Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6618-6622

  Qiu, Wen Wei ^a   Shen, Qiang ^b   Yang, Fan ^a   Wang, Bo ^a   Zou, Hui ^a   Li, Jing Ya ^b   Li, Jia ^b   Tang, Jie ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Diabetes; Inhibitor; Maslinic acid; Protein tyrosine phosphatase 1B; SAR

Indexed keywords

3 EPI MASLINIC ACID; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; AUGUSTIC ACID; CARBON; HETEROCYCLIC COMPOUND; LEUKOCYTE ANTIGEN RELATED PHOSPHATASE; MASLINIC ACID DERIVATIVE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; OLEANOLIC ACID; OLEANOLIC ACID DERIVATIVE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PYRAZOLE DERIVATIVE; SRC HOMOLOGY PHOSPHATASE 1; SRC HOMOLOGY PHOSPHATASE 2; UNCLASSIFIED DRUG; WATER;

ARTICLE; BROMINATION; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; MOLECULAR CONFORMATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 71749095585     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.017     Document Type: Article

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