-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, et al. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 82: 4245-4249.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
-
3
-
-
44549087765
-
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
-
Selkoe DJ (2008) Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 192: 106-113.
-
(2008)
Behav Brain Res
, vol.192
, pp. 106-113
-
-
Selkoe, D.J.1
-
4
-
-
34248190279
-
A beta oligomers-a decade of discovery
-
Walsh DM, Selkoe DJ (2007) A beta oligomers-a decade of discovery. J Neurochem 101: 1172-1184.
-
(2007)
J Neurochem
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
5
-
-
0033595706
-
Betasecretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, et al. (1999) Betasecretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286: 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
-
6
-
-
0037474447
-
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
-
Asai M, Hattori C, Szabo B, Sasagawa N, Maruyama K, et al. (2003) Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem Biophys Res Commun 301: 231-235.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 231-235
-
-
Asai, M.1
Hattori, C.2
Szabo, B.3
Sasagawa, N.4
Maruyama, K.5
-
7
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
8
-
-
0037176727
-
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
-
Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, et al. (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 41: 2825-2835.
-
(2002)
Biochemistry
, vol.41
, pp. 2825-2835
-
-
Weidemann, A.1
Eggert, S.2
Reinhard, F.B.3
Vogel, M.4
Paliga, K.5
-
9
-
-
0034774969
-
Presenilindependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
-
Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, et al. (2001) Presenilindependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2: 835-841.
-
(2001)
EMBO Rep
, vol.2
, pp. 835-841
-
-
Sastre, M.1
Steiner, H.2
Fuchs, K.3
Capell, A.4
Multhaup, G.5
-
10
-
-
0038652102
-
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, et al. (2003) Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A 100: 6382-6387.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 6382-6387
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
-
11
-
-
0038664363
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, et al. (2003) Reconstitution of gamma-secretase activity. Nat Cell Biol 5: 486-488.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
-
12
-
-
36349024875
-
Active gamma-secretase complexes contain only one of each component
-
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, et al. (2007) Active gamma-secretase complexes contain only one of each component. J Biol Chem 282: 33985-33993.
-
(2007)
J Biol Chem
, vol.282
, pp. 33985-33993
-
-
Sato, T.1
Diehl, T.S.2
Narayanan, S.3
Funamoto, S.4
Ihara, Y.5
-
13
-
-
15844425969
-
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
-
Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, et al. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181-190.
-
(1996)
Neuron
, vol.17
, pp. 181-190
-
-
Thinakaran, G.1
Borchelt, D.R.2
Lee, M.K.3
Slunt, H.H.4
Spitzer, L.5
-
14
-
-
5144224126
-
Coordinated and widespread expression of gamma-secretase in vivo: Evidence for size and molecular heterogeneity
-
Hebert SS, Serneels L, Dejaegere T, Horre K, Dabrowski M, et al. (2004) Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis 17: 260-272.
-
(2004)
Neurobiol Dis
, vol.17
, pp. 260-272
-
-
Hebert, S.S.1
Serneels, L.2
Dejaegere, T.3
Horre, K.4
Dabrowski, M.5
-
15
-
-
0033553564
-
Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing
-
Saura CA, Tomita T, Davenport F, Harris CL, Iwatsubo T, et al. (1999) Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing. J Biol Chem 274: 13818-13823.
-
(1999)
J Biol Chem
, vol.274
, pp. 13818-13823
-
-
Saura, C.A.1
Tomita, T.2
Davenport, F.3
Harris, C.L.4
Iwatsubo, T.5
-
16
-
-
13444268952
-
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo
-
Serneels L, Dejaegere T, Craessaerts K, Horre K, Jorissen E, et al. (2005) Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci U S A 102: 1719-1724.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1719-1724
-
-
Serneels, L.1
Dejaegere, T.2
Craessaerts, K.3
Horre, K.4
Jorissen, E.5
-
17
-
-
4744375540
-
Identification of distinct gamma-secretase complexes with different APH-1 variants
-
Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H (2004) Identification of distinct gamma-secretase complexes with different APH-1 variants. J Biol Chem 279: 41340-41345.
