targets for the pharmacology of learning and memory
    • Amadio M, Govoni S, Alkon DL, Pascale A. Emerging targets for the pharmacology of learning and memory. Pharmacol Res 2004; 50: 111-122
    • (2004) Pharmacol Res , vol.50 , pp. 111-122
    • Amadio, M.1    Govoni, S.2    Alkon, D.L.3    Pascale, A.4
  • 117
    • 42949114366 scopus 로고    scopus 로고
    • Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
    • Puglielli L. Aging of the brain, neurotrophin signaling, and Alzheimer's disease: is IGF1-R the common culprit? Neurobiol Aging 2008; 29: 795-811.
    • (2008) Neurobiol Aging , vol.29 , pp. 795-811
    • Puglielli, L.1
  • 118
    • 1842633868 scopus 로고    scopus 로고
    • The role of insulin and insulin-like growth factor 1 in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
    • Carro E, Torres-Aleman I. The role of insulin and insulin-like growth factor 1 in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur J Pharmacol 2004; 490: 127-133
    • (2004) Eur J Pharmacol , vol.490 , pp. 127-133
    • Carro, E.1    Torres-Aleman, I.2
  • 119
    • 0037119445 scopus 로고    scopus 로고
    • Region specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats
    • Chung YH, Shin CM, Joo KM, Kim MJ, Cha CI. Region specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats. Brain Res 2002; 946: 307-313
    • (2002) Brain Res , vol.946 , pp. 307-313
    • Chung, Y.H.1    Shin, C.M.2    Joo, K.M.3    Kim, M.J.4    Cha, C.I.5
  • 120
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • doi:10.1016/j.neurobiolaging.2008.04.002
    • Moloney AM, Griffin RJ, Timmons S, O'Connor R, Ravid R, O'Neill C. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 2008; doi:10.1016/j.neurobiolaging.2008.04.002
    • (2008) Neurobiol Aging
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 121
    • 47849123972 scopus 로고    scopus 로고
    • Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-β in memory-impaired older adults
    • Reger MA, Watson GS, Green PS, Baker LD, Cholerton B, Fishel MA, et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-β in memory-impaired older adults. J Alzheimers Dis 2008; 13:323-331
    • (2008) J Alzheimers Dis , vol.13 , pp. 323-331
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3    Baker, L.D.4    Cholerton, B.5    Fishel, M.A.6
  • 123
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • Huang EJ, Reichardt LF. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001; 24: 677-736.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 124
    • 0346219199 scopus 로고    scopus 로고
    • Acute and long-term synaptic modulation by neurotrophins
    • Lu B. Acute and long-term synaptic modulation by neurotrophins. Prog Brain Res 2004; 146: 137-150
    • (2004) Prog Brain Res , vol.146 , pp. 137-150
    • Lu, B.1
  • 125
    • 32644432029 scopus 로고    scopus 로고
    • Clinical relevance of the neurotrophins and their receptors
    • Lond
    • Allen SJ, Dawbarn D. Clinical relevance of the neurotrophins and their receptors. Clin Sci (Lond) 2006; 110: 175-191
    • (2006) Clin Sci , vol.110 , pp. 175-191
    • Allen, S.J.1    Dawbarn, D.2
  • 126
    • 0036830562 scopus 로고    scopus 로고
    • The neurotrophin receptor p75(NTR): Novel functions and implications for diseases of the nervous system
    • Dechant G, BardeYA. The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci 2002; 5: 1131-1136
    • (2002) Nat Neurosci , vol.5 , pp. 1131-1136
    • Dechant, G.1    Barde, Y.A.2
  • 127
    • 26844507790 scopus 로고    scopus 로고
    • A TrkAto-p75NTR molecular switch activates amyloid β-peptide generation during aging
    • Costantini C, Weindruch R, Della Valle G, Puglielli L. A TrkAto-p75NTR molecular switch activates amyloid β-peptide generation during aging. Biochem J 2005, 391: 59-67.
