p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells

American Journal of Pathology

Volumn 157, Issue 4, 2000, Pages 1247-1258

  Wang, Shiyang ^a   Bray, Paula ^b   McCaffrey, Timothy ^b   March, Keith ^a,c   Hempstead, Barbara L ^b   Kraemer, Rosemary ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Veterans Administration   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; PROTEIN P75; PROTEIN TYROSINE KINASE; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA INJURY; APOPTOSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

EID: 0033815166     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64640-8     Document Type: Article

References (49)

1. p75 and trk: A two-receptor system
2. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells: Regulation of expression in response to injury
3. The trkB tyrosine protein kinase is a receptor for neurotrophin 4
4. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
5. NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological respones
6. The trk B tyrosine kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
7. The rat trkC locus endodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC 12 cells
8. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling
9. Evidence for a role of truncated trkC receptor isoforms in mouse development
10. Apoptosis mediated by the TNF-related cytokine and receptor families
11. High affinity NGF binding requires coexpression of the trk proto-oncogene and the low affinity NGF receptor
12. Induction of cell death by endogenous nerve growth factor through its p75 receptor
13. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
14. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
15. Neurotrophin and neurotrophin receptors in human fetal kidney
16. Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development
17. Evidence for apoptosis in human atherogenesis and in a rat vascular injury model
18. Gene transfer and molecular cloning of the human NGF receptor
19. Expression and structure of the human NGF receptor
20. Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies
21. Genomic instability in the type II TGF-b1 receptor gene in atherosclerotic and restenotic vascular cells
22. Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions: Conversion from an antiproliferative to profibrotic response to TGF-beta 1
23. Specific inhibition of elF-5A and collagen hydroxylation by a single agent: Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries
24. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform-extraction
25. An improvement of the single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
26. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily
27. Expression of neurotrophins and their receptors in human bone marrow
28. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
29. A potential interaction of p75 and trk A NGF receptors revealed by affinity crosslinking and immunoprecipitation
30. Lethal effects of the anti-Fas antibody in mice
31. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
32. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
33. Evidence for apoptosis in advanced human atheroma: Colocalization with interleukin-1beta-converting enzyme
34. Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells
35. The role of Fas/APO 1 and apoptosis in the development of human atherosclerotic lesions
36. The role of Fas/APO 1 and apoptosis in the development of human atherosclerotic lesions
37. Oligodendrocyte apoptosis mediated by caspase activation
38. NMR structure of the death domain of the p75 neurotrophin receptor
39. The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death
40. Association of the p75 neurotrophin receptor with TRAF6
41. P53 is essential for developmental neuron death as regulated by the trk A and p75 neurotrophin receptors
42. Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord
43. Up-regulated p75(NTR) neurotrophin receptor on glial cells in MS plaques
44. Nerve growth factor (NGF) induces motorneuron apoptosis in rat embryonic spinal cord in vitro
45. The role of p75NTR in modulating neurotrophin survival effects in developing motorneurons
46. NGF exhibits a pro-apoptotic activity for human vascular smooth muscle cells that is inhibited by TGFb1
47. A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture
48. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis
49. Brain-derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization