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Volumn 94, Issue 6, 2009, Pages 1843-1852

The extrapancreatic effects of glucagon-like peptide-1 and related peptides

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CASPASE 3; DECAPENTAPLEGIC PROTEIN; DIPEPTIDYL PEPTIDASE IV; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCAGON LIKE PEPTIDE 1 [9-36] AMIDE; GLUCAGON LIKE PEPTIDE 1M; GLUCOSE; HORMONE RECEPTOR STIMULATING AGENT; INSULIN; INSULIN RECEPTOR; LIRAGLUTIDE; METHYLTESTOSTERONE; PEPTIDE YY [3-36]; PHENTOLAMINE; PROPRANOLOL; REACTIVE OXYGEN METABOLITE; RESERPINE; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT;

EID: 66749102158     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-1296     Document Type: Review
Times cited : (185)

References (118)
  • 1
    • 33847229483 scopus 로고    scopus 로고
    • The multiple faces of glucagon-like peptide-1 - Obesity, appetite, and stress: What is next? a review
    • DOI 10.1007/s10620-006-9096-2
    • Frezza EE, Wachtel MS, Chiriva-Internati M 2007 The multiple faces of glucagon-like peptide-1-obesity, appetite, and stress: what is next? A review. Dig Dis Sci 52:643-649 (Pubitemid 46303044)
    • (2007) Digestive Diseases and Sciences , vol.52 , Issue.3 , pp. 643-649
    • Frezza, E.E.1    Wachtel, M.S.2    Chiriva-Internati, M.3
  • 2
    • 0020596734 scopus 로고
    • Hamster preproglucagon contains the sequence of glucagon and two related peptides
    • Bell GI, Santerre RF, Mullenbach GT 1983 Hamster preproglucagon contains the sequence of glucagon and two related peptides. Nature 302:716-718
    • (1983) Nature , vol.302 , pp. 716-718
    • Bell, G.I.1    Santerre, R.F.2    Mullenbach, G.T.3
  • 4
    • 0021719480 scopus 로고
    • Pre-proglucagon messenger ribonucleic acid: Nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid
    • Heinrich G, Gros P, Lund PK, Bentley RC, Habener JF 1984 Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology 115:2176-2181 (Pubitemid 15186251)
    • (1984) Endocrinology , vol.115 , Issue.6 , pp. 2176-2181
    • Heinrich, G.1    Gros, P.2    Lund, P.K.3
  • 5
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov S, Weir GC, Habener JF 1987 Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 79:616-619
    • (1987) J Clin Invest , vol.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 6
    • 15044353651 scopus 로고    scopus 로고
    • The discovery of glucagon-like peptide 1
    • DOI 10.1016/j.regpep.2004.09.001, Proceedings from the GLP1 Meeting on the Occasion of the 80th Birthday of Prof.Dr. Med. Dr. hc (em) Werner Creutzfeltdt.
    • Lund PK 2005 The discovery of glucagon-like peptide 1. Regul Pept 128:93-96 (Pubitemid 40380909)
    • (2005) Regulatory Peptides , vol.128 , Issue.2 , pp. 93-96
    • Lund, P.K.1
  • 10
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ 1995 Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80:952-957
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 11
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA 1995 Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136:3585-3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 12
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • Drucker DJ, Nauck MA 2006 The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-1705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 13
    • 6344241190 scopus 로고    scopus 로고
    • Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents
    • Green BD, Gault VA, O'harte FP, Flatt PR 2004 Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents. Curr Pharm Des 10:3651-3662
    • (2004) Curr Pharm des , vol.10 , pp. 3651-3662
    • Green, B.D.1    Gault, V.A.2    O'Harte, F.P.3    Flatt, P.R.4
  • 14
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP 1992 Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 267:7402-7405
    • (1992) J Biol Chem , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 16
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • DOI 10.1002/hep.21006
