Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake

Journal of Nucleic Acids

Volumn 2010, Issue , 2010, Pages

  Ames, Bruce N ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; DNA; OXIDIZING AGENT; THIOCTIC ACID; TRACE ELEMENT; VITAMIN B GROUP; VITAMIN K GROUP;

AGING; ALPHA TOCOPHEROL DEFICIENCY; ASCORBIC ACID DEFICIENCY; BINDING AFFINITY; CALCIUM DEFICIENCY; CANCER PREVENTION; COENZYME; DIETARY INTAKE; DNA DAMAGE; ENZYME BINDING; FOLIC ACID DEFICIENCY; FOOD INTAKE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; LONGEVITY; MAGNESIUM DEFICIENCY; MEMBRANE FLUIDITY; MITOCHONDRION; NICOTINIC ACID DEFICIENCY; NONHUMAN; NUTRITIONAL REQUIREMENT; NUTRITIONAL VALUE; PRIORITY JOURNAL; PYRIDOXINE DEFICIENCY; RAT; RETINOL DEFICIENCY; REVIEW; ZINC DEFICIENCY;

RATTUS;

EID: 78650652726     PISSN: 20900201     EISSN: 2090021X     Source Type: Journal    
DOI: 10.4061/2010/725071     Document Type: Review

References (144)

1. Shigenaga M. K., Hagen T. M., Ames B. N., Oxidative damage and mitochondrial decay in aging. Proceedings of the National Academy of Sciences of the United States of America 1994 91 23 10771 10778 2-s2.0-0027949202 10.1073/pnas.91.23.10771 (Pubitemid 24349567)
2. Beckman K. B., Ames B. N., Mitochondrial aging: open questions. Annals of the New York Academy of Sciences 1998 854 118 127 2-s2.0-0032413244 10.1111/j.1749-6632.1998.tb09897.x (Pubitemid 29025433)
3. Marnett L. J., Hurd H. K., Hollstein M. C., Levin D. E., Esterbauer H., Ames B. N., Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutation Research 1985 148 1-2 25 34 2-s2.0-0021963042 (Pubitemid 15151659)
4. Douki T., Ames B. N., An HPLC-EC assay for 1,N2-propano adducts of 2'-deoxyguanosine with 4- hydroxynonenal and other α β -unsaturated aldehydes. Chemical Research in Toxicology 1994 7 4 511 518 2-s2.0-0028100545 10.1021/tx00040a006 (Pubitemid 24232348)
5. Lezza A. M. S., Fallacara F. P., Pesce V., Leeuwenburgh C., Cantatore P., Gadaleta M. N., Localization of abasic sites and single-strand breaks in mitochondrial DNA from brain of aged rat, treated or not with caloric restriction diet. Neurochemical Research 2008 33 12 2609 2614 2-s2.0-56349087415 10.1007/s11064-008-9866-7
6. Hagen T. M., Liu J., Lykkesfeldt J., Wehr C. M., Ingersoll R. T., Vinarsky V., Bartholomew J. C., Ames B. N., Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences of the United States of America 2002 99 4 1870 1875 2-s2.0-0037133304 10.1073/pnas.261708898 (Pubitemid 34168981)
7. Hagen T. M., Moreau R., Suh J. H., Visioli F., Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Annals of the New York Academy of Sciences 2002 959 491 507 2-s2.0-0036240256 (Pubitemid 34460683)
8. Liu J., Head E., Gharib A. M., Yuan W., Ingersoll R. T., Hagen T. M., Cotman C. W., Ames B. N., Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R- α -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America 2002 99 4 2356 2361 2-s2.0-0037133283 10.1073/pnas.261709299 (Pubitemid 34169065)
9. Liu J., Killilea D. W., Ames B. N., Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R- α -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America 2002 99 4 1876 1881 2-s2.0-0037133319 10.1073/pnas.261709098 (Pubitemid 34168982)
10. Ames B. N., Liu J., Atamna H., Hagen T. M., Delaying the mitochondrial decay of aging in the brain. Clinical Neuroscience Research 2003 2 5-6 331 338 2-s2.0-21844440141 10.1016/S1566-2772(03)00010-0 (Pubitemid 41123047)
11. Manczak M., Jung Y., Park B. S., Partovi D., Reddy P. H., Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging. Journal of Neurochemistry 2005 92 3 494 504 2-s2.0-13244292394 10.1111/j.1471-4159.2004. 02884.x (Pubitemid 40189453)
12. Suh J. H., Heath S.-H., Hagen T. M., Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress. Free Radical Biology and Medicine 2003 35 9 1064 1072 2-s2.0-0142169325 10.1016/S0891-5849(03)00468-4 (Pubitemid 37315699)
13. Gadaleta M. N., Cormio A., Pesce V., Lezza A. M. S., Cantatore P., Aging and mitochondria. Biochimie 1998 80 10 863 870 2-s2.0-0032181128 10.1016/S0300-9084(00)88881-1
14. Gadaleta M. N., Petruzzella V., Renis M., Fracasso F., Cantatote P., Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. European Journal of Biochemistry 1990 187 3 501 506 2-s2.0-0025115244 (Pubitemid 20074912)
