메뉴 건너뛰기




Volumn 51, Issue 1, 2010, Pages 15-22

Folate deficiency in human peripheral blood lymphocytes induces chromosome 8 aneuploidy but this effect is not modified by riboflavin

Author keywords

Aneuploidy; Fluorescence in situ hybridization; Folic acid; Riboflavin

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; RIBOFLAVIN;

EID: 75149124781     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20502     Document Type: Article
Times cited : (19)

References (39)
  • 1
    • 25844516380 scopus 로고    scopus 로고
    • Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei
    • Beetstra S, Thomas P, Salisbury C, Turner J, Fenech M. 2005. Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei. Mutat Res 578:317-326.
    • (2005) Mutat Res , vol.578 , pp. 317-326
    • Beetstra, S.1    Thomas, P.2    Salisbury, C.3    Turner, J.4    Fenech, M.5
  • 2
    • 50549086678 scopus 로고    scopus 로고
    • Uracil in DNA: Consequences for carcinogenesis and chemotherapy
    • Berger SH, Pittman DL, Wyatt MD. 2008. Uracil in DNA: Consequences for carcinogenesis and chemotherapy. Biochem Pharmacol 76:697-706.
    • (2008) Biochem Pharmacol , vol.76 , pp. 697-706
    • Berger, S.H.1    Pittman, D.L.2    Wyatt, M.D.3
  • 3
    • 0037293278 scopus 로고    scopus 로고
    • Abnormal chromosome 8 copy number in cytological smears from breast carcinomas detected by means of fluorescence in situ hybridization (FISH)
    • Bofin AM, Ytterhus B, Fjøsne HE, Hagmar BM. 2003. Abnormal chromosome 8 copy number in cytological smears from breast carcinomas detected by means of fluorescence in situ hybridization (FISH). Cytopathology 14:5-11.
    • (2003) Cytopathology , vol.14 , pp. 5-11
    • Bofin, A.M.1    Ytterhus, B.2    Fjøsne, H.E.3    Hagmar, B.M.4
  • 7
    • 0026551790 scopus 로고
    • Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction
    • Dunham I, Lengauer C, Cremer T, Featherstone T. 1992. Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction. Hum Genet 88:457-462.
    • (1992) Hum Genet , vol.88 , pp. 457-462
    • Dunham, I.1    Lengauer, C.2    Cremer, T.3    Featherstone, T.4
  • 8
    • 34547884338 scopus 로고    scopus 로고
    • High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort
    • Ericson U, Sonestedt E, Gullberg B, Olsson H, Wirfält E. 2007. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort. Am J Clin Nutr 86:271-273.
    • (2007) Am J Clin Nutr , vol.86 , pp. 271-273
    • Ericson, U.1    Sonestedt, E.2    Gullberg, B.3    Olsson, H.4    Wirfält, E.5
  • 9
    • 0022842769 scopus 로고
    • Role of vitamin B12 and folate deficiencies in carcinogenesis
    • Eto I, Krumdieck CL. 1986. Role of vitamin B12 and folate deficiencies in carcinogenesis. Adv Exp Med Biol 206:313-330.
    • (1986) Adv Exp Med Biol , vol.206 , pp. 313-330
    • Eto, I.1    Krumdieck, C.L.2
  • 10
    • 0035906327 scopus 로고    scopus 로고
    • The role of folic acid and vitamin B12 in genomic stability of human cells
    • Fenech M. 2001. The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res 475:56-67.
    • (2001) Mutat Res , vol.475 , pp. 56-67
    • Fenech, M.1
  • 11
    • 0037112246 scopus 로고    scopus 로고
    • Chromosomal biomarkers of genomic instability relevant to cancer
    • Fenech M. 2002a. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov Today 22:1128-1137.
    • (2002) Drug Discov Today , vol.22 , pp. 1128-1137
    • Fenech, M.1
  • 12
    • 0036286297 scopus 로고    scopus 로고
