Design and synthesis of macrocyclic inhibitors of phosphatase Cdc25B

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1673-1677

  Bäurle, Stefan ^a   Blume, Thorsten ^a   Günther, Judith ^a   Henschel, Daniela ^a   Hillig, Roman C ^a   Husemann, Manfred ^a   Mengel, Anne ^a   Parchmann, Christian ^a   Schmid, Elke ^a   Skuballa, Werner ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Macrocycles; Molecular modeling; Phosphatases; Steroids; Templates

Indexed keywords

ENZYME INHIBITOR; MACROCYCLIC COMPOUND; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; STEROID;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; KERATINOCYTE; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; DRUG DESIGN; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 12144290332     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.052     Document Type: Article

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