    • Ding X, Saxena NK, Lin S, Gupta NA, Gupta N, Anania FA 2006 Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43:173-181 (Pubitemid 43733604)
    • (2006) Hepatology , vol.43 , Issue.1 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.4    Anania, F.A.5
  • 19
    • 0035795227 scopus 로고    scopus 로고
    • Molecular evolution of proglucagon
    • DOI 10.1016/S0167-0115(00)00232-9, PII S0167011500002329
    • Irwin DM 2001 Molecular evolution of proglucagon. Regul Pept 98:1-12 (Pubitemid 32155486)
    • (2001) Regulatory Peptides , vol.98 , Issue.1-2 , pp. 1-12
    • Irwin, D.M.1
  • 20
    • 33646512858 scopus 로고    scopus 로고
    • Glucagon and glucagon-like peptide receptors as drug targets
    • Estall JL, Drucker DJ 2006 Glucagon and glucagon-like peptide receptors as drug targets. Curr Pharm Des 12:1731-1750
    • (2006) Curr Pharm des , vol.12 , pp. 1731-1750
    • Estall, J.L.1    Drucker, D.J.2
  • 24
    • 0035106978 scopus 로고    scopus 로고
    • Minireview: The glucagon-like peptides
    • DOI 10.1210/en.142.2.521
    • Drucker DJ 2001 Minireview: the glucagon-like peptides. Endocrinology 142:521-527 (Pubitemid 32222398)
    • (2001) Endocrinology , vol.142 , Issue.2 , pp. 521-527
    • Drucker, D.J.1
  • 25
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)- Cells
    • DOI 10.1007/s001250051238
    • Buteau J, Roduit R, Susini S, Prentki M 1999 Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in β (INS-1)-cells. Diabetologia 42:856-864 (Pubitemid 29325077)
    • (1999) Diabetologia , vol.42 , Issue.7 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3    Prentki, M.4
  • 26
    • 12244261646 scopus 로고    scopus 로고
    • GLP-1 and extra-islet effects
    • DOI 10.1055/s-2004-826173
    • Ahrén B 2004 GLP-1 and extra-islet effects. Horm Metab Res 36:842-845 (Pubitemid 40115908)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.11-12 , pp. 842-845
    • Ahren, B.1
  • 27
    • 0028021735 scopus 로고
    • Glucagon-like peptide 1: A potent glycogenic hormone
    • DOI 10.1016/0014-5793(94)00699-7
    • Valverde I, Morales M, Clemente F, López-Delgado MI, Delgado E, Perea A, Villanueva-Peñacarrillo ML 1994 Glucagon-like peptide 1: a potent glycogenic hormone. FEBS Lett 349:313-316 (Pubitemid 24263284)
    • (1994) FEBS Letters , vol.349 , Issue.2 , pp. 313-316
    • Valverde, I.1
  • 30
    • 0027164996 scopus 로고
    • Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C
    • DOI 10.1210/en.133.1.57
    • Wheeler MB, Lu M, Dillon JS, Leng XH, Chen C, Boyd 3rd AE 1993 Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C. Endocrinology 133:57-62 (Pubitemid 23206374)
    • (1993) Endocrinology , vol.133 , Issue.1 , pp. 57-62
    • Wheeler, M.B.1    Lu, M.2    Dillon, J.S.3    Leng, X.-H.4    Chen, C.5    Boyd III, A.E.6
  • 31
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • DOI 10.1152/physrev.00034.2006
    • Holst JJ 2007 The physiology of glucagon-like peptide 1. Physiol Rev 87:1409-1439 (Pubitemid 350041474)
    • (2007) Physiological Reviews , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 34
    • 1442311383 scopus 로고    scopus 로고
    • Effects of Glucagon-Like Peptide-1 in Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction after Successful Reperfusion
    • DOI 10.1161/01.CIR.0000120505.91348.58
    • Nikolaidis LA, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, Shannon RP 2004 Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 109:962-965 (Pubitemid 38282847)
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6    Shannon, R.P.7
  • 37
    • 30944467225 scopus 로고    scopus 로고
    • Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
    • DOI 10.1136/gut.2004.059741
    • Schirra J, Nicolaus M, Roggel R, Katschinski M, Storr M, Woerle HJ, Göke B 2006 Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans. Gut 55:243-251 (Pubitemid 43117285)
    • (2006) Gut , vol.55 , Issue.2 , pp. 243-251