15. Hagen T. M., Ingersoll R. T., Wehr C. M., Lykkesfeldt J., Vinarsky V., Bartholomew J. C., Song M.-H., Ames B. N., Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proceedings of the National Academy of Sciences of the United States of America 1998 95 16 9562 9566 2-s2.0-0032482999 10.1073/pnas.95.16.9562 (Pubitemid 28506271)
16. Hagen T. M., Ingersoll R. T., Lykkesfeldt J., Liu J., Wehr C. M., Vinarsky V., Bartholomew J. C., Ames B. N., (R)- α -lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB Journal 1999 13 2 411 418 2-s2.0-0033042929 (Pubitemid 29072418)
17. Gatti R., de Palo C. B., Spinella P., de Palo E. F., Free carnitine and acetyl carnitine plasma levels and their relationship with body muscular mass in athletes. Amino Acids 1998 14 4 361 369 2-s2.0-0031828730 10.1007/BF01318855 (Pubitemid 28349826)
18. Suh J. H., Shenvi S. V., Dixon B. M., Liu H., Jaiswal A. K., Liu R.-M., Hagen T. M., Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proceedings of the National Academy of Sciences of the United States of America 2004 101 10 3381 3386 2-s2.0-1542723493 10.1073/pnas.0400282101 (Pubitemid 38338203)
19. Suh J. H., Wang H., Liu R.-M., Liu J., Hagen T. M., (R)- α -lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Archives of Biochemistry and Biophysics 2004 423 1 126 135 2-s2.0-1042290476 10.1016/j.abb.2003.12.020 (Pubitemid 38198222)
20. Smith A. R., Shenvi S. V., Widlansky M., Suh J. H., Hagen T. M., Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Current Medicinal Chemistry 2004 11 9 1135 1146 2-s2.0-2342544918 (Pubitemid 38585058)
21. Kwak M.-K., Wakabayashi N., Itoh K., Motohashi H., Yamamoto M., Kensler T. W., Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival. Journal of Biological Chemistry 2003 278 10 8135 8145 2-s2.0-0037424262 10.1074/jbc.M211898200 (Pubitemid 36800555)
22. Wakabayashi N., Dinkova-Kostova A. T., Holtzclaw W. D., Kang M.-I., Kobayashi A., Yamamoto M., Kensler T. W., Talalay P., Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proceedings of the National Academy of Sciences of the United States of America 2004 101 7 2040 2045 2-s2.0-1242296811 10.1073/pnas.0307301101 (Pubitemid 38229011)
23. Park S.-K., Kim K., Page G. P., Allison D. B., Weindruch R., Prolla T. A., Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell 2009 8 4 484 495 2-s2.0-67651183792 10.1111/j.1474-9726.2009.00496.x
24. Ames B. N., A theory of evolutionary allocation of scarce micronutrients by enzyme triage: adequate micronutrient nutrition to delay the degenerative diseases of aging. Proceedings of the National Academy of Sciences of the United States of America 2006 103 17589 17594 (Pubitemid 44852204)
25. Ames B. N., McCann J. C., Knasmüller S., DeMarini D., Johnson I., Gerhäuser C., Foreword: prevention of cancer, and the other degenerative diseases of aging, through nutrition. Chemoprevention of Cancer and DNA Damage by Dietary Factors 2009 Weinheim, Germany Wiley-VCH
26. Ames B. N., bames@chori.org Optimal micronutrients delay mitochondrial decay and age-associated diseases. Mechanisms of Ageing and Development 2010 131 7-8 473 479 10.1016/j.mad.2010.04.005
27. Kirkwood T. B. L., Understanding ageing from an evolutionary perspective. Journal of Internal Medicine 2008 263 2 117 127 2-s2.0-38349151564 10.1111/j.1365-2796.2007.01901.x
28. Eaton S. B., Konner M., Paleolithic nutrition. A consideration of its nature and current implications. New England Journal of Medicine 1985 312 5 283 289 2-s2.0-0021965878 (Pubitemid 15199367)
29. McCann J. C., Ames B. N., Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB Journal 2008 22 4 982 1001 2-s2.0-42049095896 10.1096/fj.07-9326rev (Pubitemid 351519955)
30. McCann J. C., Ames B. N., Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? American Journal of Clinical Nutrition 2009 90 4 889 907 2-s2.0-70349787472 10.3945/ajcn.2009.27930
31. Moshfegh A., Goldman J., Cleveland L., What We Eat in America, NHANES 2001-2002: Usual Nutrient Intakes from Food Compared to Dietary Reference Intakes. U.S. Department of Agriculture, Agricultural Research Service, 2005
32. Hung Y. J., Lee C. H., Chu N. F., Shieh Y. S., Plasma protein growth arrest-specific 6 levels are associated with altered glucose tolerance, inflammation, and endothelial dysfunction. Diabetes Care 2010 33 8 1840 1844
33. Rennenberg R. J., r.rennenberg@mumc.nl de Leeuw P. W., Kessels A. G. H., Schurgers L. J., Vermeer C., Van Engelshoven J. M.A., Kemerink G. J., Kroon A. A., Calcium scores and matrix Gla protein levels: association with vitamin K status. European Journal of Clinical Investigation 2010 40 4 344 349 2-s2.0-0034711505 10.1111/j.1365-2362.2010.02275.x