-
(2004)
J Biol Chem
, vol.279
, pp. 41340-41345
-
-
Shirotani, K.1
Edbauer, D.2
Prokop, S.3
Haass, C.4
Steiner, H.5
-
18
-
-
43049163813
-
Substrate specificity of gamma-secretase and other intramembrane proteases
-
Beel AJ, Sanders CR (2008) Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci 65: 1311-1334.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 1311-1334
-
-
Beel, A.J.1
Sanders, C.R.2
-
19
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan R, Ilagan MX (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137: 216-233.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
20
-
-
0032524325
-
Nuclear access and action of notch in vivo
-
Struhl G, Adachi A (1998) Nuclear access and action of notch in vivo. Cell 93: 649-660.
-
(1998)
Cell
, vol.93
, pp. 649-660
-
-
Struhl, G.1
Adachi, A.2
-
21
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398: 518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
de Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
-
22
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393: 382-386.
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
23
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
24
-
-
56749163716
-
Notch: From neural development to neurological disorders
-
Lathia JD, Mattson MP, Cheng A (2008) Notch: from neural development to neurological disorders. J Neurochem 107: 1471-1481.
-
(2008)
J Neurochem
, vol.107
, pp. 1471-1481
-
-
Lathia, J.D.1
Mattson, M.P.2
Cheng, A.3
-
25
-
-
0028216808
-
Notch1 is essential for postimplantation development in mice
-
Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T (1994) Notch1 is essential for postimplantation development in mice. Genes Dev 8: 707-719.
-
(1994)
Genes Dev
, vol.8
, pp. 707-719
-
-
Swiatek, P.J.1
Lindsell, C.E.2
del Amo, F.F.3
Weinmaster, G.4
Gridley, T.5
-
26
-
-
0034702303
-
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
-
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, et al. (2000) Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405: 966-970.
-
(2000)
Nature
, vol.405
, pp. 966-970
-
-
Huppert, S.S.1
Le, A.2
Schroeter, E.H.3
Mumm, J.S.4
Saxena, M.T.5
-
27
-
-
0142242199
-
Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor
-
Jung KM, Tan S, Landman N, Petrova K, Murray S, et al. (2003) Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem 278: 42161-42169.
-
(2003)
J Biol Chem
, vol.278
, pp. 42161-42169
-
-
Jung, K.M.1
Tan, S.2
Landman, N.3
Petrova, K.4
Murray, S.5
-
28
-
-
0038045714
-
Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability
-
Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M, et al. (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci 23: 5425-5436.
-
(2003)
J Neurosci
, vol.23
, pp. 5425-5436
-
-
Kanning, K.C.1
Hudson, M.2
Amieux, P.S.3
Wiley, J.C.4
Bothwell, M.5
-
29
-
-
0141429160
-
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of Ncadherin is inhibited by PS1 FAD mutations
-
Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, et al. (2003) A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of Ncadherin is inhibited by PS1 FAD mutations. Cell 114: 635-645.
-
(2003)
Cell
, vol.114
, pp. 635-645
-
-
Marambaud, P.1
Wen, P.H.2
Dutt, A.3
Shioi, J.4
Takashima, A.5
-
30
-
-
33645277094
-
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling
-
Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, et al. (2006) Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. Embo J 25: 1242-1252.
-
(2006)
Embo J
, vol.25
, pp. 1242-1252
-
-
Georgakopoulos, A.1
Litterst, C.2
Ghersi, E.3
Baki, L.4
Xu, C.5
-
32
-
-
33847021476
-
Presenilin diversifies its portfolio
-
Parks AL, Curtis D (2007) Presenilin diversifies its portfolio. Trends Genet 23: 140-150.
-
(2007)
Trends Genet
, vol.23
, pp. 140-150
-
-
Parks, A.L.1
Curtis, D.2
-
33
-
-
33745632662
-
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease
-
Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sevalle J, Vincent B, et al. (2006) Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J Neurosci 26: 6377-6385.
-
(2006)
J Neurosci
, vol.26
, pp. 6377-6385
-
-
Alves da Costa, C.1
Sunyach, C.2
Pardossi-Piquard, R.3
Sevalle, J.4
Vincent, B.5
-
34
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R, Ilagan MX (2004) Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5: 499-504.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
35
-
-
0037590902
-
Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities
-
Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, et al. (2003) Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem 278: 22475-22481.
-
(2003)
J Biol Chem
, vol.278
, pp. 22475-22481
-
-
Lai, M.T.1
Chen, E.2
Crouthamel, M.C.3
DiMuzio-Mower, J.4
Xu, M.5
-
36
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, et al. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391: 387-390.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
de Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
-
37
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, et al. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A 96: 11872-11877.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
-
38
-
-
0030779784
-
Skeletal and CNS defects in Presenilin-1-deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, et al. (1997) Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89: 629-639.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
-
39
-
-
12144250683
-
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
-
Ma G, Li T, Price DL, Wong PC (2005) APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci 25: 192-198.