    • Schirra, J.1    Nicolaus, M.2    Roggel, R.3    Katschinski, M.4    Storr, M.5    Woerle, H.J.6    Goke, B.7
  • 39
    • 0034951506 scopus 로고    scopus 로고
    • The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity
    • Flint A, Raben A, Ersbøll AK, Holst JJ, Astrup A 2001 The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. Int J Obes Relat Metab Disord 25:781-792 (Pubitemid 32601369)
    • (2001) International Journal of Obesity , vol.25 , Issue.6 , pp. 781-792
    • Flint, A.1    Raben, A.2    Ersboll, A.K.3    Holst, J.J.4    Astrup, A.5
  • 40
    • 0141956380 scopus 로고    scopus 로고
    • Absence of a Memory Effect for the Insulinotropic Action of Glucagon-like Peptide 1 (GLP-1) in Healthy Volunteers
    • DOI 10.1055/s-2003-42658
    • Meier S, Hücking K, Ritzel R, Holst JJ, Schmiegel WH, Nauck MA 2003 Absence of a memory effect for the insulinotropic action of glucagon-like peptide 1 (GLP-1) in healthy volunteers. Horm Metab Res 35:551-556 (Pubitemid 37260421)
    • (2003) Hormone and Metabolic Research , vol.35 , Issue.9 , pp. 551-556
    • Meier, S.1    Hucking, K.2    Ritzel, R.3    Holst, J.J.4    Schmiegel, W.H.5    Nauck, M.A.6
  • 41
    • 0038392420 scopus 로고    scopus 로고
    • Interrelationship among insulin, glucagon and somatostatin secretory responses to exendin-4 in the perfused rat pancreas
    • DOI 10.1016/S0014-2999(03)01692-3
    • Silvestre RA, Rodríguez-Gallardo J, Egido EM, Marco J 2003 Interrelationship among insulin, glucagon and somatostatin secretory responses to exendin-4 in the perfused rat pancreas. Eur J Pharmacol 469:195-200 (Pubitemid 36629566)
    • (2003) European Journal of Pharmacology , vol.469 , Issue.1-3 , pp. 195-200
    • Silvestre, R.A.1    Rodriguez-Gallardo, J.2    Egido, E.M.3    Marco, J.4
  • 42
    • 0035069103 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice
    • DOI 10.1007/s004280000374
    • Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC 2001 Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice. Virchows Arch 438:382-387 (Pubitemid 32285364)
    • (2001) Virchows Archiv , vol.438 , Issue.4 , pp. 382-387
    • Ling, Z.1    Wu, D.2    Zambre, Y.3    Flamez, D.4    Drucker, D.J.5    Pipeleers, D.G.6    Schuit, F.C.7
  • 43
    • 1442353288 scopus 로고    scopus 로고
    • Effect of GLP-1 (Glucagon-like Peptide 1:7-36 Amide) on Porcine Pancreatic Endocrine Cell Proliferation and Insulin Secretion
    • DOI 10.1097/00006676-200403000-00004
    • Nagai K, Tsuchiya K, Ezaki T, Tsuchiya M, Ohgawara H 2004 Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion. Pancreas 28:138-145 (Pubitemid 38269773)
    • (2004) Pancreas , vol.28 , Issue.2 , pp. 138-145
    • Nagai, K.1    Tsuchiya, K.2    Ezaki, T.3    Tsuchiya, M.4    Ohgawara, H.5
  • 44
    • 50049121828 scopus 로고    scopus 로고
    • Intestinal hormones and regulation of satiety: The case for CCK, GLP-1, PYY, and Apo A-IV
    • D'Alessio D 2008 Intestinal hormones and regulation of satiety: the case for CCK, GLP-1, PYY, and Apo A-IV. JPEN J Parenter Enteral Nutr 32:567-568
    • (2008) JPEN J Parenter Enteral Nutr , vol.32 , pp. 567-568
    • D'Alessio, D.1
  • 45
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • DOI 10.1016/j.cmet.2006.01.004, PII S1550413106000283
    • Drucker DJ 2006 The biology of incretin hormones. Cell Metab 3:153-165 (Pubitemid 43316521)
    • (2006) Cell Metabolism , vol.3 , Issue.3 , pp. 153-165
    • Drucker, D.J.1
  • 47
    • 0036896243 scopus 로고    scopus 로고
    • The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
    • Kinzig KP, D'Alessio DA, Seeley RJ 2002 The diverse roles of specific GLP-1Rs in the control of food intake and the response to visceral illness. J Neurosci 22:10470-10476 (Pubitemid 35416883)
    • (2002) Journal of Neuroscience , vol.22 , Issue.23 , pp. 10470-10476
    • Kinzig, K.P.1    D'Alessio, D.A.2    Seeley, R.J.3
  • 48
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • DOI 10.1210/en.138.10.4445