34. Rennenberg R. J., van Varik B. J., Schurgers L. J., Hamulyak K., Ten Cate H., Leiner T., Vermeer C., de Leeuw P. W., Kroon A. A., Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood 2010 115 24 5121 5123 2-s2.0-77954677816 10.1182/blood-2010-01- 264598
35. Tkatchenko T. V., Moreno-Rodriguez R. A., Conway S. J., Molkentin J. D., Markwald R. R., Tkatchenko A. V., atkatche@med.wayne.edu Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiological Genomics 2009 39 3 160 168 2-s2.0-11144357346 10.1152/ physiolgenomics.00078.2009
36. Zhang Y., Wen G., Shao G., Wang C., Lin C., Fang H., Balajee A. S., Bhagat G., Hei T. K., Zhao Y., TGFBI deficiency predisposes mice to spontaneous tumor development. Cancer Research 2009 69 1 37 44 2-s2.0-58249113822 10.1158/0008-5472.CAN-08-1648
37. Nimptsch K., Rohrmann S., Nieters A., Linseisen J., Serum undercarboxylated osteocalcin as biomarker of vitamin K intake and risk of prostate cancer: a nested case-control study in the Heidelberg cohort of the European prospective investigation into cancer and nutrition. Cancer Epidemiology Biomarkers and Prevention 2009 18 1 49 56 2-s2.0-58349116248 10.1158/1055-9965.EPI-08-0554
38. Courtemanche C., Huang A. C., Elson-Schwab I., Kerry N., Ng B. Y., Ames B. N., Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB Journal 2004 18 1 209 211 2-s2.0-1342332163
39. Atamna H., Newberry J., Erlitzki R., Schultz C. S., Ames B. N., Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. Journal of Nutrition 2007 137 1 25 30 2-s2.0-33845999254 (Pubitemid 46052854)
40. Walter P. B., Knutson M. D., Paler-Martinez A., Lee S., Xu Y., Viteri F. E., Ames B. N., Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proceedings of the National Academy of Sciences of the United States of America 2002 99 4 2264 2269 2-s2.0-0037133219 10.1073/pnas.261708798 (Pubitemid 34169049)
41. Killilea D. W., Ames B. N., Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America 2008 105 15 5768 5773 2-s2.0-44449167577 10.1073/pnas.0712401105 (Pubitemid 351758447)
42. Ho E., Ames B. N., Low intracellular zinc induces oxidative DNA damage, disrupts p53, NF κ B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proceedings of the National Academy of Sciences of the United States of America 2002 99 26 16770 16775 2-s2.0-0037168653 10.1073/pnas. 222679399 (Pubitemid 36034048)
43. MacGregor J. T., Schlegel R., Wehr C. M., Alperin P., Ames B. N., Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine. Proceedings of the National Academy of Sciences of the United States of America 1990 87 24 9962 9965 2-s2.0-0025650365 10.1073/pnas.87.24.9962 (Pubitemid 120016564)
44. Knock E., Deng L., Wu Q., Lawrance A. K., Wang X.-L., Rozen R., Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate. Journal of Nutrition 2008 138 4 653 658 2-s2.0-41549112569 (Pubitemid 351469405)
45. Courtemanche C., Elson-Schwab I., Mashiyama S. T., Kerry N., Ames B. N., Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. Journal of Immunology 2004 173 5 3186 3192 2-s2.0-4344621459 (Pubitemid 39142025)
46. Mashiyama S. T., Hansen C. M., Roitman E., Sarmiento S., Leklem J. E., Shultz T. D., Ames B. N., An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency. Analytical Biochemistry 2008 372 1 21 31 2-s2.0-36049028766 10.1016/j.ab.2007.08.034 (Pubitemid 350088666)
47. Blount B. C., Mack M. M., Wehr C. M., Macgregor J. T., Hiatt R. A., Wang G., Wickramasinghe S. N., Everson R. B., Ames B. N., Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proceedings of the National Academy of Sciences of the United States of America 1997 94 7 3290 3295 2-s2.0-0030979178
48. Fenech M., The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis 2005 20 4 255 269 2-s2.0-24044508252 10.1093/mutage/gei040 (Pubitemid 41399465)
49. Leopardi P., Marcon F., Caiola S., Cafolla A., Siniscalchi E., Zijno A., Crebelli R., Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes. Mutagenesis 2006 21 5 327 333 2-s2.0-33749594285 10.1093/mutage/gel031 (Pubitemid 44546416)
50. Ni J., Lu L., Fenech M., michael.fenech@csiro.au Wang X., wangxu@fudan.edu.cn Folate deficiency in human peripheral blood lymphocytes induces chromosome 8 aneuploidy but this effect is not modified by riboflavin. Environmental and Molecular Mutagenesis 2010 51 1 15 22 2-s2.0-75149124781 10.1002/em.20502
