Rat brain γ-secretase activity is highly influenced by detergents

Biochemistry

Volumn 46, Issue 25, 2007, Pages 7647-7654

  Frånberg, Jenny ^a   Welander, Hedvig ^a   Aoki, Mikio ^a   Winblad, Bengt ^a   Tjernberg, Lars O ^a   Frykman, Susanne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CONCENTRATION (PROCESS); DETERGENTS; PATHOGENS; PROTEINS;

AMYLOID PRECURSOR PROTEIN (APP); APP INTRACELLULAR DOMAIN; SECRETASE COMPONENTS; TRANSMEMBRANE PROTEIN COMPLEX;

ENZYME ACTIVITY;

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 2 HYDROXY 1 PROPANESULFONIC ACID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DETERGENT; GAMMA SECRETASE; MEMBRANE PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LOCALIZATION; ENZYME SUBSTRATE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RAT;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; CELL MEMBRANE; CHOLIC ACIDS; DETERGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; MALE; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SUBCELLULAR FRACTIONS; TEMPERATURE; TIME FACTORS;

RATTUS;

EID: 34250831492     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0621258     Document Type: Article

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