    • Larsen PJ, Tang-Christensen M, Jessop DS 1997 Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 138:4445-4455 (Pubitemid 27408493)
    • (1997) Endocrinology , vol.138 , Issue.10 , pp. 4445-4455
    • Larsen, P.J.1    Tang-Christensen, M.2    Jessop, D.S.3
  • 51
    • 0037195478 scopus 로고    scopus 로고
    • 2+ in rat nodose ganglion neurons
    • DOI 10.1016/S1566-0702(02)00182-0, PII S1566070202001820
    • Kakei M, Yada T, Nakagawa A, Nakabayashi H 2002 Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons. Auton Neurosci 102:39-44 (Pubitemid 35305005)
    • (2002) Autonomic Neuroscience: Basic and Clinical , vol.102 , Issue.1-2 , pp. 39-44
    • Kakei, M.1    Yada, T.2    Nakagawa, A.3    Nakabayashi, H.4
  • 52
    • 4344667831 scopus 로고    scopus 로고
    • A recombinant human glucagon-like peptide (GLP)-1-albumin protein (Albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis
    • DOI 10.2337/diabetes.53.9.2492
    • Baggio LL, Huang Q, Brown TJ, Drucker DJ 2004 A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1R-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis. Diabetes 53:2492-2500 (Pubitemid 39145610)
    • (2004) Diabetes , vol.53 , Issue.9 , pp. 2492-2500
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 53
    • 21344454659 scopus 로고    scopus 로고
    • Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in heathy subjects
    • DOI 10.2337/diabetes.54.7.2212
    • Meier JJ, Kemmeries G, Holst JJ, Nauck MA 2005 Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects. Diabetes 54:2212-2218 (Pubitemid 40911286)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 2212-2218
    • Meier, J.J.1    Kemmeries, G.2    Holst, J.J.3    Nauck, M.A.4
  • 55
    • 0030962231 scopus 로고    scopus 로고
    • The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation
    • Wettergren A, Wøjdemann M, Meisner S, Stadil F, Holst JJ 1997 The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation. Gut 40:597-601 (Pubitemid 27278325)
    • (1997) Gut , vol.40 , Issue.5 , pp. 597-601
    • Wettergren, A.1    Wojdemann, M.2    Meisner, S.3    Stadil, F.4    Holst, J.J.5
  • 58
    • 0030034912 scopus 로고    scopus 로고
    • Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons
    • D'Alessio DA, Vogel R, Prigeon R, Laschansky E, Koerker D, Eng J, Ensinck JW 1996 Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons. J Clin Invest 97:133-138 (Pubitemid 26021703)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.1 , pp. 133-138
    • D'Alessio, D.A.1    Vogel, R.2    Prigeon, R.3    Laschansky, E.4    Koerker, D.5    Eng, J.6    Ensinck, J.W.7
  • 59
    • 34248169217 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes
    • DOI 10.2337/db07-0136
    • Vella A, Bock G, Giesler PD, Burton DB, Serra DB, Saylan ML, Dunning BE, Foley JE, Rizza RA, Camilleri M 2007 Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes. Diabetes 56:1475-1480 (Pubitemid 46715627)
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1475-1480
    • Vella, A.1    Bock, G.2    Giesler, P.D.3    Burton, D.B.4    Serra, D.B.5    Saylan, M.L.6    Dunning, B.E.7    Foley, J.E.8    Rizza, R.A.9    Camilleri, M.10
  • 60
    • 57349122058 scopus 로고    scopus 로고
    • Regulation of islet hormone release and gastric emptying by endogenous GLP-1 following glucose ingestion
    • Salehi M, Vahl TP, D'Alessio DA 2008 Regulation of islet hormone release and gastric emptying by endogenous GLP-1 following glucose ingestion. J Clin Endocrinol Metab 93:4909-4916
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4909-4916
    • Salehi, M.1    Vahl, T.P.2    D'Alessio, D.A.3
  • 62
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • DOI 10.1210/en.137.7.2968
    • Bullock BP, Heller RS, Habener JF 1996 Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968-2978 (Pubitemid 26192194)
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 63
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M 2008 Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 117:2340-2350