51. Duthie S. J., s.duthie@abdn.ac.uk Grant G., Pirie L. P., Watson A. J., Margison G. P., Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prevention Research 2010 3 1 92 100 2-s2.0-0031903189 10.1158/1940-6207.CAPR-09-0231
52. Everson R. B., Wehr C. M., Erexson G. L., MacGregor J. T., Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes. Journal of the National Cancer Institute 1988 80 7 525 529 2-s2.0-0023952518
53. MacGregor J. T., Wehr C. M., Hiatt R. A., Peters B., Tucker J. D., Langlois R. G., Jacob R. A., Jensen R. H., Yager J. W., Shigenaga M. K., Frei B., Eynon B. P., Ames B. N., 'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status. Mutation Research 1997 377 1 125 135 2-s2.0-0030942667 10.1016/S0027-5107(97)00070-5 (Pubitemid 27266006)
54. Murgia E., Ballardin M., Bonassi S., Rossi A. M., Barale R., Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case-control study. Mutation Research 2008 639 1-2 27 34 2-s2.0-39249083917 10.1016/j.mrfmmm.2007.10.010
55. Fenech M. F., Dreosti I. E., Rinaldi J. R., Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 1997 18 7 1329 1336 2-s2.0-0031410993 10.1093/carcin/18.7.1329 (Pubitemid 28134705)
56. Fenech M. F., michael.fenech@csiro.au Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and a road map to the future. American Journal of Clinical Nutrition 2010 91 5 1438S 1454S 2-s2.0-77951956736 10.3945/ajcn.2010.28674D
57. Ames B. N., Wakimoto P., Are vitamin and mineral deficiencies a major cancer risk? Nature Reviews Cancer 2002 2 9 694 704 2-s2.0-0036719572 10.1038/nrc886 (Pubitemid 37328920)
58. Levine A. J., ajoanlev@usc.edu Figueiredo J. C., Lee W., Conti D. V., Kennedy K., Duggan D. J., Poynter J. N., Campbell P. T., Newcomb P., Martinez M. E., Hopper J. L., Le Marchand L., Baron J. A., Limburg P. J., Ulrich C. M., Haile R. W., A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiology Biomarkers and Prevention 2010 19 7 1812 1821 2-s2.0-27744531050 10.1158/1055-9965.EPI-10-0151
59. Ford E. S., Race, education, and dietary cations: findings from the third national health and nutrition examination survey. Ethnicity and Disease 1998 8 1 10 20 2-s2.0-0032337572 (Pubitemid 128598068)
60. Fox C. H., Mahoney M. C., Ramsoomair D., Carter C. A., Magnesium deficiency in African-Americans: does it contribute to increased cardiovascular risk factors? Journal of the National Medical Association 2003 95 4 257 262 2-s2.0-0038010734 (Pubitemid 37099535)
61. Data Tables: Food and Nutrient Intakes by Income, 1994-1996. U.S. Department of Agriculture, Agricultural Research Services, 1999, http://www.ars.usda.gov/ba/bhnrc/ndl
62. Vaquero M. P., Magnesium and trace elements in the elderly: intake, status and recommendations. Journal of Nutrition, Health and Aging 2002 6 2 147 153 2-s2.0-0036241730 (Pubitemid 34415243)
63. Wakimoto P., Block G., Dietary intake, dietary patterns, and changes with age: an epidemiological perspective. Journals of Gerontology A 2001 56 2 65 80 2-s2.0-0035179428 (Pubitemid 33095240)
64. Hartwig A., Role of magnesium in genomic stability. Mutation Research 2001 475 1-2 113 121 2-s2.0-0035906322 10.1016/S0027-5107(01)00074-4 (Pubitemid 32280806)
65. Blondell J. M., The anticarcinogenic effect of magnesium. Medical Hypotheses 1980 6 8 863 871 2-s2.0-0019312118 (Pubitemid 10007858)
66. Folsom A. R., Hong C.-P., Magnesium intake and reduced risk of colon cancer in a prospective study of women. American Journal of Epidemiology 2006 163 3 232 235 2-s2.0-31344469275 10.1093/aje/kwj037 (Pubitemid 43145750)
67. He K., Liu K., Daviglus M. L., Morris S. J., Loria C. M., Van Horn L., Jacobs D. R. Jr., Savage P. J., Magnesium intake and incidence of metabolic syndrome among young adults. Circulation 2006 113 13 1675 1682 2-s2.0-33645783203 10.1161/CIRCULATIONAHA.105.588327
68. Larsson S. C., Bergkvist L., Wolk A., Magnesium intake in relation to risk of colorectal cancer in women. Journal of the American Medical Association 2005 293 1 86 89 2-s2.0-11244304492 10.1001/jama.293.1.86 (Pubitemid 40066703)
69. Leone N., Courbon D., Ducimetiere P., Zureik M., Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 2006 17 3 308 314 2-s2.0-33646794393 10.1097/01.ede.0000209454. 41466.b7
70. Institute of Medicine, Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board 1997 Washington, DC, USA National Academy of Sciences, National Academy Press