    • Micronutrients and genomic stability: A new paradigm for recommended dietary allowances (RDAs)
    • Fenech M. 2002b. Micronutrients and genomic stability: A new paradigm for recommended dietary allowances (RDAs). Food Chem Toxicol 40:1113-1117.
    • (2002) Food Chem Toxicol , vol.40 , pp. 1113-1117
    • Fenech, M.1
  • 13
    • 19844378446 scopus 로고    scopus 로고
    • Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, β-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability - results from a dietary intake and micronucleus index survey in South Australia
    • Fenech M, Baghurst P, Luderer W, Turner J, Record S, Ceppi M, Bonassi S. 2005. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, β-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability - results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 26:991-999.
    • (2005) Carcinogenesis , vol.26 , pp. 991-999
    • Fenech, M.1    Baghurst, P.2    Luderer, W.3    Turner, J.4    Record, S.5    Ceppi, M.6    Bonassi, S.7
  • 14
    • 0028242563 scopus 로고
    • Exclusion of specific human chromosomes into micronuclei by 5-azacytidine treatment of lymphocyte cultures
    • Guttenbach M, Schmid M. 1994. Exclusion of specific human chromosomes into micronuclei by 5-azacytidine treatment of lymphocyte cultures. Exp Cell Res 211:127-132.
    • (1994) Exp Cell Res , vol.211 , pp. 127-132
    • Guttenbach, M.1    Schmid, M.2
  • 15
    • 0033002901 scopus 로고    scopus 로고
    • Trisomy 8 in stage I and stage III ovarian cancer detected by fluorescence in situ hybridization
    • Hon-Fong LM, Alaa MA, Bruce AW, Das S, Mark S, Sanmy M. 1999. Trisomy 8 in stage I and stage III ovarian cancer detected by fluorescence in situ hybridization. Exp Mol Pathol 66:76-81.
    • (1999) Exp Mol Pathol , vol.66 , pp. 76-81
    • Hon-Fong, L.M.1    Alaa, M.A.2    Bruce, A.W.3    Das, S.4    Mark, S.5    Sanmy, M.6
  • 16
    • 0033869703 scopus 로고    scopus 로고
    • Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
    • Hustad S, Ueland PM, Vollset SE, Zhang Y, Bjørke-Monsen AL, Schneede J. 2000. Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem 46:1065-1071.
    • (2000) Clin Chem , vol.46 , pp. 1065-1071
    • Hustad, S.1    Ueland, P.M.2    Vollset, S.E.3    Zhang, Y.4    Bjørke-Monsen, A.L.5    Schneede, J.6
  • 17
    • 0032845227 scopus 로고    scopus 로고
    • Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
    • James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB. 1999. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 70:495-501.
    • (1999) Am J Clin Nutr , vol.70 , pp. 495-501
    • James, S.J.1    Pogribna, M.2    Pogribny, I.P.3    Melnyk, S.4    Hine, R.J.5    Gibson, J.B.6
  • 18
    • 75149128961 scopus 로고    scopus 로고
    • Primary study on the association between MTHFR genotype polymorphism and breast cancer susceptibility in human population from Yunnan. Cancer Res
    • Kan X, Zou T, Wu X, Wang X. 2007. Primary study on the association between MTHFR genotype polymorphism and breast cancer susceptibility in human population from Yunnan. Cancer Res Prev Treat 34:716-718.
    • (2007) Prev Treat , vol.34 , pp. 716-718
    • Kan, X.1    Zou, T.2    Wu, X.3    Wang, X.4
  • 19
    • 2942574352 scopus 로고    scopus 로고
    • Folate and DNA methylation: A mechanistic link between folate deficiency and colorectal cancer?
    • Kim YI. 2004. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev 13:511-519.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 511-519
