A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1092-1096

  Yang, Jin Wei ^a   He, Xiao Peng ^a,c,d   Li, Cui ^c   Gao, Li Xin ^b   Sheng, Li ^b   Xie, Juan ^d   Shi, Xiao Xin ^c   Tang, Yun ^c   Li, Jia ^b   Chen, Guo Rong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Click reaction; Docking simulation; Glycopeptides; Microwave irradiation; Protein tyrosine phosphatase inhibitor

Indexed keywords

COPPER; GLYCOPEPTIDE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRIAZOLE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CYCLOADDITION; DRUG BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MICROWAVE IRRADIATION; SIMULATION;

ALKYNES; AZIDES; BINDING SITES; CATALYSIS; CDC25 PHOSPHATASES; CLICK CHEMISTRY; COMPUTER SIMULATION; COPPER; ENZYME INHIBITORS; GLYCOPEPTIDES; HUMANS; MICROWAVES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASES; STEREOISOMERISM;

EID: 79851514311     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.126     Document Type: Article

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41. 4, filtered and concentrated then the crude product was purified by column chromatography.