71. van Dam R. M., Hu F. B., Rosenberg L., Krishnan S., Palmer J. R., Dietary calcium and magnesium, major food sources, and risk of type 2 diabetes in U.S. black women. Diabetes Care 2006 29 10 2238 2243 2-s2.0-33845187692 10.2337/dc06-1014 (Pubitemid 44899858)
72. Larsson S. C., Virtanen M. J., Mars M., Männistö S., Pietinen P., Albanes D., Virtamo J., Magnesium, calcium, potassium, and sodium intakes and risk of stroke in male smokers. Archives of Internal Medicine 2008 168 5 459 465 2-s2.0-41949137276 10.1001/archinte.168.5.459 (Pubitemid 351547209)
73. Bell L. T., Branstrator M., Roux C., Hurley L. S., Chromosomal abnormalities in maternal and fetal tissues of magnesium or zinc deficient rats. Teratology 1975 12 3 221 226 2-s2.0-0016596628
74. Blache D., Devaux S., Joubert O., Loreau N., Schneider M., Durand P., Prost M., Gaume V., Adrian M., Laurant P., Berthelot A., Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats. Free Radical Biology and Medicine 2006 41 2 277 284 2-s2.0-33745467478 10.1016/j.freeradbiomed.2006.04. 008 (Pubitemid 43949467)
75. Larsson S. C., susanna.larsson@ki.se Orsini N., Wolk A., Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. Journal of the American Medical Association 2010 303 11 1077 1083 2-s2.0-54049142559 10.1001/jama.2010.263
76. Johansson M., Relton C., Ueland P. M., Vollset S. E., Midttun O., Nygård O., Slimani N., Boffetta P., Jenab M., Clavel-Chapelon F., Boutron-Ruault M.-C., Fagherazzi G., Kaaks R., Rohrmann S., Boeing H., Weikert C., Bas Buenode-Mesquita H., Ros M. M., Van Gils C. H., Peeters P. H.M., Agudo A., Barricarte A., Navarro C., Rodríguez L., Sánchez M.-J., Larraaga N., Khaw K.-T., Wareham N., Allen N. E., Crowe F., Gallo V., Norat T., Krogh V., Masala G., Panico S., Sacerdote C., Tumino R., Trichopoulou A., Lagiou P., Trichopoulos D., Rasmuson T., Hallmans G., Riboli E., Vineis P., Brennan P., Brennan@iarc.fr Serum B vitamin levels and risk of lung cancer. Journal of the American Medical Association 2010 303 23 2377 2385 2-s2.0-8844262659 10.1001/jama.2010.808
77. Eussen S. J. P. M., Simone.Eussen@farm.uib.no Vollset S. E., Hustad S., Midttun O., Meyer K., Fredriksen Å., Ueland P. M., Jenab M., Slimani N., Ferrari P., Agudo A., Sala N., Capellá G., Del Giudice G., Palli D., Boeing H., Weikert C., Bueno-de-Mesquita H.B., Büchner F. L., Carneiro F., Berrino F., Vineis P., Tumino R., Panico S., Berglund G., Manjer J., Stenling R., Hallmans G., Martínez C., Arrizola L., Barricarte A., Navarro C., Rodriguez L., Bingham S., Linseisen J., Kaaks R., Overvad K., Tjonneland A., Peeters P. H.M., Numans M. E., Clavel-Chapelon F., Boutron-Ruault M.-C., Morois S., Trichopoulou A., Lund E., Plebani M., Riboli E., González C. A., Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers and Prevention 2010 19 1 28 38 2-s2.0-74549222230 10.1158/1055-9965.EPI-08-1096
78. Matsubara K., Komatsu S.-I., Oka T., Kato N., Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis. Journal of Nutritional Biochemistry 2003 14 5 246 250 2-s2.0-0038722119 10.1016/S0955-2863(03)00009-3 (Pubitemid 36794261)
79. Morris M. S., Picciano M. F., Jacques P. F., Selhub J., Plasma pyridoxal 5′ -phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. American Journal of Clinical Nutrition 2008 87 5 1446 1454 2-s2.0-43549088562 (Pubitemid 351679789)
80. Hvas A.-M., Juul S., Bech P., Nexo E., Vitamin B6 level is associated with symptoms of depression. Psychotherapy and Psychosomatics 2004 73 6 340 343 2-s2.0-5644282569 10.1159/000080386 (Pubitemid 39370522)
81. Kelly P. J., Shih V. E., Kistler J. P., Barron M., Lee H., Mandell R., Furie K. L., Low vitamin B6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification. Stroke 2003 34 6 e51 e54 2-s2.0-0038680324
82. Smith D. F., MacGregor J. T., Hiatt R. A., Hooper N. K., Wehr C. M., Peters B., Goldman L. R., Yuan L. A., Smith P. A., Becker C. E., Micronucleated erythrocytes as an index of cytogenetic damages in humans: demographic and dietary factors associated with micronucleated erythrocytes in splenectomized subjects. Cancer Research 1990 50 16 5049 5054 2-s2.0-0024991341 (Pubitemid 20257934)
83. Holick M. F., Vitamin D: its role in cancer prevention and treatment. Progress in Biophysics and Molecular Biology 2006 92 1 49 59 2-s2.0-33744803244 10.1016/j.pbiomolbio.2006.02.014 (Pubitemid 43831958)
84. Ishihara J., Otani T., Inoue M., Iwasaki M., Sasazuki S., Tsugane S., Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. Journal of Nutrition 2007 137 7 1808 1814 2-s2.0-34447123755 (Pubitemid 47037711)