    • (2005) Biochem J , vol.391 , pp. 59-67
    • Costantini, C.1    Weindruch, R.2    Della Valle, G.3    Puglielli, L.4
  • 128
    • 0032714367 scopus 로고    scopus 로고
    • Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus
    • Kelly A, Maguire C, Lynch MA. Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus. Neuroscience 2000; 95: 359-365
    • (2000) Neuroscience , vol.95 , pp. 359-365
    • Kelly, A.1    Maguire, C.2    Ma, L.3
  • 129
    • 28844454312 scopus 로고    scopus 로고
    • Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex
    • Saragovi H. Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex. J Neurochem 2005; 95: 1472-1480
    • (2005) J Neurochem , vol.95 , pp. 1472-1480
    • Saragovi, H.1
  • 130
    • 0029970008 scopus 로고    scopus 로고
    • Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
    • Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 1996; 381: 706-709
    • (1996) Nature , vol.381 , pp. 706-709
    • Figurov, A.1    Pozzo-Miller, L.D.2    Olafsson, P.3    Wang, T.4    Lu, B.5
  • 131
    • 0033563189 scopus 로고    scopus 로고
    • Trks: Signal transduction and intracellular pathways
    • Klesse LJ, Parada LF. Trks: signal transduction and intracellular pathways. Microsc Res Tech 1999; 45: 210-216
    • (1999) Microsc Res Tech , vol.45 , pp. 210-216
    • Klesse, L.J.1    Parada, L.F.2
  • 132
    • 0037100207 scopus 로고    scopus 로고
    • BDNF activated TrkB/IRR receptor chimera promotes survival of sympathetic neurons through Ras and PI-3 kinase signaling
    • Kelly-Spratt KS, Klesse LJ, Parada LF. BDNF activated TrkB/IRR receptor chimera promotes survival of sympathetic neurons through Ras and PI-3 kinase signaling. J Neurosci Res 2002; 69: 151-159
    • (2002) J Neurosci Res , vol.69 , pp. 151-159
    • Kelly-Spratt, K.S.1    Klesse, L.J.2    Parada, L.F.3
  • 133
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000; 10: 381-391
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 135
    • 0032752674 scopus 로고    scopus 로고
    • Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus
    • Maguire C, Casey M, Kelly A, Mullany PM, Lynch MA. Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus. Hippocampus 1999; 9: 519-526
    • (1999) Hippocampus , vol.9 , pp. 519-526
    • Maguire, C.1    Casey, M.2    Kelly, A.3    Mullany, P.M.4    Ma, L.5
  • 136
    • 4644351697 scopus 로고    scopus 로고
    • BDNF-induced LTP in dentate gyrus is impaired with age: Analysis of changes in cell signaling events
    • Gooney M, Messaoudi E, Maher FO, Bramham CR, Lynch MA. BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events. Neurobiol Aging 2004; 25: 1323-1331
    • (2004) Neurobiol Aging , vol.25 , pp. 1323-1331
    • Gooney, M.1    Messaoudi, E.2    Maher, F.O.3    Bramham, C.R.4    Ma, L.5
  • 138
    • 21544452752 scopus 로고    scopus 로고
    • Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus
    • Ramsey MM, Adams MM, Ariwodola OJ, Sonntag WE, Weiner JL. Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J Neurophysiol 2005; 94: 247-254
    • (2005) J Neurophysiol , vol.94 , pp. 247-254
    • Ramsey, M.M.1    Adams, M.M.2    Ariwodola, O.J.3    Sonntag, W.E.4    Weiner, J.L.5
  • 140
    • 2542526131 scopus 로고    scopus 로고
    • Increased IL-1β in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase
    • Maher FO, Martin DS, Lynch MA. Increased IL-1β in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase. Neurobiol Aging 2004; 25: 795-806.