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 66
    • 0032714917 scopus 로고    scopus 로고
    • Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats
    • Barragán JM, Eng J, Rodríguez R, Blázquez E 1999 Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats. Am J Physiol 277:E784-E791
    • (1999) Am J Physiol , vol.277
    • Barragán, J.M.1    Eng, J.2    Rodríguez, R.3    Blázquez, E.4
  • 67
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • DOI 10.1161/01.CIR.0000139339.85840.DD
    • Nikolaidis LA, Elahi D, Hentosz T, Doverspike A, Huerbin R, Zourelias L, Stolarski C, Shen YT, Shannon RP 2004 Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 110:955-961 (Pubitemid 39128621)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.-T.8    Shannon, R.P.9
  • 68
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-Like Peptide-1 Infusion Improves Left Ventricular Ejection Fraction and Functional Status in Patients with Chronic Heart Failure
    • DOI 10.1016/j.cardfail.2006.08.211, PII S1071916406011092
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP 2006 Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 12:694-699 (Pubitemid 44881367)
    • (2006) Journal of Cardiac Failure , vol.12 , Issue.9 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 69
    • 20044367874 scopus 로고    scopus 로고
    • Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model
    • DOI 10.1007/s10557-005-6892-4
    • Bose AK, Mocanu MM, Carr RD, Yellon DM 2005 Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model. Cardiovasc Drugs Ther 19:9-11 (Pubitemid 40767767)
    • (2005) Cardiovascular Drugs and Therapy , vol.19 , Issue.1 , pp. 9-11
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Yellon, D.M.4
  • 73
    • 0035892681 scopus 로고    scopus 로고
    • Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat
    • Golpon HA, Puechner A, Welte T, Wichert PV, Feddersen CO 2001 Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat. Regul Pept 102:81-86
    • (2001) Regul Pept , vol.102 , pp. 81-86
    • Golpon, H.A.1    Puechner, A.2    Welte, T.3    Wichert, P.V.4    Feddersen, C.O.5
  • 74
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    • DOI 10.2337/diabetes.54.1.146
    • Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM 2005 Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 54:146-151 (Pubitemid 40105106)
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 76
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1
    • Thorens B 1992 Expression cloning of the pancreatic β cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc Natl Acad Sci USA 89:8641-8645
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8641-8645
    • Thorens, B.1
  • 77
    • 28144441354 scopus 로고    scopus 로고
    • Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
    • DOI 10.1152/ajpheart.00347.2005
    • Nikolaidis LA, Elahi D, Shen YT, Shannon RP 2005 Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 289:H2401-H2408 (Pubitemid 41698549)
    • (2005) American Journal of Physiology - Heart and Circulatory Physiology , vol.289 , Issue.6
    • Nikolaidis, L.A.1    Elahi, D.2    Shen, Y.-T.3    Shannon, R.P.4
  • 78
    • 12244266501 scopus 로고    scopus 로고
    • Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase
    • DOI 10.1016/S0008-6363(02)00649-1, PII S0008636302006491
    • Brunner F, Maier R, Andrew P, Wölkart G, Zechner R, Mayer B 2003 Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase. Cardiovasc Res 57:55-62 (Pubitemid 36009436)
    • (2003) Cardiovascular Research , vol.57 , Issue.1 , pp. 55-62
    • Brunner, F.1    Maier, R.2    Andrew, P.3    Wolkart, G.4    Zechner, R.5    Mayer, B.6
  • 79
    • 58949102483 scopus 로고    scopus 로고
    • Chronic glucagon-like peptide-1 infusion sustains left ventricular function and prolongs survival in spontaneously hypertensive, heart failure prone rats