85. Grau M. V., Baron J. A., Sandler R. S., Wallace K., Haile R. W., Church T. R., Beck G. J., Summers R. W., Barry E. L., Cole B. F., Snover D. C., Rothstein R., Mandel J. S., Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial. Journal of the National Cancer Institute 2007 99 2 129 136 2-s2.0-33846975123 10.1093/jnci/djk016
86. Chavarro J. E., Stampfer M. J., Li H., Campos H., Kurth T., Ma J., A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiology Biomarkers and Prevention 2007 16 7 1364 1370 2-s2.0-34447515521 10.1158/1055-9965.EPI-06-1033 (Pubitemid 47076865)
87. Dai Q., Shrubsole M. J., Ness R. M., Schlundt D., Cai Q., Smalley W. E., Li M., Shyr Y., Zheng W., The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. American Journal of Clinical Nutrition 2007 86 3 743 751 2-s2.0-34548786712 (Pubitemid 47435843)
88. Franklin R. B., Costello L. C., Zinc as an anti-tumor agent in prostate cancer and in other cancers. Archives of Biochemistry and Biophysics 2007 463 2 211 217 2-s2.0-34250665634 10.1016/j.abb.2007.02.033 (Pubitemid 47030335)
89. Abnet C. C., Lai B., Qiao Y.-L., Vogt S., Luo X.-M., Taylor P. R., Dong Z.-W., Mark S. D., Dawsey S. M., Zinc concentration in esophageal biopsy specimens measured by X-ray fluorescence and esophageal cancer risk. Journal of the National Cancer Institute 2005 97 4 301 306 2-s2.0-13844314231 10.1093/jnci/dji042 (Pubitemid 40310278)
90. Fong L. Y. Y., Jiang Y., Farber J. L., Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. Carcinogenesis 2006 27 7 1489 1496 2-s2.0-33745592193 10.1093/carcin/ bgl012 (Pubitemid 43985422)
91. Jaiswal A. S., Narayan S., Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells. Journal of Cellular Biochemistry 2004 93 2 345 357 2-s2.0-12444336370 10.1002/jcb.20156 (Pubitemid 44264211)
92. Prasad A. S., Beck F. W. J., Doerr T. D., Shamsa F. H., Penny H. S., Marks S. C., Kaplan J., Kucuk O., Mathog R. H., Nutritional and zinc status of head and neck cancer patients: an interpretive review. Journal of the American College of Nutrition 1998 17 5 409 418 2-s2.0-0031695113 (Pubitemid 28445329)
93. Liaw K.-Y., Lee P.-H., Wu F.-C., Tsai J.-S., Lin-Shiau S.-Y., Zinc, copper, and superoxide dismutase in hepatocellular carcinoma. American Journal of Gastroenterology 1997 92 12 2260 2263 2-s2.0-0030777595
94. Fenech M., Aitken C., Rinaldi J., Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 1998 19 7 1163 1171 2-s2.0-0031903189 10.1093/carcin/19.7.1163 (Pubitemid 28375365)
95. Goh Y. I., Bollano E., Einarson T. R., Koren G., Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clinical Pharmacology and Therapeutics 2007 81 5 685 691 2-s2.0-34247268266 10.1038/sj.clpt.6100100 (Pubitemid 46625103)
96. Ribeiro M. L., Arari D. P., Squassoni A. C., Pedrazzoli J. Jr., Effects of multivitamin supplementation on DNA damage in lymphocytes from elderly volunteers. Mechanisms of Ageing and Development 2007 128 10 577 580 2-s2.0-34848889946 10.1016/j.mad.2007.08.002 (Pubitemid 47500172)
97. McCann J. C., Ames B. N., Packer L., Sies H., Eggersdorfer M., Cadenas E., Evidence required for causal inferences about effects of micronutrient deficiencies during development on brain health - DHA, choline, iron, and vitamin D. Micronutrients and Brain Health 2009 chapter 30 London, UK CRC Press
98. Ames B. N., bames@chori.org McCann J. C., Stampfer M. J., Willett W. C., Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough. American Journal of Clinical Nutrition 2007 86 2 522 524 2-s2.0-33747400934
99. Ames B. N., Increasing longevity by tuning up metabolism. EMBO Reports 2005 6 1 S20 S24 2-s2.0-24744472079 10.1038/sj.embor.7400426 (Pubitemid 44269463)
100. Ames B. N., Atamna H., Killilea D. W., Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Molecular Aspects of Medicine 2005 26 4-5 363 378 2-s2.0-24044536651 10.1016/j.mam.2005.07.007 (Pubitemid 41225359)
101. Richert D. A., Schulman M. P., Vitamin interrelationships in heme synthesis. American Journal of Clinical Nutrition 1959 7 416 425
102. Atamna H., Heme, iron, and the mitochondrial decay of ageing. Ageing Research Reviews 2004 3 3 303 318 2-s2.0-3042613609 10.1016/j.arr.2004.02.002 (Pubitemid 38844697)
103. Atamna H., Liu J., Ames B. N., Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: relevance to aging. Journal of Biological Chemistry 2001 276 51 48410 48416 2-s2.0-0035930604
