Discovery of small peptides derived from embryonic lethal abnormal vision proteins structure showing RNA-stabilizing properties

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5017-5019

  Rossi, Daniela ^a   Amadio, Marialaura ^a   Baraglia, Anna Carnevale ^a   Azzolina, Ornella ^a   Ratti, Antonia ^b   Govoni, Stefano ^a   Pascale, Alessia ^a   Collina, Simona ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HU ANTIGEN; MESSENGER RNA; NERVE PROTEIN; NOVA 1 PROTEIN; PEPTIDE DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG; VASCULOTROPIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PEPTIDE SYNTHESIS; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA DEGRADATION; RNA STABILITY; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CONSERVED SEQUENCE; ENZYME ACTIVATORS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; NERVE TISSUE PROTEINS; OLIGOPEPTIDES; PROTEIN KINASE C; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; TETRADECANOYLPHORBOL ACETATE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 69049088805     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900741e     Document Type: Article

References (21)

1. Sachs, A. B. Messenger RNA degradation in dukaryotes. Cell 1993, 74, 413-421.
2. Keene, J. D. Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 5-7.
3. Nagai, K.; Oubridge, C.; Ito, N.; Avis, J.; Evans, P. The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA. Trends Biochem. Sci. 1995, 20, 235-240.
4. Pascale, A.; Amadio, M.; Quattrone, A. Defining a neuron: neuronal ELAV proteins. Cell. Mol. Life Sci. 2008, 65, 128-140.
5. Amadio, M.; Scapagnini, G.; Laforenza, U.; Intrieri, M.; Romeo, L.; Govoni, S.; Pascale, A. Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR. Curr. Pharm. Des. 2008, 14, 2651-2658.
6. Bolognani, F.; Perrone-Bizzozero, N. I. RNA-protein interactions and control of mRNA stability in neurons. J. Neurosci. Res. 2008, 86, 481-489.
7. Quattrone, A.; Pascale, A.; Nogues, X.; Zhao, W.; Gusev, P.; Pacini, A.; Alkon, D. L. Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 11668-11673.
8. Pascale, A.; Gusev, P. A.; Amadio, M.; Dottorini, T.; Govoni, S.; Alkon, D. L.; Quattrone, A. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 1217-1222.
9. Ratti, A.; Fallini, C.; Colombrita, C.; Pascale, A.; Laforenza, U.; Quattrone, A.; Silani, V. Post-transcriptional regulation of neurooncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. J. Biol. Chem. 2008, 283, 7531-7541.
10. Amadio, M.; Pascale, A.; Wang, J.; Ho, L.; Quattrone, A.; Gandy, S.; Haroutunian, V.; Racchi, M.; Pasinetti, G. M. nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing. J. Alzheimer's Dis. 2009, 16, 409-419.
11. Deschênes-Furry, J.; Angus, L. M.; Bélanger, G.; Mwanjewe, J.; Jasmin, B. J. Role of ELAV-like RNA-binding proteins HuD and HuR in the post-transcriptional regulation of acetylcholinesterase in neurons and skeletal muscle cells. Chem.-Biol. Interact. 2005, 157-158, 43-49.
12. Abe, R.; Yamamoto, K.; Sakamoto, H. Target specificity of neuronal RNA-binding protein, Mel-N1: direct binding to the 3′ untranslated region of its own mRNA. Nucleic Acids Res. 1996, 24, 2011-2016.
13. Park, S.; Myszka,D. G.; Yu, M.; Littler, S. J.; Laird-Offringa, I. A.; HuD, R. N. A. Recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. Mol. Cell. Biol. 2000, 20, 4765-4772.
14. Wang, X.; Tanaka Hall, T. M. Structural basis for recognition of AU-rich element RNA by the HuD protein. Nat. Struct. Biol. 2001, 8, 141-145.
15. Eichler, J. Peptides as protein binding site mimetics. Curr. Opin. Chem. Biol. 2008, 12, 1-7.
16. Amadio, M.; Scapagnini, G.; Lupo, G.; Drago, F.; Govoni, S.; Pascale, A. PKCbetaII/HuR/VEGF: a new molecular cascade in retinal pericytes for the regulation of VEGF gene expression. Pharmacol. Res. 2008, 57, 60-66.
17. Perrone-Bizzozero, N.; Bolognani, F. Role of HuD and other RNA-binding proteins in neural development and plasticity. J. Neurosci. Res. 2002, 68, 121-126.
18. Jensen, K. B.; Dredge, B. K.; Stefani, G.; Zhong, R.; Buckanovich, R. J.; Okano, H. J.; Yang, Y. Y.; Darnell, R. B. Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron 2000, 25, 359-371.
19. Krum, J. M.; Mani, N.; Rosenstein, J. M. Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Exp. Neurol. 2008, 212, 108-117.
20. Ferrara, N.; Carver-Moore, K.; Chen, H.; Dowd, M.; Lu, L.; O'Shea, K. S.; Powell-Braxton, L.; Hillan, K. J.; Moore, M. W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996, 380, 439-442.
21. Pascale, A.; Amadio, M.; Scapagnini, G.; Lanni, C.; Racchi, M; Provenzani, A.; Govoni, S.; Alkon, D. L.; Quattrone, A. Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 12065-12070.