Mean nuclear volume: A supplementary prognostic factor in endometrial cancer

International Journal of Gynecological Cancer

Volumn 9, Issue 1, 1999, Pages 72-79

  Mogensen, O ^a,c   Sorensen F B ^a,b   Bichel, P ^b   Jakobsen, A ^c  

^a AARHUS UNIVERSITY   (Denmark)

^b University Institute of Pathology Arhus   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cancer antigen 125; Morphometry; Prognosis; Stereology

Indexed keywords

CA 125 ANTIGEN; TUMOR ANTIGEN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER INCIDENCE; CANCER STAGING; ENDOMETRIUM CANCER; FEMALE; HUMAN; HYSTERECTOMY; MAJOR CLINICAL STUDY; MORPHOMETRICS; PRIORITY JOURNAL; PROGNOSIS; REGRESSION ANALYSIS; SALPINGOOOPHORECTOMY; STEREOLOGY; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 0033049686     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.1999.09829.x     Document Type: Article

References (24)

1. Muir C, Waterhouse J, Mack T, Powell J, Whelan S (eds). Cancer Incidence in Five Continents, vol V. Lyon: IARC scientific publications, 1987.
2. Tulinius H, Storm HH, Pukkala E, Andersen A, Ericsson J. Cancer in the Nordic countries, 1981-86. APMIS 1992; 100(Suppl 31): 79.
3. Engeland A, Haldorsen T, Tretli S, et al. Prediction of cancer mortality in the Nordic countries up to the years 2000 and 2010, on the basis of relative survival analysis. APMIS 1995; 103(Suppl 49): 78-80.
4. Abeler VM, Kjørstad KE. Endometrial adenocarcinoma in Norway. A study of a total population. Cancer 1991; 67: 3093-103.
5. Carey MS, O'Connell GJ, Johanson CR, et al. Good outcome associated with a standardized treatment protocol using selective postoperative radiation in patients with clinical stage I adenocarcinoma of the endometrium. Gynecol Oncol 1995; 57: 138-44.
6. Grigsby PW, Perez CA, Kuten A, et al. Clinical stage I endometrial cancer: Prognostic factors for local control and distant metastasis and implications of the new FIGO surgical staging system. Int J Radiat Oncol Biol Phys 1992; 22: 905-11.
7. Poulsen HK, Jacobsen M, Bertelsen K, et al. Adjuvant radiation therapy is not necessary in the management of endometrial carcinoma stage I, low risk cases. Int J Gynecol Cancer 1996; 6: 38-43.
8. Gundersen HJG, Bagger P, Bendtsen TF, et al. The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988; 96: 857-81.
9. Gundersen HJG, Bendtsen TF, Korbo L, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988; 96: 379-94.
10. Poulsen HK. The Danish endometrial cancer study (DEMCA). Acta Oncologica 1989; 28: 589-93.
11. Gundersen HJG, Jensen EB. Stereological estimation of the volume-weighted mean volume of arbitrary particles observed on random sections. J Microsc 1985; 138: 127-42.
12. Sørensen FB. Stereological estimation of the mean and variance of nuclear volume from vertical sections. J Microsc 1991; 162: 203-29.
13. Bichel P, Jakobsen A, Ørntoft TF. Histochemical distribution of CA-125 as a prognostic indicator in patients with serous ovarian cancer. Int J Gynecol Cancer 1991; 1: 199-204.
14. Nielsen K, Colstrup H, Nilsson T, Gundersen HJG. Stereological estimates of nuclear volume correlated with histopathological grading and prognosis of bladder tumor. Virchows Arch (Cell Pathol) 1986; 52: 41-54.
15. Sørensen FB. Objective histopathologic grading of cutaneous malignant melanomas by stereologic estimation of nuclear volume. Prediction of survival and disease-free period. Cancer 1989; 63: 1784-98.
16. Sørensen FB, Bichel P, Jakobsen A. DNA-level and stereologic estimates of nuclear volume in squamous cell carcinomas of the uterine cervix. A comparative study with analysis of prognostic impact. Cancer 1992; 69: 187-99.
17. Ladekarl M. Quantitative histopathology in ductal carcinoma of the breast. Prognostic value of mean nuclear size and mitotic count. Cancer 1995; 75: 2114-22.
18. Ladekarl M, Bæk-Hansen T, Henrik-Nielsen R, Mouritzen C, Henriques U, Sørensen FB. Objective malignancy grading of squamous cell carcinoma of the lung. Stereologic estimates of mean nuclear size are of prognostic value, independent of clinical stage of disease. Cancer 1995; 76: 797-802.
19. Mogensen O, Sørensen FB, Bichel P, Jakobsen A. Nuclear volume and prognosis in ovarian cancer. Int J Gynecol Cancer 1992; 2: 141-6.
20. Van der Putten HWHM, Baak JPA, Koenders TJM, Kurver PHJ, Stolk HG, Stolte LAM. Prognostic value of qualitative pathologic features and DNA content in individual patients with stage I endometrial adenocarcinoma. Cancer 1989; 63: 1378-87.
21. Sorbe B, Risberg B, Frankendal B. DNA ploidy, morphometry, and nuclear grade as prognostic factors in endometrial carcinoma. Gynecol Oncol 1990; 38: 22-7.
22. Nielsen AL, Nyholm HCJ. Stereologic estimate of nuclear volume in endometrial adenocarcinoma of endometrioid type: reproducibility and intra-tumor variation. Histopathology 1993; 22: 17-24.
23. Baak JPA. Further evaluation of the practical applicability of nuclear morphometry for the prediction of the outcome of atypical endometrial hyperplasia. Anal Quant Cyto Histol 1986; 8: 46-48.
24. Berchuck A, Soisson AP, Clarke-Pearson DL, et al. Immunohistochemical expression of CA 125 in endometrial adenocarcinoma: Correlation of antigen expression with metastatic potential. Cancer Res 1989; 49: 2091-95.