Targeting inactive enzyme conformation: Aryl diketoacid derivatives as a new class of PTP1B inhibitors

Journal of the American Chemical Society

Volumn 130, Issue 50, 2008, Pages 17075-17084

  Liu, Sijiu ^a   Zeng, Li Fan ^a   Wu, Li ^a   Yu, Xiao ^a   Xue, Ting ^b   Gunawan, Andrea M ^a   Long, Ya Qiu ^b   Zhang, Zhong Yin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITES; BIO AVAILABILITIES; CANCER.; CELL PERMEABILITIES; DRUG DISCOVERIES; HEPATOMA CELLS; INACTIVE CONFORMATIONS; INACTIVE ENZYMES; INHIBITORY ACTIVITIES; INHIBITORY COMPOUNDS; KINETIC STUDIES; MIMETICS; NEW CLASSES; OPEN CONFORMATIONS; PHARMACOLOGICAL PROPERTIES; PHARMACOPHORES; PROTEIN TYROSINE PHOSPHATASES; PTP1B INHIBITORS;

AMIDES; AMINO ACIDS; BIOCHEMISTRY; OLIGOMERS;

DERIVATIVES;

AMIDES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; KETO ACIDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58049206736     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja8068177     Document Type: Article

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