Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation

Toxicology and Applied Pharmacology

Volumn 144, Issue 1, 1997, Pages 145-155

  Andersen, Melvin E ^a   Birnbaum, Linda S ^b   Barton, Hugh A ^a   Eklund, Christopher R ^b  

^a ICF Kaiser Engineers Inc   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 ISOENZYME;

ARTICLE; DISSOCIATION CONSTANT; ENZYME INDUCTION; GENE INDUCTION; LIVER MICROSOME METABOLISM; MODEL; NONHUMAN; PREDICTION; RAT; SIMULATION; TOXICOKINETICS;

EID: 18744421286     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.8067     Document Type: Article

References (30)

1. Abraham K., Krowke R., Neubert D. Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p. Arch. Toxicol. 62:1988;359-368.
2. Abraham K., Wiesmuller T., Brunner H., Krowke R., Hagenmaier H., Neubert D. Absorption and tissue distribution of various polychlorinated dibenzo-p. Arch. Toxicol. 63:1989;193-202.
3. Andersen M. E., Eklund C. R., Mills J. J., Barton H. A., Birnbaum L. S. A multi-compartment geometric model of the liver in relation to regional induction of cytochrome P450s. Toxicol. Appl. Pharmacol. 143:1997;135-144.
4. Andersen M. E., Mills J. J., Gargas M. L., Kedderis L., Birnbaum L. S., Neubert D., Greenlee W. F. Modeling receptor-mediated processes with dioxin: Implications for pharmacokinetics and risk assessment. J. Risk Anal. 13:1993;25-36.
5. Banks Y. B., Brewster D. W., Birnbaum L. S. Age-related changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p. Fundam. Appl. Toxicol. 15:1990;163-173.
6. Bars R. G., Elcombe C. R. Dose-dependent acinar induction of cytochrome P450 in rat liver. Evidence for a differential mechanism of induction of P450IA1 byb. Biochem. J. 277:1991;577-580.
7. Brewster D. W., Birnbaum L. S. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. Toxicol. Appl. Pharmacol. 90:1987;243-252.
8. Carrier G., Brunet R. C., Brodeur J. Modeling of the toxicokinetics of polychlorinated dibenzo-p. Toxicol. Appl. Pharmacol. 131:1995a;253-266.
9. Carrier G., Brunet R. C., Brodeur J. Modeling of the toxicokinetics of polychlorinated dibenzo-p. Toxicol. Appl. Pharmacol. 131:1995b;267-276.
10. Kedderis L. B., Diliberto J. J., Linko P., Goldstein J. A., Birnbaum L. S. Disposition of 2,3,7,8-tetrabromodibenzo-pp. Toxicol. Appl. Pharmacol. 111:1991;163-172.
11. Kedderis L. B., Mills J. J., Andersen M. E., Birnbaum L. S. A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p. Toxicol. Appl. Pharmacol. 121:1993;87-98.
12. King F. G., Dedrick R. L., Collins J. M., Matthews H. B., Birnbaum L. S. Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species. Toxicol. Appl. Pharmacol. 67:1983;390.
13. Kissel J., Rombarge G. Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic model. Chemosphere. 17:1988;2017.
14. Kohn M. C., Lucier G. W., Clark G. C., Sewall C., Tritscher A., Portier C. J. A mechanistic model of the effects of dioxin on gene expression in the rat liver. Toxicol. Appl. Pharmacol. 120:1993;138-154.
15. Lamers W. H., Hilberts A., Furt E., Smith J., Jonges G. N., Noorden C. J. F. v., Gaasbeck-Janzen J. W., Charles B., Moorman A. F. M. Hepatic enzymic zonation: A reevaluation of the concept of the liver acinus. Hepatology. 10:1989;72-76.
16. Leung H. W., Ku R. H., Paustenbach D. J., Andersen M. E. A physiologically based pharmacokinetic model for 2,3,7,8-tetrachloro-p. Toxicol. Lett. 42:1988;15-28.
17. Leung H. W., Paustenbach D. J., Murray F. J., Andersen M. E. A physiological pharmacokinetic description of the tissue distribution and enzyme inducing properties of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 103:1990a;399-410.
18. 125p. Toxicol. Appl. Pharmacol. 103:1990b;411.
19. Lutz R. J., Dedrick R. L., Matthews H. B., Eling T. E., Anderson M. W. A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. Drug Metab. Dipos. 5:1977;386-396.
20. Maronpot R. R., Foley J. F., Takahashi K., Goldsworthy T., Clark G., Tritscher A., Portier C., Lucier G. Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: Histologic, biochemical, and cell proliferation endpoints. Environ. Health Perspect. 101:1993;634-642.
21. Parkinson A., Thomas P. E., Ryan D. E., Reik L. M., Safe S. H., Robertson L. W., Levin W. Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254. Arch. Biochem. Biophys. 225:1983a;203-215.
22. Parkinson A., Thomas P. E., Ryan D. E., Levin W. Thein vivo. Arch. Biochem. Biophys. 225:1983b;216-236.
23. 125pAh. Mol. Pharmacol. 36:1989a;121-127.
24. 125pAh. Mol. Pharmacol. 36:1989b;113-120.
25. Rose J., Ramsey J., Wentzler T., Hummel R., Gehring P. The fate of 2,3,7,8-tetrachlorodibenzo-p. Toxicol. Appl. Pharmacol. 36:1976;209-226.
26. Sloop T. C., Lucier G. W. Dose-dependent elevation of Ah receptor binding by TCDD in rat liver. Toxicol. Appl. Pharmacol. 88:1987;329-337.
27. Tuey D. B., Matthews H. B. Use of a physiological pharmacokinetic model for the rat to describe the pharmacokinetics of several chlorinated biphenyls in the mouse. Drug Metab. Dispos. 8:1980;397-403.
28. Tritscher A. M., Goldstein J. A., Portier C. J., McCoy Z., Clark G. C., Lucier G. W. Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: Quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res. 52:1992;3436-3442.
29. Vanden Heuvel J. P., Clark G. C., Kohn M. C., Tritscher A. M., Greenlee W. F., Lucier G. W., Bell D. A. Dioxin-responsive genes: Examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res. 54:1994;62-68.
30. Voorman R., Aust S. D. TCDD (2,3,7,8-tetrachlorodibenzo-p. J. Biochem. Toxicol. 4:1989;105-109.