Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid β peptide in the brain

Journal of Biochemistry

Volumn 128, Issue 6, 2000, Pages 897-902

  Takaki, Yoshie ^a   Iwata, Nobuhisa ^a   Tsubuki, Satoshi ^a   Taniguchi, Sayuri ^a,b   Toyoshima, Satoshi ^b   Lu, Bao ^c   Gerard, Norma P ^c   Gerard, Craig ^c   Lee, Hahn Jun ^a   Shirotani, Keiro ^a   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b HOSHI UNIVERSITY   (Japan)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Amyloid peptide; Catabolism; Neprilysin; Neutral endopeptidase

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN PEPTIDE; MEMBRANE METALLOENDOPEPTIDASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATABOLISM; ENZYME ANALYSIS; GENE DISRUPTION; KINETICS; MALE; MOLECULAR BIOLOGY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CHROMATOGRAPHY, ION EXCHANGE; HYDROLYSIS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; NEPRILYSIN;

ANIMALIA;

EID: 0034530036     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022839     Document Type: Article

References (33)

1. Amyloid, the presenilins and Alzheimer's disease
2. Amyloid betapeptide is produced by cultured cells during normal metabolism
3. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
4. Neurons regulate extracellular levels of amyloid β-protein via proteolysis by insulin-degrading enzyme
5. Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A
6. Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-β peptide (1-40)
7. Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-β peptide degradation
8. Characterization of the thermolysin-like cleavage of biologically active peptides by Xenopus laevis peptide hormone inactivating enzyme
9. Degradation of amyloid β-protein by a serine protease-α2-macroglobulin complex
10. Proteolytic degradation of Alzheimer's disease amyloid β-peptide by a metalloproteinase from microglia cells
11. Neprilysin
12. Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells
13. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum
14. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets
15. XCE, a new member of the endothelin-converting enzyme and neutral endopeptidase family, is preferentially expressed in the CNS
16. Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
17. Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis
18. 1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
19. Catabolism of amyloid-β peptide in brain parenchyma
20. Degradation of amyloid-β peptide: A key to Alzheimer pathogenesis, prevention, and therapy
21. Neutral endopeptidase 24.11: Structure, inhibition, and experimental and clinical pharmacology
22. The presence of amyloid β-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells
23. Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and lyn kinase
24. Electronmicroscopic immunocytochemistry of pig brain shows that endopeptidase-24.11 is localized in neuronal membranes
25. Membrane peptidases in the peripheral nervous system of the pig: Their localization by immunohistochemistry at light and electron microscopic levels
26. Influence of region-specific alterations of neuropeptidase content on the catabolic fates of neuropeptides in Alzheimer's disease
27. Analysis of the human CD10/neutral endopeptidase 24.11 promoter region: Two separate regulatory elements
28. Tissue-specific expression of rat neutral endopeptidase (neprilysin) mRNAs
29. Autolytic transition of μ-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms
30. Neutral endopeptidase modulation of septic shock
31. Investigation of neutral endopeptidases (EC 3.4.24.11) and of neutral proteinases (EC 3.4.24.4) using a new sensitive two-stage enzymatic reaction
32. Neprilysin: Assay methods, purification, and characterization
33. Enzyme kinetics