    • Kim, Y.I.1
  • 20
    • 0346726185 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes
    • Kimura M, Umegaki K, Higuchi M, Thomas P, Fenech M. 2004. Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes. J Nutr 134:1-9.
    • (2004) J Nutr , vol.134 , pp. 1-9
    • Kimura, M.1    Umegaki, K.2    Higuchi, M.3    Thomas, P.4    Fenech, M.5
  • 21
    • 33847749516 scopus 로고    scopus 로고
    • Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes
    • Lindberg HK, Wang X, Järventaus H, Falck GC, Norppa H, Fenech M. 2007. Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes. Mutat Res 617:33-45.
    • (2007) Mutat Res , vol.617 , pp. 33-45
    • Lindberg, H.K.1    Wang, X.2    Järventaus, H.3    Falck, G.C.4    Norppa, H.5    Fenech, M.6
  • 22
    • 0036076711 scopus 로고    scopus 로고
    • Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements
    • McNulty H, McKinley MC, Wilson B, McPartlin J, Strain JJ, Weir DG, Scott JM. 2002. Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements. Am J Clin Nutr 76:436-441.
    • (2002) Am J Clin Nutr , vol.76 , pp. 436-441
    • McNulty, H.1    McKinley, M.C.2    Wilson, B.3    McPartlin, J.4    Strain, J.J.5    Weir, D.G.6    Scott, J.M.7
  • 23
    • 0037305374 scopus 로고    scopus 로고
    • Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype
    • Moat SJ, Ashfield-Watt PA, Powers HJ, Newcombe RG, McDowell IF. 2003. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin Chem 49:295-302.
    • (2003) Clin Chem , vol.49 , pp. 295-302
    • Moat, S.J.1    Ashfield-Watt, P.A.2    Powers, H.J.3    Newcombe, R.G.4    McDowell, I.F.5
  • 24
    • 33846853947 scopus 로고    scopus 로고
    • Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes
    • Paulsson K, Johansson B. 2007. Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes. Pathol Biol (Paris) 55:37-48.
    • (2007) Pathol Biol (Paris) , vol.55 , pp. 37-48
    • Paulsson, K.1    Johansson, B.2
  • 26
    • 0030466741 scopus 로고    scopus 로고
    • Fluorescence in situ hybridisation with chromosome-specific centromeric probes: A sensitive method to detect aneuploidy
    • Richard R, Marshall A, Murphy M, Kirkland DJ, Bentley KS. 1996. Fluorescence in situ hybridisation with chromosome-specific centromeric probes: A sensitive method to detect aneuploidy. Mutat Res 372:233-245.
    • (1996) Mutat Res , vol.372 , pp. 233-245
    • Richard, R.1    Marshall, A.2    Murphy, M.3    Kirkland, D.J.4    Bentley, K.S.5
  • 27
    • 0035306057 scopus 로고    scopus 로고
    • Aberration of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping
    • Rummukainen J, Kytola S, Karhu R, Farnebo F, Larsson C, Isola JJ. 2001. Aberration of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping. Cancer Genet Cytogenet 126:1-7.
    • (2001) Cancer Genet Cytogenet , vol.126 , pp. 1-7
    • Rummukainen, J.1    Kytola, S.2    Karhu, R.3    Farnebo, F.4    Larsson, C.5    Isola, J.J.6
  • 28
  • 30
    • 0036183416 scopus 로고    scopus 로고
    • Aneusomy 17 in breast cancer: Its role in HER-2/neu protein expression and implication for clinical assessment of HER-2/neu status
    • Wang S, Hossein Saboorian M, Frenkel EP, Haley BB, Siddiqui MT, Gokaslan S, Hynan L, Ashfaq R. 2002. Aneusomy 17 in breast cancer: its role in HER-2/neu protein expression and implication for clinical assessment of HER-2/neu status. Mod Pathol 15:137-145.