    • (2004) Neurobiol Aging , vol.25 , pp. 795-806
    • Maher, F.O.1    Martin, D.S.2    Ma, L.3
  • 141
    • 23344439553 scopus 로고    scopus 로고
    • Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival
    • Akbar M, Calderon F, Wen Z, Kim HY. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci USA 2005; 102: 10858-10863
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10858-10863
    • Akbar, M.1    Calderon, F.2    Wen, Z.3    Kim, H.Y.4
  • 142
    • 0037598588 scopus 로고    scopus 로고
    • Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator
    • Webster NJ, Park K, Pirrung MC. Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chem Biochem 2003; 4: 379-385
    • (2003) Chem Biochem , vol.4 , pp. 379-385
    • Webster, N.J.1    Park, K.2    Pirrung, M.C.3
  • 143
    • 41449096767 scopus 로고    scopus 로고
    • Neuroprotective effects of sodium orthovanadate after hypoxic-ischemic brain injury in neonatal rats
    • Feng Y, Bhatt AJ, Fratkin JD, Rhodes PG. Neuroprotective effects of sodium orthovanadate after hypoxic-ischemic brain injury in neonatal rats. Brain Res Bull 2008; 76: 102-108
    • (2008) Brain Res Bull , vol.76 , pp. 102-108
    • Feng, Y.1    Bhatt, A.J.2    Fratkin, J.D.3    Rhodes, P.G.4
  • 144
    • 0037010315 scopus 로고    scopus 로고
    • 4-Methylcatechol stimulates phosphorylation of Trk family neurotrophin receptors and MAP kinases in cultured rat cortical neurons
    • Sometani A, Nomoto H, Nitta A, Furukawa Y, Furukawa S. 4-Methylcatechol stimulates phosphorylation of Trk family neurotrophin receptors and MAP kinases in cultured rat cortical neurons. J Neurosci Res 2002; 70: 335-339
    • (2002) J Neurosci Res , vol.70 , pp. 335-339
    • Sometani, A.1    Nomoto, H.2    Nitta, A.3    Furukawa, Y.4    Furukawa, S.5
  • 145
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C. Elegans life-span by insulin-like signalling in the nervous system
    • Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. Elegans life-span by insulin-like signalling in the nervous system. Science 2000; 290: 147-150
    • (2000) Science , vol.290 , pp. 147-150
    • Wolkow, C.A.1    Kimura, K.D.2    Lee, M.S.3    Ruvkun, G.4
  • 147
    • 42149141146 scopus 로고    scopus 로고
    • Functionally significant insulin-like growth factor I receptor mutations in centenarians
    • Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, et al. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci USA 2008; 105: 3438-3442
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3438-3442
    • Suh, Y.1    Atzmon, G.2    Cho, M.O.3    Hwang, D.4    Liu, B.5    Leahy, D.J.6
  • 148
    • 0037240518 scopus 로고    scopus 로고
    • The neurobiology of memory changes in normal aging
    • Erickson CA, Barnes CA. The neurobiology of memory changes in normal aging. Exp Gerontol 2003; 38: 61-69
    • (2003) Exp Gerontol , vol.38 , pp. 61-69
    • Erickson, C.A.1    Barnes, C.A.2
  • 149
    • 0030639472 scopus 로고    scopus 로고
    • The use of animal models to study the effects of aging on cognition
    • Gallagher M, Rapp PR. The use of animal models to study the effects of aging on cognition. Annu Rev Psychol 1997; 48: 339-370
    • (1997) Annu Rev Psychol , vol.48 , pp. 339-370
    • Gallagher, M.1    Rapp, P.R.2
  • 150
    • 0031024891 scopus 로고    scopus 로고
    • Synaptic tagging and long-term potentiation
    • Frey U, Morris RG. Synaptic tagging and long-term potentiation. Nature 1997; 385: 533-536
    • (1997) Nature , vol.385 , pp. 533-536
    • Frey, U.1    Morris, R.G.2
  • 151
    • 33845864415 scopus 로고    scopus 로고
    • The late maintenance of hippocampal LTP: Requirements, phases, 'synaptic tagging', 'late-associativity' and implications
    • Reymann KG, Frey JU. The late maintenance of hippocampal LTP: requirements, phases, 'synaptic tagging', 'late-associativity' and implications. Neuropharmacology 2007; 52: 24-40.
    • (2007) Neuropharmacology , vol.52 , pp. 24-40
    • Reymann, K.G.1    Frey, J.U.2
  • 152
    • 0031912139 scopus 로고    scopus 로고
    • Messenger RNAs in dendrites: Localization, stability, and implications for neuronal function
    • Gao FB. Messenger RNAs in dendrites: localization, stability, and implications for neuronal function. Bioessays 1998; 20: 70-78
    • (1998) Bioessays , vol.20 , pp. 70-78
    • Gao, F.B.1
  • 153
    • 56749106535 scopus 로고    scopus 로고
    • Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons
    • Tiruchinapalli DM, Ehlers MD, Keene JD. Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. RNA Biol 2008; 5: 157-168
    • (2008) RNA Biol , vol.5 , pp. 157-168
    • Tiruchinapalli, D.M.1    Ehlers, M.D.2    Keene, J.D.3
