Regulation of the eukaryotic cell cycle: Molecular antagonism, hysteresis, and irreversible transitions

Journal of Theoretical Biology

Volumn 210, Issue 2, 2001, Pages 249-263

  Tyson, John J ^a   Novak, Bela ^b  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE;

ANAPHASE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL GROWTH; EUKARYOTIC CELL; HUMAN; HYSTERESIS; MODEL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANURA; EUKARYOTA; MAMMALIA;

EID: 0035926571     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2293     Document Type: Article

References (42)

1. Instabilities in phosphorylation-dephosphorylation cascades and cell cycle checkpoints
2. The retino-blastoma protein pathway and the restriction point
3. Bifurcation analysis of a model of mitotic control in frog eggs
4. Kinetic analysis of a molecular model of the budding yeast cell cycle
5. Cell cycle checkpoints: Preventing an identity crisis
6. A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase
7. An amplified sensitivity arising from covalent modification in biological systems
8. The hallmarks of cancer
9. A mathematical description of regulation of the G1-S transition of the mammalian cell cycle
10. Budding yeast Cdc20: A target of the spindle checkpoint
11. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in yeast
12. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
13. Molecular interaction map of the mammalian cell cycle control and DNA repair systems
14. Modeling M-phase control in Xenopus oocyte extracts: The surveillance mechanism for unreplicated DNA
15. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae
16. + gene
17. The genetics of cell cycle checkpoints
18. Cyclin synthesis drives the early embryonic cell cycle
19. Dominoes and clocks: The union of two views of the cell cycle
20. Evolution of the cell cycle
21. At the heart of the budding yeast cell cycle
22. A model for the adjustment of the mitotic clock by cyclin and MPF levels
23. Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos
24. Quantitative analysis of a molecular model of mitotic control in fission yeast
25. Modeling the control of DNA replication in fission yeast
26. Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions
27. Model scenarios for evolution of the eukaryotic cell cycle
28. Finishing the cell cycle
29. A model of cell cycle behavior dominated by kinetics of a pathway stimulated by growth factors
30. An essential G1 function for cyclin-like proteins in yeast
31. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
32. - cdc25Δ mutant cells
33. Mathematical analysis of binary activation of a cell cycle kinase which down-regulates its own inhibitor
34. The cyclin-dependent kinase inhibitor p40sic1 imposes the requirement for Cln G1 cyclin function at start
35. Check-points in the cell cycle from a modeler's perspective
36. Is nuclear division in Physarum controlled by a continuous limit cycle oscillator?
37. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
38. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
39. Whose end is destruction: Cell division and the anaphase-promoting complex