Synthetic small molecule Cdc25 phosphatases inhibitors

Current Medicinal Chemistry

Volumn 15, Issue 6, 2008, Pages 573-580

  Garuti, Laura ^a   Roberti, Marinella ^a   Pizzirani, Daniela ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antiproliferative activity; Cdc25 phosphatase; Cell cycle; Quinones; SAR

Indexed keywords

1,2 NAPHTHOQUINONE DERIVATIVE; 2 (2 MERCAPTOETHANOL) 3 METHYL 1,4 NAPHTHOQUINONE; 3 BENZOYL NAPHTHO[1,2 B]FURAN 4,5 DIONE; 3 METHYL 4 (O METHYL OXIMINO) 1 PHENYLPYRAZOLIN 5 ONE; 4 [1(1H INDOL 3 YL) 3,4 DIOXO 3,4 DIHYDRONAPHTHALEN 2 YLMETHYL PHENOXY]ACETIC ACID TERT BUTYL ESTER; 4 DIMETHYLAMINO 2 METHOXY 6 [METHYL[2 (4 NITROPHENYL)ETHYL]AMINOMETHYL]PHENOL; 5 (3 BENZOYLBENZOYL)OXYMETHYL 3 HEXADECANOYLTETRONIC ACID; 6 CHLORO 7 (2 MORPHOLIN 4 YLETHYLAMINO)QUINOLINE 5,8 DIONE; 7 (2 MORPHOLIN 4 YLETHYLAMINO)QUINOLINE 5,8 DIONE; 7 [(2 METHYL BENZYL) 1H INDOL 3 YL] 2,5 DIHYDROXY[1,4]BENZOQUINONE; ANTINEOPLASTIC AGENT; BENZOTHIAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; BN 82002; BN 82685; CYSTEINE; DA 3003 1; DYSIDIOLIDE; EK 6136; H 32; INDOLYLDIHYDROXYQUINONE DERIVATIVE; JUN 1111; KR 61639; MALEIMIDE DERIVATIVE; N (4 BIPHENYL) 3,4 BIS(2 HYDROXYETHYLSULFANYL)MALEIMIDE; NAPHTHOFURANDIONE DERIVATIVE; NAPHTHOQUINONE; NSC 672121; NSC 95397; PHOSPHATE; PM 20; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; QUINOLINEDIONE DERIVATIVE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARYLATION; CELL CYCLE ARREST; CELL CYCLE REGULATION; CELL GROWTH; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CDC25 PHOSPHATASES; CELL CYCLE; ENZYME INHIBITORS; HUMANS; MALEIMIDES; MOLECULAR STRUCTURE; NAPHTHOQUINONES; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42049105095     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986708783769722     Document Type: Review

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