-
(2005)
J Neurosci
, vol.25
, pp. 192-198
-
-
Ma, G.1
Li, T.2
Price, D.L.3
Wong, P.C.4
-
40
-
-
47749095968
-
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
-
Dejaegere T, Serneels L, Schafer MK, Van Biervliet J, Horre K, et al. (2008) Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proc Natl Acad Sci U S A 105: 9775-9780.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 9775-9780
-
-
Dejaegere, T.1
Serneels, L.2
Schafer, M.K.3
van Biervliet, J.4
Horre, K.5
-
41
-
-
1642585717
-
Binding sites of gamma-secretase inhibitors in rodent brain: Distribution, postnatal development, and effect of deafferentation
-
Yan XX, Li T, Rominger CM, Prakash SR, Wong PC, et al. (2004) Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation. J Neurosci 24: 2942-2952.
-
(2004)
J Neurosci
, vol.24
, pp. 2942-2952
-
-
Yan, X.X.1
Li, T.2
Rominger, C.M.3
Prakash, S.R.4
Wong, P.C.5
-
42
-
-
21844448354
-
Spatial segregation of gamma-secretase and substrates in distinct membrane domains
-
Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem 280: 25892-25900.
-
(2005)
J Biol Chem
, vol.280
, pp. 25892-25900
-
-
Vetrivel, K.S.1
Cheng, H.2
Kim, S.H.3
Chen, Y.4
Barnes, N.Y.5
-
43
-
-
40349102241
-
Active gamma-secretase is localized to detergent-resistant membranes in human brain
-
Hur JY, Welander H, Behbahani H, Aoki M, Franberg J, et al. (2008) Active gamma-secretase is localized to detergent-resistant membranes in human brain. Febs J 275: 1174-1187.
-
(2008)
Febs J
, vol.275
, pp. 1174-1187
-
-
Hur, J.Y.1
Welander, H.2
Behbahani, H.3
Aoki, M.4
Franberg, J.5
-
44
-
-
0036180950
-
Cholesteroldependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains
-
Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, et al. (2002) Cholesteroldependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9: 11-23.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
Das, P.2
Nyborg, A.C.3
McLendon, C.4
Shoji, M.5
-
45
-
-
0035808416
-
A novel gamma-secretase assay based on detection of the putative C-terminal fragmentgamma of amyloid beta protein precursor
-
Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, et al. (2001) A novel gamma-secretase assay based on detection of the putative C-terminal fragmentgamma of amyloid beta protein precursor. J Biol Chem 276: 481-487.
-
(2001)
J Biol Chem
, vol.276
, pp. 481-487
-
-
Pinnix, I.1
Musunuru, U.2
Tun, H.3
Sridharan, A.4
Golde, T.5
-
46
-
-
0037134505
-
Insulindegrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)
-
Edbauer D, Willem M, Lammich S, Steiner H, Haass C (2002) Insulindegrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). J Biol Chem 277: 13389-13393.
-
(2002)
J Biol Chem
, vol.277
, pp. 13389-13393
-
-
Edbauer, D.1
Willem, M.2
Lammich, S.3
Steiner, H.4
Haass, C.5
-
47
-
-
0034457993
-
Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1
-
Martys-Zage JL, Kim SH, Berechid B, Bingham SJ, Chu S, et al. (2000) Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. J Mol Neurosci 15: 189-204.
-
(2000)
J Mol Neurosci
, vol.15
, pp. 189-204
-
-
Martys-Zage, J.L.1
Kim, S.H.2
Berechid, B.3
Bingham, S.J.4
Chu, S.5
-
48
-
-
0033974972
-
Calcium depletion dissociates and activates heterodimeric notch receptors
-
Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, et al. (2000) Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol 20: 1825-1835.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1825-1835
-
-
Rand, M.D.1
Grimm, L.M.2
Artavanis-Tsakonas, S.3
Patriub, V.4
Blacklow, S.C.5
-
49
-
-
0028641294
-
Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision
-
Wilkinson HA, Fitzgerald K, Greenwald I (1994) Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 79: 1187-1198.