    • Poornima IB, Bhashyam S, Parikh P, Bolukoglu H, Shannon R 2008 Chronic glucagon-like peptide-1 infusion sustains left ventricular function and prolongs survival in spontaneously hypertensive, heart failure prone rats. Circ Heart Fail 1:153-160
    • (2008) Circ Heart Fail , vol.1 , pp. 153-160
    • Poornima, I.B.1    Bhashyam, S.2    Parikh, P.3    Bolukoglu, H.4    Shannon, R.5
  • 80
    • 12244303683 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on the hepatic glucose metabolism
    • DOI 10.1055/s-2004-826172
    • D'Alessio D, Vahl T, Prigeon R 2004 Effects of glucagon-like peptide 1 on the hepatic glucose metabolism. Horm Metab Res 36:837-841 (Pubitemid 40115907)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.11-12 , pp. 837-841
    • D'Alessio, D.1    Vahl, T.2    Prigeon, R.3
  • 82
    • 0031731228 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats
    • DOI 10.1210/en.139.6.2811
    • López-Delgado MI, Morales M, Villanueva-Peñacarrillo ML, Malaisse WJ, Valverde I 1998 Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase A in hepatocytes from normal and diabetic rats. Endocrinology 139:2811-2817 (Pubitemid 28512390)
    • (1998) Endocrinology , vol.139 , Issue.6 , pp. 2811-2817
    • Lopez-Delgado, M.I.1    Morales, M.2    Villanueva-Penacarrillo, M.L.3    Malaisse, W.J.4    Valverde, I.5
  • 84
    • 0028260734 scopus 로고
    • Insulin regulation of hepatic glucose transporter protein is impaired in chronic pancreatitis
    • Andersen DK, Ruiz CL, Burant CF 1994 Insulin regulation of hepatic glucose transporter protein is impaired in chronic pancreatitis. Ann Surg 219:679-686; discussion, 686-1677 (Pubitemid 24182642)
    • (1994) Annals of Surgery , vol.219 , Issue.6 , pp. 679-687
    • Andersen, D.K.1    Ruiz, C.L.2    Burant, C.F.3
  • 87
    • 34250741968 scopus 로고    scopus 로고
    • Mechanisms and emerging treatments of the metabolic complications of chronic pancreatitis
    • DOI 10.1097/mpa.0b013e31805d01b0, PII 0000667620070700000001
    • Andersen DK 2007 Mechanisms and emerging treatments of the metabolic complications of chronic pancreatitis. Pancreas 35:1-15 (Pubitemid 46956195)
    • (2007) Pancreas , vol.35 , Issue.1 , pp. 1-15
    • Andersen, D.K.1
  • 89
    • 0038359686 scopus 로고    scopus 로고
    • Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1-(9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans
    • Vahl TP, Paty BW, Fuller BD, Prigeon RL, D'Alessio DA 2003 Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1-(9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans. J Clin Endocrinol Metab 88:1772-1779
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1772-1779
    • Vahl, T.P.1    Paty, B.W.2    Fuller, B.D.3    Prigeon, R.L.4    D'Alessio, D.A.5
  • 90
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ 1995 Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44:1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 91
    • 0028325376 scopus 로고
    • Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse
    • DOI 10.1210/en.134.5.2156
    • Campos RV, Lee YC, Drucker DJ 1994 Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology 134:2156-2164 (Pubitemid 24142957)
    • (1994) Endocrinology , vol.134 , Issue.5 , pp. 2156-2164
    • Campos, R.V.1    Lee, Y.C.2    Drucker, D.J.3
  • 93
    • 31844433106 scopus 로고    scopus 로고
    • The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes
    • DOI 10.1007/s00125-005-0098-y
    • Zander M, Madsbad S, Deacon CF, Holst JJ 2006 The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes. Diabetologia 49:369-374 (Pubitemid 43185406)
    • (2006) Diabetologia , vol.49 , Issue.2 , pp. 369-374
    • Zander, M.1    Madsbad, S.2    Deacon, C.F.3    Holst, J.J.4
  • 94
  • 97
    • 33748309091 scopus 로고    scopus 로고
    • Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats
    • DOI 10.1016/j.brainres.2006.06.090, PII S0006899306019974