104. World Health Organization, Iron Deficiency Anaemia: Assessment, Prevention, and Control. A Guide for Programme Managers 2001 Geneva, Switzerland World Health Organization
105. Nead K. G., Halterman J. S., Kaczorowski J. M., Auinger P., Weitzman M., Overweight children and adolescents: a risk group for iron deficiency. Pediatrics 2004 114 1 104 108 2-s2.0-3042800605 10.1542/peds.114.1.104 (Pubitemid 38857573)
106. McCann J. C., Ames B. N., DHA and cognitive development. Pediatric Basics 2007 117 16 22
107. Beard J. L., Connor J. R., Iron status and neural functioning. Annual Review of Nutrition 2003 23 41 58 2-s2.0-0041534373 10.1146/annurev.nutr.23. 020102.075739 (Pubitemid 37059715)
108. Grantham-McGregor S., Ani C., A review of studies on the effect of iron deficiency on cognitive development in children. Journal of Nutrition 2001 131 2, supplement 2 649S 668S 2-s2.0-0033550899 (Pubitemid 32115343)
109. Hurtado E. K., Claussen A. H., Scott K. G., Early childhood anemia and mild or moderate mental retardation. American Journal of Clinical Nutrition 1999 69 1 115 119 2-s2.0-0032917501 (Pubitemid 29031260)
110. Lozoff B., Jimenez E., Hagen J., Mollen E., Wolf A. W., Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 2000 105 4, article E51
111. Atamna H., Killilea D. W., Killilea A. N., Ames B. N., Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proceedings of the National Academy of Sciences of the United States of America 2002 99 23 14807 14812 2-s2.0-0037069320 10.1073/pnas.192585799 (Pubitemid 35334565)
112. DeUngria M., Rao R., Wobken J. D., Luciana M., Nelson C. A., Georgieff M. K., Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain. Pediatric Research 2000 48 2 169 176 2-s2.0-0033944836 (Pubitemid 30497333)
113. Youdim M. B., Yehuda S., The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamine-opiate system. Cellular and Molecular Biology 2000 46 3 491 500
114. Failla M. L., Trace elements and host defense: recent advances and continuing challenges. Journal of Nutrition 2003 133 5 1443S 1447S 2-s2.0-0037656519 (Pubitemid 36548722)
115. Viteri F. E., Gonzalez H., Adverse outcomes of poor micronutrient status in childhood and adolescence. Nutrition Reviews 2002 60 5 S77 S83 2-s2.0-0036097422 (Pubitemid 34527143)
116. Dallman P. R., Biochemical basis for the manifestations of iron deficiency. Annual Review of Nutrition 1986 6 13 40 2-s2.0-0022464750
117. Chockalingam U. M., Murphy E., Ophoven J. C., Weisdorf S. A., Georgieff M. K., Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia. Journal of Pediatrics 1987 111 2 283 286 2-s2.0-0023198848 (Pubitemid 17127142)
118. Rao R., Georgieff M. K., Perinatal aspects of iron metabolism. Acta Paediatrica 2002 91 438 124 129 2-s2.0-0036432266 (Pubitemid 35347073)
119. Guiang S. F. III, Georgieff M. K., Lambert D. J., Schmidt R. L., Widness J. A., Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs. American Journal of Physiology 1997 273 6 R2124 R2131 2-s2.0-0031423574
120. Brutsaert T. D., Hernandez-Cordero S., Rivera J., Viola T., Hughes G., Haas J. D., Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. American Journal of Clinical Nutrition 2003 77 2 441 448 2-s2.0-0037304555 (Pubitemid 36133388)
121. Hercberg S., Estaquio C., Czernichow S., Mennen L., Noisette N., Bertrais S., Renversez J.-C., Brianon S., Favier A., Galan P., Iron status and risk of cancers in the SU.VI.MAX cohort. Journal of Nutrition 2005 135 11 2664 2668 2-s2.0-31544436011 (Pubitemid 43156611)
122. Pra D., Rech Franke S. I., Pegas Henriques J. A., Fenech M., A possible
123. Elmberg M., maria.elmberg@ks.se Hultcrantz R., Ekbom A., Brandt L., Olsson S., Olsson R., Lindgren S., Lööf L., Stal P., Wallerstedt S., Almer S., Sandberg-Gertzén H., Askling J., Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology 2003 125 6 1733 1741 2-s2.0-0036163634 10.1053/j.gastro.2003.09.035 (Pubitemid 37500438)
124. Killilea D. W., Atamna H., Liao C., Ames B. N., Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxidants and Redox Signaling 2003 5 5 507 516 2-s2.0-0142152329 (Pubitemid 37321344)
125. Seo A. Y., Xu J., Servais S., Hofer T., Marzetti E., Wohlgemuth S. E., Knutson M. D., Chung H. Y., Leeuwenburgh C., Mitochondrial iron accumulation with age and functional consequences. Aging Cell 2008 7 5 706 716 2-s2.0-52449121171 10.1111/j.1474-9726.2008.00418.x
