Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1

Journal of Theoretical Biology

Volumn 241, Issue 4, 2006, Pages 852-865

  Roeder, Ingo ^a   Glauche, Ingmar ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

GATA 1; Hematopoietic stem cell; Lineage specification; PU.1; Transcription factor network

Indexed keywords

TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR PU 1;

BLOOD; CELLS AND CELL COMPONENTS; DIFFERENTIATION; NUMERICAL MODEL;

ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL SPECIFICITY; ERYTHROID CELL; HEMATOPOIETIC STEM CELL; MATHEMATICAL MODEL; MOLECULAR INTERACTION; MOLECULAR MODEL; OBSERVATION; PHASE TRANSITION; PREDICTION; PRIORITY JOURNAL; STOCHASTIC MODEL; TRANSCRIPTION REGULATION;

CELL DIFFERENTIATION; CELL LINEAGE; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, GENETIC; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 33746040437     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2006.01.021     Document Type: Article

References (44)

1. Akashi K. Lineage promiscuity and plasticity in hematopoietic development. Ann. N. Y. Acad. Sci. 1044 (2005) 125-131
2. Akashi K., He X., Chen J., Iwasaki H., Niu C., Steenhard B., Zhang J., Haug J., and Li L. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101 2 (2003) 383-389
3. Becskei A., Seraphin B., and Serrano L. Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J. 20 10 (2001) 2528-2535
4. Berger S., and Felsenfeld G. Chromatin goes global. Mol. Cell. 8 2 (2001) 263-268
5. Bundschuh R., Hayot F., and Jayaprakash C. The role of dimerization in noise reduction of simple genetic networks. J. Theor. Biol. 220 2 (2003) 261-269
6. Cantor A.B., and Orkin S.H. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21 21 (2002) 3368-3376
7. Chen H., Ray-gallet D., Zhang P., Hetherington C.J., Gonzalez D.A., Zhang D.E., Moreau-gachelin F., and Tenen D.G. PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11 8 (1995) 1549-1560
8. Cinquin O., and Demongeot J. Positive and negative feedback: striking a balance between necessary antagonists. J. Theor. Biol. 216 2 (2002) 229-241
9. Cinquin O., and Demongeot J. High-dimensional switches and the modelling of cellular differentiation. J. Theor. Biol. 233 3 (2005) 391-411
10. Cross M.A., and Enver T. The lineage commitment of haemopoietic progenitor cells. Curr. Opin. Genet. Dev. 7 5 (1997) 609-613
11. Cross M.A., Heyworth C.M., Murrell A.M., Bockamp E.O., Dexter T.M., and Green A.R. Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. Oncogene 9 10 (1994) 3013-3016
12. Du J., Stankiewicz M.J., Liu Y., Xi Q., Schmitz J.E., Lekstrom-Himes J.A., and Ackerman S.J. Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. J. Biol. Chem. 277 45 (2002) 43481-43494
13. Enver T., and Greaves M. Loops, lineage, and leukemia. Cell 4 1 (1998) 9-12
14. Francois P., and Hakim V. Design of genetic networks with specified functions by evolution in silico. Proc. Natl Acad. Sci. USA 101 2 (2004) 580-585
15. Gardner T.S., Cantor C.R., and Collins J.J. Construction of a genetic toggle switch in Escherichia coli. Nature 403 6767 (2000) 339-342
16. Glass L., and Kauffman S. The logical analysis of continuous, non-linear biochemical control networks. J. Theor. Biol. 39 1 (1973) 103-129
17. Hu M., Krause D., Greaves M., Sharkis S., Dexter M., Heyworth C., and Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes Dev. 11 6 (1997) 774-785
18. Hume D. Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood 96 7 (2000) 2323-2328
19. Kaern M., Elston T., Blake W., and Collins J. Stochasticity in gene expression: from theories to phenotypes. Nat. Rev. Genet. 6 6 (2005) 451-464
20. Loeffler M., and Roeder I. Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models-a conceptual approach. Cells Tissues Organs 171 1 (2002) 8-26