    • Nakade Y, Tsukamoto K, Pappas TN, Takahashi T 2006 Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats. Brain Res 1111:117-121 (Pubitemid 44331186)
    • (2006) Brain Research , vol.1111 , Issue.1 , pp. 117-121
    • Nakade, Y.1    Tsukamoto, K.2    Pappas, T.N.3    Takahashi, T.4
  • 103
    • 0029761505 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): Characterization of binding sites for GLP-1 on α-TSH cells
    • DOI 10.1210/en.137.10.4130
    • Beak SA, Small CJ, Ilovaiskaia I, Hurley JD, Ghatei MA, Bloom SR, Smith DM1996 Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on α-TSH cells. Endocrinology 137:4130-4138 (Pubitemid 26321857)
    • (1996) Endocrinology , vol.137 , Issue.10 , pp. 4130-4138
    • Beak, S.A.1    Small, C.J.2    Ilovaiskaia, I.3    Hurley, J.D.4    Ghatei, M.A.5    Bloom, S.R.6    Smith, D.M.7
  • 105
    • 0034652302 scopus 로고    scopus 로고
    • The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    • Seeley RJ, Blake K, Rushing PA, Benoit S, Eng J, Woods SC, D'Alessio D 2000 The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride. J Neurosci 20:1616-1621
    • (2000) J Neurosci , vol.20 , pp. 1616-1621
    • Seeley, R.J.1    Blake, K.2    Rushing, P.A.3    Benoit, S.4    Eng, J.5    Woods, S.C.6    D'Alessio, D.7
  • 108
    • 42249094149 scopus 로고    scopus 로고
    • Taste cells of the gut and gastrointestinal chemosensation
    • Egan JM, Margolskee RF 2008 Taste cells of the gut and gastrointestinal chemosensation. Mol Interv 8:78-81
    • (2008) Mol Interv , vol.8 , pp. 78-81
    • Egan, J.M.1    Margolskee, R.F.2
  • 109
  • 110
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M1999 Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 48:1026-1034
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6    Denaro, M.7
  • 111
    • 33646058571 scopus 로고    scopus 로고
    • Metabolic effects of the incretin mimetic exenatide in the treatment of type 2 diabetes
    • Schnabel CA, Wintle M, Kolterman O 2006 Metabolic effects of the incretin mimetic exenatide in the treatment of type 2 diabetes. Vasc Health Risk Manag 2:69-77
    • (2006) Vasc Health Risk Manag , vol.2 , pp. 69-77
    • Schnabel, C.A.1    Wintle, M.2    Kolterman, O.3
  • 113
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: A parallel-group study
    • DOI 10.1016/S0140-6736(02)07952-7
    • Zander M, Madsbad S, Madsen JL, Holst JJ 2002 Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830 (Pubitemid 34233752)
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 114
    • 0141669196 scopus 로고    scopus 로고
    • Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes
    • DOI 10.2337/diacare.26.10.2835
    • Meneilly GS, Greig N, Tildesley H, Habener JF, Egan JM, Elahi D 2003 Effects of 3 months of continuous subcutaneous administration of glucagonlike peptide 1 in elderly patients with type 2 diabetes. Diabetes Care 26:2835-2841 (Pubitemid 37205555)
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2835-2841
    • Meneilly, G.S.1    Greig, N.2    Tildesley, H.3    Habener, J.F.4    Egan, J.M.5    Elahi, D.6
  • 116
    • 9944251347 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
    • DOI 10.1016/j.regpep.2004.08.024, PII S0167011504003179
    • Nyström T, Gonon AT, Sjöholm A, Pernow J 2005 Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Regul Pept 125:173-177 (Pubitemid 39593722)
    • (2005) Regulatory Peptides , vol.125 , Issue.1-3 , pp. 173-177
    • Nystrom, T.1    Gonon, A.T.2    Sjoholm, A.3    Pernow, J.4
  • 118
    • 34248191802 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 and long-acting analogues on cardiovascular and metabolic function
    • DOI 10.2165/00126839-200708030-00002
    • Saraceni C, Broderick TL 2007 Effects of glucagon-like peptide-1 and longacting analogues on cardiovascular and metabolic function. Drugs R D 8:145-153 (Pubitemid 46707838)
    • (2007) Drugs in R and D , vol.8 , Issue.3 , pp. 145-153
    • Saraceni, C.1    Broderick, T.L.2


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