126. Lal A., Atamna W., Killilea D. W., Suh J. H., Ames B. N., Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Report 2008 13 1 2 10 2-s2.0-41149131738 10.1179/135100008X259150 (Pubitemid 351524325)
127. Ho E., Courtemanche C., Ames B. N., Zinc deficiency induces oxidative DNA damage and increases P53 expression in human lung fibroblasts. Journal of Nutrition 2003 133 8 2543 2548 2-s2.0-0038720319 (Pubitemid 36935967)
128. Oteiza P. I., Clegg M. S., Zago M. P., Keen C. L., Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells. Free Radical Biology and Medicine 2000 28 7 1091 1099 2-s2.0-0034024644 10.1016/S0891-5849(00)00200-8 (Pubitemid 30314707)
129. Fong L. Y. Y., Zhang L., Jiang Y., Farber J. L., Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. Journal of the National Cancer Institute 2005 97 1 40 50 2-s2.0-12444283805 10.1093/jnci/dji006
130. Jaffe E. K., The porphobilinogen synthase catalyzed reaction mechanism. Bioorganic Chemistry 2004 32 5 316 325 2-s2.0-4644261553 10.1016/j.bioorg.2004. 05.010 (Pubitemid 39277439)
131. Mock D. M., Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus. Journal of Nutritional Biochemistry 2005 16 7 435 437 2-s2.0-21344433635 10.1016/j.jnutbio.2005.03.022 (Pubitemid 40909828)
132. Mock D. M., Biotin. Present Knowledge in Nutrition 1996 7th Washington, DC, USA ILSI Press
133. Stratton S. L., Bogusiewicz A., Mock M. M., Mock N. I., Wells A. M., Mock D. M., Lymphocyte propionyl-CoA carboxylase and its activation by biotin are sensitive indicators of marginal biotin deficiency in humans. American Journal of Clinical Nutrition 2006 84 2 384 388 2-s2.0-33748431257 (Pubitemid 44699149)
134. Waters D. J., Shen S., Glickman L. T., Cooley D. M., Bostwick D. G., Qian J., Combs G. F. Jr., Morris J. S., Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine model. Carcinogenesis 2005 26 7 1256 1262 2-s2.0-22844448894 10.1093/carcin/bgi077 (Pubitemid 41417903)
135. Wu J., Lyons G. H., Graham R. D., Fenech M. F., The effect of selenium, as selenomethionine, on genome stability and cytotoxicity in human lymphocytes measured using the cytokinesis-block micronucleus cytome assay. Mutagenesis 2009 24 3 225 232 2-s2.0-66749139731 10.1093/mutage/gen074
136. Ebbing M., marta.ebbing@helse-bergen.no Bonaa K. H., Nygård O., Arnesen E., Ueland P. M., Nordrehaug J. E., Rasmussen K., Njolstad I., Refsum H., Nilsen D. W., Tverdal A., Meyer K., Vollset S. E., Cancer incidence and mortality after treatment with folic acid and vitamin B12. Journal of the American Medical Association 2009 302 19 2119 2126 2-s2.0-33751161888 10.1001/jama.2009.1622
137. Ulrich C. M., Potter J. D., Folate and cancer - timing is everything. Journal of the American Medical Association 2007 297 21 2408 2409 2-s2.0-34249996794 10.1001/jama.297.21.2408 (Pubitemid 46883754)
138. Ma C., Rong Y., Radiloff D. R., Datto M. B., Centeno B., Bao S., Cheng A. W.M., Lin F., Jiang S., Yeatman T. J., Wang X.-F., wang0011@mc.duke.edu Extracellular matrix protein β ig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes and Development 2008 22 3 308 321 2-s2.0-38949174649 10.1101/gad.1632008 (Pubitemid 351214273)
139. Ames B. N., Elson-Schwab I., Silver E. A., High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms. American Journal of Clinical Nutrition 2002 75 4 616 658 2-s2.0-0036199911 (Pubitemid 34250676)
140. Ames B. N., Suh J. H., Liu J., Rodriguez J. K. R., Enzymes lose binding affinity (increase Km) for coenzymes and substrates with age: a strategy for remediation. Nutrigenomics: Discovering the Path to Personalized Nutrition 2006 Hoboken, NJ, USA John Wiley & Sons 277 293
141. Institute of Medicine, Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board 1998 Washington, DC, USA National Academy of Sciences, National Academy Press
142. Feuers R. J., The effects of dietary restriction on mitochondrial dysfunction in aging. Annals of the New York Academy of Sciences 1998 854 192 201 2-s2.0-0032423013 10.1111/j.1749-6632.1998.tb09902.x (Pubitemid 29022802)
143. Moghaddas S., Hoppel C. L., Lesnefsky E. J., Aging defect at the QO site of complex III augments oxyradical production in rat heart interfibrillar mitochondria. Archives of Biochemistry and Biophysics 2003 414 1 59 66 2-s2.0-0038367809 10.1016/S0003-9861(03)00166-8 (Pubitemid 36555445)
144. Long J., Gao F., Tong L., Cotman C. W., Ames B. N., Liu J., Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochemical Research 2009 34 4 755 763 2-s2.0-62349088898 10.1007/s11064-008-9850-2