Activation of transcription factor NF-κB requiries ELKS, an IκB kinase regulatory subunit

Science

Volumn 304, Issue 5679, 2004, Pages 1963-1967

  Sigala, Jeanette L Ducut ^a   Bottero, Virginie ^a   Young, David B ^b   Shevchenko, Andrej ^c   Mercurio, Frank ^b   Verma, Inder M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b CELGENE CORPORATION   (United States)

^c MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; FLAMMABILITY; GENE TRANSFER; SIGNAL PROCESSING; TUMORS;

APOPTOSIS; NUCLEAR FACTOR; TRANSCRIPTION;

ACTIVATION ANALYSIS;

CYCLOOXYGENASE 2; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; REGULATOR PROTEIN; TRANSCRIPTION FACTOR ELK 1;

MEDICINE;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; DNA BINDING; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SILENCING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE; CYCLOOXYGENASE 2; GENE EXPRESSION; GENES, REPORTER; HELA CELLS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERLEUKIN-1; INTERLEUKIN-8; ISOENZYMES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NERVE TISSUE PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PRECIPITIN TESTS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; TUMOR NECROSIS FACTOR-ALPHA;

CERVUS ELAPHUS;

EID: 3042523535     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098387     Document Type: Article

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32. We thank M. Erni for the gift of the ELKSα cDNA; and C. Larson, N. Somia, V. Tergoankar, R. Correa, A. Yanai, S. Withoff, P. Sigala, T. Cathomen, O. Singer, N. Tonnu, and N. Droin for helpful discussions, technical advice, and critical reading of the manuscript. I.M.V. is an American Cancer Society Professor of Molecular Biology. He is supported in part by grants from the NIH, the Larry L Hillblom Foundation, Inc., the Lebensfeld Foundation, the Wayne and Gladys Valley Foundation, and the H. N. and Frances C. Berger Foundation. J.L.D.S. is supported by the NIH National Institute of General Medical Sciences Minority Access to Research Careers predoctoral fellowship. V.B. is supported by Institut National de la Santé et de la Recherche Médicale (INSERM) and the Philippe Foundation Fellowships.