Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells

Toxicology and Applied Pharmacology

Volumn 181, Issue 2, 2002, Pages 116-123

  Suh, Jaehong ^a   Jeon, Young Jin ^b   Kim, Hwan Mook ^c   Kang, Jong Soon ^a   Kaminski, Norbert E ^d   Yang, Kyu Hwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chosun University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

AhR; AP 1; B cell; TCDD

Indexed keywords

2,2',5,5' TETRACHLOROBIPHENYL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; BIPHENYL DERIVATIVE; CHLORAMPHENICOL ACETYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; ELECTROPHORETIC MOBILITY; ENZYME INHIBITION; GENE ACTIVITY; GENE EXPRESSION; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; STEADY STATE; TARGET CELL; TRANSCRIPTION REGULATION;

EID: 0036607704     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9403     Document Type: Article

References (43)

1. Species-specific antagonism of Ah receptor action by 2,2′,5,5′-tetrachloro- and 2,2′,3,3′4,4′-hexachlorobiphenyl
2. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
3. Lipopolysaccharide-dependent transactivation of the temporally regulated immunoglobulin heavy chain 3′ enhancer
4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced changes in activities of nuclear protein kinases and phosphatases affecting DNA binding activity of c-Myc and AP-1 in the livers of guinea pigs
5. Activate NF-κB or die?
6. Cross-linking CD40 on B cells rapidly activates nuclear factor-κB
7. Induced differentiation of a transformed clone of Ly-1 + B cells by clonal T cells and antigen
8. Regulation of the B cell immune response: Induction of competence and progression in a surface IgM-bearing subset
9. Immunosuppressive activities of polychlorinated dibenzofuran congeners: Quantitative structure-activity relationships and interactive effects
10. Elucidation of cellular targets responsible for tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody responses. I. The role of the B lymphocyte
11. Evidence for a second pathway in the action mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Significance of Ah-receptor mediated activation of protein kinase under cell-free conditions
12. Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway
13. AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun
14. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-α and -β 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control
15. Alpha-naphthoflavone acts as an antagonist of 2,3,7,8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor
16. A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein: Linking dioxin signaling to the cell cycle
17. IgM receptor-mediated transactivation of the IgH 3′ enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function
18. Transforming growth factor-β1 (TGF-β1) promotes IL-2 mRNA expression through the up-regulation of NF-κB, AP-1 and NF-AT in EL4 cells
19. A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update
20. Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-κB/Re1 in lipopolysaccharide-stimulated macrophages
21. Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands
22. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
23. T cell-dependent induction of NF-κB in B cells
24. Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation
25. Up-regulation of c-fos expression is a component of the mIg signal transduction mechanism but is not indicative of competence for proliferation
26. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated gene expression in the immature rat thymus
27. A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus
28. Oligonucleotide that binds nuclear factor NF-κB acts as a lymphoid- specific and inducible enhancer element
29. Activation of transcription factors activator protein-1 and nuclear factor-κB by 2,3,7,8-tetrachlorodibenzo-p-dioxin
30. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1
31. Aryl hydrocarbon receptor-mediated signal transduction
32. c-fos expression interferes with thymus development in transgenic mice
33. An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression
34. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
35. Spontaneous murine B-cell leukaemia
36. Aryl hydrocarbon receptor-dependent suppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin of IgM secretion in activated B cells
37. Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway
38. Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1β
39. Ah receptor and NF-κB interactions, a potential mechanism for dioxin toxicity
40. Suppression of B cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
41. Heterodimer formation of c-Jun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein
42. Immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in strains of mice with different susceptibility to induction of aryl hydrocarbon hydroxylase
43. Induction of CREB activity via the surface Ig receptor of B cells