  • 154
    • 53849124668 scopus 로고    scopus 로고
    • Diverse molecular functions of Hu proteins
    • Hinman MN, Lou H. Diverse molecular functions of Hu proteins. Cell Mol Life Sci 2008; 65: 3168-3181
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3168-3181
    • Hinman, M.N.1    Lou, H.2
  • 155
    • 0842342611 scopus 로고    scopus 로고
    • Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory
    • Pascale A, Gusev PA, Amadio M, Dottorini T, Govoni S, Alkon DL, et al. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Proc Natl Acad Sci USA 2004; 101: 1217-1222
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1217-1222
    • Pascale, A.1    Gusev, P.A.2    Amadio, M.3    Dottorini, T.4    Govoni, S.5    Alkon, D.L.6
  • 157
    • 0035949678 scopus 로고    scopus 로고
    • Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins
    • Quattrone A, Pascale A, Noguès X, Zhao W, Gusev P, Pacini A, et al. Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins. Proc Natl Acad Sci USA 2001; 98: 11668-11673
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11668-11673
    • Quattrone, A.1    Pascale, A.2    Noguès, X.3    Zhao, W.4    Gusev, P.5    Pacini, A.6
  • 159
    • 33749523628 scopus 로고    scopus 로고
    • The different facets of protein kinases C: Old and new players in neuronal signal transduction pathways
    • Amadio M, Battaini F, Pascale A. The different facets of protein kinases C: old and new players in neuronal signal transduction pathways. Pharmacol Res 2006; 54: 317-325
    • (2006) Pharmacol Res , vol.54 , pp. 317-325
    • Amadio, M.1    Battaini, F.2    Pascale, A.3
  • 160
    • 0028533469 scopus 로고
    • Age-related changes in signal transduction. Implications for neuronal transmission and potential for drug intervention
    • Fülöp T, Jr, Seres I. Age-related changes in signal transduction. Implications for neuronal transmission and potential for drug intervention. Drugs Aging 1994; 5: 366-390
    • (1994) Drugs Aging , vol.5 , pp. 366-390
    • Fülöp Jr., T.1    Seres, I.2
  • 161
    • 60349090347 scopus 로고    scopus 로고
    • NELAV proteins alteration in Alzheimer's disease brain: A novel putative target for amyloid-β reverberating on AβPP processing
    • Amadio M, Pascale A, Wang J, Ho L, Quattrone A, Gandy S, et al. nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-β reverberating on AβPP processing. J Alzheimers Dis 2009; 16: 409-419
    • (2009) J Alzheimers Dis , vol.16 , pp. 409-419
    • Amadio, M.1    Pascale, A.2    Wang, J.3    Ho, L.4    Quattrone, A.5    Gandy, S.6
  • 162
    • 36148936388 scopus 로고    scopus 로고
    • Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Aβ-expressing neuroblastoma cells
    • Xu Y, Cui C, Pang C, Christen Y, Luo Y. Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Aβ-expressing neuroblastoma cells. Eur J Neurosci 2007; 26: 2931-2939
    • (2007) Eur J Neurosci , vol.26 , pp. 2931-2939
    • Xu, Y.1    Cui, C.2    Pang, C.3    Christen, Y.4    Luo, Y.5
  • 164
    • 50849125708 scopus 로고    scopus 로고
    • D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs
    • Stramiello M, Wagner JJ. D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology 2008; 55: 871-877
    • (2008) Neuropharmacology , vol.55 , pp. 871-877
    • Stramiello, M.1    Wagner, J.J.2
  • 165
    • 77950227196 scopus 로고    scopus 로고
    • The expanding universe of neurotrophic factors: Therapeutic potential in aging and age-associated disorders
    • in press
    • Lanni C, Stanga S, Racchi M, Govoni S. The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders. Curr Pharm Des 2009; in press.
    • (2009) Curr Pharm des
    • Lanni, C.1    Stanga, S.2    Racchi, M.3    Govoni, S.4
  • 166
    • 40049093565 scopus 로고    scopus 로고
    • Effects of 4-methylcatechol on spatial memory and depression
    • Sun MK, Alkon DL. Effects of 4-methylcatechol on spatial memory and depression. Neuroreport 2008; 19: 355-359
    • (2008) Neuroreport , vol.19 , pp. 355-359
    • Sun, M.K.1    Alkon, D.L.2
  • 167
    • 41949132598 scopus 로고    scopus 로고
    • Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis
    • Rispoli V, Marra R, Costa N, Rotiroti D, Tirassa P, Scipione L, et al. Choline pivaloyl ester enhances brain expression of both nerve growth factor and high-affinity receptor TrkA, and reverses memory and cognitive deficits, in rats with excitotoxic lesion of nucleus basalis magnocellularis. Behav Brain Res 2008; 190: 22-32.
    • (2008) Behav Brain Res , vol.190 , pp. 22-32
    • Rispoli, V.1    Marra, R.2    Costa, N.3    Rotiroti, D.4    Tirassa, P.5    Scipione, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.