-
(1994)
Cell
, vol.79
, pp. 1187-1198
-
-
Wilkinson, H.A.1
Fitzgerald, K.2
Greenwald, I.3
-
50
-
-
0028176821
-
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme
-
Kurochkin IV, Goto S (1994) Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 345: 33-37.
-
(1994)
FEBS Lett
, vol.345
, pp. 33-37
-
-
Kurochkin, I.V.1
Goto, S.2
-
51
-
-
0034530036
-
Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain
-
Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, et al. (2000) Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain. J Biochem 128: 897-902.
-
(2000)
J Biochem
, vol.128
, pp. 897-902
-
-
Takaki, Y.1
Iwata, N.2
Tsubuki, S.3
Taniguchi, S.4
Toyoshima, S.5
-
52
-
-
77749319891
-
Affinity pulldown of gamma-secretase and associated proteins from human and rat brain
-
Epub ahead of print
-
Teranishi Y, Hur JY, Welander H, Franberg J, Aoki M, et al. (2009) Affinity pulldown of gamma-secretase and associated proteins from human and rat brain. J Cell Mol Med. Epub ahead of print.
-
(2009)
J Cell Mol Med.
-
-
Teranishi, Y.1
Hur, J.Y.2
Welander, H.3
Franberg, J.4
Aoki, M.5
-
53
-
-
34250831492
-
Rat brain gamma-secretase activity is highly influenced by detergents
-
Franberg J, Welander H, Aoki M, Winblad B, Tjernberg LO, et al. (2007) Rat brain gamma-secretase activity is highly influenced by detergents. Biochemistry 46: 7647-7654.
-
(2007)
Biochemistry
, vol.46
, pp. 7647-7654
-
-
Franberg, J.1
Welander, H.2
Aoki, M.3
Winblad, B.4
Tjernberg, L.O.5
-
54
-
-
33645013015
-
Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease
-
Siemers ER, Quinn JF, Kaye J, Farlow MR, Porsteinsson A, et al. (2006) Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease. Neurology 66: 602-604.
-
(2006)
Neurology
, vol.66
, pp. 602-604
-
-
Siemers, E.R.1
Quinn, J.F.2
Kaye, J.3
Farlow, M.R.4
Porsteinsson, A.5
-
55
-
-
0242412482
-
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor
-
Searfoss GH, Jordan WH, Calligaro DO, Galbreath EJ, Schirtzinger LM, et al. (2003) Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J Biol Chem 278: 46107-46116.
-
(2003)
J Biol Chem
, vol.278
, pp. 46107-46116
-
-
Searfoss, G.H.1
Jordan, W.H.2
Calligaro, D.O.3
Galbreath, E.J.4
Schirtzinger, L.M.5
-
56
-
-
11144355129
-
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
-
Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, et al. (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279: 12876-12882.
-
(2004)
J Biol Chem
, vol.279
, pp. 12876-12882
-
-
Wong, G.T.1
Manfra, D.2
Poulet, F.M.3
Zhang, Q.4
Josien, H.5
-
57
-
-
41149149615
-
Abetadegrading enzymes in Alzheimer's disease
-
Miners JS, Baig S, Palmer J, Palmer LE, Kehoe PG, et al. (2008) Abetadegrading enzymes in Alzheimer's disease. Brain Pathol 18: 240-252.
-
(2008)
Brain Pathol
, vol.18
, pp. 240-252
-
-
Miners, J.S.1
Baig, S.2
Palmer, J.3
Palmer, L.E.4
Kehoe, P.G.5
-
58
-
-
59149088690
-
Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes
-
Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, et al. (2009) Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem 284: 2967-2977.
-
(2009)
J Biol Chem
, vol.284
, pp. 2967-2977
-
-
Placanica, L.1
Tarassishin, L.2
Yang, G.3
Peethumnongsin, E.4
Kim, S.H.5
-
59
-
-
64549113016
-
Gender-and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease
-
Placanica L, Zhu L, Li YM (2009) Gender-and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS One 4: e5088.
-
(2009)
PLoS One
, vol.4
-
-
Placanica, L.1
Zhu, L.2
Li, Y.M.3
-
60
-
-
0032728957
-
Mice lacking both presenilin genes exhibit early embryonic patterning defects
-
Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, et al. (1999) Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev 13: 2801-2810.
-
(1999)
Genes Dev
, vol.13
, pp. 2801-2810
-
-
Donoviel, D.B.1
Hadjantonakis, A.K.2
Ikeda, M.3
Zheng, H.4
Hyslop, P.S.5
|