21. Lord, B.I., 1997. Biology of the Haemopoietic Stem Cell. Academic Press, Cambridge, pp. 401-422.
22. McAdams H., and Arkin A. Simulation of prokaryotic genetic circuits. Annu. Rev. Biophys. Biomol. Struct. 27 (1998) 199-224
23. Nerlov C., Querfurth E., Kulessa H., and Graf T. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood 95 8 (2000) 2543-2551
24. Nishimura S., Takahashi S., Kuroha T., Suwabe N., Nagasawa T., Trainor C., and Yamamoto M. A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene. Mol. Cell. Biol. 20 2 (2000) 713-723
25. Oikawa T., Yamada T., Kihara-Negishi F., Yamamoto H., Kondoh N., Hitomi Y., and Hashimoto Y. The role of Ets family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis. Cell Death Differ. 6 7 (1999) 599-608
26. Okuno Y., Huang G., Rosenbauer F., Evans E.K., Radomska H.S., Iwasaki H., Akashi K., Moreau-Gachelin F., Li Y., Zhang P., Gottgens B., and Tenen D.G. Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol. Cell. Biol. 25 7 (2005) 2832-2845
27. Orkin S.H. Hematopoiesis: how does it happen?. Curr. Opin. Cell Biol. 7 6 (1995) 870-877
28. Orkin S.H. Diversification of haematopoietic stem cells to specific lineages. Nat. Rev. Genet. 1 1 (2000) 57-64
29. Pirone J., and Elston T. Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression. J. Theor. Biol. 226 1 (2004) 111-121
30. Potten C.S., and Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110 4 (1990) 1001-1020
31. Rekhtman N., Radparvar F., Evans T., and Skoultchi A.I. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13 11 (1999) 1398-1411
32. Rekhtman N., Choe K.S., Matushansky I., Murray S., Stopka T., and Skoultchi A.I. PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation. Mol. Cell. Biol. 23 21 (2003) 7460-7474
33. Rosmarin A., Yang Z., and Resendes K. Transcriptional regulation in myelopoiesis: hematopoietic fate choice, myeloid differentiation, and leukemogenesis. Exp. Hematol. 33 2 (2005) 131-143
34. Santillán M., and Mackey M.C. Dynamic behavior in mathematical models of the tryptophan operon. Chaos 11 (1998) 261-268
35. Santillán M., and Mackey M.C. Dynamic regulation of the tryptophan operon: a modeling study and comparison with experimental data. Proc. Natl Acad. Sci. USA 98 (2001) 1364-1369
36. Santillán M., and Mackey M.C. Why the lysogenic state of phage lambda is so stable: a mathematical modeling approach. Biophys. J. 86 1 (2004) 75-84
37. Sieweke M.H., and Graf T. A transcription factor party during blood cell differentiation. Curr. Opin. Genet. Dev. 8 5 (1998) 545-551
38. Tenen D.G. Disruption of differentiation in human cancer: AML shows the way. Nat. Rev. Cancer 3 2 (2003) 89-101
39. Tsai S.F., Strauss E., and Orkin S.H. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter. Genes Dev. 5 6 (1991) 919-931
40. Vilar J., Kueh H., Barkai N., and Leibler S. Mechanisms of noise-resistance in genetic oscillators. Proc. Natl Acad. Sci. USA 99 9 (2002) 5988-5992
41. Voso M.T., Burn T.C., Wulf G., Lim B., Leone G., and Tenen D.G. Inhibition of hematopoiesis by competitive binding of transcription factor PU.1. Proc. Natl Acad. Sci. USA 91 17 (1994) 7932-7936
42. Yamada T., Kihara-Negishi F., Yamamoto H., Yamamoto M., Hashimoto Y., and Oikawa T. Reduction of DNA binding activity of the GATA-1 transcription factor in the apoptotic process induced by overexpression of PU.1 in murine erythroleukemia cells. Exp. Cell Res. 245 1 (1998) 186-194
43. Zhang P., Behre G., Pan J., Iwama A., Wara-Aswapati N., Radomska H.S., Auron P.E., Tenen D.G., and Sun Z. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl Acad. Sci. USA 96 15 (1999) 8705-8710
44. Zhang P., Zhang X., Iwama A., Yu C., Smith K.A., Mueller B.U., Narravula S., Torbett B.E., Orkin S.H., and Tenen D.G. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood 96 8 (2000) 2641-2648