    • (2002) Mod Pathol , vol.15 , pp. 137-145
    • Wang, S.1    Hossein Saboorian, M.2    Frenkel, E.P.3    Haley, B.B.4    Siddiqui, M.T.5    Gokaslan, S.6    Hynan, L.7    Ashfaq, R.8
  • 31
    • 0037238069 scopus 로고    scopus 로고
    • A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro
    • Wang X, Fenech M. 2003. A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro. Mutagenesis 18:81-86.
    • (2003) Mutagenesis , vol.18 , pp. 81-86
    • Wang, X.1    Fenech, M.2
  • 32
    • 3042591660 scopus 로고    scopus 로고
    • Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosome 17 and 21
    • Wang X, Thomas P, Xue J, Fenech M. 2004. Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosome 17 and 21. Mutat Res 551:167-180.
    • (2004) Mutat Res , vol.551 , pp. 167-180
    • Wang, X.1    Thomas, P.2    Xue, J.3    Fenech, M.4
  • 33
    • 33344465648 scopus 로고    scopus 로고
    • A comparison of folic acid deficiency-induced genomic instability in lymphocytes of breast cancer patients and normal non-cancer controls from a Chinese population in Yunnan
    • Wang X, Wu X, Liang Z, Huang Y, Fenech M, Xue J. 2006. A comparison of folic acid deficiency-induced genomic instability in lymphocytes of breast cancer patients and normal non-cancer controls from a Chinese population in Yunnan. Mutagenesis 21:41-47.
    • (2006) Mutagenesis , vol.21 , pp. 41-47
    • Wang, X.1    Wu, X.2    Liang, Z.3    Huang, Y.4    Fenech, M.5    Xue, J.6
  • 34
    • 75149192144 scopus 로고    scopus 로고
    • Impacts of folic acid, riboflavin deficiency and MTHFR A1298C polymorphism on human lymphocytes genomic stability
    • Wang X, Wu X, Zou T. 2006. Impacts of folic acid, riboflavin deficiency and MTHFR A1298C polymorphism on human lymphocytes genomic stability. Carcinog Teratog Mutagen 19:259-262.
    • (2006) Carcinog Teratog Mutagen , vol.19 , pp. 259-262
    • Wang, X.1    Wu, X.2    Zou, T.3
  • 35
    • 75149180851 scopus 로고    scopus 로고
    • The impacts of folic acid, riboflavin and MTHER C677T polymorphism on human lymphocytes genomic stability
    • Wang X, Xia X, Wu X. 2007. The impacts of folic acid, riboflavin and MTHER C677T polymorphism on human lymphocytes genomic stability. Acta Nutrimenta Sin 29:446-452.
    • (2007) Acta Nutrimenta Sin , vol.29 , pp. 446-452
    • Wang, X.1    Xia, X.2    Wu, X.3
  • 37
    • 75149123154 scopus 로고    scopus 로고
    • The preliminary study of the effect of riboflavin deficiency on genomic stability in human lymphoblast cell lines
    • Zhu J, Wang X, Wu X. 2006. The preliminary study of the effect of riboflavin deficiency on genomic stability in human lymphoblast cell lines. Acta Nutrimenta Sin 28:531-533.
    • (2006) Acta Nutrimenta Sin , vol.28 , pp. 531-533
    • Zhu, J.1    Wang, X.2    Wu, X.3
  • 38
    • 17644363913 scopus 로고    scopus 로고
    • Zhang L, Yang W, Hubbard AE, Smith MT. 2005. Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriol. Environ Mol Mutagen 45:388-396.
    • Zhang L, Yang W, Hubbard AE, Smith MT. 2005. Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriol. Environ Mol Mutagen 45:388-396.
  • 39
    • 0031416750 scopus 로고    scopus 로고
    • Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis
    • Zingg JM, Jones PA. 1997. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 18:869-882.
    • (1997) Carcinogenesis , vol.18 , pp. 869-882
    • Zingg, J.M.1    Jones, P.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.